Rectal Suppositories
- Clotrimazole
- Provides local action within the
perianal area.
- Relieves pruritus ani, and the
pain of hemorrhoids
Cathartic Suppository
- contact type agents that directly
act on the colonic mucosa to
produce peristalsis.
Suppositories size and shape
- Pediatric suppository more
narrow and pencil shaped
- Adult suppository bullet-shaped
Urethral Suppositories
- Suppositories for urethra
administration. 5mm in diameter
- Treatment of local infections
Compounding Urethral Suppositories
- A straw or thin glass tube can be
used as the mold when preparing
urethral suppositories.
- The MUSE (alprostadil) urethral
micro suppository (Vivus ic.) is a
single-used medicated
transurethral system for the
delivery of alprostadil in the male
urethra
Vaginal Inserts
- These preparations are employed
principally to combat infections of
the female genitor urinary tract, to
restore the vaginal mucosa to its
normal state, and for
contraception.
Anti-infective agents in commercial
vaginal prep.
- Nystatin
- Butoconazole nitrate
- Terconazole
- Miconazole
Anti-fungal
- Triple sulfas
- Sulfanilamide
- Povidone Iodine
- Clindamycin phosphate
- Metronidazole
- Oxytetracyline
Vaginal Inserts (Tablets)
- Vaginal tablets are widely used
because its easy to manufactore,
more stable and less messy.
- Accompanied in their packaging,
a device for easy placement of
the tablet within the vagina.
- They are prepared by tabled
compression and commonly
formulated to contain lactose as
base or filler, starch as
disintegrating agent,
polyvinylpyrrolidone as dispersing
agent, magnesium stearate as a
table lubricant.
Medication Sticks
- A fairly recent preparation.
- Used for cosmetic and medical
purposes.
- Are prepared similar to
suppositories except that the melt
is poured into the administering
device or tube.
Melting Bases
- Cocoa butter
- Petrolatum waxes
- Polyethylene glycols (pegs)
Penetration enhancers:
- Glycerin
- Propylene glycol
- Alcohol
- Surfactants
*Using waxes, oils or plain polymers
such as PEGs alone achieves a
topical effect.
Patient Counseling
- Pharmacist should tell the patient
to apply the stick only to the
involved area and not the
surrounding skin.
- The patient should apply the
medication liberally over the area
but only as needed.
- Stick should be cleaned with a
clean tissue after each use.
Clinical Considerations
1. Position the patient on the left
side with the upper leg flexed.
2. Lubricate the suppository with a
water-soluble lubricant or a small
amount of water if needed
3. Gently insert the suppository, a
fingers depth at an angle toward
the umbilicus, so the suppository
is placed against the rectal wall
for absorption.
4. After the finger is withdrawn, hold
the buttocks together until the
urge to expel has ceased.