CHAPTER 1

INTRODUCTION
Multi-drug resistant bacterias evolved nowadays while antibiotics becoming less
effective. New studies were looking for other antimicrobial agent exerting a broadspectrum activity against to many strains of bacterias these days.

Mucosal tissues of fishes contain peptides known for its antimicrobial properties.
These peptides act as the first line of mucosal host defense by utilizing its
antimicrobial activities against pathogenic microorganisms.