TRICHOPHYTON RUBRUM

1. TAKSONOMI
- Domain : eukaryota
- Kingdom : Fungi
- Phylum : Ascomycota
- Class : Eurotiomycetes
- Order : Onygenales
- Family : Arthrodermactaceae
- Genus : Trichophyton
- Species : T.rubrum
- Synonim : T.fischeri, T.raubtschekii, T.kaneii

2. DESKRIPSI
- Penyebab dermatophytosis tersering
- Anthropophilic fungus
- Keratinophilic filamentous fungus

3. GENOME STRUCTURE
- Diketahui 5 kromosom

4. VARIANT
- Lokasi
o Africa&southern asia : Tinea corporis dan tinea capitis
o Global : tinea pedis, tinea cruris
- Kromosom
o T.megninii : portugal
o T.soudanese & T.gourvilli : subsahara africa
o T.raubitschekii : india, southeast asia, west Africa

5. COLONY STRUCTURE
- Typical : white-cream color pigemwnt with reverse side color (yellow-
brown-red wine)
- Tekstur : flat and slightly raised

6. CELL STRUCTURE
- Repro : aseksual with conidiospora (mikro dan makro)
- Hyphae : thin walled septae w/bacillus shaped/cigar shaped
7. METABOLISM
- Memiliki protease (keratinase) ingesti keratin untuk pertumbuhan
- Optimal pada pH asam

8. ECOLOGY
- Anthrophilic dermatophyte : hidup di tempat lembab atau tinggi keratin di
kulit manusia
- Bisa bertahan di bedding ataupun clothing

9. PATHOLOGY

sekresi
adhesi @
invasi keratin proteolitic
st.corneum
enzim

dermatoohyto degradasi
growth >>
sis infection kertain

10.CONFIRMATORY TEST
 - Kultur : SDA, Littman oksgali agar
- Urea test : -/+
- Microscopic test with KOH

MALASSEZIA FURFUR

1. TAKSONOMI
- Domain : eukaryota
- Kingdom : Fungi
- Division : Basidiomycota
- Subdivision : ustiaginomycotina
- Class : eksobasidiomycetes
- Order : Malasseziales
- Family : Malasseziacea
- Genus : Malasseziacea
- Species : M.furfur
- Synonim : pitysporum

2. DESKRIPSI
- 1.5-4.5m x 2-6 m
- Spherical (coccal)
- Bottle neck at one end
- Normal flora at human single cell individual (yeast)
- Pathogenic form filament form (spore)
- Lipophilic yeast butuh lemak dan minyak (35oC)
- Culture : cream-white color

3. STRUKTUR AND METABOLISM

- Coccal, (+) plasma membrane dengan laminar cell wall yang tebal (berisi
chitin)
 - Bottle neck shaped
- Butuh asam lemak dan sumber karbon
- Memproduksi
a. Tryptophan aminotransferase
L-triptophan indole pyruvat
b. B-glucosidase
Memecah selulosa glukosa
- Hyphae, induksi:
a. Cytokines induksi inflamasi
b. CHemokines direct cll movement
c. Adhesi molecule stick to epitel

4. PATOGENESIS
hidup normal
di kulit

konsumsi
natural oil and
fat (sebum
dan keringat)
>>
populasi
M.furfur
melebihi
normal

Piyriasis Dermatitis
vesicolor seborroik

indirubin &
indole
indolo melassazin pityriacirin AhR ligand Piyriarubins
(pityriarubins)
carbazole

prevent regulasi
impede interaksi mediator
maturation apoptosis UV absorbent
neutrophils dengan EGFR inflamasi
dendritic cells melanosit

skin lesion
protect fungus
mediator Hipopigemnet large plak,
from UV rash itching
inflamasi asi oily, dandruff,
radiation
hairloss

R.inflamasi

5. DIAGNOSIS