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    Wall Bacteria Cell-1

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    Richard Morales
    The document discusses mechanisms of action of beta-lactam antibiotics such as penicillins, cephalosporins, and carbapenems. It explains that these antibiotics are bactericidal and inhibit many gram-positive and gram-negative bacteria by interfering with cell wall synthesis through binding to penicillin-binding proteins and inhibiting transpeptidation reactions, which weakens the cell wall. Resistance can develop via alterations in penicillin-binding proteins or production of beta-lactamase enzymes that break down the antibiotics.

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    Wall Bacteria Cell-1

    Uploaded by

    Richard Morales
    14 views15 pages
    The document discusses mechanisms of action of beta-lactam antibiotics such as penicillins, cephalosporins, and carbapenems. It explains that these antibiotics are bactericidal and inhibit many gram-positive and gram-negative bacteria by interfering with cell wall synthesis through binding to penicillin-binding proteins and inhibiting transpeptidation reactions, which weakens the cell wall. Resistance can develop via alterations in penicillin-binding proteins or production of beta-lactamase enzymes that break down the antibiotics.

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    jurnal

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    2. Wall Bacteria Cell-1

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    The document discusses mechanisms of action of beta-lactam antibiotics such as penicillins, cephalosporins, and carbapenems. It explains that these antibiotics are bactericidal and inhibit many gram-positive and gram-negative bacteria by interfering with cell wall synthesis through binding to penicillin-binding proteins and inhibiting transpeptidation reactions, which weakens the cell wall. Resistance can develop via alterations in penicillin-binding proteins or production of beta-lactamase enzymes that break down the antibiotics.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
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    14 views15 pages

    Wall Bacteria Cell-1

    Uploaded by

    Richard Morales
    The document discusses mechanisms of action of beta-lactam antibiotics such as penicillins, cephalosporins, and carbapenems. It explains that these antibiotics are bactericidal and inhibit many gram-positive and gram-negative bacteria by interfering with cell wall synthesis through binding to penicillin-binding proteins and inhibiting transpeptidation reactions, which weakens the cell wall. Resistance can develop via alterations in penicillin-binding proteins or production of beta-lactamase enzymes that break down the antibiotics.

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    of 15

    Farmakologi dan Toksikologi 3

    2nd meet
    1. Inhibition of synthesis or damage to the peptidoglycan cell wall
    2. Inhibition of synthesis or damage to the cytoplasmic membrane
    3. Modification in synthesis or metabolism of nucleic acids
    4. Inhibition or modification of protein synthesis
    5. Modification in energy metabolism
    R. F., Clark, M. A., dan Cubeddu, L. X., 2009. Pharmacology. Lippincott Williams & Wilkins.
    Wecker, L., Crespo, L. M., dan Brody, T. M., 2010. Brodys human pharmacology: molecular to clinical. Philadelphia, PA: Mosby/Elsevier.
    Wecker, L., Crespo, L. M., dan Brody, T. M., 2010. Brodys human pharmacology: molecular to clinical. Philadelphia, PA: Mosby/Elsevier.
    Therapeutic Overview
    -Lactams

    Penicillins, Cephalosporins, Carbapenems, and Monobactams

    Bactericidal: inhibit many gram-positive and gram-negative organisms

    Agents differ by:


    Organism inhibited
    Pharmacokinetics
    Bacterial resistance
    VancomycinBactericidal; inhibits many methicillin-resistant
    staphylococci

    BacitracinBactericidal; topical use only for gram-positive bacteria


    Wall structure of microbial cells
    NAM: N-Acetylmuramate
    NAG: N-Acetylglucosamine
    1. Penicillin-binding proteins
    2. Inhibition of transpeptidase:
    3. Production of autolysins (not affected by -
    Lactams)
    NAM & NAG dihubungkan o/peptida yg
    kecil sehingga membentuk ikatan yg kuat
    krn d perantarai o/serangkaian enzim
    (trans-, carboxy & edopeptidase) PBP
    PBP bekrja mengkatalisis pembentukan
    ikatan silang antara rantai peptidoglikan
    Obat AB analog dgn PBP
    Enzim transpeptidase bekerja
    mengkatalisis reaksi transpeptidasi.
    Enzim transpeptidase pd membran
    sitoplasma dpt mengikat AB shg enzim tdk
    dpt mengkatalisis reaksi transpeptidasi
    ik. Silang tdk terbentuk dinding rapuh
    Komplek protein transpeptidase dan AB
    beta lactam akan menstimulasi
    pembentukan autolisins digesti dinding
    sel bakteri
    1. Altered PBPs
    2. production of -Lactamase

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