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Oral Medications For Adults With Type 2 Diabetes Clinician Guide
Oral Medications For Adults With Type 2 Diabetes Clinician Guide
Oral Medications For Adults With Type 2 Diabetes Clinician Guide
December 2007
Comparing Oral Medications for Adults With Type 2 Diabetes / Clinician’s Guide
other oral hypoglycemics. Most oral hypoglycemics have very little n Both rosiglitazone and pioglitazone
effect on high density lipoprotein (HDL). increase LDL, but rosiglitazone
Combining Oral Hypoglycemics
has a greater effect. Rosiglitazone
n Pioglitazone increases HDL by about
Combinations of oral hypoglycemics increases LDL by 10 mg/dl more than
3–5 mg/dl compared with metformin
will lower HbA1c about 1 percentage pioglitazone.
and sulfonylureas.
point more than monotherapy. level of confidence: ● ● ●
level of confidence: ● ● ●
n Combining metformin and a
n Pioglitazone increases HDL by about
sulfonylurea reduces HbA1c more
1–3 mg/dl more than rosiglitazone,
than using metformin or a
which also raises HDL.
sulfonylurea alone.
level of confidence: ● ● ●
level of confidence: ● ● ●
Micronase®
2
Comparing Oral Medications for Adults With Type 2 Diabetes / Clinician’s Guide
sulfonylurea and 12 percent of people than for people taking other oral Guide. It can help
taking repaglinide. hypoglycemics. people talk to their
Sulfonylureas are more likely to cause Fewer people have GI problems when health care profes-
hypoglycemia than metformin or TZDs. metformin is combined with a sulfony- sional about oral
People taking sulfonylureas have about medications for
November 2007
Biguanides
Metformin Glucophage® 500 mg daily $20 $30
500 mg bid $40 $60
850 mg bid $70 $95
1000 mg bid $85 $120
Glucophage XR® 1000 mg daily $45 $60
2000 mg daily $90 $115
Second-generation sulfonylureas
Glimepiride Amaryl® 1 mg daily $10 $15
2 mg daily $20 $25
4 mg daily $35 $45
8 mg daily $75 $85
Glipizide Glucotrol® 5 mg daily $10 $15
10 mg daily $20 $30
10 mg bid $40 $60
20 mg bid $75 $125
Glucotrol XL® 5 mg daily $10 $15
20 mg daily $50 $65
Glyburide Diabeta®, 2.5 mg bid $30 $35
Micronase® 5 mg daily $25 $30
5 mg bid $45 $65
Glynase PresTab® 1.5 mg daily $10 $20
3 mg daily $20 $35
6 mg bid $60 $115
Thiazolidinediones (TZDs)
Pioglitazone Actos® 15 mg daily NA $115
30 mg daily NA $190
45 mg daily NA $205
Rosiglitazone Avandia® 2 mg bid NA $145
4 mg daily NA $110
8 mg daily NA $200