This document provides guidelines for safe amphetamine use, including:
1) Amphetamines are psychologically addictive similar to other substances, and addiction risk increases with higher doses and binge use.
2) "Pre-treatment" of small daily doses for a week sensitizes the brain's response to amphetamines, enhancing effects and reducing neurotoxicity of later uses.
3) Tolerance lasting more than 5 days indicates neurotoxicity from excessive dosing without sufficient breaks between uses.
4) To avoid harm, doses should be moderate and spaced out with at least 5 half-lives between uses, and binge use should be avoided.
This document provides guidelines for safe amphetamine use, including:
1) Amphetamines are psychologically addictive similar to other substances, and addiction risk increases with higher doses and binge use.
2) "Pre-treatment" of small daily doses for a week sensitizes the brain's response to amphetamines, enhancing effects and reducing neurotoxicity of later uses.
3) Tolerance lasting more than 5 days indicates neurotoxicity from excessive dosing without sufficient breaks between uses.
4) To avoid harm, doses should be moderate and spaced out with at least 5 half-lives between uses, and binge use should be avoided.
This document provides guidelines for safe amphetamine use, including:
1) Amphetamines are psychologically addictive similar to other substances, and addiction risk increases with higher doses and binge use.
2) "Pre-treatment" of small daily doses for a week sensitizes the brain's response to amphetamines, enhancing effects and reducing neurotoxicity of later uses.
3) Tolerance lasting more than 5 days indicates neurotoxicity from excessive dosing without sufficient breaks between uses.
4) To avoid harm, doses should be moderate and spaced out with at least 5 half-lives between uses, and binge use should be avoided.
1. First off, Methamphetamine is only psychologically addictive.
Just like Cannabis, food, or the internet. Methamphetamine's addiction potential is equal to prescription dextroamphetamine (at similarly potent doses). If you are wondering why d-amph addicts are so much rarer, it's because d-amph is typically given out in prescription tablets only. People can still break it down and snort it, but the difference is that these prescriptions regulate their dosage every month and drastically lowers the chances of addiction. Just another reason why the drug war is such a failure really. European speed is so diluted and cut that I'd be surprised if you even got 10% dextro in your powder. No American dealer wants to sell dextroamph because it takes an extra step in synthesis and is less potent. If Europe had the availability to meth precursors like America did, absolutely NO dealer would be selling l- or d-amphetamine. Pharmaceutical companies have the incentive to use d- and l-amphetamine because meth carries such a stigma that patients won't want to take it. Big pharma has near free access to precursors and laboratories so making the slightly less potent d-amph costs almost nothing to them. It is saddening that people who are "pro-drugs except for meth" are tricked by the same misinformation that they hate so much when it's against cannabis. Hopefully by this point, you and I are on the same page and have moved past this "evil meth" label. Thus, I will refer to meth as amphetamine from now on. Significant withdrawal effects only occur when amph is continuously redosed in high dosages. Why? Because constant redosing causes neurotoxicity. The long half life of all amphetamine means that redosing will additively increase blood plasma levels and your brain will soak in that. Acute tolerance shuts out euphoria around the time you reach your first half life. Redosing = excitotoxicity and accumulation of oxidative reactive species in the absense of most of the euphoria. Daily usage is only safe at therapeutic dosages (UNDER ~0.5mg/kg). It seems like it is generally agreed upon that meth is more potent weight by weight than dextro (about 1.3x). When the dosages are matched, they have the exact same safety profile. Chronic use at anything above therapeutic level causes persisting DA striatal depletion. As in, it comes back VERY slowly (think years) and it isn't 100%. You can withdraw from Heroin and get away without lasting physical damage. The same cannot be said for amphetamines. The striatal depletions go unnoticed by binge users until they stop dosing whereupon shit gets real. Quickly. These are the only people that get severe withdrawal effects and feel extremely addicted. Just like every other drug, binging is bad. Before you call therapeutic dosages too pussylike, read the rest of my post. 2. Pre-treatment. Holy fuck I was glad to find out about this before I started using. Pre-treatment takes only one week and it permanently boosts all your subsequent amphetamine effects. It is called sensitization or reverse-tolerance. When taken at sub neurotoxic dosages, the brain becomes supersensitized to all subsequent amphetamine dosages. This effect has been tested to last longer than 120 days and is probably permanent. Animals were intially given a single small amphetamine dosage. In 120 days, they received their second dosage and the effects were dramatically boosted. Tests in human subjects show that the subjective high is nearly doubled from baseline. More research has shown that the optimal pre- treatment schedule is 0.15mg/kg daily for 7 days. The longer the withdrawal period after that, the stronger the effects (up to 30 days when it levels out). Also, did I mention that pre- treatment significantly reduces neurotoxicity in subsequent binges and high dosages? If your first few amphetamine uses were high dosage, you shocked your brain. You most likely had neurotoxic hyperthermia which diminishes sensitization. Source of pretreatment on sensitization and reverse tolerance: http://deepblue.lib.umich.edu/bitstr.../1/0000221.p df Source of pretreatment on neurotoxicity: http://www.nature.com/?file=/npp/jou.../13002 47a.html Bonus source for one dosage causing lasting sensitization: http://www.neuro.cjb.net/content/19/21/9579.sh ort (please keep in mind these dosages in the article are for rats and NOT for humans) 3. Any tolerance to amphetamines that last longer than 5 days is caused by neurotoxicity. The main reason for amphetamine's tolerance is its half life and how quickly the body adjusts to the presence of amphetamine in the blood. After only 3 days (approximately 5 half lives, i.e. ~97% of the drug is gone), this tolerance should be almost completely gone. Any persisting tolerance after 5 days was caused by striatal DA depletions as well as downregulation of D2 receptors. Again, if your tolerance lasts more than 5 days, reconsider your amount and frequency of dosage. Repeated high dosages without adequate time in between will fuck up your shit. The rewarding effects of sensitization is also severely diminished by this binge use. Source: http://www.sciencedirect.com/science...78584602002 579 (I've seen several other sources but this is one I found with a quick search) 4. If you enjoy higher dosages, you must spread them out. This goes back to my last point. Moderately high dosages can actually be safe given that you washout the drugs (about 5 half lives) before redosing. 5. If you are female, the effects of amphetamine neurotoxicity are two folds stronger and psychosis along with addiction potential occur at half the dosage for males. The presence of certain male androgens are neuroprotective against amphetamine. Sorry, women. 6. Smoking and IV have the same safety profile as other ROA's when dosages are matched for bioavailibility and may actually be safer because of their shorter half lives. Rats can take single 25mg/kg injections with no neurotoxicity because their amphetamine half life is only one hour compared to the human time of 9-12 hours. Amphetamines are one of the rare drugs where these ROAs are safer because amphetamine neurotoxicity is primarily exacerbated by the time it stays in the body. Unfortunately, binge use with smoking or IV causes half life to be irrelevant and the safety profile becomes much more dangerous. 7. If you binge, STAY out places that are hotter than room temperature! Heat literally multiplies the tolerance and deficits you are causing to your brain. And, you must have already caused a lot of deficits if you are dumb enough to be a binge user. To sum it up, DON'T FUCKING BINGE! 8. If you have suffered psychosis from amphetamine, I would consider stopping usage. Forever. And yes, even if it only happened once. The implications from psychosis are more than just some temporary effect because you didn't sleep. Amphetamine psychosis is actually caused by the repeated dosage - sleep deprivation only made your brain more vulnerable. The variables that play into psychosis are so wide that studies have yet to really be conclusive on them. Currently, it is believed that prolonged amphetamine blood plasma induces dopamine hyperreactivity. Guess how schizophrenics are diagnosed? Dopamine hyperactivity. Again, this probably causes lasting deficits. Want to avoid psychosis? Don't. Binge. It is nearly impossible to induce psychosis if there are more than 5 hours of sleep between dosages unless you were already genetically predisposed. Here's the schedule a beginner should follow for daily productive use and to prevent neurotoxicity (Assuming 99% bioavailability. Adjust dosages for your ROA bioavailability): Days 1-7: 0.15mg/kg Days 8-?: <0.5mg/kg for males, <0.25mg/kg for females No more than once a day For recreational use: Days 1-7:0.15mg/kg Days 8-?: <1.0mg/kg for males, <0.5mg/kg for females No more than once every 3-4 days After pretreatment and sensitization, 1.0mg/kg WILL bring a satisfying rush. On a 160 pound person, that would be about 72mg. If it sounds too little to you, than you have gone too far. It's that simple. Moderation is key, what a surprise huh? If everybody took amphetamines responsibly with milligram scales, we would probably be exploring the universe by now. P.S. As a bonus, take Vitamin C and E for antioxidants. Take Magnesium to slow down acute tolerance (NMDA antagonist = be higher for longer! YAY). Zinc supplementation was also found to be synergistic with amphetamine in ADHD patients. I don't know its effects on normal people, but I take it anyway. For further reading, look up "Robinson TE". He is by far my favorite researcher. Another goodie is Carl Hart. He is a forerunner on meth research and always talks about the exaggerated claims on meth. He himself said that scientists have known for a long time that methamphetamine is exactly like dextroamphetamine at a drug policy conference.
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