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Enzymes

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http://www.biology.usu.edu/courses/biol1010-
podgorski/Sp%2005/PowerPoints%2005/Energetics%20and%20Enzymes.ppt#10





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E+ S ES complex E + P
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E + S ES complex E + P
Regulation

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Preproinsulin Proinsulin Mature insulin
:2
Feedback inhibition
)2 " - feedback inhibition -

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A B C D

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( phosphorylation)
Glycogen phosphorylase

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Phosphorylase
kinase

Glycogen phosphorylase a
(more active form)

Phosphorylase
phosphatase

Glycogen phosphorylase b
(less active form)

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)(second messenger
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H H

H3C C CH3 H3 C C CH3

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Enzyme CH2OH + F P O Enzyme CH2 O P O + HF

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H3C C CH3 H3 C C CH3

H H
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Enzyme Possible Diagnosis
Glutamic oxaloacetate transaminase Infectious hepatitis, Myocardial infarction
(GOT/AST)
Glutamic pyruvic transaminase Infectious hepatitis
(GPT/ALT)
Trypsin Acute pancreatic disease
Amylase Liver & pancreatic disease
Acid phosphatase Cancer of prostate
Alkaline phosphatase Liver or bone disease
Creatine phosphokinase Myocardial infarction or muscles
Lactate dehydrogenase (LDH) Myocardial infarction, leukemia


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