Using Simple DNA Box as a Carrier to

The Drugs of Cancer

ABSTRACT:
Although many promising anti-cancer drugs have been developed over the past
50 years, effective delivery of the drugs to diseased cells remains a challenge.
Recently, nanoparticles have been used as drug delivery vehicles due to their
high delivery efficiencies and the possibility to circumvent cellular drug
resistance. However, the lack of biocompatibility to engineer spatially
addressable surfaces for multi-functional activity remains an obstacle to their
widespread use. We design a novel drug carrier system based on self-assembled,
spatially addressable DNA origami nanostructures that confronts these
limitations. All of this DNA origami nanostructures were self-assembled by
numbers of trigeminal DNA molecules. The trigeminal DNA molecules is
composed of several single stranded DNA molecules. All of this DNA origami
nanostructures have similar molecular size and structure. Anti-cancer drug was
non-covalently attached to DNA origami nanostructures.

A) nanoparticles self-assembled
B)
- What is the research about?
Anti-cancer drugs
- How did they conduct the research?(What method did the researchers
use?)
design a novel drug carrier system based on self-assembled, spatially
addressable DNA origami nanostructures that confronts these limitations.
- What are the results of the research?
No result

- What do researchers hope to find?

They want to make anti-cancer drugs

- What can the finding of the research do?

It can help patients who have cancer