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ResearchersPublishFirstEverBreastCancerRiskModel
forHispanicWomen
ByAnneHarding December23,2016
NEWYORK(ReutersHealth)ThefirsteverbreastcancerriskmodelspecificallyforHispanicwomenwaspublishedon
December20,andwillsoonbeincorporatedintotheNationalCancerInstitute'sBreastCancerRiskAssessmentTool(BCRAT).

"Wehopethisnewtoolisnotonlymoreaccurateforthatpopulationbutthathealthcareproviderswouldusethistonotonly
estimatebutalsoinformtheirHispanicfemalepatientsabouttheirriskforbreastcancer,"Dr.MatthewBanegas,acancer
disparitiesresearcherattheCenterforHealthResearchatKaiserPermanenteNorthwestinPortland,Oregon,andthelead
authorofthenewstudy,toldReutersHealthbyphone.

Hispanicsaccountfornearly17%oftheUnitedStatespopulation,withabouttwothirdsbeingborninthiscountry,Dr.Banegas
andhisteamnoteintheirreport,publishedintheJournaloftheNationalCancerInstitute.Presently,theBCRATisaccurate
fornonHispanicwhites,AfricanAmericans,andAsianandPacificIslanderAmericans,theyadd,butunderestimatesrisksfor
Hispanicwomen.

TodevelopanativityspecificmodelforHispanicwomen(meaningwhetherornotawomanwasbornintheUSwouldbe
includedasariskfactor),theresearchersuseddatafromtheSanFranciscoBayAreaBreastCancerStudy,theCalifornia
CancerRegistryandtheNCI'sSurveillance,Epidemiology,andEndResultsprogram.

Theiranalysisincluded533U.S.bornand553foreignbornbreastcancerpatientsand464U.S.bornand947foreignborn
controls.

Otherriskfactorsusedinthemodelalongwithnativityincludedageatfirstfulltermpregnancy,biopsyforbenignbreast
disease,familyhistoryofbreastcancer,andageatmenarche(fortheforeignborngrouponly).

UsingWomen'sHealthInitiativedataon6,220postmenopausalHispanicwomen,theresearchersfoundtheirmodelwas
calibratedwellforU.S.bornHispanicwomen,withanobserved/expectedratioof1.07,butthemodelappearedto
overestimateriskforforeignbornHispanicwomen(O/Eratio,0.66).Theareaunderthecurvewas0.564forwomenborninthe
U.S.and0.625forforeignbornwomen.

GiventhatthemodelisbasedondatafromCaliforniaresidents,thenewmodelwillbeappropriateforHispanicwomenliving
inthewesternU.S.,whoaremainlyofMexicanandCentralAmericandescent,theauthorsnote.

"StudieshighlightingheterogeneityinbreastcancerriskbetweenHispanicwomenunderscoretheimportanceofdifferencesin
countryoforigin,durationofresidenceintheUnitedStates,andacculturationinestimatingtheriskofbreastcancer,"they
add.

"Weasresearchersandprovidersandpatientsneedtokeepinmindwhenwe'reusingthistoolwehaven'tevaluatedthe
performanceofthisnewmodelinspecificHispanicsubgroups,yetwedohopetodoso,andIhavebeencontactedby
individualsacrosstheU.S.expressinginterestinthemodelandsayingwewouldliketotestitinourgroupofpatients,"Dr.
Banegassaid.

"Wedounderstandthatthisisnotaperfectmodelbutweagreethatit'sagreatfirststep,andwedointendtoworkwith
otherstocontinuetoimprovethismodelsothattheriskestimatesthatwegetfromthistoolonlygetbetterandbetterover
time,"headded.

Thestudydidnothavecommercialfunding.

SOURCE:http://bit.ly/2hYMDRX

JNatlCancerInst2016.
ReutersHealthInformation2016

Citethisarticle:ResearchersPublishFirstEverBreastCancerRiskModelforHispanicWomen.Medscape.Dec22,2016.

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