(For additional information see "Ibuprofen: Drug information" and see "Ibuprofen: Patient drug

information")

For abbreviations and symbols that may be used in Lexicomp (show table)

ALERT: US Boxed Warning

Serious cardiovascular thrombotic events (excluding NeoProfen):

Nonsteroidal anti-inflammatory drugs (NSAIDs) cause an increased risk of serious cardiovascular

thrombotic events, including myocardial infarction, and stroke, which can be fatal. This risk may

occur early in treatment and may increase with duration of use.

Ibuprofen is contraindicated in the setting of coronary artery bypass graft (CABG) surgery.

Serious gastrointestinal bleeding, ulcerations, and perforation (excluding NeoProfen):

NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including

bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These

events can occur at any time during use and without warning symptoms. Elderly patients and

patients with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk for

serious GI events.

Brand Names: US Addaprin [OTC]; Advil Junior Strength [OTC]; Advil Migraine [OTC]; Advil

[OTC]; Caldolor; Childrens Advil [OTC]; Childrens Motrin Jr Strength [OTC] [DSC]; Childrens Motrin

[OTC]; Dyspel [OTC]; EnovaRX-Ibuprofen; Genpril [OTC]; GoodSense Ibuprofen Childrens [OTC];

GoodSense Ibuprofen [OTC]; I-Prin [OTC]; IBU-200 [OTC]; Ibuprofen Comfort Pac; Infants Advil [OTC]

KS Ibuprofen [OTC]; Motrin IB [OTC]; Motrin Infants Drops [OTC]; Motrin Junior Strength [OTC] [DSC];

Motrin [OTC] [DSC]; NeoProfen; Provil [OTC]

Brand Names: Canada Advil; Advil Pediatric Drops; Apo-Ibuprofen; Caldolor; Childrens

Advil; Childrens Europrofen; Ibuprofen Muscle and Joint; Jamp-Ibuprofen; Motrin; Motrin (Children's);

Motrin IB; Novo-Profen; Pamprin Ibuprofen Formula; PMS-Ibuprofen; Super Strength Motrin IB Liquid

Gel Capsules

Therapeutic Category Analgesic, Nonopioid; Anti-inflammatory Agent; Antipyretic;

Nonsteroidal Anti-inflammatory Drug (NSAID), Oral; Nonsteroidal Anti-inflammatory Drug (NSAID),

Parenteral

Dosing: Neonatal
PDA closure: Note: Use birth weight to calculate all doses; monitor urine output; a decrease in

urine output may require dose adjustment or holding of therapy.