Professional Documents
Culture Documents
HB Blood Component Transfusion Mod1 Rev01
HB Blood Component Transfusion Mod1 Rev01
COMPONENT
TRANSFUSION
Module
1:
Decision
to
Transfuse
1
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INTRODUCTION
The
safe
and
appropriate
use
of
donor
blood
and
alternatives
to
donor
blood
are
important
public
health
and
clinical
governance
issues.
The
transfusion
of
blood
and
blood
products
are
an
important,
and
in
some
instances
life-
saving
and
part
of
the
treatment
of
my
patients.
The
aim
of
the
package
is
to
assist
all
healthcare
workers
to
provide
consistently
safe
and
effective
high
standards
of
clinical
practice
and
avoid
error
which
unfortunately
can
potentially
lead
to
death
or
causing
long
term
damage
to
the
recipient/patient.
Such
potentially
fatal
errors
are
almost
completely
preventable
through
consistent
good
practice
However
audits
of
practice
in
transfusion
have
shown
that
simple
preventative
measures
such
as
the
patient
having
a
correct
wristband
or
observations
being
taken
in
the
first
30
minutes
of
transfusion
can
be
overlooked
(Taylor
2005).
As
the
learner,
you
will
require
to
undertake
four
separate
modules,
followed
by
a
short
question
and
answer
tests
after
each
module
before
you
can
achieve
your
certificate.
The
four
modules
you
are
required
to
complete
are
as
follows:
Decision
to
Transfuse
Blood
Sampling
Collection
of
Blood
Components
from
Storage
and
Delivery
to
the
Clinical
Area
Administration
of
Blood
Components.
2
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This
course
and
its
contents
has
been
developed
to
ensure
that
all
healthcare
workers
can
participate
safely
in
the
transfusion
process,
in
line
with
the
Health
Service
Circular,
Better
Blood
Transfusion
-
Safe
and
Appropriate
Use
of
Blood
(2007),
UK
Blood
Services,
The
Serious
Hazards
of
Transfusion
(SHOT)
scheme,
the
National
Blood
Transfusion
Committee
(NBTC),
England
and
the
respective
committees
in
Northern
Ireland,
Scotland,
Wales
and
Republic
of
Ireland.
It
is
useful
for
staff
new
to
blood
transfusion
nursing,
current
health
workers
as
a
refresher
in
their
learning
and
non-medical
prescribers
for
blood
components.
It
will
explore
the
alternatives
to
blood
transfusions,
blood
sampling
and
knowing
which
equipment
and
materials
that
are
required
to
obtain
serology,
the
collection,
storage
and
delivery
of
components
and
legislation
that
should
be
adhered
to
meet
the
criteria
and
expectations
of
clinical
standards
of
care
and
to
gain
an
understanding
on
the
importance
of
consent,
indication
of
blood
transfusion
and
continuous
patient
monitoring
during
the
procedure.
3
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MODULE
1:
DECISION
TO
TRANFUSE
Learning
Objectives
By
the
end
of
the
course
you
will
have
achieved
the
following:
understand
transfusion
issues
Be
able
to
identify
the
blood
components
available
and
have
an
understanding
of
the
indications
of
their
use
Be
aware
of
the
benefits,
risks
and
anticipated
outcomes
to
transfuse
patients
Ensuring
your
patient
is
aware
that
they
may
be
having
a
blood
transfusion
and
that
they
understand
why
they
will
be
having
it,
what
this
will
involve
and
potential
risks.
Understand
the
importance
of
ensuring
your
patient
has
expressed
informed
consent
(except
in
exceptional
circumstances)
in
advance.
Be
able
to
access
your
local
policies
Know
the
processes
to
prescribe/authorise
blood
components.
4
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THE
DECISION
TO
TRANSFUSE
To
determine
if
it
is
an
appropriate
course
of
action
for
a
particular
patient,
there
are
a
number
of
different
factors
to
consider.
As
with
any
medical
procedure,
a
blood
transfusion
can
bring
with
it
a
range
of
risks
and
potential
benefits.
Transfusion
should
only
be
used
when
the
benefits
outweigh
the
risks
and
there
are
no
appropriate
alternatives.
Blood
transfusion
can
be
life-saving
and
is
a
key
component
of
many
modern
surgical
and
medical
interventions
and
should
only
be
considered
where
there
is
sufficient
evidence
through
clinical
assessment
and
laboratory
tests
to
suggest
that
the
patients
condition
is
likely
to
deteriorate
or
potentially
life-
threatening.
Avoiding
unnecessary
and
inappropriate
transfusions
is
both
good
for
patients
and
essential
to
ensure
blood
supplies
meet
the
increasing
demands
of
an
ageing
population.
Sound
clinical
judgement
based
on
assessment
should
be
the
most
important
factor
in
the
decision
to
transfuse
and
evidence-based
guidelines
should
be
followed
where
available.
It
is
absolutely
essential
to
consider
each
potential
transfusion
case
on
its
own
merit.
If
blood
or
component
transfusion
is
necessary,
it
must
meet
the
following
four
criteria:
The
right
blood
type,
or
component
for
the
situation
The
right
patient
-
always
ensure
that
you
have
carefully
checked
the
patients
identity
5
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The
right
time
to
be
offering
the
transfusion
The
right
place
to
be
offering
the
transfusion
Every
in-patient
who
is
having
blood
sampled
for
a
transfusion
must
be
wearing
a
correct
identity
wristband.
If
you
are
caring
for
a
patient
who
is
going
to
have
a
pre-transfusion
blood
sample
taken
and
who
does
not
have
a
wristband,
you
must
identify
the
patient
using
two
separate
identifiers
(e.g.
full
name
and
date
of
birth,
or
full
address)
and
provide
the
patient
with
an
identification
bracelet
containing
as
a
minimum
their
surname,
first
name,
hospital
number/C.H.I.
number,
gender
and
date
of
birth.
It
is
legal
and
ethical
practice
to
ensure
that
valid
consent
is
obtained
from
a
patient
before
any
medical/surgical
intervention,
including
the
administration
of
blood
products.
In
2011,
the
Advisory
Committee
on
the
Safety
of
Blood,
Tissues
and
Organs
(SaBTO)
published
a
report
Patient
Consent
for
Blood
Transfusion
which
includes
the
following
recommendations:
Valid
consent
for
blood
transfusion
should
be
obtained
and
documented
in
the
patient's
clinical
record
by
the
healthcare
professional.
There
should
be
a
modified
form
of
consent
for
long
term
multi-transfused
patients,
details
of
which
should
be
explicit
in
an
organisation's
consent
policy.
6
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Patients
who
have
received
a
blood
transfusion
and
who
were
not
able
to
give
valid
consent
prior
to
the
transfusion
should
be
provided
with
information
retrospectively.
(JPAC,
2016)
WHO
CAN
PRESCRIBE
A
TRANSFUSION?
There
is
no
specific
staff
group
who
can
authorise
transfusions
or
request
collection
from
the
laboratory,
as
blood
components
are
not
licensed.
The
task
is
frequently
delegated
by
the
Doctor
or
specialist
who
is
known
as
the
independent
prescriber.
Depending
on
your
role
and
function
you
may
be
a
supplementary
prescriber
and
asked
to
request
the
blood
component
after
the
independent
prescriber
has
assessed
the
patient.
In
some
cases,
non-medical
staff
can
also
request
blood
components
if
they
are
appropriately
trained
and
deemed
competent;
documentation
will
validate
if
this
is
the
case.
You
must
check
with
the
hospital
or
medical
centre
where
you
work
and
establish
your
understanding
of
their
processes
and
procedures.
If
you
are
unsure
of
the
process
you
must
seek
guidance
from
your
line
manager
or
shift
supervisor.
DOCUMENTATION
Each
stage
of
the
process
has
strict
documentation
guidelines
making
sure
the
process
is
safe
for
the
patient
and
that
each
component
can
be
tracked,
including
who
was
involved
in
the
transfusion
process.
7
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Pre-transfusion
requirements
The
reasons
including
laboratory
and/or
clinical
data
Any
risks,
benefits
or
possible
alternatives,
this
must
include
patient
consent
What
is
being
transfused
and
the
dosage
Any
other
special
requests
or
requirements
TRANSFUSION
PROCESS
Who
was
involved
including
all
clinical
and
nursing
staff
starting
and
completing
the
process
Date
and
time
the
transfusion
started
and
finished
The
donation
number
Observation
records
Post-transfusion
Any
outcomes
and
their
subsequent
management
Success
of
the
transfusion
8
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THE
RIGHT
BLOOD
TYPE
OR
COMPONENT
Blood
is
the
red
fluid
that
circulates
in
our
blood
vessels
veins
and
arteries.
It
acts
as
the
bodys
transport
system
to
distribute
and
circulate
oxygen
and
de-oxygenated
blood
to
vital
organs
and
also
plays
a
major
role
in
the
bodys
defence
against
infection.
There
is
no
substitute
to
blood
and
can
only
be
replaced
by
donations
from
other
individuals.
Its
consists
of
different
component
each
serving
its
own
purpose
and
can
be
separated
to
allow
patients
to
be
administered
the
specific
component
that
is
clinically
indicated
to
treat
them.
Most
common
transfused
blood
components
include;
Red
blood
cells
Red
blood
cells
contain
haemoglobin,
which
distributes
oxygen
to
body
tissues,
and
carries
waste
carbon
dioxide
back
to
the
lungs.
Red
blood
cells
are
used
to
treat
all
kinds
of
anaemia
(where
people
have
low
haemoglobin
levels)
including:
as
a
result
of
rheumatoid
arthritis
or
cancer
when
red
cells
break
down
in
new
born
babies
sickle
cell
diseases
9
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Red
blood
cell
transfusions
are
also
used
to
treat
severe
blood
loss
due
to
traumatic
injuries,
during
surgery
or
in
childbirth.
White
blood
cells
White
blood
cells
(also
known
as
leucocytes)
are
an
important
component
of
your
blood
system.
Although
your
white
blood
cells
account
for
only
about
1%
of
your
blood,
their
impact
is
significant.
White
blood
cells
are
essential
for
good
health
and
protection
against
illness
and
disease.
They
are
vital
in
the
fight
against
infection
and
are
part
of
the
body's
defence
system.
White
cell
transfusions
may
be
given
to
patients
suffering
from
life-threatening
infections
whose
normal
defence
mechanisms
don't
seem
to
be
responding
to
antibiotics.
Platelets
Platelets
are
crucial
in
helping
blood
to
clot:
they
do
this
by
clumping
together
to
stop
bleeding
after
an
injury.
They
can
be
used:
to
treat
cases
of
bone
marrow
failure
following
a
transplant
or
chemotherapy
treatments
to
treat
leukaemia
10
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Plasma
Yellow
fluid
that
transports
blood
cells
and
platelets
around
the
body
and
contains
a
number
of
substances,
including
proteins
which
are
often
important
ingredients
in
medical
procedures.
Plasma
includes:
albumin
-
a
protein
useful
for
treating
kidney
and
liver
disease
clotting
factors
-
used
to
treat
types
of
haemophilia
and
diseases
where
blood
doesnt
clot
properly
immunoglobulins
-
these
antibodies
help
protect
against
infections
There
are
also
specific
considerations
for
each
of
the
individual
blood
components
that
may
be
transfused.
Red
blood
cells
Use
restrictive
red
blood
cell
transfusion
for
patients
who
do
not
have
major
haemorrhage,
acute
coronary
syndrome
or
need
regular
blood
transfusions
due
to
anaemia.
In
these
cases,
consider
a
threshold
of
70g/litre
with
a
haemoglobin
concentration
of
70-90g/litre
after
transfusion.
For
patients
with
acute
coronary
syndrome
then
you
should
consider
a
threshold
of
80g/litre
with
a
haemoglobin
concentration
target
of
80-100g
after
transfusion.
11
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If
your
patient
has
chronic
anaemia
and
requires
regular
transfusions,
you
should
set
your
own
concentration
targets
based
on
their
individual
case.
Consider
single-unit
red
blood
cell
transfusions
(or
equivalent
volume
to
reflect
the
patients
body
weight)
in
cases
where
the
patient
is
not
bleeding.
After
any
transfusion,
you
should
recheck
the
haemoglobin
levels
and
assess
whether
further
transfusions
may
be
required.
Platelets
Patients
with
thrombocytopenia
who
are
bleeding
significantly
should
be
offered
a
platelet
transfusion
if
their
platelet
count
has
fallen
below
30x10^9
per
litre.
If
the
patient
has
severe
bleeding,
or
bleeding
from
critical
sites
such
as
the
central
nervous
system
or
the
eyes,
you
should
consider
a
platelet
threshold
of
up
to
100x10^9
per
litre.
Patients
who
are
neither
bleeding
nor
involved
in
invasive
procedures
or
surgery
may
be
offered
prophylactic
platelet
transfusions
if
they
have
a
platelet
count
below
10x10^9
per
litre
and
do
not
have
any
of
the
following
conditions:
! Chronic
bone
marrow
failure
! Heparin-induced
thrombocytopenia
! Autoimmune
thrombocytopenia
! Thrombotic
thrombocytopenic
purpura
12
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If
patients
are
having
surgery
or
invasive
procedures,
you
can
consider
prophylactic
platelet
transfusions
to
aim
to
raise
the
count
above
50x10^9
per
litre.
If
patients
have
a
high
risk
of
bleeding,
you
may
wish
to
consider
higher
thresholds
such
as
5x10^9/litre
as
long
as
you
consider:
the
cause
of
the
thrombocytopenia,
the
specific
procedure
the
patient
is
having,
whether
the
patients
platelet
count
is
decreasing,
whether
there
are
any
coexisting
causes
of
abnormal
haemostasis
and
the
cause
of
the
thrombocytopenia
in
the
first
place.
If
surgery
is
being
performed
in
critical
sites
including
the
central
nervous
system
or
the
posterior
segment
of
the
eyes,
then
you
may
wish
to
consider
raising
the
platelet
count
above
100x10^9/litre.
You
should
NOT
consider
platelet
transfusions
if
the
patient
has
any
of
the
following:
Chronic
bone
marrow
failure
Heparin
induced
thrombocytopenia
Autoimmune
thrombocytopenia
Thrombotic
thrombocytopenic
purpura
You
should
also
refrain
from
offering
platelet
transfusions
to
patients
having
procedures
with
low
risk
of
bleeding,
such
as
adults
having
central
venous
cannulation,
or
any
patients
who
are
having
bone
marrow
aspiration
and
trephine
biopsy.
Do
not
routinely
offer
more
than
a
single
dose
of
platelets.
Consider
more
than
a
single
dose
only
for
patients
with
severe
thrombocytopenia
and
bleeding
in
a
critical
site
such
as
the
central
nervous
system
or
13
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the
eyes.
Reassess
the
patients
clinical
condition
after
any
transfusion
of
platelets,
and
only
ever
give
further
doses
if
necessary.
Cryoprecipitate
(prepared
from
plasma,
delivered
as
a
frozen
blood
product)
If
patients
are
without
significant
haemorrhage,
consider
cryoprecipitate
transfusion
if
they
have
clinically
significant
bleeding
and
their
fibrinogen
level
is
below
1.5g
per
litre.
Do
not
offer
cryoprecipitate
transfusions
in
an
effort
to
correct
fibrinogen
levels
in
patients
who
are
not
bleeding
and
are
not
having
surgery
or
clinically
invasive
procedures
with
a
risk
of
clinically
significant
bleeding.
Prophylactic
cryoprecipitate
transfusions
may
be
appropriate
for
patients
who
have
a
fibrinogen
level
below
1.0g
per
litre,
are
having
surgery
or
an
invasive
procedure
with
a
clinically
significant
risk
of
bleeding.
An
adult
dose
for
cryoprecipitate
transfusions
is
2
pools.
For
children,
this
should
be
5-10ml
per
kg
up
to
a
maximum
of
2
pools.
After
the
transfusion,
monitor
and
reassess
the
patients
clinical
condition.
Always
retest
the
fibrinogen
level
before
deciding
whether
a
further
dose
is
needed.
14
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Prothrombin
complex
concentrate
This
transfusion
should
be
offered
immediately
for
an
emergency
situation
where
you
need
to
reverse
the
effects
of
warfarin
anticoagulation.
This
can
be
used
for
patients
who
are
bleeding
severely
of
who
have
head
injury
with
suspected
intracerebral
haemorrhage.
Detailed
guidance
on
what
to
do
for
patients
who
have
a
stroke
and
a
primary
intracerebral
haemorrhage
are
available
from
NICE:
https://www.nice.org.uk/guidance/cg68/chapter/1-Guidance
,
you
should
ensure
you
are
familiar
with
this
should
your
role
require
it.
You
should
also
consider
immediate
prophylactic
Prothrombin
complex
concentrate
transfusion
for
patients
who
are
having
emergency
surgery
and
you
need
to
reverse
warfarin
anticoagulation,
but
only
after
carefully
considering
the
bleeding
risk
and
the
level
of
anticoagulation
in
each
case.
INR
is
the
abbreviation
used
to
describe
the
Internal
Normalised
Ratio.
This
is
what
must
be
monitored
to
confirm
that
you
have
successfully
reversed
the
warfarin
anticoagulation.
You
must
always
check
this
before
considering
further
prothrombin
complex
concentration
transfusions.
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Fresh
frozen
plasma
Should
only
be
considered
when
patients
have
clinically
significant
bleeding
but
without
major
haemorrhage
if
they
have
abnormal
coagulation
test
results.
Do
not
offer
fresh
frozen
plasma
transfusions
to
try
and
remedy
abnormal
coagulation
if
the
patient
is
not
bleeding
(unless
they
are
having
surgery
or
clinical
procedures
with
a
clinically
significant
risk
of
bleeding),
or
to
patients
who
need
a
reversal
of
a
vitamin
K
antagonist.
Prophylactic
fresh
frozen
plasma
can
be
considered
for
patients
who
have
abnormal
coagulation
and
are
having
surgery
or
invasive
procedures
that
have
a
clinically
significant
risk
of
bleeding.
After
any
dose,
repeat
the
coagulation
tests
and
reassess
the
patients
clinical
condition
before
determining
a
further
transfusion.
Monitor
this
to
ensure
they
are
receiving
an
adequate
dose.
BLOOD
COMPONENT
TRANSFUSION
RISKS
Any
medical
procedure
is
not
without
its
share
of
risks,
blood
and
component
transfusions
are
no
different.
Steps
can
be
taken
to
mitigate
most
risks
but
it
is
important
to
understand
what
they
are
to
ensure
that
you
are
practicing
in
a
safe
way.
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Allergic
reactions
are
the
most
commonly
reported
adverse
event
during
or
following
blood
transfusion
where
the
immune
system
reacts
to
proteins
or
other
chemicals
within
the
donated
blood.
The
symptoms
of
these
reactions
are
usually
mild
and
will
appear
either
during
or
shortly
after
the
transfusion.
Symptoms
to
watch
for
include
itchy
or
red
inflamed
area
on,
oedema
or
swelling
to
extremities
including
the
hands
and
feet,
dizziness,
or
headaches.
Less
common
symptoms
may
appear
such
as
pyrexia
(high
temperature)
or
shivering,
shortness
of
breath
or
swelling
to
the
lips
and
eyes.
Most
cases
of
allergic
reaction
are
not
very
serious
and
can
be
successfully
managed
by
slowing
or
stopping
the
transfusion,
and
by
treating
the
symptoms
with
medication
such
as
antihistamines
or
possibly
paracetamol.
Rare
but
more
serious
condition
can
occur
known
as
Anaphylaxis
a
severe,
potentially
life-threatening
allergic
reaction
that
can
develop
rapidly.
It
is
also
known
as
anaphylactic
shock
and
must
be
treated
immediately,
usually
with
an
injection
of
adrenaline.
Signs
of
anaphylaxis
include:
itchy
skin
or
a
raised,
red
skin
rash
swollen
eyes,
lips,
hands
and
feet
feeling
lightheaded
or
faint
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swelling
of
the
mouth,
throat
or
tongue,
which
can
cause
breathing
and
swallowing
difficulties
wheezing
abdominal
pain,
nausea
and
vomiting
collapse
and
unconsciousness
In
some
situations,
it
is
possible
for
a
transfusion
to
result
in
too
much
blood
entering
the
body
in
a
short
time,
this
is
known
as
fluid
overload
and
is
quite
rare.
It
is
most
common
amongst
people
with
low
body
weight,
the
elderly
and
frail
patients.
The
effect
of
the
excess
fluid
is
that
the
heart
is
unable
to
pump
enough
blood
around
the
body,
potentially
causing
heart
failure.
The
lungs
can
also
become
filled
with
fluid
causing
shortness
of
breath.
Fluid
overload
is
a
greater
risk
for
older
patients,
and
those
with
serious
health
conditions
such
as
heart
disease.
Medicine
needs
to
be
given
to
people
with
fluid
overload,
usually
a
diuretic,
which
will
help
the
body
reduce
excess
fluid.
In
patients
who
have
experienced
fluid
overload,
it
is
important
to
reduce
the
speed
of
future
transfusions.
Although
very
rare,
the
risk
of
lung
injury
cannot
be
overlooked
because
it
is
so
serious.
Transfusion-
related
acute
lung
injury
(TRALI)
occurs
most
often
with
platelets
and
plasma,
rather
than
red
cells.
TRALI
occurs
when
the
patients
lungs
become
very
inflamed,
normally
within
6
hours
of
the
transfusion,
and
the
high
inflammation
causes
the
lungs
to
become
starved
of
oxygen.
Experts
currently
believe
that
this
inflammation
is
caused
by
an
unusual
immune
response
to
the
transfusion.
Treatment
normally
requires
a
ventilator
to
provide
the
body
with
oxygen
until
the
inflammation
subsides
again.
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Haemolytic
transfusion
reaction
(HTR)
is
another
recognised
complication
that
can
occur
during
or
following
a
transfusion
and
is
caused
by
the
bodys
immune
system
reacts
to
the
donated
blood
and
rejecting
by
attacking
the
cells.
This
can
happen
during
or
soon
after
a
transfusion,
or
it
may
take
a
few
days
or
even
a
week
for
the
reaction
to
take
place.
There
are
also
potential
risks
if
the
blood
to
be
transfused
has
been
contaminated.
Every
effort
will
have
been
made
to
ensure
that
the
donated
blood
is
kept
sterile
(germ-free)
but
in
very
rare
circumstances
bacteria
can
develop
in
the
blood
before
it
is
transfused.
This
can
happen
to
any
of
the
components
but
platelets
are
the
most
vulnerable
to
this
form
of
contamination.
The
reason
for
this
is
because
the
platelets
must
be
stored
at
room
temperature
rather
than
refrigerated.
Symptoms
of
blood
poisoning,
which
is
known
as
sepsis,
may
result
from
receiving
a
transfusion
of
contaminated
blood.
Things
to
watch
out
for
include
a
high
temperature,
chills,
rapid
breathing,
being
confused,
cold
and
clammy
skin,
or
a
rise
in
heartbeat.
Normal
treatment
would
be
antibiotic
injections.
Rarer
still
than
bacterial
infection
is
the
risk
of
viral
contamination
in
the
blood
such
as
blood
borne
viruses.
The
reason
this
is
so
rare
is
because
of
the
stringent
screening
and
testing
procedures
in
place.
The
sort
of
viruses
which
can
be
transferred
by
contaminated
blood
include
hepatitis
B,
hepatitis
C
and
HIV,
but
there
has
not
been
a
recorded
case
of
a
patient
developing
a
viral
infection
from
a
blood
transfusion
since
2005.
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BENEFITS
OF
TRANSFUSION
These
risks
need
to
be
balanced
against
the
many
potential
benefits
of
offering
a
blood
transfusion.
The
main
benefits
of
a
blood
transfusion
are
saving
lives
and
limiting
the
complications
of
major
blood
loss.
There
are
three
main
scenarios
where
a
patient
may
require
a
blood
component
transfusion.
During
childbirth,
surgery
or
major
accident
Treating
anaemia
Treatment
of
inherited
disorders
of
the
blood
such
as
sickle
cell
anaemia
or
thalassaemia
The
medical
benefits
of
blood
transfusions
are
more
complex
and
concentrate
on
components
of
blood
and
using
donated
blood
for
more
than
one
patient.
It
is
possible
to
treat
a
patient
with
the
specific
blood
component
which
they
are
lacking,
rather
than
transfusing
complete
blood.
This
not
only
makes
the
system
much
more
efficient
but
also
helps
to
minimise
the
risk
of
adverse
reactions
to
the
transfusion
as
you
are
introducing
less
into
the
patients
body.
By
carefully
separating
all
the
blood
components
out
and
handling
them
properly,
it
becomes
possible
to
treat
multiple
patients
from
each
blood
donation.
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It
is
also
possible
to
use
certain
blood
components
in
other
therapeutic
support.
For
example,
patients
with
Haemophilia
A
can
be
treated
with
Factor
VIII
which
can
be
made
from
plasma
which
is
not
directly
needed
for
transfusion
purposes.
Each
blood
component
has
specific
storage
requirements,
and
shelf-life.
By
separating
them
all
out
and
handling
them
correctly
it
helps
to
improve
the
quality
of
each
component
to
be
used.
ANTICIPATED
OUTCOMES
OF
TRANSFUSION
Different
types
of
blood
component
transfusions
will
bring
different
outcomes
for
the
patient.
Let
us
take
a
moment
to
consider
the
anticipated
beneficial
outcomes
of
each
type
of
transfusion:
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DECIDING
WHETHER
A
TRANSFUSION
IS
APPROPRIATE
To
determine
if
a
transfusion
is
appropriate
for
a
particular
patient
there
are
a
number
of
points
to
consider.
Firstly,
you
should
explore
whether
any
alternatives
to
the
procedure
are
available.
For
example,
for
patients
having
surgery,
intravenous
and/or
oral
iron
may
be
sufficient
to
enable
the
patient
to
recover.
Other
alternatives
for
surgical
patients
are
Tranexamic
acid,
suited
to
patients
who
are
expected
to
lose
more
than
500ml
of
blood.
Intra-operative
cell
salvage
with
tranexamic
acid
can
also
be
used
in
cases
where
patients
will
lose
a
very
high
volume
of
blood.
This
is
generally
used
during
procedures
such
as
cardiac
and
complex
vascular
surgery,
pelvic
reconstruction,
scoliosis
surgery
or
major
obstetric
procedures.
Blood
transfusions
can
be
necessary
when
treating
certain
conditions
or
undergoing
medical
procedures.
There
are
five
key
indications
that
a
blood
transfusion
would
be
the
best
course
of
action:
Tissue
perfusion
needs
to
be
maintained
because
of
a
reduction
in
blood
volume
Coagulation
is
not
working
as
well
as
it
should,
so
platelets,
coagulation
factors
or
other
plasma
proteins
need
to
be
replaced
Oxygen
capacity
of
the
blood
needs
to
be
increased
There
has
been
excessive
destruction
of
cells,
for
example
as
a
result
of
disease.
Significant
blood
loss
(bleeding
or
trauma,
or
inadequate
production
of
blood
or
a
component).
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Transfusion
is
a
serious
procedure
with
a
number
of
risks
and
an
assessment
to
transfuse
must
be
made
very
carefully.
The
decision
to
transfuse
must
be
based
on
a
thorough
clinical
assessment
of
the
patient
and
their
individual
needs.
Information
relating
to
the
appropriate
use
of
blood
components
is
not
included
in
this
guideline.
For
more
detailed
guidance
refer
to
the
following
BCSH
guidelines:
- The
clinical
use
of
red
cell
transfusion
(2001)
- Guidelines
for
the
use
of
platelet
transfusions
(2003)
- Guidelines
for
the
use
of
fresh-frozen
plasma,
cryoprecipitate
and
cryosupernatant
(2004)
and
erratum
(2007)
- Transfusion
guidelines
for
neonates
and
older
children
(2004)
and
erratum
(2007)
- Guidelines
for
management
of
massive
blood
loss
(2006)
-
The
decision
process
leading
to
transfusion
should
be
documented
in
the
patients
clinical
record.
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PATIENT
CONSENT
Before
a
decision
is
made
to
give
a
blood
transfusion
to
a
patient,
an
assessment
will
be
made
to
ensure
that
the
transfusion
is
appropriate
and
that
the
patient
gives
consent
to
go
ahead.
As
well
as
the
medical
assessments
of
the
patients
condition
which
will
indicate
which
blood
component
is
required,
it
is
really
important
to
take
all
the
time
needed
to
fully
explain
the
procedure
to
the
patient.
This
means
not
only
talking
them
through
step
by
step
how
the
transfusion
will
be
given,
but
also
explaining
the
reasons
why
it
is
being
suggested,
the
anticipated
benefits
and
also
any
potential
risks
(including
adverse
reactions).
The
hospital
or
medical
centre
you
are
working
from
may
have
their
own
information,
forms
and
guidance
on
blood
transfusions.
You
should
be
shown
these
when
you
begin
working
at
the
hospital
or
medical
centre
or
if
you
are
relocated
in
an
area
where
transfusions
are
likely
to
be
administered.
Although
ultimate
responsibility
lies
with
your
employers,
you
are
personally
responsible
to
make
sure
you
are
using
current
information
prior
to
administering
blood
or
component
transfusions.
Obviously
your
local
procedures
should
be
followed
carefully,
but
if
you
can
identify
any
areas
for
improvement
then
you
should
discuss
these
with
your
line
manager.
Having
a
written
checklist
of
things
to
cover
can
help
you
ensure
that
conversations
are
recorded
accurately
in
the
patients
record.
If,
for
any
reason,
you
were
not
able
to
inform
the
patient
before
the
transfusion
took
place,
then
once
they
have
regained
consciousness
you
will
need
to
provide
full,
accurate
information
about
the
procedure.
This
is
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www.healthierbusinessltd.co.uk
very
important,
because
a
patient
may
go
on
to
donate
blood
in
the
future,
not
knowing
they
have
received
a
blood
transfusion.
PATIENT
REFUSAL
Every
patient
has
the
right
to
either
give
informed
consent
to
a
blood
transfusion,
or
to
refuse.
Their
decision
must
be
clearly
recorded
in
the
patients
medical
record.
This
is
essential
to
ensure
that
patients
wishes
are
followed
regarding
blood
transfusion.
Some
people
may
refuse
a
transfusion
for
religious
reasons,
or
because
they
are
not
willing
to
take
the
risks
associated
with
the
process.
Your
duty
is
to
honour
their
choice,
even
if
you
do
not
agree
with
it.
You
can
question
the
patients
reasons
for
not
consenting,
and
provide
more
information
as
appropriate
but
you
are
not
allowed
to
force
them
to
change
their
mind,
or
over-rule
their
choice.
This
is
the
same
with
any
other
medical
procedure;
informed
consent
is
essential.
Obviously,
this
may
pose
an
ethical
dilemma
for
you
from
time
to
time,
and
you
should
seek
the
support
of
your
line
manager
to
help
you
resolve
these
issues.
If
a
patient
is
unconscious
and
cannot
consent,
then
emergency
life-saving
treatment
must
be
performed.
No
one
else
can
give
consent
if
the
person
normally
has
the
mental
capacity
to
understand
the
risks,
benefits
and
outcomes
of
a
transfusion.
Just
because
someone
is
unconscious
does
not
mean
someone
else
can
consent
on
their
behalf.
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If
a
person
is
adamant
that
they
do
not
want
a
transfusion
or
blood
component,
they
will
normally
have
completed
an
advanced
decision
document.
These
documents
can
normally
be
found
either
on
the
patient
or
in
their
medical
file
and
they
must
be
respected
at
all
times
if
they
are
valid.
A
prior
advanced
design
document
is
the
only
reason
that
a
transfusion
cannot
be
given
in
a
critical
or
life
threatening
situation.
The
most
common
group
of
people
globally
that
refuse
either
blood
or
blood
component
transfusions
are
Jehovahs
Witnesses.
As
with
all
groups
of
people,
each
person
may
have
made
an
independent
decision
about
the
medical
care
they
are
willing
to
accept.
You
must
never
assume
that
they
are
going
to
refuse
all
treatment
because
of
their
belief.
Most
Jehovah
Witnesses
will
have
a
clear
document
either
on
their
person
or
on
their
medical
record
of
the
components
that
they
are
willing
to
receive
and
this
must
be
followed.
If
you
are
at
all
unsure,
seek
guidance
from
the
clinical
lead
or
your
line
manager.
PROCESS
FOR
THE
SAFE
AND
EFFECTIVE
ORDERING
OF
BLOOD
COMPONENTS
It
is
important
to
take
care
to
correctly
order
the
blood
to
transfuse
to
your
patients.
A
process
known
as
a
group
and
save
should
be
used,
which
involves
finding
out
the
patients
blood
type
and
a
laboratory
test
screening
to
check
for
antibodies
which
cause
common
transfusion
reactions.
As
well
as
this
the
sample
from
the
patient
should
be
cross
checked
with
the
potential
donors
blood,
mixing
them
in
the
laboratory
to
try
and
rule
out
the
potential
for
adverse
reactions.
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In
the
event
of
an
emergency,
there
may
not
be
time
for
the
laboratory
to
process
the
cross
matching,
so
ensure
you
that
you
liaise
with
the
medical/clinical
team
as
soon
as
possible
and
adhere
to
your
internal
policies.
If
you
are
not
aware
of
the
in
house
policies
or
protocol
regarding
the
aforementioned,
ensure
you
discuss
with
your
line
manager
so
they
can
verify
that
you
have
understood
the
processes
required,
and
seek
further
training
if
you
have
any
concerns
about
how
to
follow
local
policies
regarding
blood
and
component
transfusion.
Never
carry
out
duties
or
tasks
where
you
are
not
deemed
competent
in
nor
have
received
appropriate
training.
Blood
must
be
prescribed
on
a
Prescription
Chart
or
Transfusion
Record
(TR)
that
contains
the
patients
ID
number,
surname,
first
name
and
date
of
birth.
The
prescription
must
state
the
name
of
the
blood
component/
product
to
be
transfused,
the
volume
to
be
transfused
and
rate
of
transfusion.
This
will
be
carefully
matched
with
the
information
used
to
order
the
blood
from
the
laboratory
or
storage
area.
This
information
will
be
cross
checked
at
every
stage
of
the
process
so
it
is
of
the
utmost
importance
that
it
is
correctly
recorded
and
checked
from
the
start.
You
must
also
include
the
patients
details,
their
medical
condition
and
gender
along
with
the
time,
urgency
of
transfer
and
location.
If
there
are
any
known
medical
issues
such
as
reactions
or
allergies.
If
there
are
any
special
requirements,
these
must
also
be
included
on
the
request.
The
current
guidelines
recommend
that
non-urgent
out
of
hours
requests
are
avoided
to
reduce
errors.
Equally,
using
the
telephone
to
request
blood
should
not
be
standard
practise
as
there
is
too
large
a
margin
for
error.
28
www.healthierbusinessltd.co.uk
SHOT
or
Serious
Hazard
of
Transfusion
is
an
independent
organisation
that
monitors
the
safety
and
hazards
of
blood
transfusion.
The
organisation
collate
data
on
reactions
and
adverse
events
and
identifying
risks
and
underlying
problems.
The
website
can
be
viewed
at:
http://www.shotuk.org/
with
resources
on
how
to
report
issues,
view
their
data
and
associated
information.
If
you
are
involved
in
a
transfusion
where
there
are
complications,
you
may
be
required
to
complete
the
SHOT
report.
The
NHS
has
listed
10
Transfusion
commandments
which
must
be
central
to
any
decision
you
make
about
a
transfusion
for
any
patient:
1. Transfusion
should
only
be
used
when
the
benefits
outweigh
the
risks
and
there
are
no
appropriate
alternatives.
2. Results
of
laboratory
tests
are
not
the
sole
deciding
factor
for
transfusion.
3. Transfusion
decisions
should
be
based
on
clinical
assessment
underpinned
by
evidence-based
clinical
guidelines.
4. Not
all
anaemic
patients
need
transfusion
(there
is
no
universal
transfusion
trigger).
5. Discuss
the
risks,
benefits
and
alternatives
to
transfusion
with
the
patient
and
gain
their
consent.
6. The
reason
for
transfusion
should
be
documented
in
the
patients
clinical
record.
7. Timely
provision
of
blood
component
support
in
major
haemorrhage
can
improve
outcome
good
communication
and
team
work
are
essential.
29
www.healthierbusinessltd.co.uk
8. Failure
to
check
patient
identity
can
be
fatal.
Patients
must
wear
an
ID
band
(or
equivalent)
with
name,
date
of
birth
and
unique
ID
number.
Confirm
identity
at
every
stage
of
the
transfusion
process.
Patient
identifiers
on
the
ID
band
and
blood
pack
must
be
identical.
Any
discrepancy,
DO
NOT
TRANSFUSE.
9. The
patient
must
be
monitored
during
the
transfusion.
10.
Education
and
training
underpin
safe
transfusion
practice.
30 www.healthierbusinessltd.co.uk