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Pharmaceutics II. PCC 1019 Syllabus 2017
Pharmaceutics II. PCC 1019 Syllabus 2017
Bradenton Campus
Traditional Pathway
Pharmaceutics II W/lab (PCC1019 PH1 BP1)
Spring 2017
COURSE INFORMATION:
Credits:
4 Semester hours
Lectures:
Thursday: 10:00 to 10:50 AM (LH 211)
Friday: 10:30 AM to 12:20 PM (LH 212)
Enrichment Sessions:
Monday: 5:00 to 5:30 PM (LH 212)
Wednesday: 2:00 to 2:30 PM (LH 211)
Lab Recitation:
Wednesday: 12:00 noon to 12:50 PM (LH 211)
Laboratories: (All Labs will be in MP1)
Group I: Wednesday: 2:30 to 4:30 PM
Group II: Thursday: 1:30 to 3:30 PM
Group III: Friday: 8:00 10:00 AM
Group IV: Friday: 2:00 to 4:00 PM
CONTACT INFORMATION:
Instructor
Office
272
Phone
E-mail
Course Coordinator
941-782-5692
sjambhekar@lecom.edu
(preferred contact)
Office Hours
By Appointment
Course Instructors
Nina Pavuluri, Ph.D.
Associate Professor &
Assistant Dean
Ningning Yang, Ph.D.
Assistant Professor
121
941-782-5698
npavuluri@lecom.edu
By Appointment
281
941-782-5994
nyang@lecom.edu
By Appointment
COURSE DESCRIPTION:
This second course of the two course sequence is optimally designed for first year
pharmacy students to teach basic concepts and applications of physical-chemical properties of
therapeutics agents and their importance and utility in the development of safe and effective
pharmaceutical dosage forms. This course, therefore, will integrate important concepts from
pharmaceutics I to illustrate design and development of conventional drug delivery systems as
well as novel drug delivery systems used currently in pharmacy practice. Additionally, this
course will integrate physical chemical principles in the design, development, manufacture of
stable, safe, and effective dosage forms and finished drug products. Specific topics will focus on
the formulation of safe, effective, and stable liquid dosage forms like solution, disperse systems
like and suspension and emulsion, conventional solid dosage forms like powder, tablet and
capsule, semi-solid dosage forms like creams, ointments, lotions, gels, and suppository, and
novel drug delivery systems like modified release dosage forms, transdermal patches, and
aerosols.
This second course in this series provides students with a qualitative and quantitative
overview of drug disposition and the processes important to disposition, namely, absorption,
distribution, metabolism and excretion. Sterile dosage forms will also be introduced teaching the
organization and administration of an admixture program and admixture techniques. The proper
utilization of parenteral products, as well as parenteral drug compatibility literature is also
considered. Several laboratory sessions will be devoted to sterile dosage forms.
RATIONALE FOR COURSE:
The course seeks to illustrate the application of scientific principles of chemistry, physics,
and kinetics as they apply and relate to the design, preparation, physical chemical stability,
and In Vitro and In Vivo performance of various pharmaceutical dosage forms and drug
delivery systems. The lectures will serve to present the basic fundamentals of dosage forms
design and the principles utilized in the design, production, and the performance evaluation
of dosage forms. The laboratory series will serve to develop and strengthen the
understanding of the principles presented in the lectures as well communications skills that
will be necessary later in clinical experience as well as real professional world.
Additionally, the laboratory will provide opportunities to develop verbal communications
skills with group presentations of the results of weekly laboratory experiments.
EDUCATIONAL OUTCOMES:
Toward the development of the LECOM School of Pharmacy Curricular Outcomes, this
course will help students become the following:
Learners: Develop, integrate, and apply knowledge from the foundational sciences (i.e.,
pharmaceutical, social/behavioral/administrative, and clinical sciences) to evaluate the
scientific literature, explain drug action, solve therapeutic problems, and advance
population health and patient-centered care.
Caregivers: Provide patient-centered care as the medication expert (collect and interpret
evidence, prioritize, formulate assessments and recommendations, implement, monitor and
adjust plans, and document activities).
Promoters of health and wellness: Design prevention, intervention, and educational strategies
for individuals and communities to manage chronic disease and improve health and
wellness.
Problem Solvers: Identify problems; explore and prioritize potential strategies; design,
implement, and evaluate a viable solution.
Inter-professional collaborators: Actively participate and engage as a healthcare team
member by demonstrating mutual respect, understanding, and values to meet patient care
needs.
Communicators: Effectively communicate verbally and nonverbally when interacting with an
individual, group, or organization.
COURSE SPECIFIC OUTCOMES:
At the successful completion of this course, the students must be able to understand,
discuss, and apply all of the below in various pharmacy practice set ups.
1. Develop, integrate, and apply knowledge from the foundational sciences (i.e.,
pharmaceutical, social/behavioral/administrative, and clinical sciences) to evaluate the
scientific literature, explain drug action, solve therapeutic problems, and advance
population health and patient- centered care.
2.
Understand the nomenclature and role of excipients in common dosage forms and drug
delivery systems.
Understand the role of excipients in the formulation of drug dosage forms and how they
may affect the in vitro and in vivo performance of drug from the dosage form.
6.
7.
Describe the role of the pharmacist in impacting the safety and efficacy of each component
of a typical medication use system (i.e., procurement, storage, dispensing, and
administration).
Apply standards, guidelines, best practices, and established processes related to safe and
effective medication use.
Recognize any special packaging and storage requirements for a given dosage forms
10 Evaluate and determine the suitability of a container for a given drug dosage form based
upon the physical chemical properties and stability studies of drugs.
11 Select the appropriate drug delivery systems and the route of drug administration that will
provide optimum therapeutics benefit to an individual patient.
12 Assess and interpret the physical chemical stability data and determine the expiration date
for a dosage form
13. Determine the appropriate drug delivery system for a patient based upon individual patient
needs
14 Evaluate the suitability of an extemporaneously compounded prescription formulation for
the administration of a desired drug.
15 Determine if the product is packaged in compliance with legal requirements and bears no
signs of tampering
16 Recommend the storage conditions for a particular product to the patients.
REQUIRED/SUGGESTED TEXTBOOK(S) AND MATERIAL(S):
Suggested Textbook: Ansels Pharmaceutical Dosage Forms and Drug Delivery Systems
By Loyd V. Allen, Jr., Nicholas G. Popovich, and Howard C. Ansel
Eighth Edition; Lippincott Williams and Wilkins Publishing Company
(ISBN: 0 -7817- 4612- 4)
EXAMINATIONS:
All examinations will be administered in Lecture Hall 212 during the examination block (From
2:00 to 3:50 PM)
Examination I:
Examination II:
Examination III:
Final Examination:
Exam 1
Exam 2
Exam 3
Lab Grade
Final Exam
Total
20%
20%
20%
10%
30%
100%
There will be three examinations (20% each; total 60%) and the final examination (30%).
The remaining 10% of the grade is for the laboratory portion of the course. This will
include 1% for the kick off examination, 5% for the laboratory quizzes, and 4% for the
laboratory attendance and participation. The final examination will be comprehensive,
cumulative, and integrated. The overall passing grade is 70%. Of that 70%, the didactic
portion should represent minimum of 63%.
2.
The first few minutes of the laboratory recitation component will include
calculations/problems, prescriptions, and quizzes each week.
3.
Style and format of all examinations will include multiple choice questions, definitions,
true/false statements and calculations (when applicable) and profile questions (a general
profile illustrating relationship between two variables; dependent and independent).
4.
Since the nature of the course is a bit mathematical, as one would expect, there will be
calculation and profile type questions; nonetheless, all questions will require clear
conceptual understanding of equations (when applicable) and other material.
5.
Equations will not be provided for any examination. It is expected that students should
have clear conceptual understanding of all equations.
6.
It is the students responsibility to learn to overcome the phobia for managing equations
that employ simple mathematical principles (ratio; proportion, multiplication, and
fraction; and exponential equations like e-Kt, etc.)
7.
Laboratory series will be evaluated based on the students competency in the laboratory
exercises that include maintaining a clean laboratory, completing the necessary
calculations, labeling as well as following guidelines laid down by the course
coordinator.
Examination Reminders:
Students are required and permitted to bring the following items for each examination:
1. Personal computer with the examination downloaded prior to the examination time.
2. Texas Instruments TI-30X IIS 2-Line Scientific Calculator as specified in the Student
handbook.
3. Ruler: 6 or 12 inches
4. Pen, pencils, and eraser
5. Graph paper will be provided, if required
6. Examination Decorum: In accordance with LECOM School of Pharmacy Student
Handbook, students will be allowed to bring only the above mentioned items into the
examination room. Students must leave all personal items including bags, cell phones,
and other sophisticated electronic gadgets outside the lecture halls, in their vehicles or
lockers.
7. Online quizzes will be given using Jenzabar during the first 10 minutes of recitation
session. The students are expected to follow online examination decorum. During the
online quiz, students are expected to be present in the lecture hall and are strictly
not allowed to open any other browser window on his/her computer.
8. Students must follow pre-assigned seating for recitation sessions and exams.
9. Following the completion of your test and exiting the room, please go as far away as
possible from the lecture hall (Ideally, parking lot or students lounge) and discuss
your examination as loudly as you wish
Exam Review:
We will go over the important aspects of each examination in the classroom and/or during
review sessions once grading is completed and students had a chance to review their
examination. Any discrepancies (for example, error in addition or a question is marked
incorrectly) related to a particular examination must be resolved within a week after the students
have had a chance to review the examinations.
None of the examinations including the final will be given back to the students. However
a 45 minute time will be reserved for exam review after the course coordinator records the
grades. The students will be allowed to look at their examination during the exam review. They
will be able to look at a copy of their performance report on ExamSoft and will be informed of
their performance on each question. Students can schedule individual appointments with the
course coordinator and review their exam with the coordinator for discrepancies (if any).
Missing an Exam:
Attendance is mandatory (Refer to LECOM Student Handbook). Only students with legitimate
excuses, as defined in the Student Handbook, will be allowed to take the exam at a time/day other than
the time/day designated.
The make-up examination, in addition to being different, will include short essay type questions,
definition question, and K type question. Additionally, the numerical value questions of the makeup
examination will not be in a multiple choice format; instead, you will be asked to provide the numerical
value answer, for each question, in the space provided.
A = 90-100
B = 80-89
C = 70-79
F = Below 70
The coordinator has the discretion to decrease student final grades by a maximum of 5% to
reflect professionalism, diligence, and participation. Students are expected to be present and
on time for lectures, quizzes, and exams. Emails should be written professionally and
interactions with faculty, staff, and other students should be appropriate and respectful.
Final course grades will be given according to the LECOM School of Pharmacy Student
Handbook in the section titled Grading and Credit Hours.
SPECIFIC COURSE AND INSTRUCTOR POLICIES:
The LECOM School of Pharmacy Academic Catalog and Student Handbook provide a
detailed description of classroom policies. Particular emphasis is placed on the following:
Students are expected to be prepared prior to each class, including completion of assigned
readings and any other specific assignments.
Attendance and punctuality will be monitored and will be reflected in course grading.
Cell phones are to be turned off and kept stored during all class sessions and exams.
7
Topic
Introduction to various dosage forms
Suppository as a dosage form
Instructor
Dr. Jambhekar
Dr. Yang
Dr. Yang
Hours
1
4
4
February 16
February 17
February 17
through February
23
February 24
March 2 through
March 10
March 10 through
March 17
March 17 through
April 6
April 7 through 13
Dr. Yang
Dr. Yang
Dr. Jambhekar
Dr. Jambhekar
2
5
Dr. Jambhekar
Dr. Jambhekar
Dr. Pavuluri
April 14 through
21
April 21 May 4
May 5
Dr. Pavuluri
Dr. Pavuluri
Dr. Yang
4
2
All students are expected to read the syllabus, understand its implications, and abide by it. The
course coordinator has the right to make changes to the syllabus as needed.
For all topics not covered in this syllabus, please refer to the most recent version of the student
handbook.
All students are expected to read the syllabus, understand its implications, and abide by it.
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