#6 GLYCERIN SUPPOSITORIES Tablet lubricant Magnesium stearate

Suppository - solid dosage form intended Disintegrating agent - startch

for insertion into the body orifices where
they melt, soften, dissolvem and exert Use: anti-fungal
localizied or systemic effect. Anti-infective
Contraceptive (w/ spermicide)
5 TYPES OF SUPPOSITORIES
4. otic (aural) pencil-shaped
1. rectal - cylindrical or bullet shape
5. nasal (burginarium) pencil-shaped
- 32 mm (1 inch)
CRITERIA FOR SUPPOSITORIES
- 2g adult; 1g children
1. melts at body temperature
Use: glyercin laxative effect
2. firm at room temperature
Sodium stearate (Soap); solidifying
agent 3. yields at clear melt

Cathartic acts directly on colonic 4. inert and compatible with other agent
mucosa to produce normal
5. wetting and emulsifying
peristalsis. Not appreciably affects
the motility of small intestine 6. acid value (<0-2)
Relieve pruritus ani pain
associated w/ hemorrhoids 7. saponification value (200-245) if it forms
constipation ester

2. urethral (bougies or inserts) 8. non- irritating

slender, pencil shaped.
9. iodine value (<7) determines the
Male: 4g; 140 mm long, 3-6 mm diameter unsaturation of double bonds (C=C)

Female: 2g; 60-70 mm long TYPES OF SUPPOSITORY BASES

Uses: 1. tend to melt -

o dilatation of uterus cocoa butter (theobroma oil)

o Anti-infective agent
o Erectile dysfunction
o Tx of local infection
3. vaginal (pessaries) - globular, oviform,
cone-shaped; 5 grams.
Caused by: Trichomonas vaginalis, Candida
(Monilia) albicans, Haemophilus vaginalis
Estrogenic substances
(dienestrol) used to restore the
vaginal mucosa to its normal state.
Vaginal tablets (vaginal inserts) -
easier to manufacture, more stable, and less
messy.
Anti-infective
w/ homonal substances
polymorphic
- very good suppository base for
rectal, seldom used in vagina and
urethral
- tendency to lower melting point
- inability to absorb aqueous solution
witepool C12 C18 (no polymorphism)
wecobee only suppository base that
came from coconut oil
2. tend to dissolve polyethylene gylcol
(PEG)
- PEG liquid (300, 400, 600)
- PEG semi-solid
- PEG solid- wax ( > 1000)- clear
colorless liquid
METHODS OF PREPARATION - mix -> supp. Compression device ->
apply pressure -> cool
1. hand rolling mixing and rolling in a
pile tile. 3. fusion method

2. compression - more elegant in - melting of all ingredients

appearnce - pour directly to mold
- freeze
- very simple avoid sedimentation - wrap in Aluminum foil
- not for large manufacturing