DATA SHEET

XDM Quad Single-Use Mixing System

The Xcellerex XDM Quad Mixing System is designed for convenient and
efficient mixing of buffer, media, product, and other process fluids. The single-use
system eliminates the hassle of time-consuming and costly clean-in-place (CIP),
steam-in-place (SIP), and cleaning validation. The result is more efficient processing
and rapid batch-to-batch turnover time.

The XDM Quad is comprised of a full-featured and integrated rigid containment

system complete with motor and controls, and an irradiated USP Class VI, single-
use LDPE fluid contact layer bag equipped with a disposable bottom-mounted
impeller. The engagement between motor and disposable impeller is via a robust
magnetic coupling, and agitation is driven through stainless steel bearings within The XDM Quad Mixing System is
the impeller, imparting high torque and rapid mixing to the system. available in 50L, 100L , 200L, 500L and 1000L sizes.

The system delivers flexibility with the availability of two

standard bag types that include varying numbers of tubing lines Key Features
and connections, and sampling and sensing capabilities to ac- l Powerful integrated magnetic agitator with compact VFD and AC motor
commodate a wide array of applications. Key features of the bag l Optimized, disposable impeller
and rigid container also permit seamless transitioning between l Square configuration offers enhanced mixing efficiency through natural
powder-liquid and liquid-liquid mixing applications. The XDM baffling effect.

Quad Mixing System is available in either polypropylene, single- l Workable heights and low center of gravity increase level of safety

wall stainless steel or or jacketed stainless steel (for heating and l Bottom is slanted on two planes for extremely low bag hold-up volume

cooling applications). l Compact unit with handles and casters for ease of mobility
l Fitted square bag minimizes bag wrinkles
l Real-time sensing and sampling capability via mixer window and bag probe
ports, sampling port and thermowell for non-invasive temperature sensing
l Integrated holders for 50ml conical buffer tubes
l Bags have integrated 3 Tri-clamp port for powder addition
l Translucent lid is included for protection of bag and is equipped with securing
feature for bag powder addition port and hopper
l 500L and 1,000L systems equipped with removable door for easy bag loading
l Two standard bag types: BASIC and PLUS (additional lines, probe ports, and con-
nections)
l System also available in either polypropylene, single-wall stainless steel or
jacketed stainless steel (for heating and cooling applications).
l Fully wash-down rated

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 All specifications are subject to change without notice.
XDM Quad Mixers: SYSTEM SPECIFICATIONS

XDM QUAD (Polypropylene) Systems XDM QUAD-S (Stainless Steel) Systems XDM QUAD-T (Jacketed Stainless Steel) Systems

50 Liter 100 Liter 200 Liter 500 Liter 50 Liter 100 Liter 200 Liter 500 Liter 1000 Liter 50 Liter 100 Liter 200 Liter 500 Liter 1000 Liter

Container Interior
DIMENSIONS 15.5 x 15.5 X 15.5 20 x 20 x 20 25 x 25 x 25 33 x 33 x 33 15.5 x 15.5 X 15.5 20 x 20 x 20 25 x 25 x 25 33 x 33 x 33 41 x 41 x 41 15.5 x 15.5 x 15.5 20 x 20 x 20 25 x 25 x 25 33 x 33 x 33 41 x 41 x 41
(Inches LxWxH)

Exterior 21.375 X 33.375 35.25 x 48.25 x 43.25 x 55.25 21.375 X 33.375 38 .375 x 50.375 47.5 x 58.625 x
22.5 X 27 X 45 27.5 x 33 x 41 32.5 x 38 x 40 40.5 x 46.5 x 48 24 x 33.5 x42 26.5 x 37 x 42 26.75 X37x 42 26.75 x 38.5 x 42
(Inches LxWxH) X 42 56.75 x 56.75 X 42 x 56.75 56.75

Slope to Drain ~0.5 per foot Cross-Section ~0.5 per foot Cross-Section ~0.5 per foot Cross-Section

Caster Dimensions
4x2 4x2 4x2
( x W)

Jacket Volume NA NA 1.2 L 2L 2.65 L 5.8 L 9.1 L

System Weight
WEIGHT 115 lbs. 143 lbs. 183 lbs. 304 lbs. 150 lbs. 181 lbs. 309 lbs. 397 lbs. 606 lbs. 200 lbs. 236 lbs. 381 lbs. 503 lbs. 792 lbs.
(empty)

MATERIAL OF
CONSTRUCTION Container Polypropylene 304 Stainless Steel 304 Stainless Steel

Insulation NA NA Insulation is non-asbestos, chloride free and coated with Thurmalox mastic material

Lid Acrylic Acrylic Acrylic

Casters SS / Polyurethane (Non-Marring) SS / Polyurethane (Non-Marring) SS / Polyurethane (Non-Marring)

MOTOR/VFD Type AC Motor AC Motor AC Motor

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HP 0.26 0.26 0.26

Watts 197 197 197

RPM 0-200 0-200 0-200

Electrical 115V or 230V: (50/60 Hz) 115V or 230V: (50/60 Hz) 115V or 230V: (50/60 Hz)

Functionality Run/Stop, Forward/Break/Reverse Run/Stop, Forward/Break/Reverse Run/Stop, Forward/Break/Reverse

Power Cord 10 ft. 10 ft. 10 ft.

Washdown Motor is IP66, CE Certified/Drive is IP65 NEMA 4X, CE Certified Motor is IP66, CE Certified/Drive is IP65 NEMA 4X, CE Certified Motor is IP66, CE Certified/Drive is IP65 NEMA 4X, CE Certified
 SINGLE-USE BAG SPECIFICATIONS All specifications are subject to change without notice.

50 Liter 100 Liter 200 Liter 500 Liter 1000 Liter

DIMENSIONS Dimensions (inches LxWxH) 15.5 x 15.5 x 14.5 20 x 20 x 19 25 x 25 x 24 33 x 33 x 32 41 x 41 x 37
VOLUME Maximum 55L 125 L 246 L 571 L 1019 L
Nominal 50L 100 L 200 L 500 L 1000 L
Minimum (Mix) 17 L 28 L 44 L 76 L 117 L
Hold Up <20ml < 20 mL < 20 mL < 20 mL < 20 mL
FILM Fluid Contact Layer LDPE (USP Class VI)
PRESSURE RATING Maximum, operating 2 psi, 1 psi
IMPELLER # of Blades 3
Diameter 7.5
Blade Height x Width 4.2 x 2.5
Blade Pitch 57
Material of Construction Molded HDPE impeller with 316 SS bearing
TEMPERATURE RANGE 2 60C
POWDER PORT Dimensions 3 TC
STERILIZATION Gamma Irradiated

Bag Assembly DetailS The XDM QUAD disposable impeller assembly is

XDM Quad Mixing Systems are available with two standard bag assembly types: BASIC and PLUS welded to the bottom of the bag.

SINGLE-USE BAG SPECIFICATIONS

BASIC BAG ASSEMBLY PLUS BAG ASSEMBLY
Port Description 50L 100L 200L 500L 1000L 50L 100L 200L 500L 1000L

A Fill Port: 3 inch tri-clamp powder addition port, capped

B C-flex tubing, 4 with clamp, plugged (ID indicated) inch inch inch inch inch inch inch inch inch inch

C ID C-flex tubing, 4 with clamp, female MPX connector, plugged NA NA NA NA NA

D Sample Line: 1/8 ID sample line with clamp, and luer lock connection NA NA NA NA NA

E, F Probe Port: Female Kleenpack Connector port for probe connection NA NA NA NA NA

F Female Kleenpack Connector port for probe connection NA NA NA NA NA

G Thermowell: for non-invasive temperature sensing NA NA NA NA NA

H Sample Line: 1/8 ID sample line with clamp, and luer lock connection

I Harvest/Drain: C-flex tubing, 6 with clamp, plugged (ID indicated) inch inch inch inch inch inch inch inch inch inch

XDM QUAD OPTIONS & ACCESSORIES

The following options are available for all XDM Quad Mixing Systems:
u Dual pH/Conductivity Monitoring System
u pH probe
u Conductivity probe
u RTD probe
u Probe sheath assemblies
u Level indication (floor scale or load cells for stainless steel units)
u Temperature Control Unit for heating and cooling of jacketed stainless steel systems
NOTE: All probes and instrumentation are GMP compliant.

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XDM Quad Mixer System Details

u Motor controller (fully wash down rated)

v Convenient buffer tube holders (4)
w AC motor and magnetic drive (fully wash down
rated)
x x Handles for ease of mobility
u
v y Notches for supporting bag tubing (polypro. units)
y
z Probe port window and support bar for
(A) pH/Conductivity, (B) inline sampling, and
(C) temperature.

z
A
B
C

Detail of probe port window and support bar for inline sampling
and sensing, such as pH, conductivity and temperature.

{ } { Removable lid with integrated support for powder

addition port and hopper
| Hopper and 3-inch triclamp for easy powder
addition
} Removable door for easy bag installation and
removal (500L and 1000L only)
~ Mixer bottom is slanted on two planes toward
drain for minimal holdup volume; Magnetic
| impeller drive is easily accessible

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Applications and Performance Data
6g/L NaCL, XDM500 1% NaCL in Corn Syrup, XDM200
11.5
100%

11.0
80%
Conductivity (mS/cm)

% Dissolved
10.5 60%

10.0 75% Corn Syrup, 274 cp

40%
85% Corn Syrup, 561 cp
9.5 20%
90% Corn Syrup, 1000 cp

9.0 0%
0 60 120 180 240 300 0 20 40 60 80 100
Time (seconds)
Minutes
The XDM Quad demonstrates rapid mixing of common salt solutions. The XDM Quad demonstrates effective mixing even at high viscosities

DMEM/F-12 Medium, XDM500 XDM500

DMEM/F-12 Medium Mixing Study
XDM500
DMEM/F-12 Medium Mixing Study
Glucose & L-Gln Trends Sodium Trend
Glucose & L-Gln Trends SODIUM TREND
10 100
L-Gln (mmol/L)

Component Concentration [mmol/L]

9 90
Glucose (g/L)
Na+ (mmol/L)
Component Concentration

8 80
7 70
6 60
5 50
4 40
3 30
2 20
1 10
0 0
0 60 120 180 240 300 0 60 120 180 240 300
Mix Time (Seconds)
XDM500 MixXDM500
Time (Seconds)
DMEM/F-12 Medium Mixing Study DMEM/F-12 Medium Mixing Study
POTASSIUM TREND Potassium Trend Osmolarity Trend Osmo Trend

10 400
Component Concentration [mmol/L]

9 K+ (mmol/L)
350 Osmo (mOsm/kg)
8
300
7
250
[mOsm/kg]

6
5 200
4
150
3
100
2
1 50

0 0
0 60 120 180 240 300 0 60 120 180 240 300
Mix Time (Seconds) Mix Time (Seconds)

The XDM Quad demonstrates effective mixing of common cell culture media.

VIDEO demonstration XDM Quad u Buffer and Media Prep

u
Applications u pH adjustments
Base & Acid Addition / u Resuspension
Phenolphthalein Dye Test, XDM500 u Chromatography pooling
u Viral inactivation
A video demonstration of this u UF/DF
mixing test is available at www.xcellerex.com/mixerdemo u Formulation
u Product Mixing

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Ordering Information
XDM Quad System Ordering Codes* XDM Quad Bag Assembly Ordering Codes
Product Code Size Type Product Code Size Type
XDM-50 50L Standard Polypropylene
XDM-100 100L Standard Polypropylene
888-0141 50L Basic

XDM-200 200L Standard Polypropylene

888-0351 50L Plus
XDM-500 500L Standard Polypropylene
XDM-50-S 50L Stainless Steel 888-0164 100L Basic
XDM-100-S 100L Stainless Steel
888-0154 100L Plus
XDM-200-S 200L Stainless Steel
XDM-500-S 500L Stainless Steel 888-0165 200L Basic
XDM-1000-S 1,000L Stainless Steel
888-0155 200L Plus
XDM-50-S-LC 50L Stainless Steel with Load Cells
XDM-100-S-LC 100L Stainless Steel with Load Cells 888-0166 500L Basic
XDM-200-S-LC 200L Stainless Steel with Load Cells
888-0156 500L Plus
XDM-500-S-LC 500L Stainless Steel with Load Cells
XDM-1000-S-LC 1,000L Stainless Steel with Load Cells 888-0167 1,000L Basic
XDM-50-T 50L Jacketed Stainless Steel
XDM-100-T 100L Jacketed Stainless Steel 888-0157 1,000L Plus
XDM-200-T 200L Jacketed Stainless Steel Ask about our made-to-order bags for UF/DF.
XDM-500-T 500L Jacketed Stainless Steel
XDM-1000-T 1,000L Jacketed Stainless Steel
XDM-50-T-LC 50L Jacketed Stainless Steel with Load Cells
XDM-100-T-LC 100L Jacketed Stainless Steel with Load Cells Accessory Ordering Codes
XDM-200-T-LC 200L Jacketed Stainless Steel with Load Cells
Product Code Description
XDM-500-T-LC 500L Jacketed Stainless Steel with Load Cells
XDM-1000-T-LC 1,000L Jacketed Stainless Steel with Load Cells
888-0138 Probe Sheath Assemblies
* Various electrical requirements can be accommodated. Please specify at time of order.

Hopper (includes fitting for fastening to 3

XDM-Q-HH
tri-clamp port)

XDM-Q-PB pH Probe
To order XDM Quad systems,
bag assemblies or components, XDM-Q-CB Conductivity Probe

please call XDM-MTR-P-C pH/Conductivity Monitoring System

1.866.XCELLEREX
XDM-Q-RTD RTD for Temperature Measurement
(1.866.923.5537)
1.508.480.9235

For information on Xcellerexs other innovative single-use technology, including XDR single-use
bioreactors and the FlexFactory biomanufacturing platform, please visit www.Xcellerex.com

Xcellerex, Inc. Toll Free: 1-866-Xcellerex

TM
170 Locke Drive Tel: 508-480-9235
Marlborough, MA 01752 info@xcellerex.com
USA www.xcellerex.com
rev. xdmQ-010711