Síntesis de Artículo de Crick y Watson

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Sntesis de artculo de Crick y Watson

In that time (1953), the DNA structure wasnt discovered or demonstrated with
certainty, but there were showed three possible structures of the DNA.
One structure was suggested by Pauling and Corey, in their model of the DNA
structure, three chains are inter-twined, and in it, the phosphates are close to
the fibre axis, while the bases are on the outside. This model wasnt supported
because of a lot of reasons:
1. People believed that the diagram in X rays were given by the salt (salt
its very near to the phosphates), and according to this model, the salt
would be inside, then the salt could not give the diagram.
2. Without the hydrogen, theres no other kind of force that could keep the
structure united.
3. As the phospates are charged negatively, they would repel next to the
fibre.
Another structure suggested by Fraser, shows a model where the phosphates
are outside and the bases are inside, near to the fibre axis; but as this model
was too ambiguous, it was not supported.
A third structure shows a very different model, because this one has two helical
chains, and each one is coiled to the fibre axis. Being all these forms very
suggestive, it was said that each chain has different group of phosphates, also
that the chains were perpendicular regarding to the fibre axis. Those chains
were similar to the Furbergs Model, where phosphates were outside and the
bases where inside the helix. Regarding to the Frubergs configurations, it was
suggested that the sugar was perpendicular to the fibre axis, demonstrating
that the sugar is very near to the phosphates in the chains.
Another suggestion shows that there is a residue in a determined distance and
angle, in the chain, so the residue repeats.
If the structure had low water levels, the bases would probably tilt, so the DNA
could be more compact. Also, along with the past features, it is suggested that
each base is bond to another, more specifically, a purine base to a pyrimidine
base. Both bases are together because of the hydrogen-bond, and each pair of
bases has to have its bases in the same position.
Because of a kind of forms that are unknown to me, the suggested pairs would
be adenine with thymine, and guanine with cytosine, where the adenine and
guanine are purines and the thymine and cytosine are pyrimidines. Somehow,
it has been demonstrated that the ratio of the amounts of each pair, are very
close to DNA.
Saying all these, its still information very suggestive and ambiguous, since it
hasnt done enough experiments to show an accurate result, in this case, and
accurate model, so when scientists discover exact results, we could know more
about the real structure of the DNA.

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