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Systemic Review Final Draft 586
Systemic Review Final Draft 586
Systemic Review Final Draft 586
A.J. Hicks
ahicks47@live.unc.edu
References: 20
2
Abstract
Overview: Determine the effectiveness and potential risks of various radiotherapy methods for
Methods: PubMed and Google Scholar were the main databases used for research. Articles
used had to concentrate on the effectiveness of radiotherapy post-surgical excision and its
Results: There is a fair degree of variability due to different methods of radiation administration,
scar evaluation, and post-treatment patient recall. Also, keloids were assessed differently
depending on location.
Conclusions: Any form of post-keloidectomy radiation therapy was more effective at stopping
keloid recurrence than surgical excision alone. External beam radiation therapy prevailed as the
preferred method when compared to brachytherapy. High dose rate (HDR) brachytherapy
outperformed low dose rate (LDR) brachytherapy when directly compared. The biologically
effective dose (BED) appeared to be the main determining factor of effectiveness with higher
BED leading to lower recurrence. In all, this field needs more research to determine the best
Keywords
Introduction
continuously grow beyond the site of injury; there is 20-fold collagen production in the dermis
compared to normal skin. Similar to hypertrophic scarring, these cutaneous growths are benign
and are symptomatic with chief complaints of aesthetic disfiguration, burning, itching, and
pruritus. Unlike their counterpart, keloid scars form up to years after initial injury and do not
regress over time unless addressed clinically.1 While any demographic is susceptible of forming
keloids, higher pigmentation increases the likelihood 15-fold. Black, Asian, and Hispanic
populations have the highest incident rate of 4.5-16%, the gender ratio is 1:1 and the age of
Due to the complexity of scar formation, current research on the subject is often
misleading and poorly understood. This leads to much debate about which treatment regimen
will serve as the most effective method, the goal being to decrease the recurrence rate of
previously excised scars in the safest manner. Surgical excision alone leads to recurrence rates
of >45%. Radiotherapy post-surgical excision has been identified as a method that decreases
recurrence rates to ~10-20%.4 There are 4 methods of radiation that are pertinent with keloids:
external beam radiation therapy (EBRT, megavoltage electrons), kilovoltage radiotherapy, and
high- and low-dose brachytherapy (HDR and LDR). No modality has been deemed the golden
standard of care because there are many patient factors that contraindicate the different RT
methods. With that said, this systematic review aims to assess how effective radiotherapy halts
the regrowth of keloids, which delivery method is best, and the effects it has on surrounding
tissues.
Methods
Derived from the compilation of articles from multiple online databases, this review was
made to assess the risk versus reward of using radiation therapy to stunt the recurrence of
4
keloid scars post-surgical excision. The main databases used were PubMed and Google
Scholar. Main search terms used were: (Radiotherapy OR Radiation Therapy OR External
Beam Radiation Therapy OR Brachytherapy AND keloid treatment OR keloid surgery OR keloid
excision OR scar treatment) and (Radiotherapy OR radiation therapy AND keloid treatment AND
Radiation Induced Cancer OR dose effects) and (Radiotherapy AND keloid recurrence OR
effectiveness OR efficacy OR patient satisfaction). In order for a study to qualify for this
systematic review, the article must focus on radiotherapy usage as a treatment method to
minimalize keloid scarring recurrence after being surgically excised. There will be multiple
surgical practices and methods of radiotherapy given to patients, along with multiple patient
demographics, even though there are demographics prone to scarring. Due to the lack of
substantial research around keloid scarring, there are few restrictions on study selection for the
sake of data inclusion; however, articles that focused on radiotherapy used for hypertrophic
Of the search terms used, PubMed produced 107 articles and Google Scholar produced
4218 articles making it a total of 4325 articles. There were 3 additional articles recommended
through PubMed bringing the total to 4328 articles in total. After reviewing titles and abstracts of
those articles 20 were selected as being the most relevant to the topic, this excludes 4308
Searches Conducted:
PubMed: External beam radiation therapy for keloids, Radiation Induced Cancer and Keloids,
Google Scholar: external beam radiation treatment for keloid scars, external beam radiation
Decision Tree
Decision Tree
Articles total
(n=4328)
Articles excluded
Screening Articles screened (n=4308)
n=4328)
Full-text articles
assessed for
eligibility (n=20)
Eligibility
Articles including Articles including
pertinent variables radiation risks (n=2)
(radiation therapy, keloid
recurrence) (n=18)
Results
Searches conducted mostly presented quantitative studies that focused on the use of
different forms of radiotherapy and its effect on keloid recurrence. EBRT, kilovoltage electrons,
LDR and HDR brachytherapy treatments came from different radiation sources, were given in
different doses, and had different dose scheduling depending on the article. The only common
factor between all of the articles was that radiotherapy was given post-surgical excision.
Brachytherapy was given both superficially and interstitially depending on the treatment center
administering the radiation; interstitial and superficial methods were not compared directly.
Multiple meta-analyses focused on the biologically effective dose (BED) which was determined
mathematically based on dose, dose source, and tissue irradiated. These articles also
calculated BED for all radiotherapy methods. There were 2 articles that presented laser therapy
earlobe keloids only, based on the prevalence of this kind of keloid due to ear piercing. One
article presented the comparison of steroid injections (triamcinolone) and radiotherapy post-
surgical excision. There was an article that presented shave excision and post-second intention
radiotherapy, an alternative method to classical excision and RT during the healing process.
Literature reviews assessing the pathophysiology of keloids and adverse effects of radiotherapy
Discussion
The research studies analyzed presented many significant findings. There was a general
consensus that the use of radiotherapy post-surgical excision of keloids had a significantly
positive effect on keloid recurrence.1,316 Compared individually with surgical excision alone,
radiotherapy led to decreased keloid recurrence, improved cosmetic outcomes, and increased
patient satisfaction. There was a good amount of debate between whether EBRT or
brachytherapy is the preferred method of radiation administration4,6 and it was determined that
7
EBRT led to a longer period of recurrence. There were also comparisons of HDR and LDR
brachytherapy, but there was no conclusive evidence on which method was better due to study
limitations and similar effects on recurrence.16 A significant factor that was analyzed was the
BED of radiotherapy, which determines how the tissue irradiated as a whole receives the
radiation dose. Based on location and radiation source, it was determined that higher BED led
This finding presents major concern of radiation-induced cancer (RIC), which is always a
concern when radiation is administered. As the BED goes up, the dosage administered goes up
which raises many red flags.1,7,18 This revelation opens the door for alternative post-
keloidectomy methods such as laser treatments, which eliminate the risk of RIC with minimally
proven effectiveness.2,19 The use of triamcinolone steroid injections was also compared to
While radiotherapy presents itself as an effective method for stunting keloid recurrence,
more concrete evidence is needed. While BED gives the radiation oncologist more control over
dose schedule and dose fractionation.20 There also needs to be more long-term cohort studies
understanding of keloid mechanisms could also assist in the finding of a golden standard.
8
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