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TH Dư C Lý
TH Dư C Lý
13. Trong th nghim s khi xc nh LD50: V sao phi cho chut nhn i
trc th nghim, thi gian bao nhiu? Thi gian theo di th nghim?
- Chut nhn i ti thiu 5h trc khi th nghim v:
+ C s tng tc gia thc n v thuc ban u.
+ Tng tc chuyn ha gia thc n v thuc.
- Thi gian theo di th nghim: t nht 24h sau khi dng thuc.
15. Cng thc tnh LD50 theo Karber v Behrens, gii thch cc k hiu trong
cng thc.
LD 50=Df
ab
n
Df: Liu ti thiu lm cht tt c th vt. (mg cht c/kg trng lng chut)
a: Ch s trung bnh ca s th vt cht 2 liu k tip.
b: Hiu s liu gia 2 liu k tip.
n: S th vt dng mi liu hoc s trung bnh ca nhng tr s trn: trng hp
s th vt thay i mi liu)
27. Tnh dung dch thuc tim cho 15 chut nht trng c trng lng
trung bnh 20g t dung dch thiopental 20mg/ml. Bit iu kin tim l
0.1ml/10g v liu 40mg/kg chut , hao ht 50%.
28. Pha dung dch thuc tim 20 chut cng c trng lng trung bnh
250g. Bit iu kin tim l 1ml/1kg v liu tim l 350mg/kg chut.
T k tim ta c liu lng cn tim cho 1kg chut cng l : 350mg/1ml/kg chut
Tb phi tim cho mi chut cng l 1ml/kg x 250g=0.25ml
Nh vy ta cn ng 0.25ml x 20chut= 5ml
tr hao ta c th pha 10ml dd tim cha 350mg/ml
Vy ta cn 3500mg thuc ha tan trong 10ml dung dch sinh l.