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  • Human Papilloma Virus HPV PSPD PDF

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    Henok Nugrahawanto
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    Human Papilloma Virus (HPV) is a virus that infects epithelial cells of the skin or mucosa. There are over 100 types of HPV, with some being associated with warts or cancer. HPV types 6 and 11 cause most cases of genital warts and laryngeal papillomas in children. HPV types 16 and 18 cause about 70% of cervical cancers and many other anogenital cancers. While most HPV infections are asymptomatic and transient, persistent infection can lead to precancerous lesions or cancers, especially with high-risk types. An effective vaccine protects against the most common cancer-causing HPV types.

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    Human Papilloma Virus (HPV) is a virus that infects epithelial cells of the skin or mucosa. There are over 100 types of HPV, with some being associated with warts or cancer. HPV types 6 and 11 cause most cases of genital warts and laryngeal papillomas in children. HPV types 16 and 18 cause about 70% of cervical cancers and many other anogenital cancers. While most HPV infections are asymptomatic and transient, persistent infection can lead to precancerous lesions or cancers, especially with high-risk types. An effective vaccine protects against the most common cancer-causing HPV types.

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    73 views11 pages

    Human Papilloma Virus HPV PSPD PDF

    Uploaded by

    Henok Nugrahawanto
    Human Papilloma Virus (HPV) is a virus that infects epithelial cells of the skin or mucosa. There are over 100 types of HPV, with some being associated with warts or cancer. HPV types 6 and 11 cause most cases of genital warts and laryngeal papillomas in children. HPV types 16 and 18 cause about 70% of cervical cancers and many other anogenital cancers. While most HPV infections are asymptomatic and transient, persistent infection can lead to precancerous lesions or cancers, especially with high-risk types. An effective vaccine protects against the most common cancer-causing HPV types.

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    of 11

    Human Papilloma Virus (HPV)

    Eka Yudha Rahman


    Morfologi dan sifat HPV
    Virion : struktur ikosahedraldiameter 55 nm
    Genom : bulat,DNA untai ganda
    Replikasi : tergantung pd stadium
    terdifferensiasi sel inang
    Karakteristik :
    -Potensial onkogenik (+)
    -Tropik pd sel epitel kulit dan mukosa
    Kuliah PSPD (EKA YUDHA RAHMAN) 2/21/2011
    Tipe Virus & akibat infeksinya pd manusia
    TIPEVIRUS PENYAKIT KETERANGAN

    1 Myrmecia tapak tangan, veruca plantaris Jinak


    2 Veruca vulgaris, condyloma anogenital Jinak
    3,10,28 Veruca plana, epidermoplasia verruciformis Jarang jadi ganas
    4 Veruca vulgaris et plantaris Jinak
    5,8 Epidermoplasia verruciformis 30% konversi menjadi ganas
    6,11 Condiloma accuminata, verrucae genital, Umumnya Jinak
    papiloma laring, metaplasi-displasi servik
    9,12,14,15,17,19,25,36,40 Epidermoplasia verruciformis 12,17,&20 dpt jadi ganas
    20 Basilioma Dpt jadi ganas
    13,32 Penyakit Heck Mu ngkin jadi ganas
    16,18,31,33,35,39,52 Neoplasia mukosa genital, laring, esofagus, Cenderung jadi ganas
    Pyk Bowen
    34 Pyk Bowen Dpt jadi ganas
    30, 40 Neoplasia Laring Cenderung jadi ganas
    37 Keratoacanthoma Ca in situ

    Kuliah PSPD (EKA YUDHA RAHMAN) 2/21/2011


    Gamb klinis

    Epidermodysplasia
    verruciformis

    Kuliah PSPD (EKA YUDHA RAHMAN) 2/21/2011


    Papilloma Viruses
    51 tipe teridentifikasi - paling umum tipe 6 & 11 papiloma
    laring pada anak infeksi didpt selama perjalanan dlm jalan lahir
    ibu dgn genital warts
    Papiloma laring infeksi laten lesi baru
    Kanker cervical, vulvar and penile terkait dengan tipe 16 &18
    (70% kanker penile )

    Effective Vaccine
    (quadrivalent recombinant HPV 6, 11, 16 and 18 proteins made in
    yeast - Gardasil)

    Kuliah PSPD (EKA YUDHA RAHMAN) 2/21/2011


    Clinical Warts

    Cauliflower-like lesions
    Dpt menyebabkan
    itching/burning
    Kadang tanpa symptom

    Kuliah PSPD (EKA YUDHA RAHMAN) 2/21/2011


    Sub-clinical Warts
    Flat
    Virtually invisible
    Dpt menyebabkan
    itching/burning
    Dpt tanpa symptom
    Identifikasi dgn vinegar &
    pembesaran 4-10X

    Kuliah PSPD (EKA YUDHA RAHMAN) 2/21/2011


    Transmisi

    Skin to skin contact


    Condoms offer little
    protection
    Don't treat partners
    unless symptomatic

    Kuliah PSPD (EKA YUDHA RAHMAN) 2/21/2011


    Ca Cervix

    Kuliah PSPD (EKA YUDHA RAHMAN) 2/21/2011


    Diagnosis Laboratorium
    Deteksi virion dari lesi
    Deteksi antigen virion pada jaringan lesi
    (imunofluoresensi & imunoperoksidase)
    Isolasi dan Identifikasi virus
    Pemeriksaan Histo-sitopatologi
    Deteksi Gen virus

    Kuliah PSPD (EKA YUDHA RAHMAN) 2/21/2011


    Treatment
    Ekstirpasi/eksisi lesi
    Interferon intra lesi
    Kauterisasi dgn laser atau cryosurgery
    Pemberian podofilin dan bleomisin
    Pemberian Bichloracetic Acid (BCA or TCA)

    Kuliah PSPD (EKA YUDHA RAHMAN) 2/21/2011

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