Professional Documents
Culture Documents
Fda 2010 N 0100 0005
Fda 2010 N 0100 0005
Volume 1 of 16
(Text, Figures, and Summary Tables 1-44)
STUDY TITLE
A DIETARY DEVELOPMENTAL
NEUROTOXICITY STUDY OF BISPHENOL A IN RATS
STUDY NUMBER
WIL-186056
DATA REQUIREMENT
STUDY DIRECTOR
26 June 2008
30 September 2009
PERFORMING LABORATORY
SPONSOR
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COMPLIANCE
STATEMENT
This study, designated WIL- 186056, was conducted in compliance with the United States
Environmental Protection Agency (EPA) Good Laboratory Practice Standards
(40 CFR Part 792), 18 September 1989; the Organisation for Economic Cooperation and
Development (OECD) Principles of Good Laboratory Practice [C(97) 186Rinal1,
26 November 1997, with the following exceptions. The analysis of the phytoestrogen
content in the diet (Appendix E) was not performed according to GLPs. The
characterization of the internal standard used for the analyses of test diets was unknown.
In addition, although hlly trained, completion of training was not documented for three
technicians that used the Zymark TurboVap LV Evaporator and one technician that used
the Agilent GC-MS system during the analyses of dietary formulations.
This study was also conducted in accordance with the standard operating procedures of
WIL Research Laboratories, LLC and the protocol as approved by the Sponsor.
The protocol was designed to be in accordance with the United States EPA Health Effects
Test Guidelines OPPTS 870.6300 Developmental Neurotoxicity Study, August 1998 and
the OECD Guideline for Testing of Chemicals, Guideline 426, Developmental
Neurotoxicity Study, 16 October 2007.
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TABLE OF CONTENTS
VOLUME 1 Page
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5. Parameters Evaluated.......................................................................... 38
5.1. F0 Observations...................................................................................... 38
5.1.1. Clinical Observations And Survival ....................................................... 38
5.1.2. Detailed Clinical Observations............................................................... 38
5.1.3. Body Weights ........................................................................................ 39
5.1.4. Food Consumption And Test Substance Consumption ........................... 39
5.1.5. Parturition.............................................................................................. 39
5.1.6. Anatomic Pathology............................................................................... 40
5.1.6.1. Macroscopic Examinations .................................................................... 40
5.1.6.2. Organ Weights....................................................................................... 41
5.1.6.3. Microscopic Examinations ..................................................................... 41
5.2. F1 Litter Parameters ............................................................................... 41
5.2.1. Litter Viability And Deaths.................................................................... 41
5.2.2. Litter Reduction..................................................................................... 42
5.2.3. Clinical Observations............................................................................. 42
5.2.4. Body Weights ........................................................................................ 42
5.2.5. Sex Determination ................................................................................. 43
5.2.6. Calculation Of Litter Parameters............................................................ 43
5.2.7. Weaning And Selection ......................................................................... 43
5.2.8. Developmental Landmarks, Sensory Function, And
Neurobehavioral Testing ........................................................................ 44
5.2.8.1. Surface Righting Response .................................................................... 45
5.2.8.2. Balanopreputial Separation (Subset A)................................................... 45
5.2.8.3. Vaginal Patency (Subset A) ................................................................... 45
5.2.8.4. Detailed Clinical Observations (Subset A) ............................................. 45
5.2.8.5. Auditory Startle Response (Subset A) .................................................... 46
5.2.8.6. Motor Activity (Subset A)...................................................................... 47
5.2.8.7. Biel Maze Swimming Trials (Subsets A And B) .................................... 47
5.2.9. Macroscopic And Microscopic Examinations ........................................ 49
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INDEX OF FIGURES
10. Summary Of Motor Activity Total Counts (F1 Combined Sexes - PND 13).......... 116
11. Summary Of Motor Activity Total Counts (F1 Combined Sexes - PND 17).......... 117
12. Summary Of Motor Activity Total Counts (F1 Combined Sexes - PND 21).......... 118
15. Summary Of Motor Activity Total Counts (F1 Males - PND 61) ........................... 121
16. Summary Of Motor Activity Total Counts (F1 Females - PND 61)........................ 122
17. Summary Of Startle Response Data [Max] (F1 Combined Sexes - PND 20) ......... 123
18. Summary Of Startle Response Data [Max] (F1 Combined Sexes - PND 60) ......... 124
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20. Summary Of Biel Maze Data - Mean No. Of Errors (F1 Males - PND 22) ............ 126
21. Summary Of Biel Maze Data - Mean No. Of Errors (F1 Females - PND 22)......... 127
23. Summary Of Biel Maze Data - Mean No. Of Errors (F1 Males - PND 62) ............ 129
24. Summary Of Biel Maze Data - Mean No. Of Errors (F1 Females - PND 62)......... 130
25. Summary Of Brain Morphometry [Level 1] (F1 Combined Sexes - PND 21)........ 131
26. Summary Of Brain Morphometry [Level 3] (F1 Combined Sexes - PND 21)........ 132
27. Summary Of Brain Morphometry [Level 5] (F1 Combined Sexes - PND 21)........ 133
28. Summary Of Brain Morphometry [Level 1] (F1 Combined Sexes - PND 72)........ 134
29. Summary Of Brain Morphometry [Level 3] (F1 Combined Sexes - PND 72)........ 135
30. Summary Of Brain Morphometry [Level 5] (F1 Combined Sexes - PND 72)........ 136
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INDEX OF TABLES
VOLUME 1 (continued) Page
8. Summary Of Body Weight Changes During Lactation [G] (F0) ............................. 170
10. Summary Of Food Consumption During Lactation [G/Animal/Day] (F0) ............. 174
16. Summary Of Macroscopic Findings (F0 - Pup Sex Ratio Criteria Not Met) .......... 183
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19. Summary Of Organ Weights And Organ Weights Relative To Body Weights
(F0 - Lactation Day 21)............................................................................................. 187
22. Summary Of Microscopic Findings (F0 - Pup Sex Ratio Criteria Not Met) ........... 191
23. Summary Of Microscopic Findings (F0 - Lactation Day 21) .................................. 192
30. Summary Of Pup Necropsy Findings (F1 - Pups Euthanized Due To Death
Of Dam, Sex Ratio Criteria Not Met, Or On PND 21)............................................ 216
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37. Summary Of Body Weight Changes [G] (F1 Males - Subset A)............................. 230
38. Summary Of Body Weight Changes [G] (F1 Females - Subset A) ......................... 232
42. Summary Of Startle Response Data - Max [Newtons] (F1 - Subset A) .................. 318
VOLUME 2
45. Summary Of Macroscopic Findings (F1 Males - Unscheduled Deaths) ................. 351
46. Summary Of Macroscopic Findings (F1 Females - Unscheduled Death) ............... 352
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INDEX OF APPENDICES
VOLUME 3
A4. Individual Body Weights During Gestation [G] (F0) .................................. 800
A5. Individual Body Weight Changes During Gestation [G] (F0)..................... 806
A6. Individual Body Weights During Lactation [G] (F0) .................................. 818
A7. Individual Body Weight Changes During Lactation [G] (F0)..................... 824
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VOLUME 4
VOLUME 5
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VOLUME 6
A33. Individual Clinical Observations (F1 Females - Subsets A And B) .......... 1648
A34. Individual Body Weights [G] (F1 Males - Subsets A And B)................... 1707
A35. Individual Body Weights [G] (F1 Females - Subsets A And B) ............... 1719
A36. Individual Body Weight Changes [G] (F1 Males - Subsets A And B) ..... 1731
VOLUME 7
A42. Individual Biel Maze Swim Trials (F1 - PND 22 - Subset B) ................... 2267
VOLUME 8
A44. Individual Biel Maze Swim Trials (F1 - PND 62 - Subset A)................... 2305
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A45. Individual Macroscopic Findings (F1 Males - Unscheduled Deaths) ....... 2329
A46. Individual Macroscopic Findings (F1 Females - Unscheduled Death) ..... 2332
VOLUME 9
A50. Individual Final Body And Brain Weights And Brain Measurements
(F1 - Animals Selected For Neuropathology - PND 21 - Subset C).......... 2878
VOLUME 10
A54. Individual Final Body And Brain Weights And Brain Measurements
(F1 - Animals Selected For Neuropathology - PND 72 - Subset A) ......... 3223
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VOLUME 11 Page
VOLUME 12
VOLUME 13
VOLUME 14
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VOLUME 15 Page
VOLUME 16
O. WIL Motor Activity Historical Control Data Version 1.2 [Crl:CD(SD) Rats]..... 4686
Q. WIL Biel Maze Historical Control Data Version 2.1 [Crl:CD(SD) Rats]............. 4708
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1. SUMMARY
The objective of this study was to determine the potential of the test substance,
bisphenol A, to induce functional and/or morphological effects to the nervous system of
offspring following exposure of the mother during pregnancy and lactation. The study
was conducted in accordance with and exceeded OECD Test Guideline 426 and U.S.
EPA OPPTS Guideline 870.6300 and was in conformance with Good Laboratory Practice
Regulations (40 CFR Part 792) and the OECD Principles of Good Laboratory Practice
[C(97) 186/Final]. As specified in the guidelines, positive control data, using reference
chemicals to establish the reliability and sensitivity of the test methods at the appropriate
offspring ages used for neurotoxicity endpoints, were developed by WIL Research
Laboratories, LLC and are included in Appendix L.
The test substance, bisphenol A (BPA), was offered at concentrations of 0 (control), 0.15,
1.5, 75, 750, and 2250 parts per million (ppm) on a continuous basis in the diet to
six groups of 24 bred female Crl:CD(SD) rats (F0 dams) daily from gestation day 0
through lactation day 21. The mean test substance consumption in the 0, 0.15, 1.5, 75,
750, and 2250 ppm groups was 0, 0.01, 0.12, 5.85, 56.4, and 164 mg/kg/day,
respectively, during gestation and 0, 0.03, 0.25, 13.1, 129, and 410 mg/kg/day,
respectively, during lactation.
Clinical observations, body weights, and food consumption were recorded at appropriate
intervals. In addition, detailed clinical observations (DCO) were conducted outside of the
home cage on all dams in each group on gestation days 10 and 15 and on lactation
days 10 and 21. All females were allowed to deliver and rear their offspring
(F1 generation) to lactation day 21, at which time the dams were euthanized and
necropsied. The liver and kidneys were weighed and examined microscopically for all
F0 females surviving to the scheduled necropsies.
Clinical observations, body weights, and sex were recorded for the F1 pups at appropriate
intervals. Surface righting response was evaluated for all available F1 pups beginning on
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Maternal toxicity was expressed at 750 and 2250 ppm in the F0 generation by lower mean
body weight gains during gestation (gestation days 0-20) of 9.5% and 22.4%,
respectively, with an associated reduction in mean food consumption from the onset of
test substance exposure through gestation days 10 and 20, respectively. Mean body
weight gains and food consumption in the 750 and 2250 ppm groups were similar to the
control group throughout lactation. Mean body weights, body weight gains, and food
consumption in the 0.15, 1.5, and 75 ppm groups were unaffected by test substance
exposure throughout gestation and lactation. No additional evidence of systemic toxicity
was observed in F0 females, including liver weights, kidney weights, and microscopic
changes. There were no effects on reproductive performance.
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With the exception of reduced mean pup body weights at exposure levels of 750 and
2250 ppm, there were no effects on litter or offspring developmental parameters.
Reductions in mean male and female pup body weight gains occurred during PND 7-14.
This resulted in lower mean male and female pup body weights during PND 14-17 in the
750 ppm group (up to 5.6% lower) and PND 11-21 in the 2250 ppm group (up to 8.3%
lower) relative to the control group. There were no test substance-related effects on
post-weaning body weight or the onset of sexual maturation as measured by the age of
attainment of vaginal opening or preputial separation.
For F1 males and females, there were no test substance-related effects on DCO, motor
activity, auditory startle, learning and memory, macroscopic examinations and
measurements, neuropathology, or brain morphometry at any dietary concentration at any
age. At the PND 11 DCO, two pups in the 750 ppm group and four pups in the 2250 ppm
group exhibited clonic movements that were recorded as convulsions and/or popcorn
seizures. These observations were not reproduced in a follow-up study (Stump, 2009;
WIL-186058) conducted under conditions designed to replicate, as closely as possible,
this original developmental neurotoxicity study through PND 11. A single dietary
concentration (2250 ppm) was used in the follow-up study, with DCO conducted on
twice the number of pups per litter (from 27 litters). The initial observations were not
considered to be test substance-related because they were not noted at any other age, and
they were not reproduced in the follow-up study. In addition, no other neurobehavioral
or neuropathological parameters were altered in any animals, including those that
exhibited clonic movements on PND 11.
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level (NOAEL) for systemic toxicity of BPA was 75 ppm (5.85 mg/kg/day and
13.1 mg/kg/day during gestation and lactation, respectively).
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2. INTRODUCTION
2.1. GENERAL STUDY INFORMATION
This report presents the data from A Dietary Developmental Neurotoxicity Study of
Bisphenol A in Rats. Due to software spacing constraints, the study title is presented as
Dietary Developmental Neurotoxicity Study of Bisphenol A in Rats on the report
tables. For clarification of the terminology used to differentiate the generations in the
report text, the offspring of the F0 generation were defined as the F1 litters; pups from the
F1 litters were selected to constitute the F1 generation.
The following computer protocols were used for data collection during the study:
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1
Date ranges represent the first and last dates of evaluation.
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3. STUDY DESIGNA
Acclimation period
A= In order to accommodate the introduction of variables that could have affected the study
outcome and to accommodate the logistics of data collection, the study consisted of
two cohorts starting approximately four weeks apart; each cohort was composed of
12 females per group.
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Subset C
One pup/sex/litter
Subset D
selected for in situ
Nonselected pups
perfusion; brain
necropsied on
weights, and brain
PND 21
measurements on
PND 21
Neuropathological and
morphometric
evaluations conducted
for 10 pups/sex/group
Subset B
Subset A One pup/sex/litter selected
One pup/sex/litter selected for for learning and memory
post-weaning developmental landmarks
evaluations beginning on
beginning on PND 25 or 35; startle PND 22
response evaluations on PND 20 and 60;
motor activity evaluations on PND 13, 17,
21, and 61; detailed clinical observations Gross necropsy performed
on PND 4, 11, 21, 35, 45, and 60; learning on all F1 Subset B rats
and memory evaluation beginning on following completion of
PND 62 learning and memory
evaluations
A= In order to accommodate the introduction of variables that could have affected the study
outcome and to accommodate the logistics of data collection, the study consisted of
two cohorts starting approximately four weeks apart; each cohort was composed of
12 females per group.
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Physical
Identification Description
Documentation regarding the purity and stability of the test substance is on file with the
Sponsor and WIL Research Laboratories, LLC. The Certificates of Analysis for the test
substance prepared prior to and following the experimental phase of the study were
provided by the Sponsor and are presented in Appendix B. The purity of the test
substance ranged from 99.59% to 99.62%. The test substance was stored at room
temperature in a desiccator, protected from light, and was considered stable under these
conditions. A reserve sample (1.0 g) of the test substance was collected and is stored (in
a desiccator and protected from light) in the Archives of WIL Research Laboratories,
LLC.
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for Cohort 1 (13-14 July 2008), males and females were offered the basal diet from lot
no. APR09082C. This one day of exposure to the different lot did not negatively impact
the quality or integrity of the data or the outcome of the study.
4.1.3. PREPARATION
For the control group, an appropriate volume of acetone (lot nos. [exp. dates]: 076771
[21 February 2010], 076783 [28 February 2010], and 076784 [3 March 2010]; received
from Fisher Scientific, Co. LLC, Florence, KY) was added to a glass jar. For control
group diets prepared on 4 August 2008 and thereafter, basal diet and acetone were mixed
for approximately five minutes in a Hobart mixer and disposed prior to mixing the diet
for exposure to the control group to ensure the absence of any test substance in the mixer;
a Hobart mixer and paddle were dedicated for preparation of control group diets only.
Following cleaning of the mixer, approximately 10 kilograms of PMI Nutrition
International, LLC, Certified Rodent LabDiet 5002 (meal) was placed in the Hobart
mixer, and 400 mL of acetone was added (the approximate amount added for the
preparation of the diets for Groups 2-6). The basal diet pre-mix was mixed for
approximately five minutes and the remaining 10 kilograms of basal diet (initially
weighed in a metal container) was added to the mixer and mixed for approximately
10 minutes. The prepared diet for the control group was stored in metal containers
dedicated for use for the control group diet only.
For preparation of the test diets for Groups 2 and 3, a test substance stock solution
(0.1 mg/mL) was prepared as follows. An appropriate amount of the test substance was
added to a tared weighing vessel. Approximately 50% of the acetone and the appropriate
amount of test substance were added to a volumetric flask. The flask was swirled and
acetone was added to bring the mixture to the calibration mark. This stock solution was
used to prepare the Group 2 and Group 3 stock solutions. For the Group 2 and 3 stock
solutions, the appropriate volume of the 0.1 mg/mL stock solution was added to glass
jars. The appropriate amount of acetone was added to each jar, and the contents were
mixed using a magnetic stirrer until uniform.
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Test diets for Groups 2 and 3 were prepared as follows. The appropriate amount of the
appropriate stock solution was added to a reagent sprayer. Approximately 10 kilograms
of basal diet was weighed into a metal container and added to a Hobart mixer. Using the
sprayer, approximately one-half of the desired volume of stock solution was sprayed onto
the diet. The diet was mixed for approximately two minutes and the remaining
10 kilograms of basal diet (initially weighed in a metal container) was added to the mixer
and sprayed with the remaining stock solution. The diet was mixed for approximately
15 minutes. The volume of stock solution added to the diet for Groups 2 and 3 was
approximately 15% greater than the required amount to account for the loss of stock
solution during the spraying process. Following preparation of the test diet for Group 3,
the Hobart mixer was washed with soap and water and rinsed twice with adequate
volumes of acetone. Following washing, approximately one kilogram of basal diet and
200 mL of acetone were mixed for approximately two minutes in the mixer; this diet was
then disposed.
Test diets for Groups 4-6 were prepared in a room separate from the room used to prepare
the test diets for Groups 1-3, as follows. The appropriate amount of test substance was
added to a tared glass jar. The appropriate volume of acetone was added to the glass jar,
and the contents were swirled to dissolve the test substance. The dissolved test substance
was transferred into a Hobart mixer with approximately five kilograms of diet. The
formulation was then mixed for approximately 10 minutes. The resultant formulation
was termed pre-mix and was at an approximately four-fold higher concentration than the
desired final concentration. The appropriate amount of additional diet (approximately
15 kilograms) to achieve the desired concentration was weighed in a metal container and
placed in a V-blender (i.e. twin shell blender), and the pre-mix was then added to the
blender. The diet was blended for approximately 15 minutes (an intensifier bar was used
during the first and last 5 minutes).
The control and test diets were prepared approximately bi-weekly and placed in stainless
steel storage containers. Approximately half of each formulation was stored at room
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temperature for use during the first week of exposure, and the remaining half of each
formulation was stored frozen for use during the second week of exposure.
Prior to the initiation of test substance exposure, duplicate samples (approximately 100 g)
were collected from the top, middle, and bottom of each test diet formulation prepared for
the first week of exposure and analyzed for homogeneity; samples were also collected
from the middle of the control diet. For concentration analysis, duplicate samples
(approximately 100 g) were collected from the middle of the control and test diets
prepared for the remainder of the study. One set of samples from each collection was
analyzed and the remaining set of samples was stored frozen (approximately -20C). All
analyses were performed by the Analytical Chemistry Department, WIL Research
Laboratories, LLC. The methodology and results of these analyses are presented in
Appendix C and are summarized in Section 6.1.
The animal model selected, the Crl:CD(SD) rat, is recognized by international regulatory
agencies as appropriate for developmental neurotoxicity studies. WIL Research
Laboratories, LLC, has reproductive and neurotoxicity historical control data for the
Crl:CD(SD) rat. As specified in the guidelines, positive control data, using reference
chemicals to establish the reliability and sensitivity of the test methods at the appropriate
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offspring ages used for neurotoxicity endpoints, were developed by WIL Research
Laboratories, LLC and are included in Appendix L.
Target
Group Exposure Level Exposure Level Number of Femalesa
Number Test substance (ppm) (mg/kg/day) Cohort 1 Cohort 2
1 Basal Diet 0 0 12 12
2 Bisphenol A 0.15 0.01 12 12
3 Bisphenol A 1.5 0.1 12 12
4 Bisphenol A 75 5 12 12
5 Bisphenol A 750 50 12 12
6 Bisphenol A 2250 150 12 12
a
= In order to accommodate the logistics of data collection, the study consisted of two cohorts
starting approximately four weeks apart.
Exposure levels were selected to provide doses that spanned the range from low doses
used in some published studies reporting developmental neurotoxicity (CERHR, 2007) to
a high dose that was anticipated to result in systemic toxicity in the pregnant rat. This
high dose was selected based on the results of a previous range-finding study in which
BPA was offered on a continuous basis in the diet to rats at exposure levels of 250, 750,
2500, and 7500 ppm (Stump, 2009; WIL-186055). In the range-finding study, an
exposure level of 7500 ppm exceeded the maximum tolerated dose based on maternal
body weight losses and lower body weight gain and food consumption resulting in early
termination of the group during gestation. Mean maternal body weight losses and/or
lower mean body weight gains and food consumption were also observed at exposure
levels of 750 and 2500 ppm. Slightly lower pup birth weights, pup weight gains, and
postnatal survival were noted at 2500 ppm. Based on these results and information from
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other studies with BPA, exposure levels of 0.15, 1.5, 75, 750, and 2250 ppm were
selected for the current study.
The F1 animals in the present study were potentially exposed to the test substance in
utero, as well as via the milk while nursing and via direct consumption of the diet during
the latter portion of the lactation period. To maximize exposure, the dietary
concentration was not adjusted to provide a consistent dose of BPA (mg/kg/day) during
lactation, although it is well documented that an increased food consumption (to support
milk production) would result in a higher dose to the dams during this period.
The selected route of administration was oral (dietary) because this is a potential route of
human exposure. The number of animals selected for this study was the minimum
required to meet the goals of the study and fulfulled the U.S. EPA OPPTS and OECD
testing guidelines.
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(no. JUN03082C) was used during the study and was documented in the study records,
with the following exception. During the first day of the mating period for Cohort 1
(13-14 July 2008), males and females were offered the basal diet from lot
no. APR09082C. The phytoestrogen content of feed lot no. JUN03082C (total
isoflavones of 312 ppm aglycone units) is presented in Appendix E; the phytoestrogen
content of feed lot no. APR09082C was not evaluated because the single day of exposure
to this feed lot during the mating period was not expected to have an impact on the
outcome of the study. Feeders were changed and sanitized at least once per week.
Municipal water supplying the facility is sampled for contaminants according to standard
operating procedures. The results of the diet and water analyses are maintained at WIL
Research Laboratories, LLC, and are presented in Appendix E. No contaminants were
present in animal feed or water at concentrations sufficient to interfere with the objectives
of this study. Reverse osmosis-purified (on-site) drinking water, delivered by an
automatic watering system was provided ad libitum throughout the acclimation period
and during the study; the lixits were checked daily for proper functioning. The basal diet
was provided ad libitum to all groups throughout the acclimation period, to Groups 2-6
through the day of evidence of mating, and to the control group (Group 1) throughout the
study. Beginning on gestation day 0, the appropriate test diet was offered to Groups 2-6
through lactation day/PND 21. Following weaning on PND 21 and throughout the
remainder of the study, the basal diet was provided to the F1 animals in all groups.
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22.3C) and mean daily relative humidity ranged from 37.5% to 54.8% for animals in
Cohort 1 (B Room 47). For animals in Cohort 2 (B Room 42), actual mean daily
temperature ranged from 70.2F to 72.7F (21.2C to 22.6C) and mean daily relative
humidity ranged from 40.0% to 50.8%. Fluorescent lighting controlled by light timers
were calibrated to provide a 12-hour light (0600 hours to 1800 hours)/12-hour dark
photoperiod. Air handling units were set to provide a minimum of 10 fresh air changes
per hour.
Positive evidence of mating was confirmed by the presence of a vaginal copulatory plug
or the presence of sperm in a vaginal lavage. Each mating pair was examined daily. The
day on which evidence of mating was identified was termed gestation day 0, and the
animals were separated.
The experimental design consisted of five test substance-treated groups and one control
group, composed of 24 rats each consisting of two cohorts starting approximately four
weeks apart; each cohort was composed of 12 females per group. On each gestation
day 0, the bred females were assigned to groups using a WIL Toxicology Data
Management System (WTDMS) computer program which randomized the animals
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based on stratification of the gestation day 0 body weights in a block design. Body
weight values ranged from 231 g to 297 g on gestation day 0.
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5. PARAMETERS EVALUATED
5.1. F0 OBSERVATIONS
5.1.1. CLINICAL OBSERVATIONS AND SURVIVAL
All rats were observed twice daily, once in the morning and once in the afternoon, for
moribundity and mortality. Individual clinical observations were recorded daily for each
F0 female from gestation day 0 until necropsy. The observations included, but were not
limited to, evaluations for changes in skin and fur, eyes, mucous membranes, respiratory
and circulatory systems, autonomic and central nervous systems, somatomotor activity,
and behavior. The absence or presence of findings was recorded for individual animals.
Females expected to deliver were also observed twice daily during the period of expected
parturition and at parturition for dystocia (prolonged labor, delayed labor, or other
difficulties).
Arousal Mobility
Backing Mucous membrane/eye/skin
Bizarre/stereotypic behavior color
Convulsions/tremors Muscle tone
Ease of handling animal in hand Palpebral closure
Ease of removal from cage Piloerection
Eye prominence Pupillary response
Fur appearance Red/crusty deposits
Gait Respiratory rate/character
General body posture Salivation
Grooming Urination/defecation
Lacrimation/chromodacryorrhea
The detailed clinical observation battery utilized at WIL Research Laboratories, LLC, is
based on previously developed protocols (Gad, 1982; Haggerty, 1989; Irwin, 1968;
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Moser et al. 1988; Moser et al. 1991; ODonoghue, 1989). Testing was performed by
trained biologists without knowledge of the animals group assignment.
When food consumption could not be determined for an animal during a given interval
(due to an unscheduled death, pup sex ratio criteria not met, weighing error, food
spillage, obvious erroneous value, etc.), group mean values were calculated for that
interval using the available data. The time periods when food consumption values were
unavailable for a given animal were designated as NA (Not Applicable) on the
individual report tables.
5.1.5. PARTURITION
All females were allowed to deliver naturally and rear their young to weaning (PND 21).
During the period of expected parturition, the females were observed twice daily for
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initiation and completion of parturition and for signs of dystocia. The day parturition was
initiated was designated lactation day 0 (dams) and PND 0 (pups). On the day parturition
completed (PND 0 or 1), pups were sexed and examined for gross malformations, and the
numbers of stillbirths and live pups were recorded. Individual gestation length was
calculated using the date delivery was first observed.
Tissues with gross lesions and the liver and kidneys from all F0 females were preserved
in 10% neutral-buffered formalin. The carcass of each female was then discarded.
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After fixation, the liver and kidneys were trimmed according to standard operating
procedures of WIL Research Laboratories, LLC. Trimmed tissues were processed into
paraffin blocks, sectioned at 4 to 8 microns, mounted on glass microscope slides and
stained with hematoxylin and eosin. Microscopic examination was performed by Ann
Radovsky, DVM, PhD, DACVP, DABT, WIL Research Laboratories, LLC. The
pathology report is presented in Appendix H.
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F1 animals in Subset A. All F1 animals not selected for behavioral evaluations (Subset D)
were euthanized and necropsied on PND 21. F1 animals selected for learning and memory
assessment on PND 22 (Subset B) were necropsied following completion of that
assessment.
The following table summarizes the allocation of offspring for behavioral tests, brain
weights, and neuropathological evaluation.
Selected pups retained the dam number and tattoo mark (e.g., 99999-01). Each selected
pup was uniquely identified by a metal ear tag displaying the identification number
following weaning.
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that tested positive for the event but were found dead prior to the end of the testing
period.
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Arousal Lacrimation/chromodacryorrhea
Backinga Mobilitya
Bizarre/stereotypic behavior Mucous membrane and skin
Convulsions/tremors color
Ease of handling animal in hand Muscle tone
Ease of removal from cage Palpebral closurea,b
Eye colora,b Piloerectiona,b
Eye prominencea,b Pupillary responsea,b
Fur appearancea,b Red/crusty deposits
Gaita Respiratory rate/character
General body posture Salivation
Groominga,b Urination/defecation
a
= Parameters were not assessed on PND 4 due to stage of development.
b
= Parameters were not assessed on PND 11 due to stage of development.
Auditory startle response testing was performed in a room equipped with a white-noise
generation system set to operate at 70 10 decibels [dB(A)]. Each test session consisted
of a five-minute acclimation period with a 65 5-dB(A) broadband background white
noise. The startle stimulus for each trial was a 115 5-dB(A) mixed-frequency noise
burst stimulus, approximately 20 milliseconds (ms) in duration. Responses were
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recorded during the first 100 ms following the onset of the startle stimulus for each trial.
Each test session consisted of 50 trials, with an eight-second intertrial interval. Startle
response data were analyzed in five blocks of 10 trials each. Startle response
measurements obtained were maximum response amplitude (MAX) in Newtons (N) and
latency to MAX (TMAX) in milliseconds (ms). TMAX was used as a reference to verify
analysis of the primary startle response and was not statistically analyzed.
Data for total motor activity were tabulated. Total motor activity was defined as a
combination of gross and fine (interruption of a single photobeam) motor movement.
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learning and memory phases, the time required to traverse the maze and the numbers of
errors for all trials were recorded. An error was defined as any instance when an animal
deviated from the correct channel with all four feet. The first testing interval was
initiated for each animal on PND 22 (Subset B); the second testing interval was initiated
for each animal on PND 62 (Subset A). Animals tested on PND 22 were not used for the
second testing interval.
Each testing interval consisted of three phases that were conducted over
seven consecutive days. Phase 1 was an evaluation of swimming ability and motivation
to escape from the maze, and was performed on day 1 of the Biel maze procedure. For
this evaluation, animals were placed in a straight channel opposite the escape platform,
and the time required for each animal to escape was recorded. Each animal was allowed
four trials to evaluate swimming ability and motivation. For each trial, animals were
allowed two minutes to complete the trial. At the end of each trial, the animal was
immediately placed at the starting position for another trial until all four trials were
complete.
Phase 2 of the Biel maze procedure evaluated sequential learning. This evaluation was
conducted on days 2-6 of the Biel maze procedure. Animals were allowed two trials per
day for two days to solve the maze in path A. Animals were then allowed two trials per
day for three consecutive days to solve the maze in path B (reverse of path A).
Phase 3 of the Biel maze procedure probed the animal for its memory to solve the maze
when challenged in path A. This evaluation was conducted on day 7 of the Biel maze
procedure. Each animal was allowed two trials to solve the maze in path A.
For each trial in Phases 2 and 3, animals were allowed three minutes to solve the maze.
If an animal did not escape the maze within the allotted three minutes, the animal was
placed on the escape platform for approximately 20 seconds, then removed from the
maze. The minimum intertrial interval for these phases was one hour.
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Biel maze data were evaluated as the numbers of errors committed during Phases 2 and 3
(i.e., sequential learning and memory). Time to escape was recorded to verify that the
animals were removed within the specified time (two minutes for Phase 1 and three
minutes for Phases 2 and 3). The time to escape data were not statistically analyzed and
are presented in Appendix A.
A diagram of Path A and Bath B of the Biel water maze is shown below:
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Nervous system tissues from the offspring perfused in situ at study termination (PND 72,
Subset A) were processed for neuropathological evaluation. The following tissues were
microscopically examined:
In addition to the tissues listed above, the lumbar spinal nerves associated with the
lumbar root fibers and ganglia, and the cervical spinal nerves associated with the cervical
root fibers and ganglia were examined but were tabulated only if there was an
abnormality present.
The central nervous system tissues were embedded in paraffin, and the peripheral
nervous system tissues were embedded in glycol methacrylate. Tissues were prepared for
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histopathological evaluation by sectioning and staining with hematoxylin and eosin. The
histopathologic examination included a simple morphometric analysis as described in
Section 5.2.9.3.3. Missing tissues were identified as not found at necropsy, lost at
necropsy, lost during the processing, or other designations as appropriate. Tissues may
appear on the report tables as not examined due to the tissue not being in the plane of
section, not present at trimming, etc. Neuropathology examinations of tissues from
PND 21 and PND 72 were performed by Ann Radovsky, DVM, PhD, DACVP, DABT,
WIL Research Laboratories, LLC. The pathology report is presented in Appendix H. A
peer review was performed by Robert H. Garman, DVM, Consultants in Veterinary
Pathology, Inc, Murrysville, PA. The peer review consisted of examination of brain
morphometry measurements from all PND 21 and 72 animals, microscopic evaluation of
the brains from at least 50% of the selected PND 21 and 72 animals (including those
animals euthanized on PND 72 that exhibited clonic movements on PND 11), and the
eyes with retina, optic nerves, trigeminal ganglia nerves, skeletal muscle, spinal cords,
and peripheral nerves from 25% of the selected PND 72 rats. The peer review statement
is presented in Appendix I.
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Measurements were made on homologous sections to ensure that the dimensions of the
regions were comparable. In some cases, there was deformation or irregularity of the
desired region. As a result, morphometric analysis could not be made for some regions in
a few animals and are presented as NA (Not Applicable) on the individual data tables.
Mean litter proportions (percent per litter) of pup viability and males per litter were
subjected to the Kruskal-Wallis nonparametric ANOVA test to determine intergroup
differences (Kruskal and Wallis, 1952). If the ANOVA revealed significant (p<0.05)
intergroup variance, Dunns test (Dunn, 1964) was used to compare the test
substance-treated groups to the control group. Detailed clinical observation data which
yielded scalar and descriptive data of the control group were compared to each treated
group by the Fishers Exact Test (Steel and Torrie, 1980).
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Cumulative gestation body weight gain (gestation days 0-20) was analyzed with analysis
of variance (ANOVA). Factors in the model included fixed effect TRT with COHORT
as a blocking factor. Pairwise comparisons were made for each individual test substance-
treated group with the control group using Dunnetts test (Dunnett, 1964). Dams that
failed to deliver offspring were excluded from all statistical analyses.
Pre-culling (PND 1 and 4) and post-culling (PND 4, 7, 11, 14, 17, and 21) pup body
weights and post-culling pup body weight gains (PND 4-7, 7-14, and 14-21) were
analyzed separately with a RANOVA. Factors in the model included random effects for
LITTER, fixed effects for TRT, SEX, and postnatal day (TIME), and the interaction
terms TRT*SEX, TRT*TIME, and TRT*SEX*TIME; COHORT was used as a blocking
factor. For these parameters, the first examination was whether the TRT*SEX and/or
TRT*SEX*TIME interaction was significant. If either interaction was significant, the
analysis was conducted, by sex, with a RANOVA including factors in the model for
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random effects of LITTER, fixed effects for TRT and TIME, and the interaction term
TRT*TIME; COHORT was using as a blocking factor. The covariance structure for the
RANOVA model was selected by comparing the AIC. The Kenward-Rogers adjustment
for denominator degrees of freedom was applied. In the final RANOVA model,
Dunnetts test was used for make pairwise comparisons of each individual treatment
group with the control group. If the TRT*TIME interaction was significant, Dunnetts
test was conducted for each individual day. If the TRT*TIME interaction was not
significant, Dunnetts test was conducted overall across the pooled days only.
Pre-culling pup body weight gain (PND 1-4) was analyzed with a nested ANOVA.
Factors in the model included random effects for LITTER and fixed effects of TRT and
SEX with COHORT as a blocking factor. For these parameters, the first examination
was whether the TRT*SEX interaction was significant. If the interaction was significant,
the analysis was conducted, by sex, with a nested ANOVA including factors in the model
for random effects for LITTER and fixed effects for TRT; COHORT was used as a
blocking factor. The Kenward-Rogers adjustment for denominator degrees of freedom
was applied. Pairwise comparisons were made for each individual test substance-treated
group with the control group using Dunnetts test (Dunnett, 1964).
F1 body weights for PND 28-70 were analyzed separately with a RANOVA. Factors in
the model included fixed effects of TRT, SEX, and postnatal day (TIME) and the
interaction terms TRT*SEX, TRT*TIME, and TRT*SEX*TIME; COHORT was used as
a blocking factor. For these parameters, the first examination was whether the TRT*SEX
and/or TRT*SEX*TIME interaction was significant. If either interaction was significant,
the analysis was conducted, by sex, with a RANOVA including factors in the model for
fixed effects for TRT and TIME and the interaction term TRT*TIME; COHORT was
used as a blocking factor. The covariance structure for the RANOVA model was
selected by comparing the AIC. The Kenward-Rogers adjustment for denominator
degrees of freedom was applied. In the final RANOVA model, Dunnetts test was used
to make pairwise comparisons of each individual treatment group with the control group.
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If the TRT*TIME interaction was significant, Dunnetts test was conducted for each
individual day. If the TRT*TIME interaction was not significant, Dunnetts test was
conducted overall across the pooled days only.
The mean day of attainment for balanopreputial separation (male pups) and vaginal
separation (female pups) was analyzed, individually, with a nested ANOVA. Factors in
the model included random effects for LITTER and fixed effects for TRT; COHORT was
used as a blocking factor.
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individual treated group with the control group. If the TRT*SESSION interaction was
significant, Dunnetts test was conducted for each individual session. If the
TRT*SESSION interaction was not significant, Dunnetts test was conducted overall
across the pooled sessions only.
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as a blocking factor. The covariance structure for the RANOVA model was selected by
comparing the AIC. The Kenward-Rogers adjustment for denominator degrees of
freedom was applied. In the final RANOVA model, Dunnetts test was used to make
pairwise comparisons of each individual treatment group with the control group. If the
TRT*TRIAL interaction was significant, Dunnetts test was conducted for each
individual trial block. If TRT*TRIAL was not significant, Dunnetts test was conducted
overall across the pooled trial blocks only.
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The data were analyzed separately for PND 21 and 72. First, brain weight, brain length,
and brain width were analyzed using a multivariate analysis of variance (MANOVA)
with TRT, SEX, and TRT*SEX as fixed factors and COHORT as a blocking factor. The
first examination was the TRT*SEX interaction. If that effect was not statistically
significant, the overall TRT factor was tested for statistical significance for the combined
sexes. If TRT was statistically significant, linear contrasts, as part of the MANOVA
across the dependent variables, brain weight, brain length, and brain width was used to
test for pairwise differences between each exposure group and the control group. The
Type I error rate was corrected for multiple comparisons between the control group and
each of the test substance exposure groups by dividing the original Type I error rate of
0.05 by the square root of the number of comparisons. The Type I error rate for these
comparisons was then 0.02.
If the TRT*SEX interaction effect was statistically significant, the MANOVA analysis
was conducted for each sex separately. The overall TRT factor was examined for
statistical significance for each sex separately. If TRT was statistically significant, linear
contrasts, as part of the MANOVA across the dependant variables, brain weight, brain
length, and brain width was used to test for pairwise differences between each test
substance-treated group and the control group. The Type I error rate was corrected for
multiple comparisons between the control group and each of the test substance-treated
groups as described above. The Type I error rate for these comparisons was 0.02.
For the cases where TRT was statistically significant in the MANOVA, as described
above, all the endpoints from the microscopic examination, which included at least
two measurements each from the neocortical, hippocampal and cerebellar areas, was
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analyzed statistically using a MANOVA with TRT, SEX, and TRT*SEX as fixed factors.
The first examination was the TRT*SEX interaction. If that effect was not statistically
significant, the overall TRT factor was examined for statistical significance for the
combined sexes. If TRT was statistically significant, linear contrasts, as part of the
MANOVA across the dependant variables from the microscopic examination was used to
test for pairwise differences between each test substance-treated group and the control
group. The Type I error rate was corrected for multiple comparisons between the control
group and each of the test substance-treated groups as described above. The Type I error
rate for these comparisons was 0.02. If TRT was not statistically significant when
analyzing microscopic parameters, no additional statistical analysis were conducted.
If the TRT*SEX interaction effect was statistically significant, the MANOVA analysis
were conducted for each sex separately. The overall TRT factor was examined for
statistical significance for each sex separately. If TRT was statistically significant, linear
contrasts, as part of the MANOVA across the dependant variables from the microscopic
examination was used to test for pairwise differences between each test substance-treated
group and the control group. The Type I error rate was corrected for multiple
comparisons between the control group and each of the test substance-treated groups as
described above. The Type I error rate for these comparisons was 0.02. If TRT was not
statistically significant when analyzing microscopic parameters, no additional statistical
analysis were conducted.
For the case where TRT was not statistically significant in the MANOVA analysis of
perfused brain weight, brain length, and brain width, the endpoints from the microscopic
examination were then individually analyzed using ANOVA with TRT, SEX, and
TRT*SEX as fixed factors and COHORT as a blocking factor at the two time periods.
The first examination was the TRT*SEX interaction. If that effect was not statistically
significant, Dunnetts test was conducted across the combined sexes to test for pairwise
differences between each test substance-treated group and the control group at each time
point. If the TRT*SEX interaction effect was statistically significant, the analysis was
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conducted for each sex and each time point separately. Dunnetts test was then
conducted for each sex at each time point to test for pairwise differences between each
test substance-treated group and the control group.
A reserve sample of the test substance, pertinent electronic storage media, and the
original final report are retained in the Archives at WIL Research Laboratories, LLC, in
compliance with regulatory requirements.
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6. RESULTS
6.1. ANALYTICAL CHEMISTRY
Analytical Chemistry Report: Appendix C
Text Table 1. Results of Homogeneity and Concentration Analyses for the Initial
Diet used in the Study
Group 2 Group 3 Group 4 Group 5 Group 6
(0.15 ppm) (1.5 ppm) (75 ppm) (750 ppm) (2250 ppm)
21 July 2008 0.163 (109) 1.48 (98.9) 69.9 (93.2) 726 (96.8) 2103 (93.4)
4 August 2008 0.160 (107) 1.69 (113) 75.5 (101) 786 (105) 2337 (104)
21 August 2008 0.160 (106) 1.52 (101) 69.5 (92.7) 738 (98.3) 2212 (98.3)
2 September 2008 0.147 (97.8) 1.51 (101) 70.5 (93.9) 715 (95.3) 2183 (97.0)
15 September 2008 0.0723 (48.2)* 0.862 (57.5)* 64.9 (86.6) 661 (88.1) 1994 (88.6)
19 September 2008 0.169 (113) 1.58 (105) NA NA NA
* = The 0.15 and 1.5 ppm group formulations prepared on 15 September 2008 were below
the acceptable concentrations. Therefore, these diets were not used for exposure and
were reformulated on 19 September 2008.
NA = Not applicable.
The analyzed dietary formulations were within the WIL Research Laboratories, LLCs,
standard operating procedures range (85% to 115%) and were homogeneous, with the
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following exceptions: The 0.15 and 1.5 ppm group formulations prepared on
15 September 2008 were 48.2% and 57.5% of target concentrations, respectively.
However, these test diets were not used for exposure on study and were subsequently
reformulated. The control group diet prepared on 21 July 2008 contained 0.0327 ppm
bisphenol A. As a result, this diet was not offered to control group animals. In all other
dietary formulations prepared for exposure to control group animals, test substance was
not detected or was below the lower limit of quantitation (LLOQ). Based on these
results, the protocol-specified exposure levels of test substance were administered to the
animals.
There were no test substance-related effects on pregnancy rates; the values in the control,
0.15, 1.5, 75, 750, and 2250 ppm groups were 95.8%, 95.8%, 100.0%, 100.0%, 100.0%,
and 100.0%, respectively. One female each in the control and 0.15 ppm groups failed to
deliver and were determined to be nongravid at necropsy.
In the 2250 ppm group, female no. 23237 was found dead during the process of
parturition on lactation day 0. This female delivered 12 pups and had three dead fetuses
and one early resorption retained in utero at necropsy. No remarkable clinical findings
prior to death were noted for this female, and the only other gross finding noted at
necropsy was dark red stomach contents. There were no indications of the cause of death
in the tissues (liver and kidneys) examined microscopically. Based on these findings, the
single mortality in the 2250 ppm group, in the absence of any adverse clinical findings or
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other occurrences of mortality or moribundity at any exposure level in this study, was not
attributed to test substance exposure. All other F0 females survived to the scheduled
necropsies.
No test substance-related clinical findings were noted in the F0 females at the daily
examinations. Findings noted in the test substance-treated groups, including hair loss on
various body surfaces and red material around the nose, occurred infrequently and/or at
similar frequencies in the control group.
No test substance-related findings were observed for F0 females at the detailed clinical
observations. A statistically significantly higher number of females in the 750 ppm group
(four females) was noted with red deposits around the nose compared to the control group
(zero females) on lactation day 10. However, a similar increase in the incidence of this
finding was not observed at any other time point in this group on which detailed clinical
observations were conducted (gestation days 10 and 15 and lactation day 21) or at the
daily examinations. Furthermore, a similar incidence of red deposits around the nose was
observed in the control group on lactation day 21. Thus, in the absence of any trend
towards an increase in this finding at any other exposure level, the increase in animals
with red deposits around the nose on lactation day 10 in the 750 ppm group was not
attributed to test substance exposure. No other differences were apparent between the
control and test substance-treated groups when the detailed clinical observation data were
evaluated for gestation days 10 and 15 and lactation days 10 and 21.
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Test substance-related lower mean body weight gains were noted in the 750 and
2250 ppm groups following the onset of the exposure period (gestation days 0-7); these
differences from the control group were statistically significant. Mean body weight gains
in these groups were similar to the control group during gestation days 7-14 and 14-20.
As a result of the initial reductions, mean body weight gains in the 750 and 2250 ppm
groups were statistically significantly lower (9.5% and 22.4%, respectively) compared to
the control group for the overall gestation exposure period (gestation days 0-20). In
addition, mean body weights were 4.7% to 5.2% and 8.6% to 10.7% lower in these same
respective groups during gestation days 3-20; these differences from the control group
were statistically significant.
Mean body weights and body weight gains in the 0.15, 1.5, and 75 ppm groups were
unaffected by test substance exposure during gestation and not statistically significantly
different from the control group.
6.2.4.2. LACTATION
Summary Data: Table 7, Table 8; Figure 2
Individual Data: Table A6, Table A7
Statistical Analysis Summary: Appendix J
As a result of the initial reductions in mean body weight gains during gestation days 0-7,
the mean body weights for the 750 ppm (not statistically significant) and 2250 ppm
(statistically significant) groups were lower than the control group on lactation day 1.
During lactation days 1-17, the mean body weights in the 750 and 2250 ppm groups
ranged from 3.8% to 5.2% and 8.1% to 9.6% lower, respectively, compared to the control
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Mean food consumption, evaluated as g/animal/day, in the 2250 ppm group was
generally reduced throughout gestation (gestation days 0-20) compared to the control
group. Differences from the control group achieved statistical significance during
gestation days 0-3, 3-7, and 10-14 and corresponded to a reduced mean body weight gain
during the first week (gestation days 0-7) of test diet exposure.
In the 750 ppm group, mean food consumption was statistically significantly lower
during gestation days 0-3, 3-7, and 7-10 and similar to the control group throughout the
remainder of the gestation period (gestation days 10-14 and 14-20). The reductions in
mean food consumption corresponded to a reduced mean body weight gain during the
first week (gestation days 0-7) of test diet exposure.
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Mean food consumption in the 0.15, 1.5, and 75 ppm groups was unaffected by test
substance exposure during gestation and not statistically significantly different from the
control group.
6.2.5.2. LACTATION
Summary Data: Table 10
Individual Data: Table A9
Statistical Analysis Summary: Appendix J
Mean food consumption, evaluated as g/animal/day, in the 0.15, 1.5, 75, 750, and
2250 ppm groups was unaffected by test substance exposure during lactation, with the
exception of a statistically significantly lower mean food consumption during lactation
days 7-11 in the 750 ppm group that was not considered to be test substance-related.
The mean doses of bisphenol A, consumed by the dams, are presented below. Values for
the entire lactation period of all groups were elevated, as food consumption increased to
support milk production.
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No test substance-related effects were noted on mean gestation lengths at any exposure
level. Mean F0 gestation lengths in the test substance-treated groups were similar to the
control group value and not statistically significantly different. The mean gestation
lengths in the 0.15, 1.5, 75, 750, and 2250 ppm groups were 21.7, 21.7, 22.0, 21.8, and
21.8 days, respectively, compared to mean gestation lengths of 21.7 days in the
concurrent control group and 21.8 days in the WIL historical control data. No test
substance-related effects were noted on parturition at any exposure level. As described
above, female no. 23237 in the 2250 ppm group was found dead during parturition on
lactation day 0 which was not considered test substance-related.
No test substance-related gross findings were observed at any exposure level at the
scheduled necropsies. One female each in the control and 0.15 ppm groups failed to
deliver and were determined to be nongravid at necropsy; the only macroscopic finding
for these females was clear fluid in the uterus for female no. 26528 in the control group.
No macroscopic findings were noted for the two females each in the 75 and 750 ppm
groups that were euthanized on lactation day 4 due to the pup sex ratio criteria not being
met. At the lactation day 21 necropsy, macroscopic findings noted in the test
substance-treated groups generally occurred in single females.
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At the lactation day 21 necropsy, no test substance-related effects were observed on the
number of former implantation sites and the number of unaccounted-for sites.
At necropsy, the female in the 2250 ppm group that was found dead on lactation day 0
was observed with three dead fetuses and one early resorption in utero. The only other
gross finding noted for this female was dark red stomach contents.
There were no microscopic alterations associated with test substance exposure in the
livers and kidneys of any F0 females at any exposure level. Histopathological findings
were generally consistent with background lesions or did not occur in a dose-related
manner.
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The mean number of pups born, live litter size, percentage of males per litter at birth, and
postnatal survival between birth and weaning were unaffected at all exposure levels.
No clinical observations noted for F1 pups in this study were attributed to test substance
exposure. In the 750 ppm group, three pups from one litter (nos. 23249-04, -06, and -10)
were noted with reddened forelimbs and/or hindlimbs on PND 11 or 14; all three pups
were subsequently found dead. However, because these findings were limited to a single
litter and occurred in a manner that was not exposure-related, they were not considered
test substance-related. Pups (litters) that were found dead or euthanized in extremis
numbered 9(8), 14(9), 15(8), 22(8), 14(6), and 11(7) in the control, 0.15, 1.5, 75, 750, and
2250 ppm groups, respectively. Four (4), 2(2), 3(2), 6(6), 4(4), and 4(3) pups (litters) in
the same respective groups were missing and presumed to have been cannibalized. In
addition, 12 pups (one litter) in the 2250 ppm group were sent to necropsy on PND 0 due
to the death of the dam (no. 23237).
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On PND 1, mean male and female pup body weights in the 750 and 2250 ppm groups
were similar to the control group. During PND 1-4 (pre-culling), mean combined male
and female pup body weight gains in these groups were similar to the control group.
Following culling on PND 4, mean male and female pup body weight gains in the 750
and 2250 ppm groups were similar to the control group during PND 4-7, statistically
significantly lower during PND 7-14, and similar to the control group during PND 14-21.
Mean male and female pup weights in these groups were generally similar to the control
group on PND 4 (pre- and post-culling) and 7. The mean female pup body weight in the
2250 ppm group on PND 4 (pre-culling) was statistically significantly lower (5.6%)
compared to the control group. Because of the reduced mean male and female pup body
weight gains during PND 7-14, mean male and female pup body weights in the 750 ppm
group were statistically significantly lower (4.7% to 5.6%) on PND 14 and/or 17 before
recovering by PND 21, and mean male and female body weights in the 2250 ppm group
were statistically significantly lower (4.8% to 8.3%) beginning on PND 11 and
continuing through the end of the pre-weaning period (PND 21) compared to the control
group.
Mean pup body weights and body weight changes in the 0.15, 1.5, and 75 ppm group
males and females were unaffected by test substance exposure throughout the postnatal
period. Statistically significantly higher mean male body weight gains were noted in 0.15
and 75 ppm groups during PND 14-21 compared to the control group. In addition, mean
female pup body weights in the 75 ppm group were statistically significantly higher on
PND 4 (pre-culling), mean male body weights in the 75 ppm group were statistically
significantly higher during PND 4 (pre- and post-culling) through 11 and on PND 21, and
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the mean male body weight in the 0.15 ppm group was statistically significantly higher
on PND 21 compared to the control group. However, differences from the control group
were generally slight ( 8.5%) and because no dose-related trends were apparent and no
consistent temporal trends were observed, the differences in mean body weights in the
0.15 and 75 ppm groups were not attributed to test substance exposure. In addition, at
75 ppm there were slightly fewer pups per litter at birth and gestation length was 0.3 days
longer; both of these factors may have contributed to the higher mean pup body weights
in this group. There were no other statistically significant differences from the control
group.
The numbers of pups (litters) found dead or euthanized in extremis during the
pre-weaning period (PND 0-21) numbered 9(8), 14(9), 15(8), 22(8), 14(6), and 11(7) in
the control, 0.15, 1.5, 75, 750, and 2250 ppm groups, respectively. No gross findings that
could be attributed to parental test substance exposure were noted at the necropsies of
pups that were found dead or euthanized in extremis. Aside from the presence or absence
of milk in the stomach, the following findings commonly seen at a low incidence for this
strain of rats were noted. In the 2250 ppm group, pup no. 23192-05 had
two developmental malformations (situs inversus and lobular dysgenesis of the lungs).
Pup no. 26462-04 in the 2250 ppm group was noted with a swollen liver and a
hemorrhagic ring around the right iris. Because these findings were noted in single pups,
they were not attributed to test substance exposure. In the 750 ppm group, pup
nos. 23249-06 and 23249-10 had reddened hindpaws; pup no. 23249-10 also had red
fluid in the bladder. Because these findings occurred in a single litter and were not noted
at any other exposure level, they were not attributed to test substance exposure. In the
75 ppm group, pup no. 26516-07 was noted with renal papilla not fully developed (Woo
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and Hoar Grade 1); because this finding was noted in a single pup, it was not considered
test substance-related. No other gross findings were noted in any pups from any group.
No gross findings that could be attributed to test substance exposure were noted at the
necropsy of pups euthanized due to the death of the dam, on PND 4 due to sex ratio
criteria not met, or on PND 21. Gross findings observed on PND 21 included dilated
renal pelves in pup nos. 26459-09 and 26511-11 in the 75 and 2250 ppm groups,
respectively, and eye atrophy in pup no. 26537-04 in the 750 ppm group. No other gross
findings were noted.
Surface righting response in the F1 male and female pups was not affected by test
substance exposure, with no statistically significant difference for any test
substance-treated group. The mean ages of attainment were 6.7, 6.6, 6.3, 6.2, 6.3, and
6.3 days for the F1 animals (combined sexes) in the control, 0.15, 1.5, 75, 750, and
2250 ppm groups, respectively.
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Mean ages of attainment of vaginal patency were unaffected by test substance exposure,
with no statistically significant difference for any test substance-treated group. The mean
ages of attainment of vaginal patency were 32.4, 32.9, 32.8, 33.3, and 32.7 days in the
0.15, 1.5, 75, 750, and 2250 ppm groups, respectively, compared to 32.3 days in the
control group. Additionally, mean body weights at the age of attainment in the test
substance-treated groups were similar to the control group.
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6.5. F1 GENERATION
6.5.1. CLINICAL OBSERVATIONS AND SURVIVAL
Summary Data: Table 34, Table 35
Individual Data: Table A32, Table A33
One female and three males in the control and 1.5 ppm groups, respectively, were found
dead or euthanized in extremis following the pre-weaning period. In the 1.5 ppm group,
male no. 26510-09 (Subset B) was found dead on PND 22 and male no. 23208-08
(Subset A) was found dead on PND 56; no remarkable clinical observations were noted
for either of these males. Male no. 23244-07 (Subset B) in the 1.5 ppm group was
euthanized in extremis on PND 24 due to clinical findings of impaired use of both
hindlimbs and excessive vocalization on the day of euthanasia. No remarkable gross
findings were noted at necropsy for any of the three males found dead or euthanized in
extremis. In the absence of any mortality or moribundity at any other exposure level or
any other evidence of toxicity in the 1.5 ppm group, the mortality or moribundity
observed in three males in this group were not attributed to test substance exposure. In
the control group, female no. 23182-11 (Subset A) was found dead on PND 41; no
remarkable clinical or gross findings were noted for this female. All other F1 animals in
Subsets A and B survived to the scheduled necropsies.
No test substance-related clinical findings were noted at the weekly examinations of the
F1 animals. Findings noted in the test substance-treated groups, including hair loss on
various body surfaces, occurred infrequently and/or at similar frequencies in the control
group.
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Mean post-weaning offspring body weights and body weight gains in the 0.15, 1.5, 75,
750, and 2250 ppm groups were unaffected by test substance exposure, with no
statistically significant difference for any test substance-treated group. Mean female
body weight in the 2250 ppm group was slightly lower (8.0%) on PND 28 due to reduced
mean body weight gain during the pre-weaning period. However, the difference from the
control group did not achieve statistical significance and mean female body weights in
this group were similar to the control group throughout the remainder of the
post-weaning period (PND 35-70).
No test substance-related effects were noted when detailed clinical observation data were
evaluated on PND 4, 11, 21, 35, 45, and 60. Findings in the test substance-treated groups
were noted infrequently and included the following.
On PND 11 only, two animals from the 750 ppm group and four animals from the
2250 ppm group exhibited irregular jerking movements of limbs, head, and/or body
(recorded as convulsions) and/or jumping with all four feet in the air (recorded as
popcorn seizures). These findings were not statistically significant and occurred during
the same period where statistically significantly reduced mean pup body weight gains
were noted (PND 7-14) in the 750 and 2250 ppm groups. No animals in the control
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group were noted with these findings on any evaluation day. In addition, these findings
were not observed in any animals, including these six animals, at any other age. For
these six animals, there were no other remarkable findings in the other endpoints
examined as part of the detailed clinical observations or in the histopathological
examination of the nervous system. In addition, there were no test substance-related
differences from the control group for the BPA-treated groups (which included these six
animals) for motor activity, auditory startle response, or learning behavior. The historical
control data indicated that these findings have been observed in control animals at PND
11 (two of 244 females and not observed in 243 males). Since the incidence of these
findings was greater than the historical control incidence, a follow-up study was
conducted to determine the reproducibility and, if appropriate, further characterize these
findings (Appendix N). No effects in the DCO, including the clonic movements
observed in this study on PND 11, were evident in the follow-up study (see Section 7.).
In conclusion, the PND 11 observations were not considered to be test substance-related.
The following statistically significant differences from the control group were also
observed: the number of males (six males in the 2250 ppm group) noted to be rearing on
PND 35 was statistically significantly higher compared to the control group (zero males),
the number of females (zero females) asleep in the 1.5 ppm group on PND 35 was
statistically significantly lower compared to the control group (five females), and the
mean number of defecation counts in the 75 ppm group males (0.2 counts) on PND 45
was statistically significantly higher compared to the control group (0.0 counts). Because
these findings were limited to single sexes on one evaluation day each, they were not
attributed to test substance-exposure.
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Motor activity, as measured by all activity counts, in F1 animals was unaffected by test
substance exposure at 0.15, 1.5, 75, 750, and 2250 ppm when evaluated on PND 13, 17,
21, and 61. The pattern of activity obtained from the six intervals evaluated (0-10, 11-20,
21-30, 31-40, 41-50, and 51-60 minutes) and the overall 60-minute test session values
were comparable to the concurrent control group. There were no statistically significant
differences from the control group when the data were evaluated by repeated measures
analysis. No remarkable shifts in the pattern of habituation occurred in any of the groups
exposed to the test diet when the F1 animals were evaluated at PND 13, 17, 21, and 61.
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Swimming ability on day 1 of the Biel maze assessment (PND 22 or 62) was similar
between the control, 0.15, 1.5, 75, 750, and 2250 ppm groups. Data are presented in
Appendix A.
There were no test substance-related effects observed in the number of errors committed
in either sex at PND 22 or 62. For females on PND 22, the overall mean number of
errors committed in the 0.15 and 2250 ppm groups was statistically significantly lower
than the control group for Path B (Trials 5-10). The mean number of errors for the
control group of PND 22 females in Path B was higher than historical control mean
values (Appendix Q) while the mean number of errors for these test substance-treated
groups was similar to historical control mean values, which contributed to the statistically
significant differences observed for the 0.15 and 2250 ppm groups.
In addition, the overall mean number of errors committed by males in the 0.15 ppm group
for Path A (Trials 1-4) on PND 62 were statistically significantly higher than the control
group mean. However, the mean values for the control group were lower for Trials 3
and 4 than the comparable historical control mean values (Appendix Q) which
contributed to the significant difference in the 0.15 ppm group. Furthermore, the
0.15 ppm group performed similarly to the control animals in Path B on PND 62.
In Path B, the mean number of errors for males and females combined in the 1.5 ppm
group for Trial 7 on PND 62 only were statistically significantly higher than the control
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group. However, the mean number of errors for all other trials in Path B was similar to
the control group means.
In summary, the statistically significant differences noted were considered spurious and
not test substance-related because they did not occur consistently between or within
testing periods, did not demonstrate any evidence of a dose-related trend, and/or resulted
from atypical control group responses.
One female and three males in the control and 1.5 ppm groups, respectively, were found
dead or euthanized in extremis following the pre-weaning period. No remarkable gross
findings were noted for any of these animals at necropsy.
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6.5.8. NEUROPATHOLOGY
6.5.8.1. PND 21 (SUBSET C)
6.5.8.1.1. MACROSCOPIC EXAMINATIONS
Summary Data: Table 49
Individual Data: Table A49
Pathology Report: Appendix H
At the necropsies of F1 animals selected for brain weights on PND 21, no test
substance-related gross findings were noted in the brain. In the 1.5 ppm group, female
no. 23208-12 had dark red areas on the brain and female no. 26534-08 had depressed
areas on the brain. Based on the histopathological examination, these findings were
considered to be artifacts from perfusion (Appendix H).
There were no test substance-related effects on mean brain weights or mean brain lengths
and widths at any exposure level on PND 21, with no statistically significant differences
for any test substance-treated group.
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incidental alterations were observed. Five pups (two males and one female in the 0.15
ppm group, one female in the 75 ppm group, and one male in the 2250 ppm group) each
had a nest of embryonal cells unilaterally in the lateral caudoputamen. A third male in
the 0.15 ppm group had nests of embryonal cells at the lateral aspect of the caudate
nucleus adjacent to the external capsule. These nests of embryonal cells most closely
resembled the cells of the normal subependymal zone and occurred in the lateral
caudoputamen close to the location of the lateral ventricles. These nests were most likely
migrating cells that did not complete their migration or undergo programmed cell death
by PND 21. The historical control data indicate that ectopic tissue in the basal ganglia of
the brain of PND 21 rats similar to the embryonal cell nests diagnosed in the present
study was observed in one male and one female (of 70 and 69, respectively) control rats.
The occurrence of this finding in the historical control for rats of both sexes, the lack of
an exposure-related response, and the unilateral nature of the finding in the present study
suggest that it is incidental rather than test substance-related.
One female in the 750 ppm group had mild cortical dysplasia in the molecular/plexiform
layer of the cerebral cortex where the normally hypocellular superficial layer either had a
cellular focus in Level 1, or was unusually expanded (focally wider) in Level 4. The
presence of this dysplasia in only one pup and lack of a dose response-relationship
indicated that it was a spontaneous lesion rather than a test substance-related effect.
At the necropsies of F1 animals selected for brain weights on PND 72, no test
substance-related gross findings were noted in the brain or spinal cord. One male each in
the control, 0.15, 1.5, and 75 ppm groups had dark red areas on the brain. Based on
histopathological examination, these findings were considered to be artifacts from
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perfusion (Appendix H). One male in the 0.15 ppm group had depressed areas on the
brain diagnosed as hydrocephalus upon microscopic examination (Appendix H).
Because this latter finding occurred in a single animal it was not attributed to test
substance exposure.
There were no test substance-related effects on mean brain weights or mean brain lengths
and widths at any exposure level on PND 72, with no statistically significant difference
for any test substance-treated group.
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7. DISCUSSION
The objective of this study was to determine the potential of the test substance,
bisphenol A, to induce functional and/or morphological effects to the nervous system of
offspring following exposure of the mother during pregnancy and lactation. To
accomplish this objective, the study was conducted in accordance with U.S. EPA and
OECD testing guidelines. These guidelines were exceeded by evaluation and external
peer review of neuropathology and brain morphometry for all dose groups, as well as the
concurrent control group, and in the use of five dietary levels of the test substance, as
well as the concurrent control group, ranging from very low to concentrations sufficient
to achieve maternal toxicity. As specified in the guidelines, positive control data, using
reference chemicals to establish the reliability and sensitivity of the test methods at the
appropriate offspring ages used for neurotoxicity endpoints, were developed by WIL
Research Laboratories, LLC and are included in Appendix L.
Actual mean test substance consumption in the 0.15, 1.5, 75, 750, and 2250 ppm groups
was 0.01, 0.12, 5.85, 56.4, and 164 mg/kg/day, respectively, during gestation and 0.03,
0.25, 13.1, 129, and 410 mg/kg/day, respectively, during lactation. F0 maternal survival
was unaffected by test diet exposure. There were no test substance-related effects on
clinical observations, detailed clinical observations, mean liver and kidney weights, gross
findings, or microscopic findings for maternal animals at any exposure level. However,
maternal toxicity was expressed at 750 and 2250 ppm in the F0 generation females by
lower mean body weight gains during gestation (gestation days 0-20) of 9.5% and 22.4%,
respectively.
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750 ppm group (up to 5.6% lower) and PND 11-21 in the 2250 ppm group (up to 8.3%
lower).
No test substance-related effects were observed with respect to DCO, motor activity,
auditory startle, learning and memory, macroscopic examinations and measurements,
neuropathology, or brain morphometry at any dietary concentration at any age. At the
PND 11 detailed clinical observation evaluations, two pups in the 750 ppm group and
four pups in the 2250 ppm group exhibited clonic movements that were recorded as
convulsions and/or popcorn seizures. A follow-up study, to further assess these
observations, was conducted at the highest dietary concentration (2250 ppm) with
conditions designed to replicate, as closely as possible, the original developmental
neurotoxicity study through PND 11 (Appendix N). The effects on maternal and pup
body weights were similar in both studies. For the test substance-treated group in the
follow-up study, DCO were conducted on twice the number of pups per litter and with
additional litters (i.e. two pups per sex per litter from 27 litters) on PND 11. The
observations previously recorded as clonic convulsions or popcorn seizures in this
developmental neurotoxicity study were not observed in any pup in the follow-up study.
The initial observations of clonic movements, observed only at PND 11, were not
considered to be test substance-related because they were not observed in any animals
(including the original six animals) at any other age of evaluation in this developmental
neurotoxicity study and were not reproduced in the follow-up study, which was designed
to further investigate these findings. In addition, these clonic movements were not
considered to be test substance-related because no effects were observed for any other
parameter, including other clinical observations, motor activity, auditory startle response,
learning and memory, macroscopic examinations and measurements, neuropathology, or
brain morphometry.
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8. CONCLUSIONS
There were no test substance-related effects observed in this study at dietary
concentrations of 75 ppm or lower (0.15 and 1.5 ppm). Reductions in mean body weight
and body weight gain were observed in dams and offspring at dietary concentrations of
750 and 2250 ppm. There was no evidence of non-monotonic exposure-response curves
for any parameter. Therefore, the no-observed-adverse-effect level (NOAEL) for
systemic toxicity of BPA was 75 ppm (5.85 mg/kg/day and 13.1 mg/kg/day during
gestation and lactation, respectively).
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9. KEYSTUDYPERSONNEL
ANDREPORT
SUBMISSION
Report Submitted By:
- -
Donald G. Stump, PhD, DABT
zs&i!zdbaq
Date
Director, Developmental and
Reproductive Toxicology
Study Director
30-Sep-2ooC(
Christian Sfeinfort, BS Date
Senior Study Analyst
L
Melissa J. Beck, PhD
Assistant Director, Neurosciences
30-s
q -JQq
elyn Tanchevski, BS Date
Group Supervisor, Study Analysis and Reports
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09-Oct-2008,
10-Oct-2008,
10-Dec-2008 Study Records (I-12) 10-Dec-2008 26-Jan-2009 A.Deppe
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Date(s) Date(s)
Findings Findings
Date(s) of Reported to Reported to
Inspection(s) Phase Inspected Study Director Management Auditor(s)
15-Nov-2008,
17-Nov-2008,
10-Dec-2008 Study Records (I-17) 10-Dec-2008 26-Jan-2009 A.Deppe
17-Nov-2008,
18-Nov-2008,
10-Dec-2008 Study Records (I-18) 10-Dec-2008 26-Jan-2009 A.Deppe
20-Nov-2008,
10-Dec-2008 Study Records (I-4) 10-Dec-2008 26-Jan-2009 A.Deppe
20-Nov-2008,
21-Nov-2008,
05-Dec-2008,
06-Dec-2008,
08-Dec-2008,
31-Dec-2008 Study Records (I-6) 31-Dec-2008 26-Jan-2009 A.Deppe
04-Dec-2008,
05-Dec-2008,
06-Jan-2009 Study Records (I-20) 06-Jan-2009 23-Feb-2009 A.Deppe
05-Dec-2008,
06-Dec-2008,
10-Dec-2008 Study Records (I-19) 10-Dec-2008 26-Jan-2009 A.Deppe
05-Dec-2008,
29-Dec-2008,
30-Dec-2008,
31-Dec-2008 Study Records (I-1) 31-Dec-2008 26-Jan-2009 A.Deppe
08-Dec-2008,
09-Dec-2008,
31-Dec-2008 Study Records (I-7) 31-Dec-2008 26-Jan-2009 A.Deppe
10-Dec-2008,
11-Dec-2008 Study Records (I-5) 11-Dec-2008 26-Jan-2009 A.Deppe
11-Dec-2008,
31-Dec-2008 Study Records (I-1a) 31-Dec-2008 26-Jan-2009 A.Deppe
12-Dec-2008,
31-Dec-2008 Study Records (I-2) 31-Dec-2008 26-Jan-2009 A.Deppe
13-Dec-2008,
31-Dec-2008 Study Records (I-3) 31-Dec-2008 26-Jan-2009 A.Deppe
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Date(s) Date(s)
Findings Findings
Date(s) of Reported to Reported to
Inspection(s) Phase Inspected Study Director Management Auditor(s)
16-Dec-2008,
19-Dec-2008,
31-Dec-2008 Study Records (I-8) 31-Dec-2008 26-Jan-2009 A.Deppe
19-Dec-2008,
20-Dec-2008,
31-Dec-2008 Study Records (I-9) 31-Dec-2008 26-Jan-2009 A.Deppe
16-Dec-2008,
06-Jan-2009 Study Records (I-10) 06-Jan-2009 23-Feb-2009 A.Deppe
17-Dec-2008,
18-Dec-2008,
19-Dec-2008,
06-Jan-2009 Study Records (I-11) 06-Jan-2009 23-Feb-2009 A.Deppe
18-Dec-2008,
19-Dec-2008,
06-Jan-2009 Study Records (I-15) 06-Jan-2009 23-Feb-2009 A.Deppe
18-Dec-2008,
19-Dec-2008,
06-Jan-2009 Study Records (I-16) 06-Jan-2009 23-Feb-2009 A.Deppe
20-Dec-2008,
06-Jan-2009 Study Records (I-13) 06-Jan-2009 23-Feb-2009 A.Deppe
20-Dec-2008,
22-Dec-2008,
06-Jan-2009 Study Records (I-14) 06-Jan-2009 23-Feb-2009 A.Deppe
30-Dec-2008,
31-Dec-2008,
05-Jan-2009 Study Records (Rx-1) 05-Jan-2009 23-Feb-2009 A.Deppe
02-Jan-2009,
05-Jan-2009,
09-Jan-2009 Study Records (N-2) 09-Jan-2009 23-Feb-2009 A.Deppe
05-Jan-2009,
06-Jan-2009,
07-Jan-2009,
09-Jan-2009 Study Records (N-3, N-4, N-5
N-6, N-8) 09-Jan-2009 23-Feb-2009 A.Deppe
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Date(s) Date(s)
Findings Findings
Date(s) of Reported to Reported to
Inspection(s) Phase Inspected Study Director Management Auditor(s)
05-Jan-2009,
09-Jan-2009 Study Records (N-1) 09-Jan-2009 23-Feb-2009 A.Deppe
07-Jan-2009,
09-Jan-2009 Study Records (N-7) 09-Jan-2009 23-Feb-2009 A.Deppe
27-Feb-2009,
02-Mar-2009,
03-Mar-2009,
04-Mar-2009,
05-Mar-2009 Study Records (A1 through
A-6) 05-Mar-2009 20-Apr-2009 M.Stauffer
27-Feb-2009,
02-Mar-2009,
03-Mar-2009,
04-Mar-2009,
05-Mar-2009,
06-Mar-2009,
13-Mar-2009,
14-Mar-2009,
16-Mar-2009,
17-Mar-2009 Draft Report Tables (without
Neuropathology, Statistical
Analysis and Analytical
Chemistry appendices) 17-Mar-2009 20-Apr-2009 A.Deppe
11-Jun-2009,
12-Jun-2009 Study Records (H-1) 12-Jun-2009 23-Jul-2009 A.Deppe
11-Jun-2009,
12-Jun-2009 Study Records (P-1) PND 21
Morphometry and Maternal
Liver/Kidneys 12-Jun-2009 23-Jul-2009 A.Deppe
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Date(s) Date(s)
Findings Findings
Date(s) of Reported to Reported to
Inspection(s) Phase Inspected Study Director Management Auditor(s)
28-Jul-2009,
31-Jul-2009,
03-Aug-2009,
04-Aug-2009,
05-Aug-2009,
06-Aug-2009,
07-Aug-2009,
10-Aug-2009 Draft Report (Text and updated
Tables without Statistical
Analysis, Pathology and
Analytical Chemistry
appendices) 10-Aug-2009 23-Sep-2009 A.Deppe
30-Jul-2009,
31-Jul-2009,
03-Aug-2009,
07-Aug-2009 Pathology Appendix 07-Aug-2009 23-Sep-2009 A.Deppe
This study was inspected in accordance with the U.S. EPA Good Laboratory Practice
Standards (40 CFR Part 792), the OECD Principles of Good Laboratory Practice, the
standard operating procedures of WIL Research Laboratories, LLC, and the Sponsor's
protocol and protocol amendments with the following exceptions. The data located in
Appendix B (Certificates of Analysis) were the responsibility of the Sponsor and the data
located in Appendix I (Peer Review Statement) were the responsibility of Consultants in
Veterinary Pathology, Inc. Quality Assurance findings, derived from the inspections
during the conduct of the study and from the inspections of the raw data and draft report,
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are documented and have been reported to the Study Director. Review of the protocol
and protocol amendments as well as a yearly internal facility inspection are conducted by
the WIL Quality Assurance Unit. A status report is submitted to management monthly.
This report accurately reflects the data generated during the study. The methods and
procedures used in the study were those specified in the protocol, its amendments, and
the standard operating procedures of WIL Research Laboratories, LLC.
The raw data, the retention sample, and the final report will be stored in the Archives at
WIL Research Laboratories, LLC, or another location specified by the Sponsor.
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10.2. APPROVAL
w -
compliance Specialist
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11. REFERENCES
Adams, J.; Buelke-Sam, J.; Kimmel, C.A.; Nelson, C.J.; Reiter, L.W.; Sobotka, T.J.;
Tilson, H.A.; Nelson, B.K. Collaborative behavioral teratology study: protocol
design and testing procedure. Neurobehavioral Toxicology and Teratology 1985, 7,
579-586.
Biel, W.C. Early age differences in maze performance in the albino rat. Journal of
Genetic Psychology 1940, 56, 439-453.
Dunn, O.J. Multiple comparisons using rank sums. Technometrics 1964, 6(3),
241-252.
Dunnett, C.W. New tables for multiple comparisons with a control. Biometrics
1964, 20, 482-491.
Holson, R.; Freshwater, L.; Maurissen, P. J.; Moser, V. C.; Phang, W. Statistical
issues and techniques appropriate for developmental neurotoxicity testing: a report
from the ILSI Research Foundation/Risk Science Institute expert working group on
neurodevelopmental endpoints. Neurotoxicology and teratology 2007, 30(4),
326-48.
Page 99 of 4796
WIL-186056 Bisphenol A
American Chemistry Council
Moser, V.C.; McDaniel, K.L.; Phillips, P.M. Rat strain and stock comparisons using
a functional observational battery: Baseline values and effects of Amitraz.
Toxicology and Applied Pharmacology 1991, 108, 267-283.
National Research Council. Guide for the Care and Use of Laboratory Animals,
Institute of Laboratory Animal Resources, Commission on Life Sciences; National
Academy Press: Washington, DC, 1996.
Paxinos, G.; Watson, C. The Rat Brain in Stereotaxic Coordinates, Fourth Edition.
Academic Press: New York, NY, 1998.
Stuckhardt, J.L.; Poppe, S.M. Fresh visceral examination of rat and rabbit fetuses
used in teratogenicity testing. Teratogenesis, Carcinogenesis and Mutagenesis
1984, 4, 181-188.
Protocol Section 4.6 states that the test substance would be stored at room
temperature, protected from light, and desiccated. Prior to the initiation of the study,
the test substance was stored without desiccation from 5 December 2007 to
22 January 2008. In addition, 2 samples of the test substance used for calibration and
quality control stock solutions were received in amber bottles from the formulations
department; however, protection from light was not documented.
Protocol Section 5.5 states that animals would have a body weight of at least 220 g at
the initiation of the breeding period. Female no. 23265 had a body weight of 218 g
on 13 July 2008 and was paired with a male on 15 July 2008. The female was
unpaired on 17 July 2008 without evidence of mating and was not placed on study.
Protocol Section 6.2 states that fluorescent lighting would provide illumination for a
12-hour light (0600 hours to 0600 hours)/dark photoperiod. The 12-hour light
photoperiod was interrupted for approximately 28 minutes for animals receiving a
PND 60 detailed clinical observation on 6 October 2008. On the morning of
30 October 2008, the light photoperiod was interrupted for approximately 15 minutes
(0615 hours to 0630 hours) due to a power outage. In addition, the 12-hour light
photoperiod was interrupted for approximately 34 minutes for animals receiving a
motor activity assessment on 5 November 2008.
Protocol Section 6.4 states that a single lot of diet would be used for the entire study.
The single lot selected for use throughout the study was lot no. JUN03082C.
However, during the first day of the mating period (13-14 July 2008) for Cohort 1,
males and females were offered the basal diet from lot no. APR09082C. In addition,
the lot of diet used was not documented during 1-16 July 2008.
Protocol Section 7.7.2 states that all dams would be examined for detailed clinical
observations on gestation days 10 and 15 and lactation days 10 and 21. Female
no. 26505 in the 0.15 ppm group was not examined for detailed clinical observations
on gestation day 10.
Protocol Section 7.8.1 states that individual pup body weights would be recorded
whenever they are removed from their cages for behavioral testing. The appropriate
body weights were not recorded for PND 4 animals receiving a detailed clinical
observation on 8 August 2008; however, the scheduled PND 4 body weights were
collected for these animals. Additionally, the appropriate weight was not collected
for female nos. 23261-10 and 23264-13 in the 0.15 ppm group and female
no. 23260-11 in the 1.5 ppm group prior to the PND 21 detailed clinical observations;
however, the scheduled PND 21 body weights were collected for these animals.
Protocol Section 7.9.3 states that all pups would be examined for surface righting
reflex beginning on PND 2 and would continue to be evaluated until attainment of the
criterion or until the pup was selected for culling and did not have a positive response
by PND 4. Pup no. 23248-09 (1.5 ppm group) was not examined for surface righting
reflex on PND 11; this animal exhibited a negative response on PND 10 and a
positive response on PND 12.
Protocol Section 7.10.1 states that the same animals would be evaluated for detailed
clinical observations on PND 4, 11, 21, 35, 45, and 60. Female nos. 23207-10,
23244-11, and 23257-16 in the 0, 1.5 and 2250 ppm groups, respectively, received
detailed clinical observations on PND 4 and were found dead or missing prior to the
PND 11 evaluation. As a result, these same respective animals were replaced on
study by female nos. 23207-14, 23244-17, and 23257-11, respectively, for subsequent
evaluations. Male no. 23244-01 in the 1.5 ppm group received detailed clinical
observations on PND 4 and 11 and was found dead on PND 13. As a result, this
animal was replaced on study by male no. 23244-04 for subsequent evaluations.
Protocol Section 7.10.2 states that motor activity would be evaluated for
1 pup/sex/litter (animals assigned to Subset A) on PND 13, 17, 21, and 61. Motor
activity counts were not recorded as scheduled for female no. 26514-14 in the
1.5 ppm group on PND 17 due to an equipment malfunction.
Protocol Section 7.10.4 states that the minimum intertrial interval would be 1 hour
for learning and memory evaluation. The time that male no. 23203-08 in the control
group was placed in the Biel Maze was not recorded for Trial 12 of the PND 22
learning and memory evaluation; therefore, it was not possible to confirm that the
animal rested for 1 hour between trials. However, the animals evaluated before
(no. 23203-13) and after (no. 23201-04) this male both received at least 1 hour of rest
between trials.
Protocol Section 7.10.4 states that the time to escape and number of errors in the Biel
maze would be recorded. The time to escape for male no. 23217-04 in the 1.5 ppm
group was not recorded appropriately for Trial 12 on PND 28. The time to escape for
male no. 26479-03 in the 0.15 ppm group was not recorded for Trial 4 on PND 64.
Additionally, the number of errors was not recorded for female no. 23247-13 in the
750 ppm group for Trial 8 on PND 67.
Protocol Section 8.1.1 states that the number and location of former implantation
sites would be recorded. The number of former implantation sites was not recorded
for female no. 26481 in the 750 ppm group.
Protocol Section 8.1.6 states that the liver and kidneys would be examined
microscopically for all maternal animals. In addition to the protocol-required tissues,
gross lesions from female nos. 23210 (thymus) and 23184 (stomach) in the 75 ppm
group and female no. 23234 (diaphragm and ureters) in the 2250 ppm group were
processed to slide and examined microscopically.
Protocol Section 8.3.1.2 and 8.4.2 state that neuropathological examinations would
be performed on 1 pup/litter (10 pups/sex) from all groups and any pups that showed
potential exposure-related effects on neurobehavioral observations or measurements.
In addition to the protocol-required examinations, the brain of an additional female
pup (no. 26534-08) in the 1.5 ppm group was microscopically examined on PND 21
and the brain from an additional male pup (no. 26492-03) in the 0.15 ppm group was
microscopically examined on PND 72 due to macroscopic findings. As only limited
tissues were examined for these two animals, the microscopic data for these animals
was not included on the summary tables but are presented on the individual animal
data tables.
Protocol Section 8.3.1.2 and 8.4.2 state that a neuropathological examination would
be performed on any pup not selected in the original 10 pups/sex/group that showed
potential treatment-related effects on neurobehavioral observations or measurements.
The protocol specified that the histopathological examination would include a simple
morphometric analysis. Although a neuropathology examination was performed on
all six pups observed with clonic movements, brain morphometry measurements were
not recorded for four of these pups (male no. 23223-08 in the 750 ppm group and
female nos. 23211-11, 23234-08, and 26465-12 in the 2250 ppm group) because the
tissue sections for PND 72 morphometry for these animals were generally not
adequate for measurement of all levels.
Protocol Section 8.4.1 states that after perfusion, the nervous system tissues would
be retained for all animals and the central and peripheral nervous system tissues from
all animals would be dissected and preserved in 10% neutral-buffered formalin; the
brains were to be retained following measurements. The heads for all animals
perfused on 15 and 16 October 2008 (6, 4, 6, 2, 4, and 2 animals in the control, 0.15,
1.5, 75, 750, and 2250 groups, respectively) were not retained after measurement;
therefore, the eyes, optic nerves, and trigeminal nerves were not retained for these
animals.
Protocol Section 8.4.2 states that specific brain morphometry measurements would
be conducted according to WIL Research Laboratories, LLCs standard operating
procedures. However, the first measurement on Level 5 was changed to the height of
the cerebellum perpendicular to the brainstem from the heel of the Purkinje cell layer
of lobule 10 at a scale of 1:2. Additionally, a scale of 1:1 was used for measuring the
cortex thickness of Level 1 at the apex of the cingulum, and a scale of 3:1 was used
for the first measurement on Level 1 due to the size of the images.
Protocol Section 8.5 states that the pathology peer review of the microscopic
evaluation of brains would be conducted on 50% of the selected PND 21 animals
(5/sex/group). However, all male rats from the control and 2250 ppm groups
(10/group) were evaluated by the peer review pathologist.
These deviations did not negatively impact the quality or integrity of the data or the
outcome of the study.
FIGURES 1 - 30
450
400
*
MEAN BODY WEIGHT [G] (SE)
*
350
*
Page 107 of 4796
*
*
300
* *
* *
* *
250
*
200
150
0 3 7 10 14 17 20
GESTATION DAY
0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
* = Significantly different from the control group at 0.05 using Dunnett's test
BW v1.00 02/11/2009
PROJECT NO.:WIL-186056 FIGURE 2 (F0 FEMALES)
SPONSOR:ACC SUMMARY OF BODY WEIGHTS DURING LACTATION [G]
380
360
340
MEAN BODY WEIGHT [G] (SE)
* *
320
*
*
Page 108 of 4796
*
300
*
*
280
*
260
240
220
200
1 4 7 11 14 17 21
LACTATION DAY
0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
* = Significantly different from the control group at 0.05 using Dunnett's test
BW v1.00 02/12/2009
PROJECT NO.:WIL-186056 FIGURE 3 (F0 FEMALES)
SPONSOR:ACC SUMMARY OF TEST SUBSTANCE CONSUMPTION DURING GESTATION [MG/KG/DAY]
TEST SUBSTANCE CONSUMPTION [MG/KG/DAY] (SE)
1000
100
10
Page 109 of 4796
0.1
0.01
0.001
GESTATION DAYS 0-20
0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
PROJECT NO.:WIL-186056 FIGURE 4 (F0 FEMALES)
SPONSOR:ACC SUMMARY OF TEST SUBSTANCE CONSUMPTION DURING LACTATION [MG/KG/DAY]
1000
TEST SUBSTANCE CONSUMPTION [MG/KG/DAY] (SE)
100
10
Page 110 of 4796
0.1
0.01
0.001
LACTATION DAYS 1-21
0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
PROJECT NO.:WIL-186056 FIGURE 5 (F1 MALES)
SPONSOR:ACC SUMMARY OF OFFSPRING WEIGHTS [G]
60
*
*
50
*
MEAN BODY WEIGHT [G] (SE)
40
**
Page 111 of 4796
30 **
*
*
20
*
* *
10
0
1 4 (pre- 4 (post- 7 11 14 17 21
culling) culling)
POSTNATAL DAY
0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
* = Significantly different from the control group at 0.05 using Dunnett's test
BW v1.00 02/12/2009
PROJECT NO.:WIL-186056 FIGURE 6 (F1 FEMALES)
SPONSOR:ACC SUMMARY OF OFFSPRING WEIGHTS [G]
60
50
MEAN BODY WEIGHT [G] (SE)
40
*
Page 112 of 4796
30 *
*
*
20
*
10
*
0
1 4 (pre- 4 (post- 7 11 14 17 21
culling) culling)
POSTNATAL DAY
0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
* = Significantly different from the control group at 0.05 using Dunnett's test
BW v1.00 02/12/2009
PROJECT NO.:WIL-186056A FIGURE 7 (F1 MALES)
SPONSOR:ACC SUMMARY OF POST-WEANING BODY WEIGHTS [G]
500
450
400
MEAN BODY WEIGHT [G] (SE)
350
300
Page 113 of 4796
250
200
150
100
50
0
28 35 42 49 56 63 70
POSTNATAL DAY
0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
BW v1.00 02/12/2009
PROJECT NO.:WIL-186056D FIGURE 8 (F1 FEMALES)
SPONSOR:ACC SUMMARY OF POST-WEANING BODY WEIGHTS [G]
300
250
MEAN BODY WEIGHT [G] (SE)
200
Page 114 of 4796
150
100
50
0
28 35 42 49 56 63 70
POSTNATAL DAY
0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
BW v1.00 02/12/2009
PROJECT NO.:WIL-186056S FIGURE 9 (F1 COMBINED SEXES - PND 13, 17, AND 21)
SPONSOR:ACC SUMMARY OF MOTOR ACTIVITY TOTAL COUNTS BY SESSION
4500
4000
3500
TOTAL COUNTS IN SESSION (SE)
3000
Page 115 of 4796
2500
2000
1500
1000
500
0
PND 13 PND 17 PND 21
0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
PROJECT NO.:WIL-186056S FIGURE 10 (F1 COMBINED SEXES - PND 13)
SPONSOR:ACC SUMMARY OF MOTOR ACTIVITY TOTAL COUNTS
700
600
500
MEAN TOTAL COUNTS (SE)
Page 116 of 4796
400
300
200
100
0
0-10 11-20 21-30 31-40 41-50 51-60
TIME (MINUTES)
0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
PROJECT NO.:WIL-186056S FIGURE 11 (F1 COMBINED SEXES - PND 17)
SPONSOR:ACC SUMMARY OF MOTOR ACTIVITY TOTAL COUNTS
1600
1400
1200
MEAN TOTAL COUNTS (SE)
1000
Page 117 of 4796
800
600
400
200
0
0-10 11-20 21-30 31-40 41-50 51-60
TIME (MINUTES)
0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
PROJECT NO.:WIL-186056S FIGURE 12 (F1 COMBINED SEXES - PND 21)
SPONSOR:ACC SUMMARY OF MOTOR ACTIVITY TOTAL COUNTS
1800
1600
1400
MEAN TOTAL COUNTS (SE)
1200
Page 118 of 4796
1000
800
600
400
200
0
0-10 11-20 21-30 31-40 41-50 51-60
TIME (MINUTES)
0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
PROJECT NO.:WIL-186056S FIGURE 13 (F1 MALES - PND 61)
SPONSOR:ACC SUMMARY OF MOTOR ACTIVITY TOTAL COUNTS BY SESSION
7000
6000
TOTAL COUNTS IN SESSION (SE)
5000
Page 119 of 4796
4000
3000
2000
1000
0
MALES
7000
6000
TOTAL COUNTS IN SESSION (SE)
5000
Page 120 of 4796
4000
3000
2000
1000
0
FEMALES
1800
1600
1400
MEAN TOTAL COUNTS (SE)
1200
Page 121 of 4796
1000
800
600
400
200
0
0-10 11-20 21-30 31-40 41-50 51-60
TIME (MINUTES)
0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
PROJECT NO.:WIL-186056S FIGURE 16 (F1 FEMALES - PND 61)
SPONSOR:ACC SUMMARY OF MOTOR ACTIVITY TOTAL COUNTS
2500
2000
MEAN TOTAL COUNTS (SE)
Page 122 of 4796
1500
1000
500
0
0-10 11-20 21-30 31-40 41-50 51-60
TIME (MINUTES)
0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
PROJECT NO.:WIL-186056S FIGURE 17 (F1 COMBINED SEXES - PND 20)
SPONSOR:ACC SUMMARY OF STARTLE RESPONSE DATA [MAX]
2.5
MAX [NEWTONS] (SE)
2
Page 123 of 4796
1.5
0.5
0
0-10 11-20 21-30 31-40 41-50
TIME (MINUTES)
0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
PROJECT NO.:WIL-186056S FIGURE 18 (F1 COMBINED SEXES - PND 60)
SPONSOR:ACC SUMMARY OF STARTLE RESPONSE DATA [MAX]
3.5
3
MAX [NEWTONS] (SE)
2.5
Page 124 of 4796
1.5
0.5
0
0-10 11-20 21-30 31-40 41-50
TIME (MINUTES)
0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
PROJECT NO.:WIL-186056W FIGURE 19 (F1 COMBINED SEXES - PND 22)
SPONSOR:ACC SUMMARY OF BIEL MAZE DATA - MEAN NO. OF ERRORS
40
35
30
MEAN NO. OF ERRORS (SE)
25
Page 125 of 4796
20
15
10
0
1 2 3 4 5 6 7 8 9 10 11 12
PATH A PATH B PATH A
TRIAL
0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
PROJECT NO.:WIL-186056W FIGURE 20 (F1 MALES - PND 22)
SPONSOR:ACC SUMMARY OF BIEL MAZE DATA - MEAN NO. OF ERRORS
45
40
35
MEAN NO. OF ERRORS (SE)
30
Page 126 of 4796
25
20
15
10
0
1 2 3 4 5 6 7 8 9 10 11 12
PATH A PATH B PATH A
TRIAL
0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
PROJECT NO.:WIL-186056W FIGURE 21 (F1 FEMALES - PND 22)
SPONSOR:ACC SUMMARY OF BIEL MAZE DATA - MEAN NO. OF ERRORS
45
40
35
MEAN NO. OF ERRORS (SE)
30
Page 127 of 4796
25
20
15
10
0
1 2 3 4 5 6 7 8 9 10 11 12
PATH A PATH B PATH A
TRIAL
0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
PROJECT NO.:WIL-186056S FIGURE 22 (F1 COMBINED SEXES - PND 62)
SPONSOR:ACC SUMMARY OF BIEL MAZE DATA - MEAN NO. OF ERRORS
35
30
MEAN NO. OF ERRORS (SE)
25
Page 128 of 4796
20
*
15
10
0
1 2 3 4 5 6 7 8 9 10 11 12
PATH A PATH B PATH A
TRIAL
0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
* = Significantly different from the control group at 0.05 using Dunnett's test
PROJECT NO.:WIL-186056S FIGURE 23 (F1 MALES - PND 62)
SPONSOR:ACC SUMMARY OF BIEL MAZE DATA - MEAN NO. OF ERRORS
35
30
MEAN NO. OF ERRORS (SE)
25
Page 129 of 4796
20
15
10
0
1 2 3 4 5 6 7 8 9 10 11 12
PATH A PATH B PATH A
TRIAL
0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
PROJECT NO.:WIL-186056S FIGURE 24 (F1 FEMALES - PND 62)
SPONSOR:ACC SUMMARY OF BIEL MAZE DATA - MEAN NO. OF ERRORS
40
35
30
MEAN NO. OF ERRORS (SE)
25
Page 130 of 4796
20
15
10
0
1 2 3 4 5 6 7 8 9 10 11 12
PATH A PATH B PATH A
TRIAL
0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
PROJECT NO.:WIL-186056U FIGURE 25 (F1 COMBINED SEXES - PND 21)
SPONSOR:ACC SUMMARY OF BRAIN MORPHOMETRY [LEVEL 1]
0.8
0.7
0.6
CENTIMETERS (SE)
0.5
Page 131 of 4796
0.4
0.3
0.2
0.1
0
HT HEMISPHERE V THICKNESS CORTEX
0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
HT = HEIGHT V = VERTICAL
PROJECT NO.:WIL-186056U FIGURE 26 (F1 COMBINED SEXES - PND 21)
SPONSOR:ACC SUMMARY OF BRAIN MORPHOMETRY [LEVEL 3]
0.18
0.16
0.14
0.12
CENTIMETERS (SE)
Page 132 of 4796
0.1
0.08
0.06
0.04
0.02
0
RADIAL THICKNESS CORTEX V HT BTW HIPPOCAMPAL V HT DENTATE HILUS LENGTH VENTRAL LIMB
PYRAMIDAL NEURON LAYERS DENTATE HILUS
0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
HT = HEIGHT V = VERTICAL BTW = BETWEEN
PROJECT NO.:WIL-186056U FIGURE 27 (F1 COMBINED SEXES - PND 21)
SPONSOR:ACC SUMMARY OF BRAIN MORPHOMETRY [LEVEL 5]
0.6
0.5
0.4
CENTIMETERS (SE)
Page 133 of 4796
0.3
0.2
0.1
0
V HEIGHT OF THE CEREBELLUM BASE OF LOBULE 9
0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
V = VERTICAL
PROJECT NO.:WIL-186056U FIGURE 28 (F1 COMBINED SEXES - PND 72)
SPONSOR:ACC SUMMARY OF BRAIN MORPHOMETRY [LEVEL 1]
0.8
0.7
0.6
CENTIMETERS (SE)
0.5
Page 134 of 4796
0.4
0.3
0.2
0.1
0
HT HEMISPHERE V THICKNESS CORTEX
0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
HT = HEIGHT V = VERTICAL
PROJECT NO.:WIL-186056U FIGURE 29 (F1 COMBINED SEXES - PND 72)
SPONSOR:ACC SUMMARY OF BRAIN MORPHOMETRY [LEVEL 3]
0.2
0.18
0.16
0.14
CENTIMETERS (SE)
0.12
Page 135 of 4796
0.1
0.08
0.06
0.04
0.02
0
RADIAL THICKNESS CORTEX V HT BTW HIPPOCAMPAL V HT DENTATE HILUS LENGTH VENTRAL LIMB
PYRAMIDAL NEURON LAYERS DENTATE HILUS
0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
HT = HEIGHT V = VERTICAL BTW = BETWEEN
PROJECT NO.:WIL-186056U FIGURE 30 (F1 COMBINED SEXES - PND 72)
SPONSOR:ACC SUMMARY OF BRAIN MORPHOMETRY [LEVEL 5]
0.6
0.5
0.4
CENTIMETERS (SE)
Page 136 of 4796
0.3
0.2
0.1
0
V HEIGHT OF THE CEREBELLUM BASE OF LOBULE 9
0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
V = VERTICAL
WIL-186056 Bisphenol A
American Chemistry Council
TABLES 1 -44
-----------------------------------------------------------------------------------------------------------------------------------
DOSE GROUP : 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NO. % NO. % NO. % NO. % NO. % NO. %
FEMALES ON STUDY 24 24 24 24 24 24
MANUALv1.0
12/17/2008
R:12/17/2008
TABLE 2 (F0 - DAILY EXAMINATIONS)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS
----- F E M A L E -----
-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NORMAL
-NO SIGNIFICANT CLINICAL OBSERVATIONS 967/24 832/23 904/24 878/24 894/24 855/24
DISPOSITION
-FOUND DEAD 0/ 0 0/ 0 0/ 0 0/ 0 0/ 0 1/ 1
-SCHEDULED EUTHANASIA; POST-MATING DAY 25 1/ 1 1/ 1 0/ 0 0/ 0 0/ 0 0/ 0
-SENT TO NECROPSY; SEX RATIO CRITERIA 0/ 0 0/ 0 0/ 0 2/ 2 2/ 2 0/ 0
NOT MET
-SCHEDULED EUTHANASIA; LACTATION DAY 21 23/23 23/23 24/24 22/22 22/22 23/23
BEHAVIOR/CNS
Page 139 of 4796
-BODY FLATTENED 0/ 0 0/ 0 0/ 0 0/ 0 1/ 1 0/ 0
BODY/INTEGUMENT
-HAIR LOSS RIGHT FORELIMB 59/ 5 193/ 9 127/ 5 118/ 5 88/ 4 77/ 5
-HAIR LOSS LEFT FORELIMB 49/ 4 190/ 8 120/ 5 127/ 6 97/ 4 71/ 5
-HAIR LOSS RIGHT HINDLIMB 0/ 0 0/ 0 0/ 0 0/ 0 17/ 1 107/ 3
-HAIR LOSS LEFT HINDLIMB 0/ 0 0/ 0 0/ 0 0/ 0 15/ 1 97/ 3
-HAIR LOSS RUMP 0/ 0 0/ 0 0/ 0 0/ 0 1/ 1 72/ 3
-HAIR LOSS RIGHT LATERAL ABDOMINAL AREA 0/ 0 0/ 0 0/ 0 0/ 0 0/ 0 54/ 3
-HAIR LOSS VENTRAL ABDOMINAL AREA 1/ 1 0/ 0 9/ 1 0/ 0 0/ 0 75/ 3
-HAIR LOSS LEFT LATERAL ABDOMINAL AREA 0/ 0 0/ 0 0/ 0 0/ 0 0/ 0 40/ 3
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
TABLE 2 (F0 - DAILY EXAMINATIONS)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS
----- F E M A L E -----
-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
BODY/INTEGUMENT
-HAIR LOSS RIGHT INGUINAL AREA 0/ 0 0/ 0 0/ 0 0/ 0 0/ 0 35/ 3
-HAIR LOSS LEFT INGUINAL AREA 0/ 0 0/ 0 0/ 0 0/ 0 0/ 0 29/ 1
-HAIR LOSS VENTRAL THORACIC AREA 1/ 1 0/ 0 0/ 0 0/ 0 0/ 0 3/ 2
-HAIR LOSS RIGHT LATERAL THORACIC AREA 0/ 0 0/ 0 0/ 0 0/ 0 0/ 0 4/ 1
-HAIR LOSS UROGENITAL AREA 0/ 0 0/ 0 0/ 0 0/ 0 0/ 0 15/ 2
-SCABBING LEFT FORELIMB 0/ 0 0/ 0 0/ 0 1/ 1 1/ 1 0/ 0
-SCABBING VENTRAL ABDOMINAL AREA 0/ 0 0/ 0 5/ 1 4/ 1 0/ 0 0/ 0
-SCABBING RIGHT FORELIMB 0/ 0 0/ 0 11/ 1 2/ 1 0/ 0 0/ 0
-WET RED MATERIAL UROGENITAL AREA 0/ 0 0/ 0 0/ 0 0/ 0 1/ 1 0/ 0
Page 140 of 4796
CARDIO-PULMONARY
-INCREASED RESPIRATION 0/ 0 0/ 0 0/ 0 0/ 0 1/ 1 0/ 0
EYES/EARS/NOSE
-DRIED RED MATERIAL AROUND NOSE 1/ 1 1/ 1 2/ 2 2/ 1 5/ 3 9/ 5
-DRIED RED MATERIAL AROUND RIGHT EYE 0/ 0 1/ 1 0/ 0 5/ 1 0/ 0 0/ 0
-WET RED MATERIAL AROUND NOSE 0/ 0 0/ 0 1/ 1 1/ 1 0/ 0 0/ 0
-DRIED RED MATERIAL AROUND LEFT EYE 0/ 0 0/ 0 3/ 1 0/ 0 0/ 0 0/ 0
EXCRETA
-DECREASED DEFECATION 0/ 0 0/ 0 0/ 0 0/ 0 4/ 2 1/ 1
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
TABLE 2 (F0 - DAILY EXAMINATIONS)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 3
SPONSOR:ACC SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS
----- F E M A L E -----
-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
EXCRETA
-WET RED VAGINAL DISCHARGE 0/ 0 0/ 0 0/ 0 0/ 0 0/ 0 1/ 1
ORAL/DENTAL
-WET RED MATERIAL AROUND MOUTH 0/ 0 0/ 0 0/ 0 0/ 0 2/ 2 0/ 0
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
PCSUv4.07
12/16/2008
Page 141 of 4796
TABLE 3 (F0 - GESTATION)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS GD 10
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 22 24 24 24 24
LACRIMATION
NONE 23 22 24 24 24 24
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
GD= GESTATIONAL DAY
None significantly different from control group
TABLE 3 (F0 - GESTATION)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS GD 10
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 22 24 24 24 24
CHROMODACRYORRHEA
ABSENT 23 22 24 24 24 24
SALIVATION
NONE 23 22 24 24 24 24
PILOERECTION
NONE 23 22 24 24 24 24
FUR APPEARANCE
NORMAL: CLEAN AND GROOMED 23 22 24 24 24 24
Page 143 of 4796
PALPEBRAL CLOSURE
EYELIDS WIDE OPEN 23 22 24 24 24 24
RESPIRATORY RATE
NORMAL (80-110) 23 22 24 24 24 24
RESPIRATORY CHARACTER
NORMAL 23 22 24 24 24 24
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 22 24 24 24 24
ABSENT 23 22 24 24 24 24
EYE COLOR
PINK 23 22 24 24 24 24
SKIN COLOR
PINK 23 22 24 24 24 24
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
GD= GESTATIONAL DAY
None significantly different from control group
TABLE 3 (F0 - GESTATION)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 4
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS GD 10
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 22 24 24 24 24
EYE PROMINENCE
NORMAL 23 22 24 24 24 24
MUSCLE TONE
FIRM BUT NOT HARD 23 22 24 24 24 24
MOBILITY
NORMAL 23 22 24 24 24 24
GAIT
NORMAL 23 22 24 24 24 24
Page 145 of 4796
CONVULSIONS-CLONIC
ABSENT 23 22 24 24 24 24
CONVULSIONS-TONIC
ABSENT 23 22 24 24 24 24
TREMORS
NONE 23 22 24 24 24 24
AROUSAL
NORMAL 23 22 24 24 24 24
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
GD= GESTATIONAL DAY
None significantly different from control group
TABLE 3 (F0 - GESTATION)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 5
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS GD 10
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 22 24 24 24 24
BIZARRE/STEREOTYPIC BEHAVIOR
NONE 23 22 24 24 24 24
PUPILLARY RESPONSE
PRESENT 23 22 24 24 24 24
BACKING COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.00 0.00 0.00
N 23 22 24 24 24 24
GROOMING COUNTS
Page 146 of 4796
URINATION COUNTS
MEAN 0.3 0.4 0.3 0.3 0.3 0.3
S.D. 0.49 0.50 0.69 0.55 0.69 0.53
N 23 22 24 24 24 24
DEFECATION COUNTS
MEAN 0.3 0.3 0.2 0.7 0.5 0.7
S.D. 0.76 0.77 0.66 1.40 1.38 2.12
N 23 22 24 24 24 24
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
GD= GESTATIONAL DAY
None significantly different from control group
TABLE 3 (F0 - GESTATION)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 6
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS GD 15
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 24 24 24
LACRIMATION
NONE 23 23 24 24 24 24
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
GD= GESTATIONAL DAY
None significantly different from control group
TABLE 3 (F0 - GESTATION)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 7
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS GD 15
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 24 24 24
CHROMODACRYORRHEA
ABSENT 23 23 24 24 24 24
SALIVATION
NONE 23 23 24 24 24 24
PILOERECTION
NONE 23 23 24 24 24 24
FUR APPEARANCE
NORMAL: CLEAN AND GROOMED 23 23 24 24 24 24
Page 148 of 4796
PALPEBRAL CLOSURE
EYELIDS WIDE OPEN 23 23 24 24 24 24
RESPIRATORY RATE
NORMAL (80-110) 23 23 24 24 24 24
RESPIRATORY CHARACTER
NORMAL 23 23 24 24 24 24
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 24 24 24
ABSENT 23 23 24 24 24 24
EYE COLOR
PINK 23 23 24 24 24 24
SKIN COLOR
PINK 23 23 24 24 24 24
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
GD= GESTATIONAL DAY
None significantly different from control group
TABLE 3 (F0 - GESTATION)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 9
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS GD 15
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 24 24 24
EYE PROMINENCE
NORMAL 23 23 24 24 24 24
MUSCLE TONE
FIRM BUT NOT HARD 23 23 24 24 24 24
MOBILITY
NORMAL 23 23 24 24 24 24
GAIT
NORMAL 23 23 24 24 24 24
Page 150 of 4796
CONVULSIONS-CLONIC
ABSENT 23 23 24 24 24 24
CONVULSIONS-TONIC
ABSENT 23 23 24 24 24 24
TREMORS
NONE 23 23 24 24 24 24
AROUSAL
NORMAL 23 23 24 24 24 24
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
GD= GESTATIONAL DAY
None significantly different from control group
TABLE 3 (F0 - GESTATION)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 10
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS GD 15
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 24 24 24
BIZARRE/STEREOTYPIC BEHAVIOR
NONE 23 23 24 24 24 24
PUPILLARY RESPONSE
PRESENT 23 23 24 24 24 24
BACKING COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.00 0.00 0.00
N 23 23 24 24 24 24
GROOMING COUNTS
Page 151 of 4796
URINATION COUNTS
MEAN 0.3 0.2 0.3 0.3 0.1 0.2
S.D. 0.56 0.52 0.62 0.61 0.28 0.38
N 23 23 24 24 24 24
DEFECATION COUNTS
MEAN 0.5 0.6 0.3 0.4 0.3 0.2
S.D. 1.53 1.23 0.74 1.35 0.85 0.66
N 23 23 24 24 24 24
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
GD= GESTATIONAL DAY
None significantly different from control group
PFOBGv1.52
01/12/2009
R:01/12/2009
TABLE 4 (F0 - LACTATION)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS LD 10
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
MODERATELY DIFFICULT - - - - 1 -
WITH VOCALIZATION - - - - 1 -
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
LD= LACTATIONAL DAY
None significantly different from control group
TABLE 4 (F0 - LACTATION)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS LD 10
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
LACRIMATION
NONE 23 23 24 21 22 22
SLIGHT - - - 1 - 1
Page 153 of 4796
CHROMODACRYORRHEA
ABSENT 23 23 24 22 22 23
SALIVATION
NONE 23 23 24 22 22 23
PILOERECTION
NONE 23 23 24 22 22 23
FUR APPEARANCE
NORMAL: CLEAN AND GROOMED 23 23 24 22 22 22
SLIGHTLY SOILED - - - - - 1
PALPEBRAL CLOSURE
EYELIDS WIDE OPEN 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
LD= LACTATIONAL DAY
None significantly different from control group
TABLE 4 (F0 - LACTATION)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 3
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS LD 10
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
RESPIRATORY RATE
NORMAL (80-110) 23 23 24 22 22 23
RESPIRATORY CHARACTER
NORMAL 23 23 24 22 22 23
ABSENT 23 23 24 21 18+ 23
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
EYE COLOR
PINK 23 23 24 22 22 23
SKIN COLOR
Page 155 of 4796
PINK 23 23 24 22 22 23
EYE PROMINENCE
NORMAL 23 23 24 22 22 23
MUSCLE TONE
FIRM BUT NOT HARD 23 23 24 22 22 23
MOBILITY
NORMAL 23 23 24 22 22 23
GAIT
NORMAL 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
LD= LACTATIONAL DAY
None significantly different from control group
TABLE 4 (F0 - LACTATION)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 5
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS LD 10
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
CONVULSIONS-CLONIC
ABSENT 23 23 24 22 22 23
CONVULSIONS-TONIC
ABSENT 23 23 24 22 22 23
TREMORS
NONE 23 23 24 22 22 23
AROUSAL
NORMAL 23 23 24 22 22 23
Page 156 of 4796
BIZARRE/STEREOTYPIC BEHAVIOR
NONE 23 23 24 22 22 23
PUPILLARY RESPONSE
PRESENT 23 23 24 22 22 23
BACKING COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.00 0.00 0.00
N 23 23 24 22 22 23
GROOMING COUNTS
MEAN 0.0 0.3 0.2 0.1 0.2 0.0
S.D. 0.00 0.54 0.64 0.43 0.53 0.00
N 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
LD= LACTATIONAL DAY
None significantly different from control group
TABLE 4 (F0 - LACTATION)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 6
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS LD 10
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
URINATION COUNTS
MEAN 0.3 0.2 0.3 0.5 0.4 0.2
S.D. 0.49 0.49 0.53 0.60 0.58 0.42
N 23 23 24 22 22 23
DEFECATION COUNTS
MEAN 0.4 0.4 0.7 0.7 0.8 0.7
S.D. 0.90 0.99 1.46 1.24 1.97 1.54
N 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
Page 157 of 4796
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
LD= LACTATIONAL DAY
None significantly different from control group
TABLE 4 (F0 - LACTATION)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 7
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS LD 21
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
LACRIMATION
NONE 23 23 23 21 22 23
SLIGHT - - 1 1 - -
CHROMODACRYORRHEA
ABSENT 23 23 24 22 22 23
SALIVATION
NONE 23 23 24 22 22 23
PILOERECTION
NONE 23 23 24 22 22 23
Page 159 of 4796
FUR APPEARANCE
NORMAL: CLEAN AND GROOMED 23 23 24 22 20 23
SLIGHTLY SOILED - - - - 2 -
PALPEBRAL CLOSURE
EYELIDS WIDE OPEN 23 23 24 22 22 23
RESPIRATORY RATE
NORMAL (80-110) 23 23 24 22 22 23
RESPIRATORY CHARACTER
NORMAL 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
LD= LACTATIONAL DAY
None significantly different from control group
TABLE 4 (F0 - LACTATION)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 9
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS LD 21
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
EYE COLOR
PINK 23 23 24 22 22 23
SKIN COLOR
PINK 23 23 24 22 22 23
EYE PROMINENCE
NORMAL 23 23 24 22 22 23
MUSCLE TONE
FIRM BUT NOT HARD 23 23 24 22 22 23
Page 161 of 4796
MOBILITY
NORMAL 23 23 24 22 22 23
GAIT
NORMAL 23 23 24 22 22 23
CONVULSIONS-CLONIC
ABSENT 23 23 24 22 22 23
CONVULSIONS-TONIC
ABSENT 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
LD= LACTATIONAL DAY
None significantly different from control group
TABLE 4 (F0 - LACTATION)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 11
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS LD 21
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
TREMORS
NONE 22 23 24 22 22 23
SLIGHT (1.5MM) 1 - - - - -
AROUSAL
LOW 1 - - - - 1
NORMAL 22 23 24 22 22 22
BIZARRE/STEREOTYPIC BEHAVIOR
NONE 23 23 24 22 22 23
Page 162 of 4796
PUPILLARY RESPONSE
ABSENT - 1 - - - -
PRESENT 23 22 24 22 22 23
BACKING COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.00 0.00 0.00
N 23 23 24 22 22 23
GROOMING COUNTS
MEAN 0.1 0.0 0.2 0.2 0.1 0.1
S.D. 0.46 0.21 0.59 0.53 0.47 0.29
N 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
LD= LACTATIONAL DAY
None significantly different from control group
TABLE 4 (F0 - LACTATION)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 12
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS LD 21
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
URINATION COUNTS
MEAN 0.3 0.2 0.2 0.3 0.2 0.2
S.D. 0.78 0.42 0.48 0.48 0.39 0.39
N 23 23 24 22 22 23
DEFECATION COUNTS
MEAN 0.3 0.1 0.6 1.0 0.3 1.0
S.D. 0.93 0.46 1.32 1.88 0.70 1.61
N 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
Page 163 of 4796
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
LD= LACTATIONAL DAY
None significantly different from control group
PFOBGv1.52
01/12/2009
R:01/12/2009
TABLE 5 (F0)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF BODY WEIGHTS DURING GESTATION [G]
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 5 (F0)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC SUMMARY OF BODY WEIGHTS DURING GESTATION [G]
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
Overall = Used for statistical model but not for interpretative purposes.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 6 (F0)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF BODY WEIGHT CHANGES DURING GESTATION [G]
GD00_07 Mean 31 34 32 31 21 2
S.D. 9.9 8.5 8.6 7.0 8.0 15.6
S.E. of Mean 2.1 1.8 1.7 1.4 1.6 3.2
N 23 23 24 24 24 24
LSMean 31 34 32 31 21 2
Dunnett p-value# 0.749 0.999 1.000 0.003* <.001*
GD07_14 Mean 38 39 40 34 36 35
S.D. 6.9 7.4 8.4 11.6 8.2 9.7
S.E. of Mean 1.4 1.5 1.7 2.4 1.7 2.0
N 23 23 24 24 24 24
Page 166 of 4796
LSMean 38 39 40 34 36 35
Dunnett p-value# 0.994 0.940 0.427 0.913 0.603
GD14_20 Mean 78 78 79 78 75 77
S.D. 9.5 8.1 8.9 12.7 14.7 10.2
S.E. of Mean 2.0 1.7 1.8 2.6 3.0 2.1
N 23 23 24 24 24 24
LSMean 78 78 79 78 75 77
Dunnett p-value# 1.000 0.995 1.000 0.819 0.991
Overall LSMean 49 50 50 48 44 38
Dunnett p-value# NT NT NT NT NT
Treatment*Time p-value# <.001*
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
Overall = Used for statistical model but not for interpretative purposes.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 6 (F0)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC SUMMARY OF BODY WEIGHT CHANGES DURING GESTATION [G]
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 7 (F0)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF BODY WEIGHTS DURING LACTATION [G]
N 23 23 24 24 24 23
LSMean 312 317 316 310 297 282
Dunnett p-value# 0.923 0.951 0.994 0.060 <.001*
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 7 (F0)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC SUMMARY OF BODY WEIGHTS DURING LACTATION [G]
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
Overall = Used for statistical model but not for interpretative purposes.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 8 (F0)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF BODY WEIGHT CHANGES DURING LACTATION [G]
GROUP: 0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
-----------------------------------------------------------------------------------------------------------------------------------
DAY 1- 4
MEAN 11. 8. 13. 13. 9. 9.
S.D. 8.5 8.4 8.3 7.1 11.6 9.7
S.E. 1.8 1.7 1.7 1.5 2.4 2.0
N 23 23 24 24 24 23
DAY 4- 7
MEAN 6. 7. 5. 6. 10. 10.
S.D. 9.7 9.0 12.6 9.1 9.7 6.7
S.E. 2.0 1.9 2.6 2.0 2.1 1.4
N 23 23 24 22 22 23
DAY 7- 11
MEAN 16. 12. 13. 12. 11. 14.
Page 170 of 4796
DAY 11- 14
MEAN 12. 10. 10. 9. 9. 7.
S.D. 13.6 12.7 20.8 7.8 7.5 12.3
S.E. 2.8 2.7 4.2 1.7 1.6 2.6
N 23 23 24 22 22 23
DAY 14- 17
MEAN 11. 9. 8. 10. 13. 8.
S.D. 13.4 15.6 14.7 16.8 12.6 22.0
S.E. 2.8 3.3 3.0 3.6 2.7 4.6
N 23 23 24 22 22 23
DAY 17- 21
MEAN -17. -9. -8. -21. -8. 8.
S.D. 21.1 18.7 16.8 21.5 13.0 28.9
S.E. 4.4 3.9 3.4 4.6 2.8 6.0
N 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
MEAN DIFFERENCES CALCULATED FROM INDIVIDUAL DIFFERENCES
TABLE 8 (F0)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC SUMMARY OF BODY WEIGHT CHANGES DURING LACTATION [G]
GROUP: 0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
-----------------------------------------------------------------------------------------------------------------------------------
DAY 1- 21
MEAN 38. 37. 41. 30. 44. 58.
S.D. 16.7 15.4 15.1 18.3 15.1 13.6
S.E. 3.5 3.2 3.1 3.9 3.2 2.8
N 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
MEAN DIFFERENCES CALCULATED FROM INDIVIDUAL DIFFERENCES
PLBWSUv5.07
01/12/2009
Page 171 of 4796
TABLE 9 (F0)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF FOOD CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]
GD03_07 Mean 25 25 25 24 20 20
S.D. 2.1 2.3 2.4 2.1 3.3 3.7
S.E. of Mean 0.4 0.5 0.5 0.4 0.7 0.8
N 23 23 24 24 23 24
LSMean 25 25 25 24 20 20
Page 172 of 4796
GD07_10 Mean 25 25 24 24 22 23
S.D. 1.7 2.3 2.7 2.2 2.5 5.3
S.E. of Mean 0.4 0.5 0.5 0.5 0.5 1.1
N 23 23 24 24 24 24
LSMean 25 25 24 24 22 23
Dunnett p-value# 1.000 0.987 0.558 0.030* 0.191
GD10_14 Mean 26 26 26 25 25 23
S.D. 1.8 2.5 3.1 2.7 3.4 2.5
S.E. of Mean 0.4 0.5 0.6 0.6 0.7 0.5
N 23 23 24 24 24 23
LSMean 26 26 26 25 25 23
Dunnett p-value# 1.000 1.000 0.217 0.174 0.001*
GD14_17 Mean 26 27 27 26 26 25
S.D. 1.9 2.7 3.2 2.7 3.8 2.1
S.E. of Mean 0.4 0.6 0.6 0.6 0.8 0.4
N 23 23 24 24 24 24
LSMean 26 27 27 26 26 25
Dunnett p-value# 0.964 0.969 0.988 0.905 0.076
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 9 (F0)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC SUMMARY OF FOOD CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]
GD17_20 Mean 27 27 26 27 27 25
S.D. 2.4 2.7 2.9 2.4 3.2 2.4
S.E. of Mean 0.5 0.6 0.6 0.5 0.7 0.5
N 23 23 23 24 24 24
LSMean 27 27 26 27 27 25
Dunnett p-value# 1.000 0.980 0.993 0.993 0.053
Overall LSMean 25 25 25 24 23 21
Dunnett p-value# NT NT NT NT NT
Treatment*Time p-value# <.001*
Page 173 of 4796
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
Overall = Used for statistical model but not for interpretative purposes.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 10 (F0)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF FOOD CONSUMPTION DURING LACTATION [G/ANIMAL/DAY]
04_07 Mean 41 43 42 44 42 41
S.D. 3.7 4.9 4.0 5.0 5.7 4.1
S.E. of Mean 0.8 1.1 0.8 1.1 1.3 0.9
N 22 22 24 22 21 21
LSMean 41 43 42 44 42 42
Page 174 of 4796
07_11 Mean 54 53 53 54 50 51
S.D. 4.6 4.4 5.2 3.8 6.3 4.0
S.E. of Mean 1.0 0.9 1.1 0.8 1.4 0.9
N 23 22 24 22 21 20
LSMean 54 53 53 54 50 51
Dunnett p-value# 0.987 0.900 1.000 0.021* 0.147
11_14 Mean 63 63 62 62 59 59
S.D. 4.6 5.7 6.5 4.2 10.2 5.1
S.E. of Mean 1.0 1.2 1.3 0.9 2.2 1.1
N 23 23 24 22 22 23
LSMean 63 63 62 62 59 59
Dunnett p-value# 0.994 1.000 0.996 0.330 0.177
14_17 Mean 66 66 65 66 62 62
S.D. 6.2 5.6 5.5 7.1 7.7 7.5
S.E. of Mean 1.3 1.2 1.1 1.5 1.6 1.6
N 23 23 24 22 22 23
LSMean 66 66 65 66 62 62
Dunnett p-value# 1.000 0.998 1.000 0.245 0.292
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 10 (F0)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC SUMMARY OF FOOD CONSUMPTION DURING LACTATION [G/ANIMAL/DAY]
17_21 Mean 70 75 71 72 71 76
S.D. 6.2 9.0 8.4 5.7 11.2 8.3
S.E. of Mean 1.3 1.9 1.7 1.3 2.4 1.7
N 23 23 24 20 22 23
LSMean 70 75 71 73 71 76
Dunnett p-value# 0.218 0.997 0.871 1.000 0.081
Overall LSMean 55 56 55 56 53 54
Dunnett p-value# NT NT NT NT NT
Treatment*Time p-value# <.001*
Page 175 of 4796
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
Overall = Used for statistical model but not for interpretative purposes.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 11 (F0)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF CALCULATED GESTATION TEST SUBSTANCE CONSUMPTION [MG/KG/DAY]
GROUP: 0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
-----------------------------------------------------------------------------------------------------------------------------------
DAY 0- 3
MEAN 0.00 0.01 0.13 6.04 51.05 93.84
S.D. 0.000 0.001 0.008 0.443 9.564 21.962
S.E. 0.000 0.000 0.002 0.090 1.952 4.483
N 23 23 24 24 24 24
DAY 3- 7
MEAN 0.00 0.01 0.13 6.43 56.37 178.46
S.D. 0.000 0.001 0.009 0.491 8.137 32.511
S.E. 0.000 0.000 0.002 0.100 1.697 6.636
N 23 23 24 24 23 24
DAY 7- 10
MEAN 0.00 0.01 0.12 6.04 59.25 195.76
Page 176 of 4796
DAY 10- 14
MEAN 0.00 0.01 0.12 5.93 60.94 182.43
S.D. 0.000 0.001 0.009 0.592 6.533 16.434
S.E. 0.000 0.000 0.002 0.121 1.334 3.427
N 23 23 24 24 24 23
DAY 14- 17
MEAN 0.00 0.01 0.12 5.86 59.31 178.79
S.D. 0.000 0.001 0.009 0.570 6.122 13.757
S.E. 0.000 0.000 0.002 0.116 1.250 2.808
N 23 23 24 24 24 24
-----------------------------------------------------------------------------------------------------------------------------------
NONGRAVID WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN
TABLE 11 (F0)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC SUMMARY OF CALCULATED GESTATION TEST SUBSTANCE CONSUMPTION [MG/KG/DAY]
GROUP: 0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
-----------------------------------------------------------------------------------------------------------------------------------
DAY 17- 20
MEAN 0.00 0.01 0.10 5.32 54.55 161.89
S.D. 0.000 0.001 0.007 0.445 5.599 15.350
S.E. 0.000 0.000 0.002 0.091 1.143 3.133
N 23 23 23 24 24 24
DAY 0- 20
MEAN 0.00 0.01 0.12 5.85 56.43 163.93
S.D. 0.000 0.001 0.007 0.355 4.332 13.189
S.E. 0.000 0.000 0.002 0.072 0.884 2.692
N 23 23 23 24 24 24
-----------------------------------------------------------------------------------------------------------------------------------
NONGRAVID WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN
Page 177 of 4796
PGFWSUv5.14
01/12/2009
R:01/12/2009
TABLE 12 (F0)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF CALCULATED LACTATION TEST SUBSTANCE CONSUMPTION [MG/KG/DAY]
GROUP: 0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
-----------------------------------------------------------------------------------------------------------------------------------
DAY 1- 4
MEAN 0.00 0.02 0.18 9.31 86.87 287.74
S.D. 0.000 0.002 0.020 0.921 17.331 48.206
S.E. 0.000 0.000 0.004 0.201 3.614 11.692
N 19 20 20 21 23 17
DAY 4- 7
MEAN 0.00 0.02 0.20 10.61 104.11 326.04
S.D. 0.000 0.002 0.015 1.121 13.621 30.768
S.E. 0.000 0.000 0.003 0.239 2.972 6.714
N 22 22 24 22 21 21
DAY 7- 11
MEAN 0.00 0.02 0.24 12.57 119.82 384.13
Page 178 of 4796
DAY 11- 14
MEAN 0.00 0.03 0.28 13.93 138.34 426.15
S.D. 0.000 0.003 0.027 1.197 21.192 39.448
S.E. 0.000 0.001 0.006 0.255 4.518 8.225
N 23 23 24 22 22 23
DAY 14- 17
MEAN 0.00 0.03 0.28 14.47 140.56 440.97
S.D. 0.000 0.003 0.022 1.453 16.281 46.944
S.E. 0.000 0.001 0.005 0.310 3.471 9.789
N 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
TABLE 12 (F0)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC SUMMARY OF CALCULATED LACTATION TEST SUBSTANCE CONSUMPTION [MG/KG/DAY]
GROUP: 0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
-----------------------------------------------------------------------------------------------------------------------------------
DAY 17- 21
MEAN 0.00 0.03 0.31 16.13 158.03 526.70
S.D. 0.000 0.004 0.041 1.462 23.691 64.798
S.E. 0.000 0.001 0.008 0.327 5.051 13.511
N 23 23 24 20 22 23
DAY 1- 21
MEAN 0.00 0.03 0.25 13.14 128.61 410.45
S.D. 0.000 0.002 0.019 0.983 13.162 34.871
S.E. 0.000 0.000 0.004 0.220 2.806 8.458
N 19 20 20 20 22 17
-----------------------------------------------------------------------------------------------------------------------------------
PLFWSUv5.20
Page 179 of 4796
01/12/2009
R:01/12/2009
TABLE 13 (F0)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF GESTATION LENGTHS [DAYS]
GROUP: 0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
-----------------------------------------------------------------------------------------------------------------------------------
GESTATION LENGTH (DAYS)
MEAN 21.7 21.7 21.7 22.0 21.8 21.8
S.D. 0.45 0.45 0.46 0.20 0.51 0.41
S.E. 0.09 0.09 0.09 0.04 0.10 0.08
N 23 23 24 24 24 24
-----------------------------------------------------------------------------------------------------------------------------------
None significantly different from control group
PGLv5.06
12/16/2008
R:07/13/2009
Page 180 of 4796
TABLE 14 (F0 - UNSCHEDULED DEATH)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF MACROSCOPIC FINDINGS
SKIN
-MATTING, RED 0 0 0 0 0 1
STOMACH
-CONTENTS, DARK RED 0 0 0 0 0 1
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
Page 181 of 4796
PGRSI2v4.07
03/26/2009
TABLE 15 (F0 - FAILED TO DELIVER)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF MACROSCOPIC FINDINGS
SCHEDULED NECROPSY
-----------------------------------------------------------------------------------------------------------------------------------
----- F E M A L E -----
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS IN DOSE GROUP 24 24 24 24 24 24
NUMBER OF ANIMALS EXAMINED 1 1 0 0 0 0
UTERUS
-CONTENTS, CLEAR FLUID 1 0 0 0 0 0
PGRSI2v4.07
Page 182 of 4796
03/26/2009
TABLE 16 (F0 - PUP SEX RATIO CRITERIA NOT MET)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF MACROSCOPIC FINDINGS
SCHEDULED NECROPSY
-----------------------------------------------------------------------------------------------------------------------------------
----- F E M A L E -----
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS IN DOSE GROUP 24 24 24 24 24 24
NUMBER OF ANIMALS EXAMINED 0 0 0 2 2 0
PGRSI2v4.07
03/26/2009
Page 183 of 4796
TABLE 17 (F0 - LACTATION DAY 21)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF MACROSCOPIC FINDINGS
SCHEDULED NECROPSY
-----------------------------------------------------------------------------------------------------------------------------------
----- F E M A L E -----
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS IN DOSE GROUP 24 24 24 24 24 24
NUMBER OF ANIMALS EXAMINED 23 23 24 22 22 23
DIAPHRAGM
-HERNIA 0 0 0 0 0 1
KIDNEYS
-AREA(S), DEPRESSED 0 2 1 2 1 1
-PALE 0 1 0 1 1 0
-DILATED PELVIS 0 0 0 0 0 2
Page 184 of 4796
LIVER
-DISCOLORATION, DARK RED 0 0 0 0 0 1
LUNGS
-AREA(S), DARK RED 0 0 0 0 0 1
SKIN
-MATTING, RED 0 0 0 0 0 1
-HAIR LOSS 0 0 0 0 0 1
SPLEEN
-NODULE(S) 0 0 1 0 0 0
-AREA(S), WHITE 0 0 1 0 0 0
STOMACH
-AREA(S), DARK RED 0 0 0 2 0 0
-CONTENTS, YELLOW 1 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
TABLE 17 (F0 - LACTATION DAY 21)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC SUMMARY OF MACROSCOPIC FINDINGS
SCHEDULED NECROPSY
-----------------------------------------------------------------------------------------------------------------------------------
----- F E M A L E -----
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS IN DOSE GROUP 24 24 24 24 24 24
NUMBER OF ANIMALS EXAMINED 23 23 24 22 22 23
THYMUS
-AREA(S), DARK RED 0 0 0 2 0 0
URETERS
-DISTENDED 0 0 0 0 0 1
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
PGRSI2v4.07
08/18/2009
TABLE 18 (F0)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF IMPLANTATION SITES
-----------------------------------------------------------------------------------------------------------------------------------
GROUP: 0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
-----------------------------------------------------------------------------------------------------------------------------------
IMPLANTATION SITES
MEAN 16.3 16.3 16.5 16.0 15.7 16.2
S.D. 1.28 2.20 1.90 2.35 1.86 1.50
S.E. 0.27 0.46 0.40 0.48 0.39 0.31
N 22-A 23 23-A 24 23 24
NUMBER BORN
MEAN 15.7 15.2 15.8 14.9 14.4 15.3
S.D. 1.55 2.19 1.86 2.87 1.90 1.69
S.E. 0.32 0.46 0.38 0.59 0.40 0.34
N 23 23 24 24 23 24
UNACCOUNTED SITES
MEAN 0.8 1.1 0.7 1.0 1.3 0.7
Page 186 of 4796
-----------------------------------------------------------------------------------------------------------------------------------
None significantly different from control group
NOTE: ONLY DAMS THAT HAVE DELIVERED ONE OR MORE PUPS ARE INCLUDED IN CALCULATION OF MEAN.
A = NUMBER OF PUPS BORN EXCEEDED NUMBER OF IMPLANTATION SITES FOR 1 FEMALE; NOT INCLUDED IN CALCULATION OF MEANS.
B = FEMALE NO. 23237 WAS FOUND DEAD ON LACTATION DAY 0 WITH 3 FETUSES AND 1 EARLY RESORPTION RETAINED IN UTERO; NOT INCLUDED
IN CALCULATION OF MEAN.
PISSUv5.07
12/17/2008
R:07/13/2009
TABLE 19 (F0 - LACTATION DAY 21)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF ORGAN WEIGHTS AND ORGAN WTS. RELATIVE TO BODY WTS.
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 19 (F0 - LACTATION DAY 21)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC SUMMARY OF ORGAN WEIGHTS AND ORGAN WTS. RELATIVE TO BODY WTS.
-------------------------------------------------------------------------------------------------------------------------------------
Organ weight ratios relative to final body weights not statistically analyzed.
TABLE 20 (F0 - UNSCHEDULED DEATH)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF MICROSCOPIC FINDINGS
KIDNEYS
TOTAL NUMBER EXAMINED 0 0 0 0 0 1
EXAMINED, UNREMARKABLE 0 0 0 0 0 1
LIVER
TOTAL NUMBER EXAMINED 0 0 0 0 0 1
EXAMINED, UNREMARKABLE 0 0 0 0 0 1
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
Page 189 of 4796
PHSI2v4.30
03/26/2009
R:07/13/2009
TABLE 21 (F0 - FAILED TO DELIVER)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF MICROSCOPIC FINDINGS
KIDNEYS
TOTAL NUMBER EXAMINED 1 1 0 0 0 0
EXAMINED, UNREMARKABLE 1 0 0 0 0 0
-MINERALIZATION 0 1 0 0 0 0
MINIMAL NONE 1 NONE NONE NONE NONE
LIVER
TOTAL NUMBER EXAMINED 1 1 0 0 0 0
EXAMINED, UNREMARKABLE 0 1 0 0 0 0
Page 190 of 4796
-INFILTRATE, MONONUCLEAR 1 0 0 0 0 0
MINIMAL 1 NONE NONE NONE NONE NONE
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
PHSI2v4.30
03/26/2009
R:07/13/2009
TABLE 22 (F0 - PUP SEX RATIO CRITERIA NOT MET)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF MICROSCOPIC FINDINGS
KIDNEYS
TOTAL NUMBER EXAMINED 0 0 0 2 2 0
EXAMINED, UNREMARKABLE 0 0 0 1 0 0
-CYST 0 0 0 1 0 0
PRESENT NONE NONE NONE 1 NONE NONE
-MINERALIZATION 0 0 0 0 2 0
MINIMAL NONE NONE NONE NONE 2 NONE
-MINERALIZATION, PAPILLARY TUBULAR 0 0 0 0 1 0
MINIMAL NONE NONE NONE NONE 1 NONE
Page 191 of 4796
LIVER
TOTAL NUMBER EXAMINED 0 0 0 2 2 0
EXAMINED, UNREMARKABLE 0 0 0 1 1 0
-HEMATOPOIESIS, EXTRAMEDULLARY 0 0 0 1 0 0
MILD NONE NONE NONE 1 NONE NONE
-INFILTRATE, MONONUCLEAR 0 0 0 1 1 0
MINIMAL NONE NONE NONE 1 1 NONE
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
PHSI2v4.30
03/26/2009
R:07/13/2009
TABLE 23 (F0 - LACTATION DAY 21)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF MICROSCOPIC FINDINGS
DIAPHRAGM
TOTAL NUMBER EXAMINED NA NA NA NA NA 1
EXAMINED, UNREMARKABLE NA NA NA NA NA 0
-FIBROSIS NA NA NA NA NA 1
MILD NA NA NA NA NA 1
KIDNEYS
TOTAL NUMBER EXAMINED 23 23 24 22 22 23
EXAMINED, UNREMARKABLE 8 7 5 6 8 7
Page 192 of 4796
-#M NEPHROBLASTOMA 0 0 0 1 0 0
PRESENT NONE NONE NONE 1 NONE NONE
-BASOPHILIC TUBULES 0 1 0 0 1 1
MINIMAL NONE 1 NONE NONE 1 NONE
MODERATE NONE NONE NONE NONE NONE 1
-CYST 0 0 0 0 1 1
PRESENT NONE NONE NONE NONE 1 1
-DILATATION, TUBULAR 0 0 1 0 0 1
MINIMAL NONE NONE 1 NONE NONE 1
-HYDRONEPHROSIS 0 0 0 0 0 2
MILD NONE NONE NONE NONE NONE 2
-INFILTRATE, MONONUCLEAR 4 4 6 8 2 2
MINIMAL 4 4 6 8 2 2
-MINERALIZATION 8 9 12 10 6 11
MINIMAL 7 9 10 10 4 8
MILD 1 NONE 2 NONE 2 3
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
# = NEOPLASM, M = MALIGNANT
NA = NOT APPLICABLE
TABLE 23 (F0 - LACTATION DAY 21)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC SUMMARY OF MICROSCOPIC FINDINGS
KIDNEYS - CONTINUED
-MINERALIZATION, PAPILLARY TUBULAR 0 1 0 1 1 1
MINIMAL NONE 1 NONE 1 1 1
-NEPHROPATHY, CHRONIC PROGRESSIVE 6 7 6 2 5 1
MINIMAL 6 6 6 2 5 1
MILD NONE 1 NONE NONE NONE NONE
LIVER
TOTAL NUMBER EXAMINED 23 23 24 22 22 23
EXAMINED, UNREMARKABLE 3 1 2 1 0 5
Page 193 of 4796
-FIBROSIS 0 0 0 0 0 1
MILD NONE NONE NONE NONE NONE 1
-HEMATOPOIESIS, EXTRAMEDULLARY 0 0 0 0 2 0
MINIMAL NONE NONE NONE NONE 2 NONE
-HEMORRHAGE 0 0 0 0 0 1
MILD NONE NONE NONE NONE NONE 1
-HYPERPLASIA, BILE DUCT 0 0 1 0 0 0
MINIMAL NONE NONE 1 NONE NONE NONE
-INFILTRATE, MONONUCLEAR 20 22 22 21 22 18
MINIMAL 19 22 21 21 22 18
MILD 1 NONE 1 NONE NONE NONE
-NECROSIS 1 0 1 0 1 0
MINIMAL NONE NONE 1 NONE 1 NONE
MILD 1 NONE NONE NONE NONE NONE
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
TABLE 23 (F0 - LACTATION DAY 21)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 3
SPONSOR:ACC SUMMARY OF MICROSCOPIC FINDINGS
LIVER - CONTINUED
-PIGMENT, BROWN 0 0 0 0 0 1
MILD NONE NONE NONE NONE NONE 1
STOMACH
TOTAL NUMBER EXAMINED NA NA NA 1 NA NA
EXAMINED, UNREMARKABLE NA NA NA 0 NA NA
-EROSION NA NA NA 1 NA NA
MINIMAL NA NA NA 1 NA NA
Page 194 of 4796
THYMUS
TOTAL NUMBER EXAMINED NA NA NA 1 NA NA
EXAMINED, UNREMARKABLE NA NA NA 0 NA NA
-HEMORRHAGE NA NA NA 1 NA NA
MINIMAL NA NA NA 1 NA NA
URETERS
TOTAL NUMBER EXAMINED NA NA NA NA NA 1
EXAMINED, UNREMARKABLE NA NA NA NA NA 0
-DILATATION, LUMEN NA NA NA NA NA 1
MILD NA NA NA NA NA 1
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
NA = NOT APPLICABLE
PHSI2v4.30
08/18/2009
TABLE 24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF PND 0 LITTER DATA
GROUP : 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER BORN
MEAN 15.7 15.2 15.8 14.9 14.5 15.3
S.D. 1.55 2.19 1.86 2.87 1.89 1.69
S.E. 0.32 0.46 0.38 0.59 0.39 0.34
N 23 23 24 24 24 24
GROUP : 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
PND 0 TO PND 1
MEAN 99.8 99.4 99.3 96.6 98.6 98.6
S.D. 1.16 1.99 2.52 10.26 4.73 2.76
S.E. 0.24 0.42 0.51 2.09 0.97 0.58
N 23 23 24 24 24 23
PND 7 TO PND 14
MEAN 98.9 100.0 98.3 100.0 97.7 99.5
S.D. 3.60 0.00 4.64 0.00 10.66 2.61
S.E. 0.75 0.00 0.95 0.00 2.27 0.54
N 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
-----------------------------------------------------------------------------------------------------------------------------------
None significantly different from control group
TABLE 25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC SUMMARY OF POSTNATAL SURVIVAL [% PER LITTER]
GROUP : 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
PND 14 TO PND 21
MEAN 100.0 100.0 98.6 100.0 100.0 100.0
S.D. 0.00 0.00 6.80 0.00 0.00 0.00
S.E. 0.00 0.00 1.39 0.00 0.00 0.00
N 23 23 24 22 22 23
NORMAL
NO REMARKABLE OBSERVATIONS 712/ 348 696/ 332 733/ 365 681/ 329 670/ 333 704/ 340
DISPOSITION
FOUND DEAD 9/ 9 14/ 14 15/ 15 22/ 22 13/ 13 11/ 11
EUTHANIZED IN EXTREMIS 0/ 0 0/ 0 0/ 0 0/ 0 1/ 1 0/ 0
SCHEDULED EUTHANASIA (PND 21) 90/ 90 92/ 92 90/ 90 88/ 88 84/ 84 90/ 90
CULLED ON SCHEDULED DAY (PND 4) 166/ 166 149/ 149 177/ 177 142/ 142 144/ 144 159/ 159
SCHEDULED EUTHANASIA; SEX RATIO CRITERIA NOT MET (PND 4) 0/ 0 0/ 0 0/ 0 12/ 12 16/ 16 0/ 0
MISSING 4/ 4 2/ 2 3/ 3 6/ 6 4/ 4 4/ 4
SENT TO NECROPSY DUE TO DEATH OF DAM 0/ 0 0/ 0 0/ 0 0/ 0 0/ 0 12/ 12
Page 198 of 4796
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 92/ 92 92/ 92 95/ 95 88/ 88 86/ 86 92/ 92
BEHAVIOR/CNS
HYPOACTIVITY 0/ 0 0/ 0 1/ 1 0/ 0 0/ 0 0/ 0
BODY/INTEGUMENT
LACERATION 0/ 0 1/ 1 0/ 0 1/ 1 1/ 1 1/ 1
SUBCUTANEOUS HEMORRHAGE(S) 1/ 1 1/ 1 0/ 0 0/ 0 1/ 1 0/ 0
SMALL STATURE 1/ 1 1/ 1 10/ 7 1/ 1 3/ 3 3/ 3
BODY PALE 1/ 1 3/ 3 1/ 1 0/ 0 1/ 1 1/ 1
BODY COOL 0/ 0 1/ 1 0/ 0 0/ 0 2/ 2 0/ 0
REDDENED PLANTAR SURFACE OF LEFT HINDLIMB 0/ 0 0/ 0 0/ 0 0/ 0 3/ 3 0/ 0
REDDENED PLANTAR SURFACE OF RIGHT HINDLIMB 0/ 0 0/ 0 0/ 0 0/ 0 3/ 3 0/ 0
REDDENED PALMAR SURFACE OF RIGHT FORELIMB 0/ 0 0/ 0 0/ 0 0/ 0 1/ 1 0/ 0
REDDENED PALMAR SURFACE OF LEFT FORELIMB 0/ 0 0/ 0 0/ 0 0/ 0 1/ 1 0/ 0
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
TABLE 26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC SUMMARY OF PUP CLINICAL OBSERVATIONS
BODY/INTEGUMENT
SCABBING 0/ 0 1/ 1 0/ 0 0/ 0 1/ 1 0/ 0
CARDIO-PULMONARY
GASPING 0/ 0 0/ 0 3/ 3 4/ 4 2/ 2 0/ 0
LABORED RESPIRATION 0/ 0 0/ 0 0/ 0 0/ 0 1/ 1 0/ 0
EYES/EARS/NOSE
EXOPHTHALMUS 0/ 0 2/ 1 0/ 0 0/ 0 0/ 0 0/ 0
BUPHTHALMOS 0/ 0 2/ 1 0/ 0 0/ 0 0/ 0 0/ 0
EYELIDS COMPLETELY SHUT 0/ 0 0/ 0 0/ 0 0/ 0 2/ 1 0/ 0
Page 199 of 4796
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
P = Sexes combined.
Overall = Used for statistical model but not for interpretative purposes.
TABLE 27 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC SUMMARY OF OFFSPRING WEIGHTS [G]
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
P = Sexes combined. A = Body weight following culling.
TABLE 27 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 3
SPONSOR:ACC SUMMARY OF OFFSPRING WEIGHTS [G]
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
P = Sexes combined.
Overall = Used for statistical model but not for interpretative purposes.
TABLE 27 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 4
SPONSOR:ACC SUMMARY OF OFFSPRING WEIGHTS [G]
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
Overall = Used for statistical model but not for interpretative purposes.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 27 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 5
SPONSOR:ACC SUMMARY OF OFFSPRING WEIGHTS [G]
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
Overall = Used for statistical model but not for interpretative purposes.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 27 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 7
SPONSOR:ACC SUMMARY OF OFFSPRING WEIGHTS [G]
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
Overall = Used for statistical model but not for interpretative purposes.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 27 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 8
SPONSOR:ACC SUMMARY OF OFFSPRING WEIGHTS [G]
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
Overall = Used for statistical model but not for interpretative purposes.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 28 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF OFFSPRING WEIGHT CHANGES [G]
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
P = Sexes combined.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 28 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC SUMMARY OF OFFSPRING WEIGHT CHANGES [G]
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
P = Sexes combined. A = Body weight following culling.
Overall = Used for statistical model but not for interpretative purposes.
TABLE 28 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 3
SPONSOR:ACC SUMMARY OF OFFSPRING WEIGHT CHANGES [G]
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed due to lack of a statistically significant TRT*SEX interaction.
Page 211 of 4796
TABLE 28 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 4
SPONSOR:ACC SUMMARY OF OFFSPRING WEIGHT CHANGES [G]
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
A = Body weight following culling.
Overall = Used for statistical model but not for interpretative purposes.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 28 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 5
SPONSOR:ACC SUMMARY OF OFFSPRING WEIGHT CHANGES [G]
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed due to lack of a statistically significant TRT*SEX interaction.
Page 213 of 4796
TABLE 28 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 6
SPONSOR:ACC SUMMARY OF OFFSPRING WEIGHT CHANGES [G]
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
A = Body weight following culling.
Overall = Used for statistical model but not for interpretative purposes.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 29 (F1 - FOUND DEAD OR EUTHANIZED IN EXTREMIS PUPS)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF PUP NECROPSY FINDINGS
PAWS
REDDENED 0 0 0 0 2 0 0 0 0 0 1 0
EYES
HEMORRHAGIC RING AROUND THE IRIS 0 0 0 0 0 1 0 0 0 0 0 1
LIVER
SWOLLEN 0 0 0 0 0 1 0 0 0 0 0 1
Page 215 of 4796
STOMACH
MILK NOT PRESENT 7 8 3 14 7 4 6 5 3 4 3 4
MILK PRESENT 0 0 0 0 1 0 0 0 0 0 1 0
KIDNEY
RENAL PAPILLA NOT FULLY DEVELOPED (WOO AND HOAR GRADE 1) 0 0 0 1 0 0 0 0 0 1 0 0
BLADDER
CONTENTS, RED FLUID 0 0 0 0 1 0 0 0 0 0 1 0
MALFORMATION
LUNGS- LOBULAR DYSGENESIS 0 0 0 0 0 1 0 0 0 0 0 1
SITUS INVERSUS 0 0 0 0 0 1 0 0 0 0 0 1
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
-----------------------------------------------------------------------------------------------------------------------------------
PPNSIv4.03
12/17/2008
R:07/13/2009
TABLE 30 (F1 - PUPS EUTHANIZED DUE TO DEATH OF DAM, SEX RATIO CRITERIA NOT MET, OR ON PND 21)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF PUP NECROPSY FINDINGS
EUTHANIZED PUPS
-----------------------------------------------------------------------------------------------------------------------------------
P U P S L I T T E R S
DOSE GROUP: 1 2 3 4 5 6 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
EYES
ATROPHY 0 0 0 0 1 0 0 0 0 0 1 0
KIDNEY
DILATED PELVIS 0 0 0 1 0 1 0 0 0 1 0 1
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
-----------------------------------------------------------------------------------------------------------------------------------
Page 216 of 4796
PPNSIv4.03
12/17/2008
R:07/13/2009
TABLE 31 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF DEVELOPMENTAL LANDMARKS SURFACE RIGHTING RESPONSE
N (Litters) 23 23 24 22 22 23
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
P = Sexes combined.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 32 (F1 SUBSET A)
PROJECT NO.:WIL-186056A DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF DEVELOPMENTAL LANDMARKS BALANOPREPUTIAL SEPARATION
N 23 23 24 22 21 23
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 33 (F1 SUBSET A)
PROJECT NO.:WIL-186056D DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF DEVELOPMENTAL LANDMARKS VAGINAL PATENCY
N 23 23 24 22 22 23
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 34 (F1 MALES - SUBSETS A AND B)
PROJECT NO.:WIL-186056A DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS
----- M A L E -----
-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 08-31-08 TO 11-16-08
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NORMAL
-NO SIGNIFICANT CLINICAL OBSERVATIONS 212/46 213/46 227/46 210/44 207/42 228/46
DISPOSITION
-EUTHANIZED IN EXTREMIS 0/ 0 0/ 0 1/ 1 0/ 0 0/ 0 0/ 0
-SCHEDULED EUTHANASIA; SUBSET B 23/23 23/23 22/22 22/22 21/21 23/23
-FOUND DEAD 0/ 0 0/ 0 2/ 2 0/ 0 0/ 0 0/ 0
-SCHEDULED EUTHANASIA; SUBSET A 23/23 23/23 23/23 22/22 21/21 23/23
BEHAVIOR/CNS
-IMPAIRED USE OF LEFT HINDLIMB 0/ 0 0/ 0 1/ 1 0/ 0 0/ 0 0/ 0
Page 220 of 4796
BODY/INTEGUMENT
-HAIR LOSS RIGHT FORELIMB 6/ 1 8/ 2 1/ 1 10/ 3 3/ 1 2/ 1
-HAIR LOSS LEFT FORELIMB 0/ 0 9/ 3 1/ 1 6/ 2 3/ 1 2/ 1
-SCABBING VENTRAL NECK 1/ 1 0/ 0 1/ 1 0/ 0 0/ 0 0/ 0
-SCABBING DORSAL HEAD 1/ 1 0/ 0 0/ 0 0/ 0 0/ 0 0/ 0
-HAIR LOSS DORSAL HEAD 1/ 1 1/ 1 0/ 0 0/ 0 0/ 0 0/ 0
-SCABBING RIGHT FORELIMB 0/ 0 1/ 1 0/ 0 0/ 0 0/ 0 0/ 0
-SCABBING LEFT FORELIMB 0/ 0 1/ 1 0/ 0 0/ 0 0/ 0 0/ 0
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
TABLE 34 (F1 MALES - SUBSETS A AND B)
PROJECT NO.:WIL-186056A DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS
----- M A L E -----
-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 08-31-08 TO 11-16-08
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
BODY/INTEGUMENT
-SCABBING RIGHT LATERAL THORACIC AREA 1/ 1 0/ 0 0/ 0 0/ 0 0/ 0 0/ 0
EYES/EARS/NOSE
-DRIED RED MATERIAL AROUND NOSE 0/ 0 0/ 0 1/ 1 0/ 0 0/ 0 0/ 0
-LACRIMATION RIGHT EYE 2/ 1 0/ 0 1/ 1 0/ 0 0/ 0 0/ 0
-OPACITY LEFT EYE 9/ 1 0/ 0 0/ 0 0/ 0 0/ 0 0/ 0
-OPACITY RIGHT EYE 9/ 1 9/ 1 0/ 0 0/ 0 0/ 0 0/ 0
-DRIED RED MATERIAL AROUND RIGHT EYE 2/ 1 0/ 0 3/ 1 0/ 0 0/ 0 1/ 1
ORAL/DENTAL
Page 221 of 4796
----- F E M A L E -----
-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 09-01-08 TO 11-16-08
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NORMAL
-NO SIGNIFICANT CLINICAL OBSERVATIONS 215/46 219/46 226/47 212/44 217/44 223/46
DISPOSITION
-SCHEDULED EUTHANASIA; SUBSET B 23/23 23/23 23/23 22/22 22/22 23/23
-FOUND DEAD 1/ 1 0/ 0 0/ 0 0/ 0 0/ 0 0/ 0
-SCHEDULED EUTHANASIA; SUBSET A 22/22 23/23 24/24 22/22 22/22 23/23
BODY/INTEGUMENT
-SCABBING RIGHT LATERAL NECK 0/ 0 1/ 1 0/ 0 0/ 0 0/ 0 0/ 0
-HAIR LOSS RIGHT FORELIMB 5/ 3 5/ 1 8/ 3 5/ 2 0/ 0 7/ 2
Page 222 of 4796
EYES/EARS/NOSE
-OPACITY RIGHT EYE 0/ 0 6/ 1 0/ 0 0/ 0 0/ 0 0/ 0
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
TABLE 35 (F1 FEMALES - SUBSETS A AND B)
PROJECT NO.:WIL-186056D DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS
----- F E M A L E -----
-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 09-01-08 TO 11-16-08
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
EYES/EARS/NOSE
-LACRIMATION RIGHT EYE 0/ 0 1/ 1 0/ 0 1/ 1 0/ 0 0/ 0
-DRIED RED MATERIAL AROUND RIGHT EYE 0/ 0 0/ 0 0/ 0 2/ 1 0/ 0 0/ 0
-EXOPHTHALMUS LEFT EYE 0/ 0 0/ 0 4/ 1 0/ 0 0/ 0 0/ 0
-RIGHT PUPIL ELONGATED VERTICALLY; PUPIL 0/ 0 1/ 1 0/ 0 0/ 0 2/ 1 0/ 0
ORIENTED TOWARD BOTTOM EDGE OF EYE
ORAL/DENTAL
-UPPER INCISORS MALALIGNED 0/ 0 0/ 0 0/ 0 1/ 1 0/ 0 0/ 0
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
Page 223 of 4796
PCSUv4.07
02/04/2009
R:07/13/2009
TABLE 36 (F1 SUBSET A)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF BODY WEIGHTS [G]
P PND028 Mean 90 93 90 91 88 86
% Difference Control 3.3 0.0 1.1 -2.2 -4.4
S.D. 9.1 10.0 9.7 10.6 11.8 10.3
S.E. of Mean 1.3 1.5 1.4 1.6 1.8 1.5
N 46 46 48 44 43 46
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
P = Sexes combined.
TABLE 36 (F1 SUBSET A)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC SUMMARY OF BODY WEIGHTS [G]
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
P = Sexes combined.
Overall = Used for statistical model but not for interpretative purposes.
TABLE 36 (F1 SUBSET A)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 3
SPONSOR:ACC SUMMARY OF BODY WEIGHTS [G]
M PND028 Mean 94 97 94 96 93 91
% Difference Control 3.2 0.0 2.1 -1.1 -3.2
S.D. 8.6 11.1 8.7 10.4 11.7 8.7
S.E. of Mean 1.8 2.3 1.8 2.2 2.6 1.8
N 23 23 24 22 21 23
LSMean 94 97 94 96 92 91
Dunnett p-value# NT NT NT NT NT
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 36 (F1 SUBSET A)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 4
SPONSOR:ACC SUMMARY OF BODY WEIGHTS [G]
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
Overall = Used for statistical model but not for interpretative purposes.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 36 (F1 SUBSET A)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 5
SPONSOR:ACC SUMMARY OF BODY WEIGHTS [G]
F PND028 Mean 87 89 86 85 85 80
% Difference Control 2.3 -1.1 -2.3 -2.3 -8.0
S.D. 8.0 6.9 8.9 8.2 10.6 9.3
S.E. of Mean 1.7 1.4 1.8 1.8 2.3 1.9
N 23 23 24 22 22 23
LSMean 87 89 86 85 85 80
Dunnett p-value# NT NT NT NT NT
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 36 (F1 SUBSET A)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 6
SPONSOR:ACC SUMMARY OF BODY WEIGHTS [G]
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
Overall = Used for statistical model but not for interpretative purposes.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 37 (F1 MALES - SUBSET A)
PROJECT NO.:WIL-186056A DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF BODY WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
MALES
GROUP: 0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
-----------------------------------------------------------------------------------------------------------------------------------
PND 28- 35
MEAN 62. 64. 62. 63. 62. 59.
S.D. 6.8 8.5 4.8 6.8 7.0 7.3
S.E. 1.4 1.8 1.0 1.4 1.5 1.5
N 23 23 24 22 21 23
PND 35- 42
MEAN 67. 69. 67. 69. 67. 67.
S.D. 6.3 7.4 5.8 6.0 7.0 7.5
S.E. 1.3 1.6 1.2 1.3 1.5 1.6
N 23 23 24 22 21 23
PND 42- 49
Page 230 of 4796
PND 49- 56
MEAN 59. 64. 60. 62. 61. 62.
S.D. 7.9 10.3 7.9 7.5 9.9 10.7
S.E. 1.6 2.1 1.6 1.6 2.2 2.2
N 23 23 23 22 21 23
PND 56- 63
MEAN 39. 40. 42. 42. 39. 38.
S.D. 8.9 8.9 14.5 6.8 7.8 7.0
S.E. 1.9 1.9 3.0 1.4 1.7 1.5
N 23 23 23 22 21 23
-----------------------------------------------------------------------------------------------------------------------------------
MEAN DIFFERENCES CALCULATED FROM INDIVIDUAL DIFFERENCES
TABLE 37 (F1 MALES - SUBSET A)
PROJECT NO.:WIL-186056A DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC SUMMARY OF BODY WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
MALES
GROUP: 0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
-----------------------------------------------------------------------------------------------------------------------------------
PND 63- 70
MEAN 29. 28. 30. 31. 31. 28.
S.D. 7.0 8.3 8.1 7.3 7.2 9.6
S.E. 1.5 1.7 1.7 1.6 1.6 2.0
N 23 23 23 22 21 23
PND 70- 72
MEAN 12. 12. 10. 11. 12. 13.
S.D. 5.3 6.4 5.0 6.4 5.4 9.7
S.E. 1.1 1.3 1.1 1.4 1.2 2.0
N 23 23 23 22 21 23
PND 28- 72
Page 231 of 4796
-----------------------------------------------------------------------------------------------------------------------------------
MEAN DIFFERENCES CALCULATED FROM INDIVIDUAL DIFFERENCES
PJTBWSUv5.15
03/24/2009
R:07/13/2009
TABLE 38 (F1 FEMALES - SUBSET A)
PROJECT NO.:WIL-186056D DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF BODY WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
FEMALES
GROUP: 0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
-----------------------------------------------------------------------------------------------------------------------------------
PND 28- 35
MEAN 46. 49. 46. 45. 45. 45.
S.D. 6.3 6.1 6.2 4.1 6.1 4.9
S.E. 1.3 1.3 1.3 0.9 1.3 1.0
N 23 23 24 22 22 23
PND 35- 42
MEAN 38. 40. 38. 39. 36. 38.
S.D. 6.2 5.4 7.1 8.0 7.0 6.4
S.E. 1.3 1.1 1.5 1.7 1.5 1.3
N 22 23 24 22 22 23
PND 42- 49
Page 232 of 4796
PND 49- 56
MEAN 24. 25. 22. 25. 25. 24.
S.D. 7.1 10.0 8.5 5.2 8.4 7.6
S.E. 1.5 2.1 1.7 1.1 1.8 1.6
N 22 23 24 22 22 23
PND 56- 63
MEAN 20. 23. 21. 19. 18. 17.
S.D. 7.5 8.1 8.1 5.8 5.3 6.6
S.E. 1.6 1.7 1.7 1.2 1.1 1.4
N 22 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
MEAN DIFFERENCES CALCULATED FROM INDIVIDUAL DIFFERENCES
TABLE 38 (F1 FEMALES - SUBSET A)
PROJECT NO.:WIL-186056D DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC SUMMARY OF BODY WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
FEMALES
GROUP: 0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
-----------------------------------------------------------------------------------------------------------------------------------
PND 63- 70
MEAN 14. 12. 13. 14. 16. 13.
S.D. 8.0 8.0 8.7 5.8 4.7 6.1
S.E. 1.7 1.7 1.8 1.2 1.0 1.3
N 22 23 24 22 22 23
PND 70- 72
MEAN 5. 7. 5. 4. 5. 7.
S.D. 7.5 6.5 8.0 6.1 7.6 5.8
S.E. 1.6 1.4 1.6 1.3 1.6 1.2
N 22 23 24 22 22 23
PND 28- 72
Page 233 of 4796
-----------------------------------------------------------------------------------------------------------------------------------
MEAN DIFFERENCES CALCULATED FROM INDIVIDUAL DIFFERENCES
PJTBWSUv5.14
01/12/2009
R:07/13/2009
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 4
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
LACRIMATION
NONE 23 23 24 22 22 23
CHROMODACRYORRHEA
ABSENT 23 23 24 22 22 23
SALIVATION
NONE 23 23 24 22 22 23
RESPIRATORY RATE
NORMAL (80-110) 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 4
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
RESPIRATORY CHARACTER
NORMAL 23 23 24 22 22 23
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
SKIN COLOR
PINK 23 23 24 22 22 23
MUSCLE TONE
FIRM BUT NOT HARD 23 23 24 22 22 23
CONVULSIONS-CLONIC
ABSENT 23 23 24 22 22 23
Page 236 of 4796
CONVULSIONS-TONIC
ABSENT 23 23 24 22 22 23
TREMORS
NONE 23 23 24 22 22 23
AROUSAL
NORMAL 23 23 24 22 22 23
BIZARRE/STEREOTYPIC BEHAVIOR
NONE 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 4
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 4
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
URINATION COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.00 0.00 0.00
N 23 23 24 22 22 23
DEFECATION COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.00 0.00 0.00
N 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
Page 237 of 4796
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 5
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 4
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
LACRIMATION
NONE 23 23 24 22 22 23
CHROMODACRYORRHEA
ABSENT 23 23 24 22 22 23
SALIVATION
NONE 23 23 24 22 22 23
RESPIRATORY RATE
NORMAL (80-110) 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 6
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 4
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
RESPIRATORY CHARACTER
NORMAL 23 23 24 22 22 23
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
SKIN COLOR
PINK 23 23 24 22 22 22
PALE - - - - - 1
MUSCLE TONE
FIRM BUT NOT HARD 23 23 24 22 22 23
CONVULSIONS-CLONIC
ABSENT 23 23 24 22 22 23
CONVULSIONS-TONIC
Page 240 of 4796
ABSENT 23 23 24 22 22 23
TREMORS
NONE 23 23 24 22 22 23
AROUSAL
NORMAL 23 23 24 22 22 23
BIZARRE/STEREOTYPIC BEHAVIOR
NONE 23 23 24 22 22 23
URINATION COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.21 0.00 0.00
N 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 8
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 4
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
DEFECATION COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.00 0.00 0.00
N 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
Page 241 of 4796
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 9
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 11
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
LOW 20 21 21 20 21 20
MODERATELY LOW 3 2 3 2 1 3
WITH VOCALIZATION 2 2 3 2 - 2
WITHOUT VOCALIZATION 1 - - - 1 1
LACRIMATION
NONE 23 23 24 22 22 23
CHROMODACRYORRHEA
ABSENT 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 10
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 11
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
SALIVATION
NONE 23 23 24 22 22 23
RESPIRATORY RATE
NORMAL (80-110) 23 23 24 22 22 23
RESPIRATORY CHARACTER
NORMAL 23 23 24 22 22 23
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
SKIN COLOR
PINK 23 23 23 22 22 23
PALE - - 1 - - -
MUSCLE TONE
Page 244 of 4796
MOBILITY
NORMAL 23 23 24 22 22 23
GAIT
NORMAL 23 23 24 22 22 23
CONVULSIONS-CLONIC
ABSENT 23 23 24 22 21 22
CONVULSIONS, POPCORN SEIZURE - - - - 1 1
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 12
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 11
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
CONVULSIONS-TONIC
ABSENT 23 23 24 22 22 23
TREMORS
NONE 23 23 24 22 22 23
AROUSAL
LOW - - 1 - 1 -
NORMAL 23 23 23 22 21 23
BIZARRE/STEREOTYPIC BEHAVIOR
NONE 23 23 24 22 22 23
Page 245 of 4796
BACKING COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.00 0.00 0.00
N 23 23 24 22 22 23
URINATION COUNTS
MEAN 0.2 0.3 0.3 0.3 0.3 0.3
S.D. 0.39 0.47 0.46 0.48 0.48 0.45
N 23 23 24 22 22 23
DEFECATION COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.21 0.00 0.00
N 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 13
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 11
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
MODERATELY LOW 3 1 1 - - 4
WITH VOCALIZATION 3 1 1 - - 4
LACRIMATION
NONE 23 23 24 22 22 23
CHROMODACRYORRHEA
ABSENT 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 14
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 11
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
SALIVATION
NONE 23 23 24 22 22 23
RESPIRATORY RATE
NORMAL (80-110) 23 23 24 22 22 23
RESPIRATORY CHARACTER
NORMAL 23 23 24 22 22 23
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
SKIN COLOR
PINK 23 23 24 22 22 23
MUSCLE TONE
FIRM BUT NOT HARD 23 23 24 22 22 23
Page 248 of 4796
MOBILITY
NORMAL 23 23 24 22 22 23
GAIT
NORMAL 23 23 24 22 22 23
CONVULSIONS-CLONIC
ABSENT 23 23 24 22 21 20
CONVULSIONS - - - - 1 1
CONVULSIONS, POPCORN SEIZURE - - - - - 2
CONVULSIONS-TONIC
ABSENT 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 16
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 11
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
TREMORS
NONE 23 23 24 22 22 23
AROUSAL
NORMAL 23 23 24 22 22 23
BIZARRE/STEREOTYPIC BEHAVIOR
NONE 23 23 24 22 22 23
BACKING COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
Page 249 of 4796
URINATION COUNTS
MEAN 0.4 0.3 0.2 0.2 0.5 0.3
S.D. 0.50 0.54 0.41 0.43 0.60 0.47
N 23 23 24 22 22 23
DEFECATION COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.00 0.00 0.00
N 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 17
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 21
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 21 23
LOW 23 23 24 22 21 22
MODERATELY LOW - - - - - 1
WITH VOCALIZATION - - - - - 1
LACRIMATION
NONE 23 23 24 22 21 23
CHROMODACRYORRHEA
ABSENT 23 23 24 22 21 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 18
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 21
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 21 23
SALIVATION
NONE 23 23 24 22 21 23
PILOERECTION
NONE 23 23 24 22 21 23
FUR APPEARANCE
NORMAL: CLEAN AND GROOMED 23 23 24 22 21 23
PALPEBRAL CLOSURE
EYELIDS WIDE OPEN 23 23 24 22 21 23
Page 251 of 4796
RESPIRATORY RATE
NORMAL (80-110) 23 23 24 22 21 23
RESPIRATORY CHARACTER
NORMAL 23 23 24 22 21 23
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 21 23
EYE COLOR
PINK 23 23 23 22 21 23
PALE - - 1 - - -
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 20
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 21
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 21 23
SKIN COLOR
PINK 23 23 23 22 21 23
PALE - - 1 - - -
EYE PROMINENCE
NORMAL 23 23 24 22 21 23
MUSCLE TONE
FIRM BUT NOT HARD 23 23 24 22 21 23
MOBILITY
Page 253 of 4796
NORMAL 23 23 24 22 21 23
GAIT
NORMAL 23 23 24 22 21 23
CONVULSIONS-CLONIC
ABSENT 23 23 24 22 21 23
CONVULSIONS-TONIC
ABSENT 23 23 24 22 21 23
TREMORS
NONE 23 23 24 22 21 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 21
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 21
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 21 23
AROUSAL
NORMAL 23 23 24 22 21 23
BIZARRE/STEREOTYPIC BEHAVIOR
NONE 23 23 24 22 21 23
PUPILLARY RESPONSE
ABSENT 1 - - - - -
PRESENT 22 23 24 22 21 23
BACKING COUNTS
Page 254 of 4796
GROOMING COUNTS
MEAN 0.1 0.0 0.0 0.1 0.0 0.0
S.D. 0.29 0.21 0.20 0.29 0.00 0.00
N 23 23 24 22 21 23
URINATION COUNTS
MEAN 0.2 0.0 0.1 0.2 0.1 0.1
S.D. 0.49 0.21 0.34 0.39 0.36 0.46
N 23 23 24 22 21 23
DEFECATION COUNTS
MEAN 0.7 0.5 0.7 0.7 0.4 0.5
S.D. 1.18 0.95 1.08 1.16 0.98 0.99
N 23 23 24 22 21 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 22
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 21
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
LOW 23 22 23 21 22 23
MODERATELY LOW - 1 1 1 - -
WITH VOCALIZATION - 1 1 1 - -
LACRIMATION
NONE 23 23 24 22 22 23
CHROMODACRYORRHEA
ABSENT 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 23
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 21
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
SALIVATION
NONE 23 23 24 22 22 23
PILOERECTION
NONE 23 23 24 22 22 23
FUR APPEARANCE
NORMAL: CLEAN AND GROOMED 23 23 24 22 22 23
PALPEBRAL CLOSURE
EYELIDS WIDE OPEN 23 23 24 22 22 23
Page 256 of 4796
RESPIRATORY RATE
NORMAL (80-110) 23 23 24 22 22 23
RESPIRATORY CHARACTER
NORMAL 23 23 24 22 22 23
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
EYE COLOR
PINK 23 23 23 22 22 23
PALE - - 1 - - -
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 25
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 21
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
SKIN COLOR
PINK 23 23 23 22 22 23
PALE - - 1 - - -
EYE PROMINENCE
NORMAL 23 23 24 22 22 23
MUSCLE TONE
FIRM BUT NOT HARD 23 23 24 22 22 23
MOBILITY
NORMAL 23 23 24 22 22 23
Page 258 of 4796
GAIT
NORMAL 23 23 24 22 22 23
CONVULSIONS-CLONIC
ABSENT 23 23 24 22 22 23
CONVULSIONS-TONIC
ABSENT 23 23 24 22 22 23
TREMORS
NONE 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 26
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 21
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
AROUSAL
NORMAL 23 23 24 22 22 23
BIZARRE/STEREOTYPIC BEHAVIOR
NONE 23 23 24 22 22 23
PUPILLARY RESPONSE
PRESENT 23 23 24 22 22 23
BACKING COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.00 0.00 0.00
Page 259 of 4796
N 23 23 24 22 22 23
GROOMING COUNTS
MEAN 0.0 0.0 0.0 0.0 0.1 0.1
S.D. 0.00 0.21 0.20 0.21 0.29 0.63
N 23 23 24 22 22 23
URINATION COUNTS
MEAN 0.0 0.1 0.0 0.1 0.0 0.0
S.D. 0.00 0.29 0.20 0.29 0.00 0.21
N 23 23 24 22 22 23
DEFECATION COUNTS
MEAN 0.2 0.4 0.5 0.3 0.3 0.4
S.D. 0.58 1.12 1.02 0.70 0.63 0.84
N 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 27
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 35
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 21 23
LACRIMATION
NONE 23 23 24 22 21 23
CHROMODACRYORRHEA
ABSENT 23 23 24 22 21 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
+ = Significantly different from the control group at 0.05 using Fisher's Exact test
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 28
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 35
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 21 23
SALIVATION
NONE 23 23 24 22 21 23
PILOERECTION
NONE 23 23 24 22 21 23
FUR APPEARANCE
NORMAL: CLEAN AND GROOMED 23 23 24 22 21 23
PALPEBRAL CLOSURE
EYELIDS WIDE OPEN 23 23 24 22 21 23
Page 261 of 4796
RESPIRATORY RATE
NORMAL (80-110) 23 23 24 22 21 23
RESPIRATORY CHARACTER
NORMAL 23 23 24 22 21 23
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 21 23
ABSENT 23 23 24 22 21 23
EYE COLOR
PINK 23 23 24 22 21 23
SKIN COLOR
PINK 23 23 24 22 21 23
EYE PROMINENCE
NORMAL 23 23 24 22 21 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 30
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 35
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 21 23
MUSCLE TONE
FIRM BUT NOT HARD 23 23 24 22 21 23
MOBILITY
NORMAL 23 23 24 22 21 23
GAIT
NORMAL 23 23 24 22 21 23
CONVULSIONS-CLONIC
ABSENT 23 23 24 22 21 23
Page 263 of 4796
CONVULSIONS-TONIC
ABSENT 23 23 24 22 21 23
TREMORS
NONE 23 23 24 22 21 23
AROUSAL
NORMAL 23 23 24 22 21 23
BIZARRE/STEREOTYPIC BEHAVIOR
NONE 23 23 24 22 21 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 31
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 35
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 21 23
PUPILLARY RESPONSE
ABSENT 1 - - - - -
PRESENT 22 23 24 22 21 23
BACKING COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.00 0.00 0.00
N 23 23 24 22 21 23
GROOMING COUNTS
MEAN 0.0 0.0 0.0 0.0 0.2 0.0
Page 264 of 4796
URINATION COUNTS
MEAN 0.1 0.2 0.2 0.2 0.0 0.3
S.D. 0.29 0.42 0.51 0.39 0.00 0.45
N 23 23 24 22 21 23
DEFECATION COUNTS
MEAN 0.0 0.3 0.6 0.1 0.6 0.1
S.D. 0.21 1.30 1.59 0.64 1.66 0.42
N 23 23 24 22 21 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 32
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 35
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
LACRIMATION
NONE 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
+ = Significantly different from the control group at 0.05 using Fisher's Exact test
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 33
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 35
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
CHROMODACRYORRHEA
ABSENT 23 23 24 22 22 23
SALIVATION
NONE 23 23 24 22 22 23
PILOERECTION
NONE 23 23 24 22 22 23
FUR APPEARANCE
NORMAL: CLEAN AND GROOMED 23 23 24 22 22 23
Page 266 of 4796
PALPEBRAL CLOSURE
EYELIDS WIDE OPEN 23 23 24 22 22 23
RESPIRATORY RATE
NORMAL (80-110) 23 23 24 22 22 23
RESPIRATORY CHARACTER
NORMAL 23 23 24 22 22 23
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
PRESENT 1 - 1 - 1 -
ABSENT 22 23 23 22 21 23
EYE COLOR
PINK 23 23 24 22 22 23
SKIN COLOR
PINK 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 35
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 35
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
EYE PROMINENCE
NORMAL 23 23 24 22 22 23
MUSCLE TONE
FIRM BUT NOT HARD 23 23 24 22 22 23
MOBILITY
NORMAL 23 23 24 22 22 23
GAIT
NORMAL 23 23 24 22 22 23
Page 268 of 4796
CONVULSIONS-CLONIC
ABSENT 23 23 24 22 22 23
CONVULSIONS-TONIC
ABSENT 23 23 24 22 22 23
TREMORS
NONE 23 23 24 22 22 23
AROUSAL
NORMAL 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 36
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 35
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 22 23
BIZARRE/STEREOTYPIC BEHAVIOR
NONE 23 23 24 22 22 23
PUPILLARY RESPONSE
PRESENT 23 23 24 22 22 23
BACKING COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.00 0.00 0.00
N 23 23 24 22 22 23
GROOMING COUNTS
Page 269 of 4796
URINATION COUNTS
MEAN 0.1 0.1 0.1 0.0 0.0 0.2
S.D. 0.29 0.29 0.34 0.00 0.21 0.52
N 23 23 24 22 22 23
DEFECATION COUNTS
MEAN 0.0 0.2 0.2 0.0 0.0 0.0
S.D. 0.00 1.04 0.82 0.00 0.00 0.00
N 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 37
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 45
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 21 23
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 21 23
LACRIMATION
NONE 22 23 24 22 21 23
SEVERE 1 - - - - -
CHROMODACRYORRHEA
ABSENT 22 23 24 22 21 23
PRESENT 1 - - - - -
SALIVATION
NONE 23 23 24 22 21 23
PILOERECTION
Page 271 of 4796
NONE 23 23 24 22 21 23
FUR APPEARANCE
NORMAL: CLEAN AND GROOMED 23 23 24 22 21 23
PALPEBRAL CLOSURE
EYELIDS WIDE OPEN 23 23 24 22 21 23
RESPIRATORY RATE
NORMAL (80-110) 23 23 24 22 21 23
RESPIRATORY CHARACTER
NORMAL 23 23 24 22 21 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 39
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 45
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 21 23
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 21 23
EYE COLOR
PINK 23 23 24 22 21 23
SKIN COLOR
PINK 23 23 24 22 21 23
EYE PROMINENCE
NORMAL 23 23 24 22 21 23
MUSCLE TONE
FIRM BUT NOT HARD 23 23 24 22 21 23
Page 273 of 4796
MOBILITY
NORMAL 23 23 24 22 21 23
GAIT
NORMAL 23 23 24 22 21 23
CONVULSIONS-CLONIC
ABSENT 23 23 24 22 21 23
CONVULSIONS-TONIC
ABSENT 23 23 24 22 21 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 41
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 45
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 21 23
TREMORS
NONE 23 23 24 22 21 23
AROUSAL
NORMAL 23 23 24 22 21 23
BIZARRE/STEREOTYPIC BEHAVIOR
NONE 23 23 24 22 21 23
PUPILLARY RESPONSE
ABSENT 1 - - - - -
PRESENT 22 23 24 22 21 23
Page 274 of 4796
BACKING COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.00 0.00 0.00
N 23 23 24 22 21 23
GROOMING COUNTS
MEAN 0.1 0.1 0.1 0.0 0.0 0.1
S.D. 0.63 0.42 0.28 0.00 0.00 0.29
N 23 23 24 22 21 23
URINATION COUNTS
MEAN 0.5 0.4 0.3 0.3 0.3 0.1
S.D. 0.85 0.95 0.64 0.70 0.64 0.29
N 23 23 24 22 21 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 42
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 45
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 24 22 21 23
DEFECATION COUNTS
MEAN 0.0 0.0 0.0 0.2* 0.0 0.0
S.D. 0.00 0.00 0.20 0.61 0.00 0.00
N 23 23 24 22 21 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
* = Significantly different from the control group at 0.05 using Dunnett's test
Page 275 of 4796
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 43
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 45
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 22 23 24 22 22 23
LACRIMATION
NONE 22 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 44
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 45
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 22 23 24 22 22 23
CHROMODACRYORRHEA
ABSENT 22 23 24 22 22 23
SALIVATION
NONE 22 23 24 22 22 23
PILOERECTION
NONE 22 23 24 22 22 23
FUR APPEARANCE
NORMAL: CLEAN AND GROOMED 22 23 24 22 22 23
Page 277 of 4796
PALPEBRAL CLOSURE
EYELIDS WIDE OPEN 22 23 24 22 22 23
RESPIRATORY RATE
NORMAL (80-110) 22 23 24 22 22 23
RESPIRATORY CHARACTER
NORMAL 22 23 24 21 22 23
RALES - - - 1 - -
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 22 23 24 22 22 23
ABSENT 21 23 24 22 22 23
EYE COLOR
PINK 22 23 24 22 22 23
SKIN COLOR
PINK 22 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 46
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 45
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 22 23 24 22 22 23
EYE PROMINENCE
NORMAL 22 23 23 22 22 23
EXOPHTHALMUS - - 1 - - -
MUSCLE TONE
FIRM BUT NOT HARD 22 23 24 22 22 23
MOBILITY
NORMAL 22 23 24 22 22 23
GAIT
Page 279 of 4796
NORMAL 22 23 24 22 22 23
CONVULSIONS-CLONIC
ABSENT 22 23 24 22 22 23
CONVULSIONS-TONIC
ABSENT 22 23 24 22 22 23
TREMORS
NONE 22 23 24 22 22 23
AROUSAL
NORMAL 21 23 24 22 20 23
SOMEWHAT HIGH 1 - - - 2 -
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 47
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 45
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 22 23 24 22 22 23
BIZARRE/STEREOTYPIC BEHAVIOR
NONE 22 23 24 22 22 23
PUPILLARY RESPONSE
ABSENT - - 1 1 - -
PRESENT 22 23 23 21 22 23
BACKING COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.00 0.00 0.00
N 22 23 24 22 22 23
Page 280 of 4796
GROOMING COUNTS
MEAN 0.0 0.0 0.0 0.2 0.0 0.0
S.D. 0.00 0.00 0.00 0.66 0.00 0.00
N 22 23 24 22 22 23
URINATION COUNTS
MEAN 0.0 0.0 0.0 0.1 0.0 0.0
S.D. 0.21 0.21 0.00 0.35 0.21 0.00
N 22 23 24 22 22 23
DEFECATION COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.21 0.00 0.00
N 22 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 48
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 60
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 23 22 21 23
LACRIMATION
NONE 23 23 22 22 21 23
SLIGHT - - 1 - - -
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 49
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 60
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 23 22 21 23
CHROMODACRYORRHEA
ABSENT 23 23 22 22 21 23
PRESENT - - 1 - - -
SALIVATION
NONE 23 23 23 22 21 23
PILOERECTION
NONE 23 23 23 22 21 23
FUR APPEARANCE
NORMAL: CLEAN AND GROOMED 23 23 23 22 21 23
Page 282 of 4796
PALPEBRAL CLOSURE
EYELIDS WIDE OPEN 23 23 23 22 21 23
RESPIRATORY RATE
NORMAL (80-110) 23 23 23 22 21 23
RESPIRATORY CHARACTER
NORMAL 23 23 23 22 21 23
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 23 22 21 23
ABSENT 23 23 23 22 21 23
EYE COLOR
PINK 23 23 23 22 21 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 51
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 60
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 23 22 21 23
SKIN COLOR
PINK 23 23 23 22 21 23
EYE PROMINENCE
NORMAL 23 23 23 22 21 23
MUSCLE TONE
FIRM BUT NOT HARD 23 23 23 22 21 23
MOBILITY
NORMAL 23 23 23 22 21 23
Page 284 of 4796
GAIT
NORMAL 23 23 23 22 21 23
CONVULSIONS-CLONIC
ABSENT 23 23 23 22 21 23
CONVULSIONS-TONIC
ABSENT 23 23 23 22 21 23
TREMORS
NONE 23 23 23 22 21 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 52
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 60
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 23 23 22 21 23
AROUSAL
NORMAL 22 23 23 22 21 23
SOMEWHAT HIGH 1 - - - - -
BIZARRE/STEREOTYPIC BEHAVIOR
NONE 23 23 23 22 21 23
PUPILLARY RESPONSE
ABSENT 1 - - - - -
PRESENT 22 23 23 22 21 23
Page 285 of 4796
BACKING COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.00 0.00 0.00
N 23 23 23 22 21 23
GROOMING COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.21 0.00 0.00 0.00
N 23 23 23 22 21 23
URINATION COUNTS
MEAN 0.9 0.5 0.5 0.6 0.5 0.5
S.D. 0.97 0.59 0.90 0.95 0.75 0.90
N 23 23 23 22 21 23
DEFECATION COUNTS
MEAN 0.1 0.0 0.0 0.1 0.0 0.0
S.D. 0.63 0.00 0.00 0.29 0.00 0.00
N 23 23 23 22 21 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 53
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 60
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 22 23 24 22 22 23
LOW 22 22 24 22 22 23
MODERATELY LOW - 1 - - - -
WITH VOCALIZATION - 1 - - - -
LACRIMATION
NONE 22 23 24 21 22 23
PRESENT - - - 1 - -
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 54
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 60
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 22 23 24 22 22 23
CHROMODACRYORRHEA
ABSENT 22 23 24 22 22 23
SALIVATION
NONE 22 23 24 22 22 23
PILOERECTION
NONE 22 23 24 22 22 23
FUR APPEARANCE
NORMAL: CLEAN AND GROOMED 22 23 24 22 22 23
Page 287 of 4796
PALPEBRAL CLOSURE
EYELIDS WIDE OPEN 22 23 24 22 22 23
RESPIRATORY RATE
NORMAL (80-110) 22 23 24 22 22 23
RESPIRATORY CHARACTER
NORMAL 22 23 24 22 22 23
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 22 23 24 22 22 23
ABSENT 22 23 24 22 22 23
EYE COLOR
PINK 22 23 24 22 22 23
SKIN COLOR
PINK 22 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 56
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 60
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 22 23 24 22 22 23
EYE PROMINENCE
NORMAL 22 23 24 22 22 23
MUSCLE TONE
FIRM BUT NOT HARD 22 23 24 22 22 23
MOBILITY
NORMAL 22 23 24 22 22 23
GAIT
NORMAL 22 23 24 22 22 23
Page 289 of 4796
CONVULSIONS-CLONIC
ABSENT 22 23 24 22 22 23
CONVULSIONS-TONIC
ABSENT 22 23 24 22 22 23
TREMORS
NONE 22 23 24 22 22 23
AROUSAL
NORMAL 22 23 22 22 22 22
SOMEWHAT HIGH - - 2 - - 1
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 57
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 60
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 22 23 24 22 22 23
BIZARRE/STEREOTYPIC BEHAVIOR
NONE 22 23 24 22 22 23
PUPILLARY RESPONSE
PRESENT 22 23 24 22 22 23
BACKING COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.00 0.00 0.00
N 22 23 24 22 22 23
Page 290 of 4796
GROOMING COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.00 0.00 0.00
N 22 23 24 22 22 23
URINATION COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.21 0.00 0.00
N 22 23 24 22 22 23
DEFECATION COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.00 0.00 0.00
N 22 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
None significantly different from control group
PFOBGv1.52
02/03/2009
R:07/13/2009
TABLE 40 (F1 SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF MOTOR ACTIVITY COUNTS ACROSS SESSIONS - TOTAL COUNTS
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
P = Sexes combined.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 40 (F1 SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC SUMMARY OF MOTOR ACTIVITY COUNTS ACROSS SESSIONS - TOTAL COUNTS
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed due to lack of a statistically significant TRT*SEX or TRT*SEX*SESSION interaction.
TABLE 40 (F1 SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 3
SPONSOR:ACC SUMMARY OF MOTOR ACTIVITY COUNTS ACROSS SESSIONS - TOTAL COUNTS
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed due to lack of a statistically significant TRT*SEX or TRT*SEX*SESSION interaction.
TABLE 41 (F1 SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF MOTOR ACTIVITY COUNTS WITHIN SESSIONS - TOTAL COUNTS
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
P = Sexes combined.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 41 (F1 SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC SUMMARY OF MOTOR ACTIVITY COUNTS WITHIN SESSIONS - TOTAL COUNTS
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
P = Sexes combined.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 41 (F1 SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 3
SPONSOR:ACC SUMMARY OF MOTOR ACTIVITY COUNTS WITHIN SESSIONS - TOTAL COUNTS
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed due to lack of a statistically significant TRT*SEX or TRT*SEX*TIME interaction.
TABLE 41 (F1 SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 4
SPONSOR:ACC SUMMARY OF MOTOR ACTIVITY COUNTS WITHIN SESSIONS - TOTAL COUNTS
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed due to lack of a statistically significant TRT*SEX or TRT*SEX*TIME interaction.
TABLE 41 (F1 SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 5
SPONSOR:ACC SUMMARY OF MOTOR ACTIVITY COUNTS WITHIN SESSIONS - TOTAL COUNTS
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed due to lack of a statistically significant TRT*SEX or TRT*SEX*TIME interaction.
TABLE 41 (F1 SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 6
SPONSOR:ACC SUMMARY OF MOTOR ACTIVITY COUNTS WITHIN SESSIONS - TOTAL COUNTS
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed due to lack of a statistically significant TRT*SEX or TRT*SEX*TIME interaction.
TABLE 41 (F1 SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 7
SPONSOR:ACC SUMMARY OF MOTOR ACTIVITY COUNTS WITHIN SESSIONS - TOTAL COUNTS
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
P = Sexes combined.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 41 (F1 SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 8
SPONSOR:ACC SUMMARY OF MOTOR ACTIVITY COUNTS WITHIN SESSIONS - TOTAL COUNTS
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
P = Sexes combined.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 41 (F1 SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 9
SPONSOR:ACC SUMMARY OF MOTOR ACTIVITY COUNTS WITHIN SESSIONS - TOTAL COUNTS
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed due to lack of a statistically significant TRT*SEX or TRT*SEX*TIME interaction.
TABLE 41 (F1 SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 10
SPONSOR:ACC SUMMARY OF MOTOR ACTIVITY COUNTS WITHIN SESSIONS - TOTAL COUNTS
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed due to lack of a statistically significant TRT*SEX or TRT*SEX*TIME interaction.
TABLE 41 (F1 SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 11
SPONSOR:ACC SUMMARY OF MOTOR ACTIVITY COUNTS WITHIN SESSIONS - TOTAL COUNTS
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed due to lack of a statistically significant TRT*SEX or TRT*SEX*TIME interaction.
TABLE 41 (F1 SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 12
SPONSOR:ACC SUMMARY OF MOTOR ACTIVITY COUNTS WITHIN SESSIONS - TOTAL COUNTS
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed due to lack of a statistically significant TRT*SEX or TRT*SEX*TIME interaction.
TABLE 41 (F1 SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 13
SPONSOR:ACC SUMMARY OF MOTOR ACTIVITY COUNTS WITHIN SESSIONS - TOTAL COUNTS
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
P = Sexes combined.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 41 (F1 SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 14
SPONSOR:ACC SUMMARY OF MOTOR ACTIVITY COUNTS WITHIN SESSIONS - TOTAL COUNTS
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
P = Sexes combined.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 41 (F1 SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 15
SPONSOR:ACC SUMMARY OF MOTOR ACTIVITY COUNTS WITHIN SESSIONS - TOTAL COUNTS
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed due to lack of a statistically significant TRT*SEX or TRT*SEX*TIME interaction.
TABLE 41 (F1 SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 16
SPONSOR:ACC SUMMARY OF MOTOR ACTIVITY COUNTS WITHIN SESSIONS - TOTAL COUNTS
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed due to lack of a statistically significant TRT*SEX or TRT*SEX*TIME interaction.
TABLE 41 (F1 SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 17
SPONSOR:ACC SUMMARY OF MOTOR ACTIVITY COUNTS WITHIN SESSIONS - TOTAL COUNTS
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed due to lack of a statistically significant TRT*SEX or TRT*SEX*TIME interaction.
TABLE 41 (F1 SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 18
SPONSOR:ACC SUMMARY OF MOTOR ACTIVITY COUNTS WITHIN SESSIONS - TOTAL COUNTS
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed due to lack of a statistically significant TRT*SEX or TRT*SEX*TIME interaction.
TABLE 41 (F1 SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 19
SPONSOR:ACC SUMMARY OF MOTOR ACTIVITY COUNTS WITHIN SESSIONS - TOTAL COUNTS
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
P = Sexes combined.
TABLE 41 (F1 SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 20
SPONSOR:ACC SUMMARY OF MOTOR ACTIVITY COUNTS WITHIN SESSIONS - TOTAL COUNTS
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 41 (F1 SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 22
SPONSOR:ACC SUMMARY OF MOTOR ACTIVITY COUNTS WITHIN SESSIONS - TOTAL COUNTS
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 41 (F1 SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 23
SPONSOR:ACC SUMMARY OF MOTOR ACTIVITY COUNTS WITHIN SESSIONS - TOTAL COUNTS
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 41 (F1 SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 24
SPONSOR:ACC SUMMARY OF MOTOR ACTIVITY COUNTS WITHIN SESSIONS - TOTAL COUNTS
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 42 (F1 SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF STARTLE RESPONSE DATA MAX [NEWTONS]
N (Litters) 23 23 24 22 22 23
LSMean 1.818 1.846 1.779 1.968 1.937 1.592
Dunnett p-value# NT NT NT NT NT
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
P = Sexes combined.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 42 (F1 SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC SUMMARY OF STARTLE RESPONSE DATA MAX [NEWTONS]
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
P = Sexes combined.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 42 (F1 SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 3
SPONSOR:ACC SUMMARY OF STARTLE RESPONSE DATA MAX [NEWTONS]
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed due to lack of a statistically significant TRT*SEX or TRT*SEX*TRIAL interaction.
TABLE 42 (F1 SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 4
SPONSOR:ACC SUMMARY OF STARTLE RESPONSE DATA MAX [NEWTONS]
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed due to lack of a statistically significant TRT*SEX or TRT*SEX*TRIAL interaction.
TABLE 42 (F1 SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 5
SPONSOR:ACC SUMMARY OF STARTLE RESPONSE DATA MAX [NEWTONS]
N 44 46 47 44 43 46
LSMean 1.782 1.631 1.608 2.149 1.455 1.382
Dunnett p-value# NT NT NT NT NT
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
P = Sexes combined.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 42 (F1 SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 6
SPONSOR:ACC SUMMARY OF STARTLE RESPONSE DATA MAX [NEWTONS]
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
P = Sexes combined.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 42 (F1 SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 7
SPONSOR:ACC SUMMARY OF STARTLE RESPONSE DATA MAX [NEWTONS]
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed due to lack of a statistically significant TRT*SEX or TRT*SEX*TRIAL interaction.
TABLE 42 (F1 SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 8
SPONSOR:ACC SUMMARY OF STARTLE RESPONSE DATA MAX [NEWTONS]
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed due to lack of a statistically significant TRT*SEX or TRT*SEX*TRIAL interaction.
TABLE 43 (F1 PND 22 - SUBSET B)
PROJECT NO.:WIL-186056W DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF BIEL MAZE SWIM TRIALS - MEAN NUMBER OF ERRORS
2 (Path A) Mean 13 12 14 15 11 16
% Difference Control -7.7 7.7 15.4 -15.4 23.1
S.D. 8.2 7.3 7.6 7.8 7.3 8.0
S.E. of Mean 1.7 1.5 1.6 1.7 1.6 1.7
Page 326 of 4796
N (Litters) 23 23 23 22 22 23
LSMean 13 12 14 15 11 16
Dunnett p-value# NT NT NT NT NT
3 (Path A) Mean 11 16 13 13 15 14
% Difference Control 45.5 18.2 18.2 36.4 27.3
S.D. 8.0 9.0 9.4 10.3 6.8 8.6
S.E. of Mean 1.7 1.9 2.0 2.2 1.4 1.8
N (Litters) 23 23 23 22 22 23
LSMean 11 16 14 13 14 14
Dunnett p-value# NT NT NT NT NT
4 (Path A) Mean 10 12 9 10 10 9
% Difference Control 20.0 -10.0 0.0 0.0 -10.0
S.D. 8.3 7.4 5.8 6.1 8.3 5.7
S.E. of Mean 1.7 1.5 1.2 1.3 1.8 1.2
N (Litters) 23 23 23 22 22 23
LSMean 10 12 9 10 10 9
Dunnett p-value# NT NT NT NT NT
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
P = Sexes combined.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 43 (F1 PND 22 - SUBSET B)
PROJECT NO.:WIL-186056W DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC SUMMARY OF BIEL MAZE SWIM TRIALS - MEAN NUMBER OF ERRORS
P Overall LSMean 13 13 13 14 13 13
(Path A) Dunnett p-value# 0.962 1.000 0.451 1.000 0.981
Treatment*Sex p-value# 0.476
Treatment*Trial p-value# 0.222
Treatment*Sex*Trial p-value# 0.103
Page 327 of 4796
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
P = Sexes combined.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 43 (F1 PND 22 - SUBSET B)
PROJECT NO.:WIL-186056W DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 3
SPONSOR:ACC SUMMARY OF BIEL MAZE SWIM TRIALS - MEAN NUMBER OF ERRORS
M 1 (Path A) Mean 16 14 17 16 14 14
% Difference Control -12.5 6.3 0.0 -12.5 -12.5
S.D. 11.7 9.8 11.2 11.3 10.2 11.3
S.E. of Mean 2.4 2.1 2.3 2.4 2.2 2.3
N (Litters) 23 23 23 22 21 23
2 (Path A) Mean 9 13 15 15 10 19
% Difference Control 44.4 66.7 66.7 11.1 111.1
S.D. 7.8 12.4 10.0 11.9 8.0 12.3
S.E. of Mean 1.6 2.6 2.1 2.5 1.8 2.6
N (Litters) 23 23 23 22 21 23
Page 328 of 4796
3 (Path A) Mean 10 16 14 12 12 15
% Difference Control 60.0 40.0 20.0 20.0 50.0
S.D. 10.1 13.1 13.0 11.3 9.5 12.5
S.E. of Mean 2.1 2.7 2.8 2.4 2.1 2.6
N (Litters) 23 23 22 22 21 23
4 (Path A) Mean 11 9 7 15 12 10
% Difference Control -18.2 -36.4 36.4 9.1 -9.1
S.D. 13.7 7.8 6.1 11.4 14.5 8.8
S.E. of Mean 2.9 1.6 1.3 2.4 3.2 1.8
N (Litters) 23 23 22 22 21 23
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed due to lack of a statistically significant TRT*SEX or TRT*SEX*TRIAL interaction
TABLE 43 (F1 PND 22 - SUBSET B)
PROJECT NO.:WIL-186056W DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 4
SPONSOR:ACC SUMMARY OF BIEL MAZE SWIM TRIALS - MEAN NUMBER OF ERRORS
F 1 (Path A) Mean 17 14 13 22 17 13
% Difference Control -17.6 -23.5 29.4 0.0 -23.5
S.D. 12.3 8.2 10.3 13.9 8.0 11.0
S.E. of Mean 2.6 1.7 2.2 3.0 1.7 2.3
N (Litters) 23 23 23 22 22 23
2 (Path A) Mean 16 11 13 16 13 14
% Difference Control -31.3 -18.8 0.0 -18.8 -12.5
S.D. 13.4 9.4 9.9 13.4 13.6 9.8
S.E. of Mean 2.8 2.0 2.1 2.9 2.9 2.0
N (Litters) 23 23 23 22 22 23
Page 329 of 4796
3 (Path A) Mean 13 16 13 14 17 14
% Difference Control 23.1 0.0 7.7 30.8 7.7
S.D. 10.2 12.0 11.6 15.3 11.8 11.7
S.E. of Mean 2.1 2.5 2.4 3.3 2.5 2.4
N (Litters) 23 23 23 22 22 23
4 (Path A) Mean 9 14 10 6 8 8
% Difference Control 55.6 11.1 -33.3 -11.1 -11.1
S.D. 8.4 12.8 8.2 6.0 8.5 6.8
S.E. of Mean 1.8 2.7 1.7 1.3 1.8 1.4
N (Litters) 23 23 23 22 22 23
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed due to lack of a statistically significant TRT*SEX or TRT*SEX*TRIAL interaction
TABLE 43 (F1 PND 22 - SUBSET B)
PROJECT NO.:WIL-186056W DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 5
SPONSOR:ACC SUMMARY OF BIEL MAZE SWIM TRIALS - MEAN NUMBER OF ERRORS
P 5 (Path B) Mean 36 32 33 33 32 32
% Difference Control -11.1 -8.3 -8.3 -11.1 -11.1
S.D. 7.1 9.7 11.6 9.6 10.5 8.8
S.E. of Mean 1.5 2.0 2.4 2.1 2.2 1.8
N (Litters) 23 23 23 22 22 23
6 (Path B) Mean 32 29 27 26 27 25
% Difference Control -9.4 -15.6 -18.8 -15.6 -21.9
S.D. 8.9 10.3 12.8 9.6 11.3 8.9
S.E. of Mean 1.9 2.2 2.7 2.0 2.4 1.9
N (Litters) 23 23 23 22 22 23
Page 330 of 4796
7 (Path B) Mean 28 24 26 24 23 21
% Difference Control -14.3 -7.1 -14.3 -17.9 -25.0
S.D. 10.4 12.5 13.3 12.0 10.7 12.6
S.E. of Mean 2.2 2.6 2.8 2.6 2.3 2.6
N (Litters) 23 23 23 22 22 23
8 (Path B) Mean 20 21 27 17 18 16
% Difference Control 5.0 35.0 -15.0 -10.0 -20.0
S.D. 7.6 10.4 12.7 9.1 11.0 10.2
S.E. of Mean 1.6 2.2 2.7 1.9 2.4 2.1
N (Litters) 23 23 23 22 22 23
9 (Path B) Mean 21 17 24 11 18 18
% Difference Control -19.0 14.3 -47.6 -14.3 -14.3
S.D. 11.9 12.1 13.5 8.0 11.8 12.9
S.E. of Mean 2.5 2.5 2.8 1.7 2.5 2.7
N (Litters) 23 23 23 22 22 23
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
P = Sexes combined.
TABLE 43 (F1 PND 22 - SUBSET B)
PROJECT NO.:WIL-186056W DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 6
SPONSOR:ACC SUMMARY OF BIEL MAZE SWIM TRIALS - MEAN NUMBER OF ERRORS
P 10 (Path B) Mean 13 13 15 9 12 13
% Difference Control 0.0 15.4 -30.8 -7.7 0.0
S.D. 10.4 9.4 10.4 6.8 7.9 13.5
S.E. of Mean 2.2 2.0 2.2 1.4 1.7 2.8
N (Litters) 23 23 23 22 22 23
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
P = Sexes combined.
TABLE 43 (F1 PND 22 - SUBSET B)
PROJECT NO.:WIL-186056W DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 7
SPONSOR:ACC SUMMARY OF BIEL MAZE SWIM TRIALS - MEAN NUMBER OF ERRORS
M 5 (Path B) Mean 34 32 34 34 33 37
% Difference Control -5.9 0.0 0.0 -2.9 8.8
S.D. 11.8 14.6 14.5 14.5 13.8 11.7
S.E. of Mean 2.5 3.0 3.1 3.1 3.0 2.5
N (Litters) 23 23 22 22 21 22
LSMean 34 32 34 34 33 37
Dunnett p-value# NT NT NT NT NT
6 (Path B) Mean 28 32 29 23 29 26
% Difference Control 14.3 3.6 -17.9 3.6 -7.1
S.D. 16.2 15.4 16.1 15.4 13.1 15.0
Page 332 of 4796
7 (Path B) Mean 26 28 25 22 26 21
% Difference Control 7.7 -3.8 -15.4 0.0 -19.2
S.D. 15.4 15.4 16.9 17.6 16.9 14.9
S.E. of Mean 3.2 3.2 3.6 3.8 3.7 3.1
N (Litters) 23 23 22 22 21 23
LSMean 26 28 25 22 26 21
Dunnett p-value# NT NT NT NT NT
8 (Path B) Mean 16 25 26 15 19 15
% Difference Control 56.3 62.5 -6.3 18.8 -6.3
S.D. 15.2 14.3 17.9 14.4 16.7 14.8
S.E. of Mean 3.2 3.0 3.8 3.1 3.6 3.1
N (Litters) 23 23 22 22 21 23
LSMean 16 26 26 15 19 15
Dunnett p-value# NT NT NT NT NT
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 43 (F1 PND 22 - SUBSET B)
PROJECT NO.:WIL-186056W DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 8
SPONSOR:ACC SUMMARY OF BIEL MAZE SWIM TRIALS - MEAN NUMBER OF ERRORS
M 9 (Path B) Mean 16 22 24 8 17 18
% Difference Control 37.5 50.0 -50.0 6.3 12.5
S.D. 15.1 17.4 16.5 10.2 15.3 14.9
S.E. of Mean 3.2 3.6 3.5 2.2 3.3 3.1
N (Litters) 23 23 22 22 21 23
LSMean 16 22 24 8 17 19
Dunnett p-value# NT NT NT NT NT
10 (Path B) Mean 14 16 11 6 10 13
% Difference Control 14.3 -21.4 -57.1 -28.6 -7.1
S.D. 14.8 15.7 11.1 6.6 10.6 14.4
Page 333 of 4796
Overall LSMean 22 26 25 18 22 22
(Path B) Dunnett p-value# 0.511 0.871 0.361 1.000 0.999
Treatment*Trial p-value# 0.350
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 43 (F1 PND 22 - SUBSET B)
PROJECT NO.:WIL-186056W DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 9
SPONSOR:ACC SUMMARY OF BIEL MAZE SWIM TRIALS - MEAN NUMBER OF ERRORS
F 5 (Path B) Mean 39 31 34 32 32 27
% Difference Control -20.5 -12.8 -17.9 -17.9 -30.8
S.D. 8.2 13.4 13.9 15.0 13.5 14.9
S.E. of Mean 1.7 2.8 2.9 3.2 2.9 3.1
N (Litters) 23 23 23 22 22 23
LSMean 39 31 34 32 32 27
Dunnett p-value# NT NT NT NT NT
6 (Path B) Mean 35 27 27 29 26 24
% Difference Control -22.9 -22.9 -17.1 -25.7 -31.4
S.D. 12.7 14.9 14.4 14.0 15.2 14.2
Page 334 of 4796
7 (Path B) Mean 31 20 29 27 21 20
% Difference Control -35.5 -6.5 -12.9 -32.3 -35.5
S.D. 17.5 16.7 17.3 18.2 18.1 15.7
S.E. of Mean 3.7 3.5 3.6 3.9 3.9 3.3
N (Litters) 23 23 23 22 22 23
LSMean 31 20 28 27 21 20
Dunnett p-value# NT NT NT NT NT
8 (Path B) Mean 24 16 29 18 18 17
% Difference Control -33.3 20.8 -25.0 -25.0 -29.2
S.D. 13.4 15.0 16.4 14.6 16.7 13.8
S.E. of Mean 2.8 3.1 3.4 3.1 3.6 2.9
N (Litters) 23 23 23 22 22 23
LSMean 24 16 29 18 18 17
Dunnett p-value# NT NT NT NT NT
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 43 (F1 PND 22 - SUBSET B)
PROJECT NO.:WIL-186056W DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 10
SPONSOR:ACC SUMMARY OF BIEL MAZE SWIM TRIALS - MEAN NUMBER OF ERRORS
F 9 (Path B) Mean 25 11 25 15 19 18
% Difference Control -56.0 0.0 -40.0 -24.0 -28.0
S.D. 17.4 11.6 17.4 15.5 16.9 17.7
S.E. of Mean 3.6 2.4 3.6 3.3 3.6 3.7
N (Litters) 23 23 23 22 22 23
LSMean 25 11 24 15 19 18
Dunnett p-value# NT NT NT NT NT
10 (Path B) Mean 13 9 20 13 14 14
% Difference Control -30.8 53.8 0.0 7.7 7.7
S.D. 11.5 11.8 16.0 12.2 13.2 18.0
Page 335 of 4796
Overall LSMean 28 19 27 22 22 20
(Path B) Dunnett p-value# 0.007* 1.000 0.167 0.096 0.025*
Treatment*Trial p-value# 0.522
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 43 (F1 PND 22 - SUBSET B)
PROJECT NO.:WIL-186056W DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 11
SPONSOR:ACC SUMMARY OF BIEL MAZE SWIM TRIALS - MEAN NUMBER OF ERRORS
P 11 (Path A) Mean 24 23 24 24 28 25
% Difference Control -4.2 0.0 0.0 16.7 4.2
S.D. 10.4 9.3 12.9 12.0 12.0 11.1
S.E. of Mean 2.2 1.9 2.7 2.6 2.6 2.3
N (Litters) 23 23 23 22 22 23
LSMean 24 23 24 24 27 25
Dunnett p-value# NT NT NT NT NT
12 (Path A) Mean 18 16 14 14 18 14
% Difference Control -11.1 -22.2 -22.2 0.0 -22.2
S.D. 12.0 8.5 6.9 6.4 10.5 12.6
Page 336 of 4796
Overall LSMean 21 20 19 19 23 19
(Path A) Dunnett p-value# 0.996 0.964 0.894 0.878 0.983
Treatment*Sex p-value# 0.511
Treatment*Trial p-value# 0.757
Treatment*Sex*Trial p-value# 0.122
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
P = Sexes combined.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 43 (F1 PND 22 - SUBSET B)
PROJECT NO.:WIL-186056W DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 12
SPONSOR:ACC SUMMARY OF BIEL MAZE SWIM TRIALS - MEAN NUMBER OF ERRORS
M 11 (Path A) Mean 24 18 20 21 27 27
% Difference Control -25.0 -16.7 -12.5 12.5 12.5
S.D. 14.8 12.7 15.5 15.3 13.4 16.8
S.E. of Mean 3.1 2.7 3.3 3.3 2.9 3.5
N (Litters) 23 23 22 22 21 23
12 (Path A) Mean 16 15 15 14 20 12
% Difference Control -6.3 -6.3 -12.5 25.0 -25.0
S.D. 14.0 11.0 11.4 13.4 12.3 11.6
S.E. of Mean 2.9 2.3 2.4 2.9 2.7 2.4
N (Litters) 23 23 22 22 21 23
Page 337 of 4796
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed due to lack of a statistically significant TRT*SEX or TRT*SEX*TRIAL interaction
TABLE 43 (F1 PND 22 - SUBSET B)
PROJECT NO.:WIL-186056W DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 13
SPONSOR:ACC SUMMARY OF BIEL MAZE SWIM TRIALS - MEAN NUMBER OF ERRORS
F 11 (Path A) Mean 23 29 28 26 27 23
% Difference Control 26.1 21.7 13.0 17.4 0.0
S.D. 16.8 13.4 18.1 15.1 18.3 15.9
S.E. of Mean 3.5 2.8 3.8 3.2 3.9 3.3
N (Litters) 23 23 23 22 22 23
12 (Path A) Mean 20 17 13 13 17 16
% Difference Control -15.0 -35.0 -35.0 -15.0 -20.0
S.D. 16.5 13.2 9.4 9.0 13.6 17.9
S.E. of Mean 3.4 2.8 2.0 1.9 2.9 3.7
N (Litters) 23 23 23 22 22 23
Page 338 of 4796
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed due to lack of a statistically significant TRT*SEX or TRT*SEX*TRIAL interaction
TABLE 44 (F1 PND 62 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF BIEL MAZE SWIM TRIALS - MEAN NUMBER OF ERRORS
P 1 (Path A) Mean 16 14 17 15 16 16
% Difference Control -12.5 6.3 -6.3 0.0 0.0
S.D. 9.1 10.2 10.4 9.7 11.2 10.1
S.E. of Mean 1.4 1.5 1.5 1.5 1.7 1.5
N 45 46 47 44 42 46
2 (Path A) Mean 10 13 10 12 12 11
% Difference Control 30.0 0.0 20.0 20.0 10.0
S.D. 9.1 11.2 7.9 9.9 7.7 10.5
S.E. of Mean 1.4 1.6 1.2 1.5 1.2 1.5
N 45 46 47 44 43 46
Page 339 of 4796
3 (Path A) Mean 5 10 7 9 8 9
% Difference Control 100.0 40.0 80.0 60.0 80.0
S.D. 5.9 8.6 8.4 10.0 10.7 7.4
S.E. of Mean 0.9 1.3 1.2 1.5 1.6 1.1
N 45 46 47 44 43 46
4 (Path A) Mean 4 6 4 4 5 4
% Difference Control 50.0 0.0 0.0 25.0 0.0
S.D. 5.1 5.3 3.2 4.6 5.6 4.9
S.E. of Mean 0.8 0.8 0.5 0.7 0.8 0.7
N 45 46 47 44 43 46
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
P = Sexes combined.
TABLE 44 (F1 PND 62 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC SUMMARY OF BIEL MAZE SWIM TRIALS - MEAN NUMBER OF ERRORS
2 (Path A) Mean 12 16 12 10 12 10
% Difference Control 33.3 0.0 -16.7 0.0 -16.7
S.D. 9.5 12.7 9.6 9.1 8.6 8.4
S.E. of Mean 2.0 2.6 2.0 1.9 1.9 1.8
Page 340 of 4796
N 23 23 23 22 21 23
LSMean 12 16 12 10 12 10
Dunnett p-value# NT NT NT NT NT
3 (Path A) Mean 5 13 8 10 5 10
% Difference Control 160.0 60.0 100.0 0.0 100.0
S.D. 6.2 9.3 8.9 11.0 5.7 7.4
S.E. of Mean 1.3 1.9 1.9 2.3 1.2 1.5
N 23 23 23 22 21 23
LSMean 5 13 8 10 5 10
Dunnett p-value# NT NT NT NT NT
4 (Path A) Mean 3 7 5 4 6 4
% Difference Control 133.3 66.7 33.3 100.0 33.3
S.D. 3.5 5.1 4.0 5.1 7.0 5.5
S.E. of Mean 0.7 1.1 0.8 1.1 1.5 1.1
N 23 23 23 22 21 23
LSMean 3 7 5 4 6 4
Dunnett p-value# NT NT NT NT NT
Overall LSMean 9 13 10 9 11 10
(Path A) Dunnett p-value# 0.037* 0.811 1.000 0.466 0.989
Treatment*Trial p-value# 0.113
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 44 (F1 PND 62 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 3
SPONSOR:ACC SUMMARY OF BIEL MAZE SWIM TRIALS - MEAN NUMBER OF ERRORS
2 (Path A) Mean 9 10 8 13 11 12
% Difference Control 11.1 -11.1 44.4 22.2 33.3
S.D. 8.6 8.7 5.3 10.8 6.9 12.3
S.E. of Mean 1.8 1.8 1.1 2.3 1.5 2.6
Page 341 of 4796
N 22 23 24 22 22 23
LSMean 9 10 8 13 11 12
Dunnett p-value# NT NT NT NT NT
3 (Path A) Mean 5 8 6 7 11 8
% Difference Control 60.0 20.0 40.0 120.0 60.0
S.D. 5.6 7.2 8.0 8.8 13.4 7.3
S.E. of Mean 1.2 1.5 1.6 1.9 2.9 1.5
N 22 23 24 22 22 23
LSMean 4 8 6 7 11 8
Dunnett p-value# NT NT NT NT NT
4 (Path A) Mean 5 5 3 4 4 4
% Difference Control 0.0 -40.0 -20.0 -20.0 -20.0
S.D. 6.4 5.6 2.1 4.0 3.8 4.3
S.E. of Mean 1.4 1.2 0.4 0.9 0.8 0.9
N 22 23 24 22 22 23
LSMean 5 5 3 4 4 4
Dunnett p-value# NT NT NT NT NT
Overall LSMean 9 9 8 10 10 11
(Path A) Dunnett p-value# 0.995 1.000 0.471 0.906 0.374
Treatment*Trial p-value# 0.208
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 44 (F1 PND 62 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 4
SPONSOR:ACC SUMMARY OF BIEL MAZE SWIM TRIALS - MEAN NUMBER OF ERRORS
6 (Path B) Mean 18 19 19 18 19 19
% Difference Control 5.6 5.6 0.0 5.6 5.6
S.D. 14.0 14.3 13.6 12.8 13.0 13.1
S.E. of Mean 2.1 2.1 2.0 1.9 2.0 1.9
Page 342 of 4796
N 45 46 47 44 43 46
LSMean 18 19 19 18 19 19
Dunnett p-value# 0.997 1.000 1.000 1.000 1.000
7 (Path B) Mean 10 14 18 14 14 12
% Difference Control 40.0 80.0 40.0 40.0 20.0
S.D. 12.2 12.9 14.5 13.1 12.7 12.3
S.E. of Mean 1.8 1.9 2.1 2.0 1.9 1.8
N 45 46 47 44 43 46
LSMean 10 14 18 14 14 12
Dunnett p-value# 0.611 0.026* 0.519 0.448 0.981
8 (Path B) Mean 11 12 9 8 11 7
% Difference Control 9.1 -18.2 -27.3 0.0 -36.4
S.D. 13.6 13.2 10.2 9.7 10.3 7.3
S.E. of Mean 2.0 1.9 1.5 1.5 1.6 1.1
N 45 46 47 44 42 46
LSMean 11 12 9 8 10 7
Dunnett p-value# 1.000 0.805 0.403 0.986 0.125
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
P = Sexes combined.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 44 (F1 PND 62 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 5
SPONSOR:ACC SUMMARY OF BIEL MAZE SWIM TRIALS - MEAN NUMBER OF ERRORS
P 9 (Path B) Mean 5 7 6 7 9 7
% Difference Control 40.0 20.0 40.0 80.0 40.0
S.D. 7.8 9.8 7.9 9.2 8.9 7.0
S.E. of Mean 1.2 1.5 1.2 1.4 1.4 1.0
N 45 46 47 44 43 46
LSMean 5 7 7 7 9 7
Dunnett p-value# 0.439 0.738 0.661 0.110 0.677
10 (Path B) Mean 6 4 7 4 5 5
% Difference Control -33.3 16.7 -33.3 -16.7 -16.7
S.D. 9.5 6.2 8.9 5.2 8.4 7.8
Page 343 of 4796
Overall LSMean 13 14 15 13 14 12
(Path B) Dunnett p-value# NT NT NT NT NT
Treatment*Sex p-value# 0.732
Treatment*Trial p-value# 0.043*
Treatment*Sex*Trial p-value# 0.540
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
P = Sexes combined.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 44 (F1 PND 62 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 6
SPONSOR:ACC SUMMARY OF BIEL MAZE SWIM TRIALS - MEAN NUMBER OF ERRORS
M 5 (Path B) Mean 26 30 29 26 27 26
% Difference Control 15.4 11.5 0.0 3.8 0.0
S.D. 12.6 12.9 9.6 9.8 11.8 10.0
S.E. of Mean 2.6 2.7 2.0 2.1 2.6 2.1
N 23 23 23 22 21 23
6 (Path B) Mean 17 19 20 20 17 17
% Difference Control 11.8 17.6 17.6 0.0 0.0
S.D. 14.4 16.0 11.8 12.6 11.8 12.4
S.E. of Mean 3.0 3.3 2.5 2.7 2.6 2.6
N 23 23 23 22 21 23
Page 344 of 4796
7 (Path B) Mean 10 14 16 13 14 12
% Difference Control 40.0 60.0 30.0 40.0 20.0
S.D. 12.0 13.2 14.7 12.3 12.9 13.0
S.E. of Mean 2.5 2.8 3.1 2.6 2.8 2.7
N 23 23 23 22 21 23
8 (Path B) Mean 8 12 11 11 11 8
% Difference Control 50.0 37.5 37.5 37.5 0.0
S.D. 11.5 13.0 10.9 12.0 11.4 8.7
S.E. of Mean 2.4 2.7 2.3 2.6 2.5 1.8
N 23 23 23 22 21 23
9 (Path B) Mean 3 5 9 8 8 8
% Difference Control 66.7 200.0 166.7 166.7 166.7
S.D. 7.5 7.3 9.1 11.1 8.5 8.3
S.E. of Mean 1.6 1.5 1.9 2.4 1.9 1.7
N 23 23 23 22 21 23
10 (Path B) Mean 6 4 7 4 5 6
% Difference Control -33.3 16.7 -33.3 -16.7 0.0
S.D. 8.4 6.9 6.9 5.4 8.0 10.3
S.E. of Mean 1.7 1.4 1.4 1.2 1.7 2.1
N 23 23 23 22 21 23
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed due to lack of a statistically significant TRT*SEX or TRT*SEX*TRIAL interaction
TABLE 44 (F1 PND 62 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 7
SPONSOR:ACC SUMMARY OF BIEL MAZE SWIM TRIALS - MEAN NUMBER OF ERRORS
F 5 (Path B) Mean 23 31 26 32 27 25
% Difference Control 34.8 13.0 39.1 17.4 8.7
S.D. 12.4 16.2 14.3 13.5 15.2 13.5
S.E. of Mean 2.6 3.4 2.9 2.9 3.2 2.8
N 22 23 24 22 22 23
6 (Path B) Mean 20 20 18 17 21 21
% Difference Control 0.0 -10.0 -15.0 5.0 5.0
S.D. 13.7 12.7 15.4 13.0 14.0 13.8
S.E. of Mean 2.9 2.6 3.1 2.8 3.0 2.9
N 22 23 24 22 22 23
Page 345 of 4796
7 (Path B) Mean 10 14 19 15 14 11
% Difference Control 40.0 90.0 50.0 40.0 10.0
S.D. 12.6 12.9 14.5 14.1 12.9 11.8
S.E. of Mean 2.7 2.7 3.0 3.0 2.8 2.5
N 22 23 24 22 22 23
8 (Path B) Mean 15 11 8 5 11 5
% Difference Control -26.7 -46.7 -66.7 -26.7 -66.7
S.D. 15.0 13.6 9.5 5.3 9.3 5.6
S.E. of Mean 3.2 2.8 1.9 1.1 2.0 1.2
N 22 23 24 22 21 23
9 (Path B) Mean 6 9 4 5 9 5
% Difference Control 50.0 -33.3 -16.7 50.0 -16.7
S.D. 8.1 11.7 5.8 6.5 9.5 5.1
S.E. of Mean 1.7 2.4 1.2 1.4 2.0 1.1
N 22 23 24 22 22 23
10 (Path B) Mean 6 4 7 4 5 4
% Difference Control -33.3 16.7 -33.3 -16.7 -33.3
S.D. 10.8 5.6 10.6 5.0 9.0 4.0
S.E. of Mean 2.3 1.2 2.2 1.1 1.9 0.8
N 22 23 24 22 22 23
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed due to lack of a statistically significant TRT*SEX or TRT*SEX*TRIAL interaction
TABLE 44 (F1 PND 62 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 8
SPONSOR:ACC SUMMARY OF BIEL MAZE SWIM TRIALS - MEAN NUMBER OF ERRORS
P 11 (Path A) Mean 15 16 18 18 14 17
% Difference Control 6.7 20.0 20.0 -6.7 13.3
S.D. 12.3 12.0 13.1 12.3 11.3 12.8
S.E. of Mean 1.8 1.8 1.9 1.8 1.7 1.9
N 45 46 47 44 43 46
LSMean 15 16 18 18 14 17
Dunnett p-value# NT NT NT NT NT
12 (Path A) Mean 8 7 7 8 8 7
% Difference Control -12.5 -12.5 0.0 0.0 -12.5
S.D. 9.4 6.6 8.6 10.1 7.7 6.4
Page 346 of 4796
Overall LSMean 11 11 12 13 11 12
(Path A) Dunnett p-value# 1.000 0.912 0.732 1.000 0.974
Treatment*Sex p-value# 0.389
Treatment*Trial p-value# 0.376
Treatment*Sex*Trial p-value# 0.677
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
P = Sexes combined.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 44 (F1 PND 62 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 9
SPONSOR:ACC SUMMARY OF BIEL MAZE SWIM TRIALS - MEAN NUMBER OF ERRORS
M 11 (Path A) Mean 16 14 16 17 14 20
% Difference Control -12.5 0.0 6.3 -12.5 25.0
S.D. 14.4 7.1 12.8 10.2 7.9 12.7
S.E. of Mean 3.0 1.5 2.7 2.2 1.7 2.6
N 23 23 23 22 21 23
12 (Path A) Mean 9 7 6 9 7 7
% Difference Control -22.2 -33.3 0.0 -22.2 -22.2
S.D. 10.8 7.1 6.9 10.9 7.3 6.6
S.E. of Mean 2.3 1.5 1.4 2.3 1.6 1.4
N 23 23 23 22 21 23
Page 347 of 4796
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed due to lack of a statistically significant TRT*SEX or TRT*SEX*TRIAL interaction
TABLE 44 (F1 PND 62 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 10
SPONSOR:ACC SUMMARY OF BIEL MAZE SWIM TRIALS - MEAN NUMBER OF ERRORS
F 11 (Path A) Mean 14 19 20 19 13 15
% Difference Control 35.7 42.9 35.7 -7.1 7.1
S.D. 9.9 15.3 13.4 14.2 14.0 12.7
S.E. of Mean 2.1 3.2 2.7 3.0 3.0 2.6
N 22 23 24 22 22 23
12 (Path A) Mean 7 6 8 7 9 7
% Difference Control -14.3 14.3 0.0 28.6 0.0
S.D. 7.8 6.3 9.9 9.5 8.1 6.5
S.E. of Mean 1.7 1.3 2.0 2.0 1.7 1.3
N 22 23 24 22 22 23
Page 348 of 4796
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed due to lack of a statistically significant TRT*SEX or TRT*SEX*TRIAL interaction
FINAL REPORT
Volume 2 of 16
(Summary Tables 45-56 and Appendix A [Table A1])
STUDY TITLE
A DIETARY DEVELOPMENTAL
NEUROTOXICITY STUDY OF BISPHENOL A IN RATS
STUDY NUMBER
WIL-186056
DATA REQUIREMENT
STUDY DIRECTOR
26 June 2008
30 September 2009
PERFORMING LABORATORY
SPONSOR
TABLES 45 -56
SKIN
-MATTING, RED 0 0 1 0 0 0
PGRSI2v4.07
03/27/2009
Page 351 of 4796
R:07/13/2009
TABLE 46 (F1 FEMALES - UNSCHEDULED DEATH)
PROJECT NO.:WIL-186056D DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF MACROSCOPIC FINDINGS
PGRSI2v4.07
03/27/2009
R:07/13/2009
Page 352 of 4796
TABLE 47 (F1 MALES - SCHEDULED NECROPSY - SUBSET B)
PROJECT NO.:WIL-186056A DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF MACROSCOPIC FINDINGS
SCHEDULED NECROPSY
-----------------------------------------------------------------------------------------------------------------------------------
----- M A L E -----
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS EXAMINED 23 23 22 22 21 23
LUNGS
-AREA(S), DARK RED 1 0 0 0 0 0
THYMUS
-AREA(S), DARK RED 1 1 0 0 0 0
PGRSI2v4.07
03/26/2009
R:07/13/2009
TABLE 48 (F1 FEMALES - SCHEDULED NECROPSY - SUBSET B)
PROJECT NO.:WIL-186056D DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF MACROSCOPIC FINDINGS
SCHEDULED NECROPSY
-----------------------------------------------------------------------------------------------------------------------------------
----- F E M A L E -----
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS EXAMINED 23 23 23 22 22 23
KIDNEYS
-CYST(S) 0 0 1 0 1 0
SPLEEN
-AREA(S), WHITE 0 0 0 1 0 0
PGRSI2v4.07
03/26/2009
R:07/13/2009
TABLE 49 (F1 - ANIMALS SELECTED FOR NEUROPATHOLOGY - PND 21 - SUBSET C)
PROJECT NO.:WIL-186056U DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF MACROSCOPIC FINDINGS
SCHEDULED NECROPSY
-----------------------------------------------------------------------------------------------------------------------------------
----- M A L E -----
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS EXAMINED 23 23 24 22 22 23
SCHEDULED NECROPSY
-----------------------------------------------------------------------------------------------------------------------------------
----- F E M A L E -----
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS EXAMINED 23 23 23 22 22 23
BRAIN
-AREA(S), DARK RED 0 0 1 0 0 0
-AREA(S), DEPRESSED 0 0 1 0 0 0
PGRSI2v4.07
Page 356 of 4796
08/17/2009
R:08/17/2009
TABLE 50 (F1 ANIMALS SELECTED FOR NEUROPATHOLOGY PND 21 SUBSET C)
PROJECT NO.:WIL-186056U DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF BRAIN WEIGHTS AND MEASUREMENTS
PND21 P Brain (GRAMS) Mean 1.6003 1.6481 1.5978 1.6095 1.5979 1.5880
% Difference Control 3.0 -0.2 0.6 -0.1 -0.8
S.D. 0.07569 0.10094 0.10753 0.08183 0.07596 0.06898
S.E. of Mean 0.01692 0.02257 0.02404 0.01830 0.01699 0.01542
N 20 20 20 20 20 20
LSMean 1.6003 1.6447 1.6012 1.6061 1.5945 1.5813
Dunnett p-value# 0.148 1.000 0.999 0.999 0.842
Treatment*Sex p-value# 0.738
Brain Length (MM) Mean 18.1 18.2 18.1 18.1 18.1 18.0
S.D. 0.27 0.38 0.45 0.45 0.32 0.37
Page 357 of 4796
Brain Width (MM) Mean 14.6 14.7 14.5 14.6 14.5 14.6
S.D. 0.31 0.39 0.44 0.25 0.20 0.29
S.E. of Mean 0.07 0.09 0.10 0.06 0.05 0.07
N 20 20 20 20 20 20
LSMean 14.6 14.7 14.5 14.6 14.5 14.6
Dunnett p-value# 0.348 0.985 1.000 0.842 0.999
Treatment*Sex p-value# 0.156
MANOVA
Wilks' Lambda Trt p-value# 0.422
Wilks' Lambda Trt*Sex p-value# 0.301
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 50 (F1 ANIMALS SELECTED FOR NEUROPATHOLOGY PND 21 SUBSET C)
PROJECT NO.:WIL-186056U DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC SUMMARY OF BRAIN WEIGHTS AND MEASUREMENTS
PND21 M Brain (GRAMS) Mean 1.6379 1.6909 1.6619 1.6461 1.6428 1.6191
% Difference Control 3.2 1.5 0.5 0.3 -1.1
S.D. 0.08954 0.11710 0.08955 0.08289 0.05422 0.04342
S.E. of Mean 0.02831 0.03703 0.02832 0.02621 0.01714 0.01373
N 10 10 10 10 10 10
Brain Length (MM) Mean 18.3 18.3 18.3 18.3 18.3 18.1
S.D. 0.26 0.34 0.37 0.45 0.18 0.37
S.E. of Mean 0.08 0.11 0.12 0.14 0.06 0.12
N 10 10 10 10 10 10
Page 358 of 4796
Brain Width (MM) Mean 14.7 15.0 14.8 14.6 14.6 14.8
S.D. 0.28 0.31 0.37 0.29 0.23 0.15
S.E. of Mean 0.09 0.10 0.12 0.09 0.07 0.05
N 10 10 10 10 10 10
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed.
TABLE 50 (F1 ANIMALS SELECTED FOR NEUROPATHOLOGY PND 21 SUBSET C)
PROJECT NO.:WIL-186056U DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 3
SPONSOR:ACC SUMMARY OF BRAIN WEIGHTS AND MEASUREMENTS
PND21 F Brain (GRAMS) Mean 1.5627 1.6053 1.5338 1.5729 1.5529 1.5570
% Difference Control 2.7 -1.8 0.7 -0.6 -0.4
S.D. 0.03062 0.06100 0.08526 0.06548 0.06898 0.07755
S.E. of Mean 0.00968 0.01929 0.02696 0.02071 0.02181 0.02452
N 10 10 10 10 10 10
Brain Length (MM) Mean 18.0 18.1 17.9 17.9 17.9 17.9
S.D. 0.20 0.41 0.46 0.37 0.33 0.34
S.E. of Mean 0.06 0.13 0.14 0.12 0.10 0.11
N 10 10 10 10 10 10
Page 359 of 4796
Brain Width (MM) Mean 14.5 14.5 14.3 14.5 14.5 14.4
S.D. 0.31 0.35 0.37 0.20 0.18 0.29
S.E. of Mean 0.10 0.11 0.12 0.06 0.06 0.09
N 10 10 10 10 10 10
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed.
TABLE 51 (F1 - ANIMALS SELECTED FOR NEUROPATHOLOGY - PND 21 - SUBSET C)
PROJECT NO.:WIL-186056U DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF MICROSCOPIC FINDINGS
BASAL GANGLIA
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 7 10 10 10 9
-EMBRYONAL CELL NEST 0 3 0 0 0 1
MINIMAL NONE 2 NONE NONE NONE 1
MILD NONE 1 NONE NONE NONE NONE
CEREBELLUM
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
Page 360 of 4796
CEREBRAL CORTEX
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
HIPPOCAMPUS
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
HYPOTHALAMUS
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
TABLE 51 (F1 - ANIMALS SELECTED FOR NEUROPATHOLOGY - PND 21 - SUBSET C)
PROJECT NO.:WIL-186056U DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC SUMMARY OF MICROSCOPIC FINDINGS
MEDULLA OBLONG.
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
MIDBRAIN
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
OLFACTORY BULBS
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
Page 361 of 4796
PONS
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
THALAMUS
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
TABLE 51 (F1 - ANIMALS SELECTED FOR NEUROPATHOLOGY - PND 21 - SUBSET C)
PROJECT NO.:WIL-186056U DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 3
SPONSOR:ACC SUMMARY OF MICROSCOPIC FINDINGS
BASAL GANGLIA
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 9 10 9 10 10
-EMBRYONAL CELL NEST 0 1 0 1 0 0
MINIMAL NONE 1 NONE 1 NONE NONE
CEREBELLUM
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
Page 362 of 4796
CEREBRAL CORTEX
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 9 10
-CORTICAL DYSPLASIA 0 0 0 0 1 0
MILD NONE NONE NONE NONE 1 NONE
HIPPOCAMPUS
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
HYPOTHALAMUS
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
TABLE 51 (F1 - ANIMALS SELECTED FOR NEUROPATHOLOGY - PND 21 - SUBSET C)
PROJECT NO.:WIL-186056U DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 4
SPONSOR:ACC SUMMARY OF MICROSCOPIC FINDINGS
MEDULLA OBLONG.
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
MIDBRAIN
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
OLFACTORY BULBS
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
Page 363 of 4796
PONS
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
THALAMUS
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
PHSI2v4.30
08/17/2009
R:08/17/2009
TABLE 52 (F1 ANIMALS SELECTED FOR NEUROPATHOLOGY PND 21 SUBSET C)
PROJECT NO.:WIL-186056U DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF BRAIN MORPHOMETRY [CM]
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 52 (F1 ANIMALS SELECTED FOR NEUROPATHOLOGY PND 21 SUBSET C)
PROJECT NO.:WIL-186056U DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC SUMMARY OF BRAIN MORPHOMETRY [CM]
PND21 P Level 3 - V HT Btw Mean 0.0910 0.0901 0.0892 0.0889 0.0909 0.0906
Hippo Pyramidal
Neuron Layers
S.D. 0.00617 0.00406 0.00430 0.00608 0.00571 0.00559
S.E. of Mean 0.00138 0.00091 0.00096 0.00136 0.00128 0.00125
N 20 20 20 20 20 20
LSMean 0.0910 0.0899 0.0893 0.0887 0.0907 0.0902
Dunnett p-value# 0.942 0.764 0.467 1.000 0.985
Treatment*Sex p-value# 0.557
Dentate Hilus
S.D. 0.00409 0.00387 0.00389 0.00396 0.00351 0.00377
S.E. of Mean 0.00092 0.00087 0.00087 0.00089 0.00078 0.00084
N 20 20 20 20 20 20
LSMean 0.0495 0.0488 0.0489 0.0482 0.0491 0.0482
Dunnett p-value# 0.966 0.986 0.742 0.999 0.742
Treatment*Sex p-value# 0.779
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 52 (F1 ANIMALS SELECTED FOR NEUROPATHOLOGY PND 21 SUBSET C)
PROJECT NO.:WIL-186056U DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 3
SPONSOR:ACC SUMMARY OF BRAIN MORPHOMETRY [CM]
PND21 P Level 5 - V Height Mean 0.4774 0.4748 0.4706 0.4784 0.4710 0.4683
of the Cerebellum
S.D. 0.01600 0.02931 0.03502 0.03097 0.02815 0.02729
S.E. of Mean 0.00358 0.00655 0.00803 0.00693 0.00629 0.00626
N 20 20 19 20 20 19
LSMean 0.4774 0.4736 0.4722 0.4772 0.4698 0.4650
Dunnett p-value# 0.988 0.956 1.000 0.816 0.426
Treatment*Sex p-value# 0.803
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 52 (F1 ANIMALS SELECTED FOR NEUROPATHOLOGY PND 21 SUBSET C)
PROJECT NO.:WIL-186056U DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 4
SPONSOR:ACC SUMMARY OF BRAIN MORPHOMETRY [CM]
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed.
TABLE 52 (F1 ANIMALS SELECTED FOR NEUROPATHOLOGY PND 21 SUBSET C)
PROJECT NO.:WIL-186056U DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 5
SPONSOR:ACC SUMMARY OF BRAIN MORPHOMETRY [CM]
PND21 M Level 3 - V HT Btw Mean 0.0904 0.0905 0.0900 0.0904 0.0904 0.0919
Hippo Pyramidal
Neuron Layers
S.D. 0.00730 0.00386 0.00516 0.00661 0.00512 0.00498
S.E. of Mean 0.00231 0.00122 0.00163 0.00209 0.00162 0.00157
N 10 10 10 10 10 10
N 10 10 10 10 10 10
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed.
TABLE 52 (F1 ANIMALS SELECTED FOR NEUROPATHOLOGY PND 21 SUBSET C)
PROJECT NO.:WIL-186056U DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 6
SPONSOR:ACC SUMMARY OF BRAIN MORPHOMETRY [CM]
------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed.
TABLE 52 (F1 ANIMALS SELECTED FOR NEUROPATHOLOGY PND 21 SUBSET C)
PROJECT NO.:WIL-186056U DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 7
SPONSOR:ACC SUMMARY OF BRAIN MORPHOMETRY [CM]
PND21 F Level 3 - V HT Btw Mean 0.0915 0.0897 0.0883 0.0873 0.0915 0.0892
Hippo Pyramidal
Neuron Layers
S.D. 0.00515 0.00442 0.00332 0.00539 0.00647 0.00610
S.E. of Mean 0.00163 0.00140 0.00105 0.00170 0.00205 0.00193
N 10 10 10 10 10 10
N 10 10 10 10 10 10
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed.
TABLE 53 (F1 - ANIMALS SELECTED FOR NEUROPATHOLOGY - PND 72 - SUBSET A)
PROJECT NO.:WIL-186056V DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF MACROSCOPIC FINDINGS
SCHEDULED NECROPSY
-----------------------------------------------------------------------------------------------------------------------------------
----- M A L E -----
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS EXAMINED 23 23 23 22 21 23
BRAIN
-AREA(S), DARK RED 1 1 1 1 0 0
-AREA(S), DEPRESSED 0 1 0 0 0 0
SCHEDULED NECROPSY
-----------------------------------------------------------------------------------------------------------------------------------
----- F E M A L E -----
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS EXAMINED 22 23 24 22 22 23
PGRSI2v4.07
08/17/2009
R:09/18/2009
Page 372 of 4796
TABLE 54 (F1 ANIMALS SELECTED FOR NEUROPATHOLOGY PND 72 SUBSET A)
PROJECT NO.:WIL-186056V DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF BRAIN WEIGHTS AND MEASUREMENTS
PND72 P Brain (GRAMS) Mean 2.1015 2.1665 2.1170 2.0830 2.0660 2.0650
% Difference Control 3.1 0.7 -0.9 -1.7 -1.7
S.D. 0.11310 0.12175 0.10048 0.12974 0.13040 0.13225
S.E. of Mean 0.02529 0.02722 0.02247 0.02901 0.02916 0.02957
N 20 20 20 20 20 20
LSMean 2.1052 2.1665 2.1170 2.0812 2.0642 2.0632
Pairwise p-value# 0.029 0.670 0.389 0.142 0.133
Brain Length (MM) Mean 20.7 20.7 20.8 20.6 20.7 20.6
S.D. 0.47 0.50 0.52 0.44 0.38 0.46
S.E. of Mean 0.11 0.11 0.12 0.10 0.09 0.10
Page 373 of 4796
N 20 20 20 20 20 20
LSMean 20.7 20.7 20.8 20.6 20.7 20.6
Pairwise p-value# 0.965 0.428 0.121 0.417 0.283
Brain Width (MM) Mean 15.4 15.5 15.4 15.3 15.2 15.3
S.D. 0.36 0.41 0.35 0.39 0.38 0.42
S.E. of Mean 0.08 0.09 0.08 0.09 0.09 0.09
N 20 20 20 20 20 20
LSMean 15.4 15.5 15.4 15.3 15.2 15.3
Pairwise p-value# 0.295 0.833 0.230 0.024 0.331
MANOVA
Wilks' Lambda Trt p-value# 0.015*
Wilks' Lambda Trt*Sex p-value# 0.822
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested at 0.02 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 54 (F1 ANIMALS SELECTED FOR NEUROPATHOLOGY PND 72 SUBSET A)
PROJECT NO.:WIL-186056V DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC SUMMARY OF BRAIN WEIGHTS AND MEASUREMENTS
PND72 M Brain (GRAMS) Mean 2.1820 2.2530 2.1720 2.1840 2.1520 2.1500
% Difference Control 3.3 -0.5 0.1 -1.4 -1.5
S.D. 0.08270 0.08274 0.10163 0.08140 0.09473 0.11324
S.E. of Mean 0.02615 0.02616 0.03214 0.02574 0.02996 0.03581
N 10 10 10 10 10 10
Brain Length (MM) Mean 21.0 21.0 21.2 20.9 20.9 20.9
S.D. 0.45 0.47 0.36 0.24 0.28 0.37
S.E. of Mean 0.14 0.15 0.11 0.08 0.09 0.12
N 10 10 10 10 10 10
Page 374 of 4796
Brain Width (MM) Mean 15.6 15.7 15.6 15.6 15.5 15.6
S.D. 0.24 0.25 0.32 0.25 0.25 0.39
S.E. of Mean 0.07 0.08 0.10 0.08 0.08 0.12
N 10 10 10 10 10 10
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed.
TABLE 54 (F1 ANIMALS SELECTED FOR NEUROPATHOLOGY PND 72 SUBSET A)
PROJECT NO.:WIL-186056V DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 3
SPONSOR:ACC SUMMARY OF BRAIN WEIGHTS AND MEASUREMENTS
PND72 F Brain (GRAMS) Mean 2.0210 2.0800 2.0620 1.9820 1.9800 1.9800
% Difference Control 2.9 2.0 -1.9 -2.0 -2.0
S.D. 0.07593 0.08844 0.06529 0.07899 0.10242 0.08969
S.E. of Mean 0.02401 0.02797 0.02065 0.02498 0.03239 0.02836
N 10 10 10 10 10 10
Brain Length (MM) Mean 20.5 20.5 20.5 20.2 20.4 20.4
S.D. 0.29 0.36 0.34 0.32 0.34 0.40
S.E. of Mean 0.09 0.11 0.11 0.10 0.11 0.13
Page 375 of 4796
N 10 10 10 10 10 10
Brain Width (MM) Mean 15.1 15.2 15.2 15.0 15.0 15.1
S.D. 0.28 0.38 0.18 0.17 0.32 0.25
S.E. of Mean 0.09 0.12 0.06 0.05 0.10 0.08
N 10 10 10 10 10 10
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed.
TABLE 55 (F1 - ANIMALS SELECTED FOR NEUROPATHOLOGY - PND 72 - SUBSET A)
PROJECT NO.:WIL-186056V DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF MICROSCOPIC FINDINGS
BASAL GANGLIA
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
BRAIN
TOTAL NUMBER EXAMINED NA NA 2 NA NA NA
EXAMINED, UNREMARKABLE NA NA 0 NA NA NA
-HYDROCEPHALUS NA NA 2 NA NA NA
MINIMAL NA NA 2 NA NA NA
Page 376 of 4796
CEREBELLUM
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
CEREBRAL CORTEX
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
EYES
TOTAL NUMBER EXAMINED 9 9 8 9 9 9
EXAMINED, UNREMARKABLE 8 9 8 9 9 8
NOT PRESENT FOR EXAMINATION 1 1 2 1 1 1
-DYSPLASIA, RETINAL 0 0 0 0 0 1
MINIMAL NONE NONE NONE NONE NONE 1
-KERATITIS 1 0 0 0 0 0
MINIMAL 1 NONE NONE NONE NONE NONE
-MINERALIZATION, CORNEAL 1 0 0 0 0 0
MILD 1 NONE NONE NONE NONE NONE
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
TABLE 55 (F1 - ANIMALS SELECTED FOR NEUROPATHOLOGY - PND 72 - SUBSET A)
PROJECT NO.:WIL-186056V DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 3
SPONSOR:ACC SUMMARY OF MICROSCOPIC FINDINGS
GASTROC. MUSCLE
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 8 7 7 8 9
-DEGENERATION, MUSCLE 0 2 2 2 2 1
MINIMAL NONE 2 2 2 2 1
-INFILTRATE, MONONUCLEAR 0 0 1 1 1 0
MINIMAL NONE NONE 1 1 1 NONE
HIPPOCAMPUS
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
Page 378 of 4796
HYPOTHALAMUS
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
MEDULLA OBLONG.
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
MIDBRAIN
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
TABLE 55 (F1 - ANIMALS SELECTED FOR NEUROPATHOLOGY - PND 72 - SUBSET A)
PROJECT NO.:WIL-186056V DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 5
SPONSOR:ACC SUMMARY OF MICROSCOPIC FINDINGS
OLFACTORY BULBS
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
OPTIC NERVE
TOTAL NUMBER EXAMINED 9 9 8 9 9 9
EXAMINED, UNREMARKABLE 9 9 8 9 9 9
NOT PRESENT FOR EXAMINATION 1 1 2 1 1 1
PERONEAL NERVE
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
Page 380 of 4796
EXAMINED, UNREMARKABLE 10 9 9 6 8 9
-DEGENERATION, AXONAL 0 1 1 4 2 1
MINIMAL NONE 1 1 4 2 1
PONS
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
SCIATIC NERVE
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 4 3 4 2 3 4
-DEGENERATION, AXONAL 6 7 6 8 7 6
MINIMAL 6 7 6 8 7 6
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
TABLE 55 (F1 - ANIMALS SELECTED FOR NEUROPATHOLOGY - PND 72 - SUBSET A)
PROJECT NO.:WIL-186056V DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 6
SPONSOR:ACC SUMMARY OF MICROSCOPIC FINDINGS
SPINAL C.-CERV.
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 9 9 10 10 10 10
-DEGENERATION, AXONAL 1 1 0 0 0 0
MINIMAL 1 1 NONE NONE NONE NONE
SPINAL C.-LUMB.
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 9 10 10 9
Page 381 of 4796
-DEGENERATION, AXONAL 0 0 1 0 0 1
MINIMAL NONE NONE 1 NONE NONE 1
SURAL NERVE
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 8 10 10 10 10 10
-DEGENERATION, AXONAL 2 0 0 0 0 0
MINIMAL 2 NONE NONE NONE NONE NONE
THALAMUS
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
TABLE 55 (F1 - ANIMALS SELECTED FOR NEUROPATHOLOGY - PND 72 - SUBSET A)
PROJECT NO.:WIL-186056V DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 7
SPONSOR:ACC SUMMARY OF MICROSCOPIC FINDINGS
TIBIAL NERVE
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 9 6 8 8 8
-DEGENERATION, AXONAL 0 1 4 2 2 2
MINIMAL NONE 1 4 2 2 2
TRIG. GANGLION
TOTAL NUMBER EXAMINED 9 9 8 9 9 9
EXAMINED, UNREMARKABLE 9 9 8 9 9 9
NOT PRESENT FOR EXAMINATION 1 1 2 1 1 1
Page 382 of 4796
TRIGEMINAL NERVE
TOTAL NUMBER EXAMINED 9 9 8 9 9 9
EXAMINED, UNREMARKABLE 8 9 8 8 9 8
NOT PRESENT FOR EXAMINATION 1 1 2 1 1 1
-DEGENERATION, AXONAL 1 0 0 1 0 1
MINIMAL 1 NONE NONE 1 NONE 1
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
TABLE 55 (F1 - ANIMALS SELECTED FOR NEUROPATHOLOGY - PND 72 - SUBSET A)
PROJECT NO.:WIL-186056V DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 8
SPONSOR:ACC SUMMARY OF MICROSCOPIC FINDINGS
BASAL GANGLIA
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
CEREBELLUM
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
CEREBRAL CORTEX
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
Page 383 of 4796
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
EYES
TOTAL NUMBER EXAMINED 8 9 10 10 10 10
EXAMINED, UNREMARKABLE 8 9 9 10 9 10
NOT PRESENT FOR EXAMINATION 2 1 0 0 0 0
-DYSPLASIA, RETINAL 0 0 1 0 1 0
MINIMAL NONE NONE 1 NONE 1 NONE
GASTROC. MUSCLE
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 9 9 9 10 9 9
-DEGENERATION, MUSCLE 0 1 1 0 1 1
Page 384 of 4796
HIPPOCAMPUS
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
HYPOTHALAMUS
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
TABLE 55 (F1 - ANIMALS SELECTED FOR NEUROPATHOLOGY - PND 72 - SUBSET A)
PROJECT NO.:WIL-186056V DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 10
SPONSOR:ACC SUMMARY OF MICROSCOPIC FINDINGS
MEDULLA OBLONG.
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
MIDBRAIN
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
OLFACTORY BULBS
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
Page 386 of 4796
OPTIC NERVE
TOTAL NUMBER EXAMINED 8 9 10 10 10 10
EXAMINED, UNREMARKABLE 8 9 10 10 10 10
NOT PRESENT FOR EXAMINATION 2 1 0 0 0 0
PERONEAL NERVE
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 9 8 9 9 6 8
-DEGENERATION, AXONAL 1 2 1 1 4 2
MINIMAL 1 2 1 1 4 2
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
TABLE 55 (F1 - ANIMALS SELECTED FOR NEUROPATHOLOGY - PND 72 - SUBSET A)
PROJECT NO.:WIL-186056V DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 12
SPONSOR:ACC SUMMARY OF MICROSCOPIC FINDINGS
PONS
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
SCIATIC NERVE
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 4 5 3 6 6 2
-DEGENERATION, AXONAL 6 4 7 3 4 8
MINIMAL 6 4 7 3 4 7
MILD NONE NONE NONE NONE NONE 1
-ECTOPIC TISSUE 0 1 0 1 0 0
Page 387 of 4796
SPINAL C.-CERV.
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
SPINAL C.-LUMB.
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 9 10 10 10
-CYST, KERATIN 0 0 1 0 0 0
MILD NONE NONE 1 NONE NONE NONE
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
TABLE 55 (F1 - ANIMALS SELECTED FOR NEUROPATHOLOGY - PND 72 - SUBSET A)
PROJECT NO.:WIL-186056V DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 13
SPONSOR:ACC SUMMARY OF MICROSCOPIC FINDINGS
SURAL NERVE
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 9 9 9 10 10 10
-DEGENERATION, AXONAL 1 1 1 0 0 0
MINIMAL 1 1 1 NONE NONE NONE
THALAMUS
TOTAL NUMBER EXAMINED 10 10 10 10 10 10
EXAMINED, UNREMARKABLE 10 10 10 10 10 10
TIBIAL NERVE
Page 388 of 4796
TRIG. GANGLION
TOTAL NUMBER EXAMINED 8 9 10 10 10 10
EXAMINED, UNREMARKABLE 8 9 10 10 10 10
NOT PRESENT FOR EXAMINATION 2 1 0 0 0 0
TRIGEMINAL NERVE
TOTAL NUMBER EXAMINED 8 9 10 10 10 10
EXAMINED, UNREMARKABLE 8 9 10 10 10 10
NOT PRESENT FOR EXAMINATION 2 1 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
PHSI2v4.30
08/17/2009
R:09/09/2009
TABLE 56 (F1 ANIMALS SELECTED FOR NEUROPATHOLOGY PND 72 SUBSET A)
PROJECT NO.:WIL-186056V DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF BRAIN MORPHOMETRY [CM]
N 20 20 20 20 20 20
LSMean 0.1770 0.1809 0.1793 0.1771 0.1747 0.1773
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested at 0.02 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 56 (F1 ANIMALS SELECTED FOR NEUROPATHOLOGY PND 72 SUBSET A)
PROJECT NO.:WIL-186056V DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC SUMMARY OF BRAIN MORPHOMETRY [CM]
PND72 P Level 3 - V HT Btw Mean 0.0947 0.0971 0.0954 0.0954 0.0920 0.0918
Hippo Pyramidal
Neuron Layers
S.D. 0.00470 0.00531 0.00755 0.00930 0.00786 0.00742
S.E. of Mean 0.00105 0.00119 0.00169 0.00208 0.00176 0.00166
N 20 20 20 20 20 20
LSMean 0.0959 0.0976 0.0966 0.0969 0.0924 0.0923
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested at 0.02 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 56 (F1 ANIMALS SELECTED FOR NEUROPATHOLOGY PND 72 SUBSET A)
PROJECT NO.:WIL-186056V DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 3
SPONSOR:ACC SUMMARY OF BRAIN MORPHOMETRY [CM]
PND72 P Level 5 - V Height Mean 0.5141 0.5174 0.5088 0.5105 0.4990 0.4928
of the Cerebellum
S.D. 0.02751 0.03020 0.02004 0.02488 0.02480 0.02552
S.E. of Mean 0.00631 0.00675 0.00448 0.00556 0.00555 0.00571
N 19 20 20 20 20 20
LSMean 0.5136 0.5184 0.5083 0.5120 0.5000 0.4914
N 19 20 20 20 20 20
LSMean 0.0739 0.0738 0.0720 0.0729 0.0747 0.0745
MANOVA
Wilks' Lambda Trt p-value# 0.071
Wilks' Lambda Trt*Sex p-value# 0.817
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested at 0.02 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 56 (F1 ANIMALS SELECTED FOR NEUROPATHOLOGY PND 72 SUBSET A)
PROJECT NO.:WIL-186056V DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 4
SPONSOR:ACC SUMMARY OF BRAIN MORPHOMETRY [CM]
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed.
TABLE 56 (F1 ANIMALS SELECTED FOR NEUROPATHOLOGY PND 72 SUBSET A)
PROJECT NO.:WIL-186056V DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 5
SPONSOR:ACC SUMMARY OF BRAIN MORPHOMETRY [CM]
PND72 M Level 3 - V HT Btw Mean 0.0966 0.0972 0.0967 0.0982 0.0935 0.0951
Hippo Pyramidal
Neuron Layers
S.D. 0.00412 0.00505 0.00854 0.01058 0.00867 0.00744
S.E. of Mean 0.00130 0.00160 0.00270 0.00335 0.00274 0.00235
N 10 10 10 10 10 10
N 9 10 9 9 10 9
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed.
TABLE 56 (F1 ANIMALS SELECTED FOR NEUROPATHOLOGY PND 72 SUBSET A)
PROJECT NO.:WIL-186056V DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 6
SPONSOR:ACC SUMMARY OF BRAIN MORPHOMETRY [CM]
------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed.
TABLE 56 (F1 ANIMALS SELECTED FOR NEUROPATHOLOGY PND 72 SUBSET A)
PROJECT NO.:WIL-186056V DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 7
SPONSOR:ACC SUMMARY OF BRAIN MORPHOMETRY [CM]
PND72 F Level 3 - V HT Btw Mean 0.0929 0.0971 0.0940 0.0926 0.0904 0.0885
Hippo Pyramidal
Neuron Layers
S.D. 0.00466 0.00583 0.00658 0.00728 0.00707 0.00606
S.E. of Mean 0.00148 0.00184 0.00208 0.00230 0.00224 0.00192
N 10 10 10 10 10 10
N 9 9 9 10 9 10
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed.
WIL-186056 Bisphenol A
American Chemistry Council
APPENDIX A
TABLE A1
23236 F 1.5 PPM BODY/INTEGUMENT 08-03-08 10:20 1 HAIR LOSS RIGHT FORELIMB
08-03-08 10:21 1 HAIR LOSS LEFT FORELIMB
08-04-08 7:43 1 HAIR LOSS RIGHT FORELIMB
08-04-08 7:43 1 HAIR LOSS LEFT FORELIMB
08-05-08 13:33 1 HAIR LOSS RIGHT FORELIMB
08-05-08 13:33 1 HAIR LOSS LEFT FORELIMB
08-07-08 13:29 1 HAIR LOSS RIGHT FORELIMB
08-07-08 13:29 1 HAIR LOSS LEFT FORELIMB
08-10-08 14:22 1 HAIR LOSS RIGHT FORELIMB
08-10-08 14:22 1 HAIR LOSS LEFT FORELIMB
08-19-08 13:33 1 HAIR LOSS RIGHT FORELIMB
08-20-08 13:43 1 HAIR LOSS RIGHT FORELIMB
08-22-08 7:01 1 HAIR LOSS RIGHT FORELIMB
08-23-08 6:41 1 HAIR LOSS RIGHT FORELIMB
08-25-08 6:47 1 HAIR LOSS RIGHT FORELIMB
08-26-08 9:29 1 HAIR LOSS RIGHT FORELIMB
-----------------------------------------------------------------------------------------------------------------------------------
GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT
TABLE A1 (F0 - DAILY EXAMINATIONS)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 89
SPONSOR:ACC INDIVIDUAL CLINICAL OBSERVATIONS
23244 F 1.5 PPM BODY/INTEGUMENT 07-22-08 14:39 1 HAIR LOSS RIGHT FORELIMB
07-22-08 14:39 1 HAIR LOSS LEFT FORELIMB
07-23-08 10:54 1 HAIR LOSS RIGHT FORELIMB
07-23-08 10:54 1 HAIR LOSS LEFT FORELIMB
07-24-08 6:28 1 HAIR LOSS RIGHT FORELIMB
07-24-08 6:28 1 HAIR LOSS LEFT FORELIMB
07-25-08 7:43 1 HAIR LOSS RIGHT FORELIMB
07-25-08 7:43 1 HAIR LOSS LEFT FORELIMB
07-26-08 6:41 1 HAIR LOSS RIGHT FORELIMB
07-26-08 6:41 1 HAIR LOSS LEFT FORELIMB
07-27-08 6:41 1 HAIR LOSS RIGHT FORELIMB
07-27-08 6:41 1 HAIR LOSS LEFT FORELIMB
07-28-08 7:33 1 HAIR LOSS RIGHT FORELIMB
07-28-08 7:33 1 HAIR LOSS LEFT FORELIMB
07-29-08 7:22 1 HAIR LOSS RIGHT FORELIMB
07-29-08 7:22 1 HAIR LOSS LEFT FORELIMB
-----------------------------------------------------------------------------------------------------------------------------------
GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT
TABLE A1 (F0 - DAILY EXAMINATIONS)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 96
SPONSOR:ACC INDIVIDUAL CLINICAL OBSERVATIONS
26532 F 1.5 PPM DISPOSITION 09-24-08 10:31 P SCHEDULED EUTHANASIA; LACTATION DAY 21
26507 F 1.5 PPM NORMAL 08-14-08 9:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS
08-13-08 10:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS
08-15-08 8:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS
08-16-08 13:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS
08-17-08 11:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS
08-18-08 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS
08-19-08 8:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS
08-20-08 11:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS
08-21-08 8:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS
08-22-08 9:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS
08-23-08 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS
08-24-08 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS
08-25-08 13:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS
08-26-08 8:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS
08-27-08 11:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS
-----------------------------------------------------------------------------------------------------------------------------------
GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT
TABLE A1 (F0 - DAILY EXAMINATIONS)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 113
SPONSOR:ACC INDIVIDUAL CLINICAL OBSERVATIONS
26478 F 750 PPM DISPOSITION 09-24-08 10:33 P SCHEDULED EUTHANASIA; LACTATION DAY 21
26501 F 750 PPM NORMAL 08-12-08 10:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS
08-13-08 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS
08-14-08 9:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS
08-15-08 8:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS
08-16-08 13:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS
08-17-08 11:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS
08-18-08 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS
08-19-08 9:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS
08-20-08 11:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS
08-21-08 8:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS
08-22-08 9:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS
08-23-08 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS
08-24-08 8:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS
08-25-08 13:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS
08-26-08 8:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS
-----------------------------------------------------------------------------------------------------------------------------------
GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT
TABLE A1 (F0 - DAILY EXAMINATIONS)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 187
SPONSOR:ACC INDIVIDUAL CLINICAL OBSERVATIONS
Volume 3 of 16
(Appendix A [Tables A2-A17])
STUDY TITLE
A DIETARY DEVELOPMENTAL
NEUROTOXICITY STUDY OF BISPHENOL A IN RATS
STUDY NUMBER
WIL-186056
DATA REQUIREMENT
STUDY DIRECTOR
26 June 2008
30 September 2009
PERFORMING LABORATORY
SPONSOR
APPENDIX A
TABLES A2-A17
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0 3 7 10 14 17 20
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
23243 G 261. 274. 294. 309. 328. 362. 414.
23213 G 276. 297. 315. 325. 339. 366. 414.
23203 G 258. 282. 290. 317. 342. 374. 437.
23207 G 232. 247. 242. 267. 293. 326. 362.
23226 G 238. 246. 256. 275. 285. 312. 358.
23242 G 249. 260. 273. 294. 305. 343. 390.
23209 G 251. 262. 278. 297. 319. 345. 394.
23178 G 256. 261. 264. 282. 296. 325. 359.
23186 G 262. 276. 290. 307. 332. 363. 410.
23194 G 271. 280. 300. 326. 343. 379. 433.
23182 G 263. 272. 291. 301. 322. 345. 400.
Page 800 of 4796
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0 3 7 10 14 17 20
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
23195 G 261. 279. 307. 321. 341. 363. 412.
23180 G 263. 286. 293. 320. 345. 382. 433.
23176 G 259. 273. 280. 307. 326. 352. 400.
23251 G 247. 269. 275. 302. 328. 354. 403.
23235 G 240. 251. 266. 285. 301. 332. 382.
23199 NG 243. 258. 273. 293. 288. 279. 278.
23231 G 253. 268. 278. 304. 314. 342. 394.
23216 G 259. 284. 303. 324. 349. 379. 437.
23261 G 260. 277. 288. 307. 323. 346. 397.
23205 G 289. 311. 330. 362. 377. 413. 460.
23181 G 271. 283. 311. 318. 345. 375. 417.
Page 801 of 4796
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0 3 7 10 14 17 20
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
23248 G 258. 275. 298. 319. 353. 384. 439.
23217 G 272. 294. 300. 332. 360. 404. 466.
23190 G 260. 270. 274. 291. 318. 339. 386.
23236 G 242. 258. 268. 284. 310. 335. 385.
23260 G 239. 265. 284. 304. 322. 352. 397.
23221 G 242. 245. 259. 272. 288. 317. 365.
23263 G 252. 260. 271. 289. 302. 333. 377.
23253 G 254. 270. 283. 297. 327. 359. 415.
23244 G 265. 278. 296. 316. 336. 365. 414.
23218 G 269. 285. 306. 317. 341. 373. 430.
23208 G 297. 310. 318. 348. 375. 416. 462.
Page 802 of 4796
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0 3 7 10 14 17 20
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 4: 75 PPM
---------------------------------------
23179 G 259. 271. 292. 310. 325. 350. 387.
23212 G 266. 287. 294. 324. 341. 367. 429.
23201 G 257. 266. 277. 301. 327. 360. 399.
23259 G 234. 246. 253. 267. 284. 304. 344.
23210 G 237. 242. 258. 279. 298. 329. 378.
23256 G 247. 258. 267. 288. 303. 332. 385.
23238 G 253. 268. 281. 298. 312. 349. 402.
23228 G 255. 268. 284. 294. 314. 342. 401.
23246 G 262. 278. 287. 304. 320. 351. 378.
23220 G 270. 288. 308. 330. 349. 382. 429.
23183 G 253. 267. 286. 300. 321. 334. 377.
Page 803 of 4796
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0 3 7 10 14 17 20
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 5: 750 PPM
---------------------------------------
23198 G 246. 253. 268. 283. 301. 331. 366.
23233 G 266. 273. 293. 304. 325. 361. 391.
23241 G 256. 270. 284. 310. 334. 365. 399.
23254 G 236. 245. 243. 261. 264. 290. 346.
23239 G 241. 249. 263. 291. 311. 333. 377.
23245 G 243. 252. 262. 279. 288. 312. 350.
23223 G 252. 271. 285. 301. 324. 353. 409.
23191 G 254. 237. 255. 276. 301. 331. 381.
23247 G 265. 272. 289. 306. 326. 358. 411.
23230 G 266. 270. 285. 305. 321. 353. 407.
23249 G 254. 245. 279. 288. 314. 333. 378.
Page 804 of 4796
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0 3 7 10 14 17 20
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 6: 2250 PPM
---------------------------------------
23255 G 237. 240. 242. 262. 270. 314. 345.
23237 G 262. 262. 268. 282. 302. 335. 387.
23215 G 257. 237. 259. 286. 311. 335. 394.
23214 G 250. 245. 237. 261. 278. 299. 355.
23192 G 241. 204. 228. 244. 253. 281. 328.
23219 G 247. 239. 251. 257. 276. 304. 355.
23211 G 251. 250. 259. 274. 284. 307. 342.
23189 G 257. 242. 264. 266. 292. 323. 368.
23204 G 265. 246. 229. 253. 275. 310. 375.
23257 G 288. 285. 291. 312. 317. 338. 390.
23234 G 289. 265. 284. 300. 317. 342. 391.
Page 805 of 4796
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0- 3 3- 7 7-10 10-14 14-17 17-20 0- 7 7-14 14-20
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
23243 G 13. 20. 15. 19. 34. 52. 33. 34. 86.
23213 G 21. 18. 10. 14. 27. 48. 39. 24. 75.
23203 G 24. 8. 27. 25. 32. 63. 32. 52. 95.
23207 G 15. -5. 25. 26. 33. 36. 10. 51. 69.
23226 G 8. 10. 19. 10. 27. 46. 18. 29. 73.
23242 G 11. 13. 21. 11. 38. 47. 24. 32. 85.
23209 G 11. 16. 19. 22. 26. 49. 27. 41. 75.
23178 G 5. 3. 18. 14. 29. 34. 8. 32. 63.
23186 G 14. 14. 17. 25. 31. 47. 28. 42. 78.
23194 G 9. 20. 26. 17. 36. 54. 29. 43. 90.
23182 G 9. 19. 10. 21. 23. 55. 28. 31. 78.
Page 806 of 4796
23240 G 26. 17. 19. 17. 24. 42. 43. 36. 66.
26521 G 16. 18. 16. 21. 33. 50. 34. 37. 83.
26449 G 19. 18. 16. 26. 33. 41. 37. 42. 74.
26473 G 24. 19. 14. 27. 32. 41. 43. 41. 73.
26452 G 20. 12. 21. 12. 31. 55. 32. 33. 86.
26528 NG 7. 16. 14. -6. -2. -2. 23. 8. -4.
26491 G 11. 25. 19. 19. 31. 44. 36. 38. 75.
26512 G 23. 23. 29. 17. 28. 35. 46. 46. 63.
26454 G 17. 19. 21. 18. 28. 56. 36. 39. 84.
26529 G 12. 13. 13. 29. 28. 54. 25. 42. 82.
26453 G 11. 22. 20. 18. 43. 55. 33. 38. 98.
26527 G 5. 19. 11. 21. 21. 46. 24. 32. 67.
26489 G 14. 29. 18. 26. 23. 58. 43. 44. 81.
MEAN 15. 16. 18. 20. 30. 48. 31. 38. 78.
S.D. 6.1 7.3 5.1 5.4 5.2 7.7 9.9 6.9 9.5
S.E. 1.3 1.5 1.1 1.1 1.1 1.6 2.1 1.4 2.0
N 23 23 23 23 23 23 23 23 23
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0-20
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
23243 G 153.
23213 G 138.
23203 G 179.
23207 G 130.
23226 G 120.
23242 G 141.
23209 G 143.
23178 G 103.
23186 G 148.
23194 G 162.
23182 G 137.
Page 807 of 4796
23240 G 145.
26521 G 154.
26449 G 153.
26473 G 157.
26452 G 151.
26528 NG 27.
26491 G 149.
26512 G 155.
26454 G 159.
26529 G 149.
26453 G 169.
26527 G 123.
26489 G 168.
MEAN 147.
S.D. 17.0
S.E. 3.6
N 23
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0- 3 3- 7 7-10 10-14 14-17 17-20 0- 7 7-14 14-20
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
23195 G 18. 28. 14. 20. 22. 49. 46. 34. 71.
23180 G 23. 7. 27. 25. 37. 51. 30. 52. 88.
23176 G 14. 7. 27. 19. 26. 48. 21. 46. 74.
23251 G 22. 6. 27. 26. 26. 49. 28. 53. 75.
23235 G 11. 15. 19. 16. 31. 50. 26. 35. 81.
23199 NG 15. 15. 20. -5. -9. -1. 30. 15. -10.
23231 G 15. 10. 26. 10. 28. 52. 25. 36. 80.
23216 G 25. 19. 21. 25. 30. 58. 44. 46. 88.
23261 G 17. 11. 19. 16. 23. 51. 28. 35. 74.
23205 G 22. 19. 32. 15. 36. 47. 41. 47. 83.
23181 G 12. 28. 7. 27. 30. 42. 40. 34. 72.
Page 808 of 4796
23264 G 27. 18. 14. 16. 35. 42. 45. 30. 77.
26474 G 25. 25. 19. 31. 37. 48. 50. 50. 85.
26476 G 23. 23. 10. 26. 32. 54. 46. 36. 86.
26496 G 24. 18. 11. 30. 31. 34. 42. 41. 65.
26505 G 15. 20. 19. 17. 22. 46. 35. 36. 68.
26483 G 12. 19. 17. 17. 24. 37. 31. 34. 61.
26479 G 8. 18. 29. 3. 34. 30. 26. 32. 64.
26450 G 13. 13. 25. 18. 38. 43. 26. 43. 81.
26457 G 10. 23. 20. 13. 36. 49. 33. 33. 85.
26492 G 11. 23. 21. 18. 32. 49. 34. 39. 81.
26493 G 13. 15. 17. 33. 30. 60. 28. 50. 90.
26488 G 6. 21. 10. 22. 28. 54. 27. 32. 82.
26520 G 11. 16. 16. 15. 30. 48. 27. 31. 78.
MEAN 16. 17. 19. 20. 30. 47. 34. 39. 78.
S.D. 6.2 6.3 6.7 7.2 4.9 7.1 8.5 7.4 8.1
S.E. 1.3 1.3 1.4 1.5 1.0 1.5 1.8 1.5 1.7
N 23 23 23 23 23 23 23 23 23
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0-20
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
23195 G 151.
23180 G 170.
23176 G 141.
23251 G 156.
23235 G 142.
23199 NG 35.
23231 G 141.
23216 G 178.
23261 G 137.
23205 G 171.
23181 G 146.
Page 809 of 4796
23264 G 152.
26474 G 185.
26476 G 168.
26496 G 148.
26505 G 139.
26483 G 126.
26479 G 122.
26450 G 150.
26457 G 151.
26492 G 154.
26493 G 168.
26488 G 141.
26520 G 136.
MEAN 151.
S.D. 16.1
S.E. 3.4
N 23
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0- 3 3- 7 7-10 10-14 14-17 17-20 0- 7 7-14 14-20
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
23248 G 17. 23. 21. 34. 31. 55. 40. 55. 86.
23217 G 22. 6. 32. 28. 44. 62. 28. 60. 106.
23190 G 10. 4. 17. 27. 21. 47. 14. 44. 68.
23236 G 16. 10. 16. 26. 25. 50. 26. 42. 75.
23260 G 26. 19. 20. 18. 30. 45. 45. 38. 75.
23221 G 3. 14. 13. 16. 29. 48. 17. 29. 77.
23263 G 8. 11. 18. 13. 31. 44. 19. 31. 75.
23253 G 16. 13. 14. 30. 32. 56. 29. 44. 88.
23244 G 13. 18. 20. 20. 29. 49. 31. 40. 78.
23218 G 16. 21. 11. 24. 32. 57. 37. 35. 89.
23208 G 13. 8. 30. 27. 41. 46. 21. 57. 87.
Page 810 of 4796
23252 G 16. 22. 12. 25. 25. 53. 38. 37. 78.
26510 G 18. 26. 10. 18. 29. 44. 44. 28. 73.
26519 G 26. 14. 20. 25. 33. 41. 40. 45. 74.
26468 G 16. 16. 11. 25. 33. 45. 32. 36. 78.
26475 G 15. 18. 21. 23. 32. 43. 33. 44. 75.
26532 G 10. 14. 17. 18. 33. 43. 24. 35. 76.
26507 G 13. 20. 22. 23. 41. 50. 33. 45. 91.
26480 G 19. 21. 22. 15. 40. 48. 40. 37. 88.
26482 G 9. 17. 14. 25. 31. 43. 26. 39. 74.
26522 G 16. 22. 18. 23. 25. 42. 38. 41. 67.
26517 G 20. 19. 13. 25. 33. 41. 39. 38. 74.
26514 G 13. 16. 11. 19. 30. 40. 29. 30. 70.
26534 G 15. 22. 11. 20. 27. 58. 37. 31. 85.
MEAN 15. 16. 17. 23. 32. 48. 32. 40. 79.
S.D. 5.3 5.7 5.8 5.0 5.5 6.1 8.6 8.4 8.9
S.E. 1.1 1.2 1.2 1.0 1.1 1.2 1.7 1.7 1.8
N 24 24 24 24 24 24 24 24 24
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0-20
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
23248 G 181.
23217 G 194.
23190 G 126.
23236 G 143.
23260 G 158.
23221 G 123.
23263 G 125.
23253 G 161.
23244 G 149.
23218 G 161.
23208 G 165.
Page 811 of 4796
23252 G 153.
26510 G 145.
26519 G 159.
26468 G 146.
26475 G 152.
26532 G 135.
26507 G 169.
26480 G 165.
26482 G 139.
26522 G 146.
26517 G 151.
26514 G 129.
26534 G 153.
MEAN 151.
S.D. 17.3
S.E. 3.5
N 24
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0- 3 3- 7 7-10 10-14 14-17 17-20 0- 7 7-14 14-20
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 4: 75 PPM
---------------------------------------
23179 G 12. 21. 18. 15. 25. 37. 33. 33. 62.
23212 G 21. 7. 30. 17. 26. 62. 28. 47. 88.
23201 G 9. 11. 24. 26. 33. 39. 20. 50. 72.
23259 G 12. 7. 14. 17. 20. 40. 19. 31. 60.
23210 G 5. 16. 21. 19. 31. 49. 21. 40. 80.
23256 G 11. 9. 21. 15. 29. 53. 20. 36. 82.
23238 G 15. 13. 17. 14. 37. 53. 28. 31. 90.
23228 G 13. 16. 10. 20. 28. 59. 29. 30. 87.
23246 G 16. 9. 17. 16. 31. 27. 25. 33. 58.
23220 G 18. 20. 22. 19. 33. 47. 38. 41. 80.
23183 G 14. 19. 14. 21. 13. 43. 33. 35. 56.
Page 812 of 4796
23184 G 11. 21. 10. 25. 19. 49. 32. 35. 68.
26516 G 9. 20. 8. 14. 33. 40. 29. 22. 73.
26497 G 26. 17. 16. 19. 28. 52. 43. 35. 80.
26495 G 24. 12. 14. 30. 31. 44. 36. 44. 75.
26499 G 15. 21. 23. 21. 33. 57. 36. 44. 90.
26494 G 13. 19. 14. 19. 26. 36. 32. 33. 62.
26533 G 9. 21. 18. 17. 24. 47. 30. 35. 71.
26502 G 10. 19. 21. 14. 34. 65. 29. 35. 99.
26451 G 15. 20. 20. 18. 36. 61. 35. 38. 97.
26535 G 3. 22. 18. 16. 35. 46. 25. 34. 81.
26456 G 10. 20. 18. 13. 44. 51. 30. 31. 95.
26518 G 7. 28. -9. -3. 51. 39. 35. -12. 90.
26459 G 21. 26. 17. 26. 30. 54. 47. 43. 84.
MEAN 13. 17. 17. 18. 30. 48. 31. 34. 78.
S.D. 5.7 5.7 7.3 6.2 7.8 9.4 7.0 11.6 12.7
S.E. 1.2 1.2 1.5 1.3 1.6 1.9 1.4 2.4 2.6
N 24 24 24 24 24 24 24 24 24
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0-20
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 4: 75 PPM
---------------------------------------
23179 G 128.
23212 G 163.
23201 G 142.
23259 G 110.
23210 G 141.
23256 G 138.
23238 G 149.
23228 G 146.
23246 G 116.
23220 G 159.
23183 G 124.
Page 813 of 4796
23184 G 135.
26516 G 124.
26497 G 158.
26495 G 155.
26499 G 170.
26494 G 127.
26533 G 136.
26502 G 163.
26451 G 170.
26535 G 140.
26456 G 156.
26518 G 113.
26459 G 174.
MEAN 143.
S.D. 18.8
S.E. 3.8
N 24
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0- 3 3- 7 7-10 10-14 14-17 17-20 0- 7 7-14 14-20
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 5: 750 PPM
---------------------------------------
23198 G 7. 15. 15. 18. 30. 35. 22. 33. 65.
23233 G 7. 20. 11. 21. 36. 30. 27. 32. 66.
23241 G 14. 14. 26. 24. 31. 34. 28. 50. 65.
23254 G 9. -2. 18. 3. 26. 56. 7. 21. 82.
23239 G 8. 14. 28. 20. 22. 44. 22. 48. 66.
23245 G 9. 10. 17. 9. 24. 38. 19. 26. 62.
23223 G 19. 14. 16. 23. 29. 56. 33. 39. 85.
23191 G -17. 18. 21. 25. 30. 50. 1. 46. 80.
23247 G 7. 17. 17. 20. 32. 53. 24. 37. 85.
23230 G 4. 15. 20. 16. 32. 54. 19. 36. 86.
23249 G -9. 34. 9. 26. 19. 45. 25. 35. 64.
Page 814 of 4796
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0-20
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 5: 750 PPM
---------------------------------------
23198 G 120.
23233 G 125.
23241 G 143.
23254 G 110.
23239 G 136.
23245 G 107.
23223 G 157.
23191 G 127.
23247 G 146.
23230 G 141.
23249 G 124.
Page 815 of 4796
23258 G 79.
26485 G 154.
26478 G 118.
26501 G 143.
26486 G 119.
26464 G 113.
26498 G 154.
26481 G 177.
26472 G 146.
26537 G 172.
26506 G 144.
26471 G 109.
26455 G 116.
MEAN 133.
S.D. 22.6
S.E. 4.6
N 24
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0- 3 3- 7 7-10 10-14 14-17 17-20 0- 7 7-14 14-20
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 6: 2250 PPM
---------------------------------------
23255 G 3. 2. 20. 8. 44. 31. 5. 28. 75.
23237 G 0. 6. 14. 20. 33. 52. 6. 34. 85.
23215 G -20. 22. 27. 25. 24. 59. 2. 52. 83.
23214 G -5. -8. 24. 17. 21. 56. -13. 41. 77.
23192 G -37. 24. 16. 9. 28. 47. -13. 25. 75.
23219 G -8. 12. 6. 19. 28. 51. 4. 25. 79.
23211 G -1. 9. 15. 10. 23. 35. 8. 25. 58.
23189 G -15. 22. 2. 26. 31. 45. 7. 28. 76.
23204 G -19. -17. 24. 22. 35. 65. -36. 46. 100.
23257 G -3. 6. 21. 5. 21. 52. 3. 26. 73.
23234 G -24. 19. 16. 17. 25. 49. -5. 33. 74.
Page 816 of 4796
23227 G -6. 21. 17. 14. 29. 55. 15. 31. 84.
26509 G 1. 30. 10. 23. 34. 30. 31. 33. 64.
26448 G 5. 12. 15. 29. 34. 33. 17. 44. 67.
26508 G -9. 12. 12. 15. 33. 49. 3. 27. 82.
26463 G 4. 15. 11. 21. 40. 35. 19. 32. 75.
26504 G -16. 24. 23. 22. 33. 40. 8. 45. 73.
26465 G -26. 0. 33. 12. 36. 52. -26. 45. 88.
26477 G -6. 11. 11. 23. 32. 27. 5. 34. 59.
26511 G -7. 18. 14. 19. 27. 42. 11. 33. 69.
26466 G -12. 25. 4. 23. 40. 54. 13. 27. 94.
26462 G -29. 0. 32. 30. 35. 40. -29. 62. 75.
26523 G -17. 25. 9. 18. 31. 59. 8. 27. 90.
26470 G -20. 25. 2. 35. 18. 52. 5. 37. 70.
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0-20
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 6: 2250 PPM
---------------------------------------
23255 G 108.
23237 G 125.
23215 G 137.
23214 G 105.
23192 G 87.
23219 G 108.
23211 G 91.
23189 G 111.
23204 G 110.
23257 G 102.
23234 G 102.
Page 817 of 4796
23227 G 130.
26509 G 128.
26448 G 128.
26508 G 112.
26463 G 126.
26504 G 126.
26465 G 107.
26477 G 98.
26511 G 113.
26466 G 134.
26462 G 108.
26523 G 125.
26470 G 112.
MEAN 114.
S.D. 13.5
S.E. 2.8
N 24
-----------------------------------------------------------------------------------------------------------------------------------
DAY 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
23243 298. 300. 322. 348. 329. 337. 354.
23213 313. 312. 331. 342. 351. 364. 342.
23203 310. 320. 318. 344. 338. 340. 348.
23207 266. 270. 292. 292. 317. 336. 321.
23226 259. 267. 268. 287. 299. 338. 319.
23242 285. 293. 296. 328. 339. 376. 351.
23209 287. 314. 315. 307. 338. 315. 337.
23178 273. 288. 277. 296. 306. 337. 310.
23186 311. 318. 332. 341. 349. 372. 362.
23194 319. 312. 312. 325. 353. 354. 358.
23182 298. 321. 332. 339. 362. 366. 314.
Page 818 of 4796
-----------------------------------------------------------------------------------------------------------------------------------
DAY 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
23195 313. 306. 320. 342. 346. 330. 343.
23180 319. 328. 324. 329. 346. 372. 349.
23176 283. 299. 313. 328. 334. 346. 350.
23251 299. 311. 323. 337. 352. 365. 361.
23235 284. 281. 292. 317. 321. 332. 339.
23231 298. 293. 306. 322. 324. 346. 343.
23216 325. 335. 330. 309. 354. 310. 346.
23261 293. 307. 312. 332. 340. 369. 343.
23205 351. 362. 358. 329. 374. 369. 385.
23181 317. 345. 349. 348. 352. 383. 338.
23264 328. 335. 342. 366. 369. 371. 368.
Page 819 of 4796
-----------------------------------------------------------------------------------------------------------------------------------
DAY 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
23248 326. 341. 349. 374. 369. 377. 384.
23217 330. 327. 345. 351. 361. 391. 379.
23190 281. 296. 297. 307. 327. 335. 339.
23236 285. 284. 301. 313. 330. 353. 337.
23260 301. 310. 319. 333. 342. 374. 355.
23221 265. 281. 278. 335. 298. 307. 315.
23263 270. 282. 291. 287. 314. 334. 312.
23253 298. 317. 311. 326. 332. 338. 347.
23244 308. 325. 321. 333. 338. 359. 362.
23218 313. 324. 332. 305. 376. 341. 354.
23208 362. 389. 354. 336. 389. 366. 396.
Page 820 of 4796
-----------------------------------------------------------------------------------------------------------------------------------
DAY 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 4: 75 PPM
---------------------------------------
23179 306. 313. 332. 341. 350. 346. 335.
23212 298. 325. 334. 331. 352. 365. 343.
23201 296. 308. 315. 330. 346. 367. 348.
23259 256. 271. 278. 283. 307. 340. 313.
23210 277. 297. 292. 312. 317. 327. 309.
23256 278. 289. 292. 313. 313. 344. 340.
23238 291. 313. 311. 325. 324. 346. 342.
23228 290. 299. 296. 317. 324. 294. 305.
23246 310. 320. SENT TO NECROPSY; SEX RATIO CRITERIA NOT MET
23220 321. 347. 337. 353. 367. 392. 357.
23183 287. 297. 319. 318. 318. 367. 278.
Page 821 of 4796
-----------------------------------------------------------------------------------------------------------------------------------
DAY 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 5: 750 PPM
---------------------------------------
23198 265. 264. 281. 289. 310. 336. 319.
23233 306. 306. 325. 324. 338. 365. 354.
23241 297. 311. 326. 331. 333. 351. 346.
23254 261. 258. SENT TO NECROPSY; SEX RATIO CRITERIA NOT MET
23239 289. 305. 306. 318. 327. 342. 345.
23245 254. 257. 270. 285. 286. 309. 301.
23223 290. 308. 306. 312. 328. 338. 353.
23191 249. 285. 303. 298. 306. 330. 325.
23247 303. 327. 333. 344. 340. 378. 349.
23230 320. 327. 335. 339. 350. 381. 362.
23249 290. 301. 320. 315. 329. 327. 330.
Page 822 of 4796
-----------------------------------------------------------------------------------------------------------------------------------
DAY 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 6: 2250 PPM
---------------------------------------
23255 246. 258. 267. 282. 286. 300. 297.
23237 DIED DAY 0
23215 289. 284. 291. 304. 321. 335. 329.
23214 251. 257. 271. 284. 298. 307. 324.
23192 225. 233. 246. 258. 270. 291. 279.
23219 249. 273. 279. 268. 299. 277. 326.
23211 260. 265. 280. 291. 297. 314. 326.
23189 254. 281. 300. 305. 319. 323. 319.
23204 255. 266. 269. 289. 299. 303. 314.
23257 292. 305. 312. 328. 332. 370. 376.
23234 286. 282. 302. 320. 308. 245. 346.
Page 823 of 4796
-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0- 3 3- 7 7-10 10-14 14-17 17-20
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
23243 G 21. 25. 25. 26. 28. 31.
23213 G 24. 27. 26. 27. 27. 28.
23203 G 23. 27. 25. 27. 29. 30.
23207 G 20. 19. 22. 25. 25. 24.
23226 G 19. 21. 21. 22. 23. 25.
23242 G 22. 24. 25. 26. 27. 26.
23209 G 20. 24. 24. 27. 26. 27.
23178 G 21. 22. 22. 23. 25. 24.
23186 G 23. 27. 26. 29. 30. 30.
23194 G 23. 26. 28. 28. 30. 32.
23182 G 22. 23. 24. 25. 27. 28.
Page 830 of 4796
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0- 3 3- 7 7-10 10-14 14-17 17-20
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
23195 G 24. 28. 27. 28. 30. 30.
23180 G 24. 24. 27. 29. 31. 30.
23176 G 21. 25. 26. 25. 26. 25.
23251 G 22. 26. 26. 28. 27. 25.
23235 G 19. 22. 22. 23. 24. 24.
23199 NG 20. 24. 24. 22. 18. 16.
23231 G 21. 22. 23. 26. 27. 29.
23216 G 26. 30. 29. 33. 32. 31.
23261 G 21. 24. 23. 25. 24. 29.
23205 G 26. 29. 31. 30. 30. 32.
23181 G 24. 25. 25. 28. 31. 30.
Page 831 of 4796
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0- 3 3- 7 7-10 10-14 14-17 17-20
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
23248 G 24. 28. 28. 31. 34. 32.
23217 G 24. 28. 26. 28. 30. 30.
23190 G 20. 21. 21. 23. 24. 24.
23236 G 21. 24. 23. 25. 26. NA
23260 G 23. 26. 26. 27. 28. 27.
23221 G 18. 21. 20. 22. 25. 24.
23263 G 21. 23. 22. 24. 25. 25.
23253 G 23. 25. 24. 28. 28. 28.
23244 G 23. 26. 26. 28. 28. 29.
23218 G 25. 29. 27. 31. 28. 28.
23208 G 26. 30. 31. 35. 36. 34.
Page 832 of 4796
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0- 3 3- 7 7-10 10-14 14-17 17-20
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 4: 75 PPM
---------------------------------------
23179 G 23. 26. 24. 26. 27. 28.
23212 G 24. 26. 28. 27. 27. 32.
23201 G 20. 24. 25. 26. 29. 27.
23259 G 17. 19. 20. 21. 22. 23.
23210 G 19. 27. 25. 26. 25. 26.
23256 G 19. 21. 22. 23. 25. 25.
23238 G 22. 23. 22. 24. 25. 26.
23228 G 23. 28. 26. 27. 28. 30.
23246 G 22. 23. 22. 25. 29. 29.
23220 G 22. 25. 25. 27. 28. 25.
23183 G 22. 23. 25. 27. 28. 29.
Page 833 of 4796
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0- 3 3- 7 7-10 10-14 14-17 17-20
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 5: 750 PPM
---------------------------------------
23198 G 15. 19. 21. 23. 25. 24.
23233 G 20. 24. 23. 27. 29. 26.
23241 G 20. 23. 25. 28. 29. 27.
23254 G 15. 13. 19. 18. 20. 29.
23239 G 19. 22. 28. 27. 26. 28.
23245 G 18. 23. 24. 25. 25. 23.
23223 G 24. 25. 24. 27. 29. 29.
23191 G 9. 15. 23. 29. 28. 28.
23247 G 22. 25. 25. 28. 28. 29.
23230 G 18. 23. 22. 26. 27. 28.
23249 G 14. 22. 24. 27. 27. 29.
Page 834 of 4796
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0- 3 3- 7 7-10 10-14 14-17 17-20
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 6: 2250 PPM
---------------------------------------
23255 G 11. 15. 21. 22. 26. 24.
23237 G 14. 22. 23. 26. 26. 28.
23215 G 9. 24. 23. 25. 27. 29.
23214 G 10. 16. 21. 22. 23. 24.
23192 G 3. 18. 22. 21. 22. 25.
23219 G 8. 21. 16. 22. 22. 24.
23211 G 12. 17. 20. 20. 21. 25.
23189 G 9. 19. 17. 24. 25. 23.
23204 G 10. 13. 21. NA 26. 30.
23257 G 17. 19. 21. 26. 22. 26.
23234 G 10. 20. 19. 24. 25. 28.
Page 835 of 4796
-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0- 3 3- 7 7-10 10-14 14-17 17-20 0-20
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
23243 G 0.00 0.00 0.00 0.00 0.00 0.00 0.00
23213 G 0.00 0.00 0.00 0.00 0.00 0.00 0.00
23203 G 0.00 0.00 0.00 0.00 0.00 0.00 0.00
23207 G 0.00 0.00 0.00 0.00 0.00 0.00 0.00
23226 G 0.00 0.00 0.00 0.00 0.00 0.00 0.00
23242 G 0.00 0.00 0.00 0.00 0.00 0.00 0.00
23209 G 0.00 0.00 0.00 0.00 0.00 0.00 0.00
23178 G 0.00 0.00 0.00 0.00 0.00 0.00 0.00
23186 G 0.00 0.00 0.00 0.00 0.00 0.00 0.00
23194 G 0.00 0.00 0.00 0.00 0.00 0.00 0.00
23182 G 0.00 0.00 0.00 0.00 0.00 0.00 0.00
Page 842 of 4796
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0- 3 3- 7 7-10 10-14 14-17 17-20 0-20
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
23195 G 0.01 0.01 0.01 0.01 0.01 0.01 0.01
23180 G 0.01 0.01 0.01 0.01 0.01 0.01 0.01
23176 G 0.01 0.01 0.01 0.01 0.01 0.01 0.01
23251 G 0.01 0.01 0.01 0.01 0.01 0.01 0.01
23235 G 0.01 0.01 0.01 0.01 0.01 0.01 0.01
23199 NG 0.01 0.01 0.01 0.01 0.01 0.01 0.01
23231 G 0.01 0.01 0.01 0.01 0.01 0.01 0.01
23216 G 0.01 0.02 0.01 0.01 0.01 0.01 0.01
23261 G 0.01 0.01 0.01 0.01 0.01 0.01 0.01
23205 G 0.01 0.01 0.01 0.01 0.01 0.01 0.01
23181 G 0.01 0.01 0.01 0.01 0.01 0.01 0.01
Page 843 of 4796
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0- 3 3- 7 7-10 10-14 14-17 17-20 0-20
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
23248 G 0.14 0.15 0.14 0.14 0.14 0.12 0.13
23217 G 0.13 0.14 0.12 0.12 0.12 0.10 0.12
23190 G 0.11 0.12 0.11 0.11 0.11 0.10 0.11
23236 G 0.12 0.14 0.12 0.13 0.12 NA NA
23260 G 0.14 0.14 0.13 0.13 0.12 0.11 0.13
23221 G 0.11 0.12 0.11 0.12 0.12 0.11 0.11
23263 G 0.12 0.13 0.12 0.12 0.12 0.11 0.12
23253 G 0.13 0.14 0.12 0.14 0.12 0.11 0.12
23244 G 0.13 0.14 0.13 0.13 0.12 0.11 0.12
23218 G 0.14 0.14 0.13 0.14 0.12 0.10 0.13
23208 G 0.13 0.14 0.14 0.14 0.14 0.12 0.13
Page 844 of 4796
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0- 3 3- 7 7-10 10-14 14-17 17-20 0-20
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 4: 75 PPM
---------------------------------------
23179 G 6.51 6.79 6.06 6.14 5.93 5.63 6.11
23212 G 6.51 6.78 6.72 6.09 5.79 6.03 6.21
23201 G 5.64 6.56 6.40 6.27 6.33 5.27 6.00
23259 G 5.21 5.79 5.67 5.58 5.61 5.40 5.49
23210 G 5.85 7.95 6.89 6.69 6.06 5.45 6.39
23256 G 5.74 6.07 6.04 5.90 5.83 5.30 5.72
23238 G 6.24 6.22 5.70 5.78 5.67 5.26 5.70
23228 G 6.60 7.54 6.66 6.66 6.40 5.99 6.54
23246 G 6.11 5.97 5.67 5.89 6.48 5.90 5.95
23220 G 6.00 6.35 5.88 5.96 5.75 4.69 5.69
23183 G 6.44 6.17 6.40 6.40 6.41 6.05 6.25
Page 845 of 4796
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0- 3 3- 7 7-10 10-14 14-17 17-20 0-20
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 5: 750 PPM
---------------------------------------
23198 G 46.08 53.26 58.06 59.08 59.33 52.36 54.34
23233 G 56.58 62.28 56.96 63.20 64.13 52.52 58.84
23241 G 57.98 60.92 63.97 64.64 62.94 52.36 59.89
23254 G 47.81 38.42 55.57 52.14 55.04 67.62 51.80
23239 G 58.16 65.18 74.92 67.90 61.33 58.46 63.56
23245 G 54.55 67.12 66.54 66.80 62.50 52.86 61.33
23223 G 68.83 67.45 61.43 64.20 63.52 57.09 62.66
23191 G 26.49 44.20 65.90 74.74 67.24 58.99 56.50
23247 G 62.38 66.85 63.85 65.27 60.68 57.21 61.76
23230 G 49.45 60.81 56.77 62.30 60.09 55.26 56.97
23249 G 41.09 62.26 64.36 67.27 63.36 61.88 60.14
Page 846 of 4796
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0- 3 3- 7 7-10 10-14 14-17 17-20 0-20
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 6: 2250 PPM
---------------------------------------
23255 G 100.67 137.70 184.54 181.87 197.80 161.64 159.57
23237 G 117.41 184.68 188.19 196.49 181.35 172.46 172.28
23215 G 84.98 213.21 192.62 190.33 188.08 179.01 174.62
23214 G 87.91 144.72 189.76 185.76 176.81 167.40 157.09
23192 G 33.68 187.49 209.75 190.15 188.17 182.29 165.10
23219 G 77.13 188.26 144.65 181.53 170.69 161.64 154.73
23211 G 107.78 150.30 166.07 163.31 162.41 173.34 153.34
23189 G 84.13 171.20 147.15 195.57 185.33 149.78 156.17
23204 G 88.06 120.78 199.15 NA 202.54 199.24 158.78
23257 G 133.52 146.47 159.19 182.43 148.88 162.76 154.60
23234 G 81.22 161.89 148.95 175.05 172.96 169.88 151.88
Page 847 of 4796
-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
GESTATION GESTATION GESTATION GESTATION GESTATION GESTATION
ANIMAL LENGTH ANIMAL LENGTH ANIMAL LENGTH ANIMAL LENGTH ANIMAL LENGTH ANIMAL LENGTH
-----------------------------------------------------------------------------------------------------------------------------------
23243 21. 23195 22. 23248 21. 23179 22. 23198 22. 23255 22.
23213 22. 23180 22. 23217 21. 23212 22. 23233 22. 23237 22.
23203 22. 23176 21. 23190 21. 23201 22. 23241 22. 23215 22.
23207 21. 23251 22. 23236 22. 23259 22. 23254 23. 23214 22.
23226 21. 23235 21. 23260 21. 23210 22. 23239 22. 23192 21.
23242 21. 23231 21. 23221 22. 23256 22. 23245 21. 23219 22.
23209 22. 23216 22. 23263 22. 23238 22. 23223 22. 23211 22.
23178 22. 23261 22. 23253 22. 23228 22. 23191 22. 23189 22.
23186 21. 23205 22. 23244 22. 23246 22. 23247 22. 23204 22.
23194 22. 23181 22. 23218 22. 23220 22. 23230 21. 23257 21.
23182 22. 23264 21. 23208 22. 23183 22. 23249 22. 23234 22.
Page 854 of 4796
23240 22. 26474 22. 23252 22. 23184 22. 23258 22. 23227 21.
26521 22. 26476 22. 26510 22. 26516 22. 26485 21. 26509 22.
26449 22. 26496 22. 26519 21. 26497 22. 26478 22. 26448 22.
26473 22. 26505 22. 26468 22. 26495 22. 26501 22. 26508 22.
26452 22. 26483 22. 26475 22. 26499 22. 26486 22. 26463 22.
26491 22. 26479 22. 26532 21. 26494 21. 26464 22. 26504 21.
26512 22. 26450 22. 26507 21. 26533 22. 26498 21. 26465 22.
26454 22. 26457 21. 26480 22. 26502 22. 26481 22. 26477 22.
26529 22. 26492 21. 26482 22. 26451 22. 26472 21. 26511 22.
26453 22. 26493 22. 26522 22. 26535 22. 26537 22. 26466 22.
26527 21. 26488 22. 26517 22. 26456 22. 26506 21. 26462 22.
26489 22. 26520 22. 26514 22. 26518 22. 26471 22. 26523 21.
26534 22. 26459 22. 26455 22. 26470 22.
-----------------------------------------------------------------------------------------------------------------------------------
MEAN 21.7 21.7 21.7 22.0 21.8 21.8
S.D. 0.45 0.45 0.46 0.20 0.51 0.41
S.E. 0.09 0.09 0.09 0.04 0.10 0.08
N 23 23 24 24 24 24
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
PGLv5.06
12/16/2008
TABLE A13 (F0 - UNSCHEDULED DEATH)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC INDIVIDUAL ANIMAL CAUSE OF DEATH
BY CAUSE OF DEATH
FEMALES
CAUSE OF DEATH GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
OTHER
UNDETERMINED
- - - - - 23237
-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
# = NEOPLASM, B = BENIGN, M = MALIGNANT, m = ANIMAL HAS MULTIPLE CAUSES OF DEATH
PPCDv4.09
03/26/2009
Page 855 of 4796
TABLE A14 (F0 - UNSCHEDULED DEATH)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS
ANIMAL NO. 23237 GROUP 6: 2250 PPM FEMALE FOUND DEAD 08/06/08 DATE OF DEATH: 08/06/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
GENERAL COMMENT GROSS: IMPLANTATION SITES (LEFT,RIGHT) P
10,6
GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P
10,6
GENERAL COMMENT GROSS: GRAVID P
UTERUS: LEFT- 3 FETUSES, 7 FORMER IMPLANTATION SITES; RIGHT-
5 FORMER IMPLANTATION SITES, 1 EARLY RESORPTION
OVARIES: CORPORA LUTEA- 10, LEFT; 6, RIGHT
FETAL GROSS OBSERVATIONS
3 DEAD FETUSES, CROWN-RUMP LENGTHS: 4.0 TO 4.4 CM, NO
APPARENT MALFORMATIONS, 3 MALES
SKIN GROSS: MATTING, RED P
BUCCAL; UROGENITAL
Page 856 of 4796
ANIMAL NO. 26528 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 09/07/08 DATE OF DEATH: 09/07/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: NONGRAVID- AMMONIUM SULFIDE NEGATIVE P
LIVER 9.81 3.554 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
KIDNEYS 1.86 0.674 UTERUS GROSS: CONTENTS, CLEAR FLUID P
FINAL BODY WT(G) 276. BOTH HORNS
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS
Page 857 of 4796
ANIMAL NO. 23199 GROUP 2: 0.15 PPM FEMALE SCHEDULED EUTH 08/10/08 DATE OF DEATH: 08/10/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) GENERAL COMMENT GROSS: NONGRAVID- AMMONIUM SULFIDE NEGATIVE P
LIVER 10.01 KIDNEYS MICRO: MINERALIZATION 1
KIDNEYS 2.10 AT CORTICOMEDULLARY JUNCTION
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:LIVER
Page 858 of 4796
ANIMAL NO. 23246 GROUP 4: 75 PPM FEMALE SCHEDULED EUTH 08/11/08 DATE OF DEATH: 08/11/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 13.21 4.128 14,3
KIDNEYS 2.46 0.769 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P
FINAL BODY WT(G) 320. 16,5
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS LIVER
Page 859 of 4796
ANIMAL NO. 26516 GROUP 4: 75 PPM FEMALE SCHEDULED EUTH 09/06/08 DATE OF DEATH: 09/06/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 12.07 4.220 6,9
KIDNEYS 2.18 0.762 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P
FINAL BODY WT(G) 286. 10,9
KIDNEYS MICRO: CYST P
CORTEX; UNILATERAL
LIVER MICRO: HEMATOPOIESIS, EXTRAMEDULLARY 2
INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
Page 860 of 4796
ANIMAL NO. 23254 GROUP 5: 750 PPM FEMALE SCHEDULED EUTH 08/12/08 DATE OF DEATH: 08/12/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 10.50 4.070 8,9
KIDNEYS 1.97 0.764 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P
FINAL BODY WT(G) 258. 9,10
KIDNEYS MICRO: MINERALIZATION 1
AT CORTICOMEDULLARY JUNCTION
MINERALIZATION, PAPILLARY TUBULAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
Page 861 of 4796
ANIMAL NO. 26485 GROUP 5: 750 PPM FEMALE SCHEDULED EUTH 09/06/08 DATE OF DEATH: 09/06/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 13.33 3.898 6,10
KIDNEYS 2.44 0.713 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P
FINAL BODY WT(G) 342. 8,10
KIDNEYS MICRO: MINERALIZATION 1
AT CORTICOMEDULLARY JUNCTION
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
Page 862 of 4796
ANIMAL NO. 23243 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 08/25/08 DATE OF DEATH: 08/25/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 17.88 5.051 7,8
KIDNEYS 2.65 0.749 KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1
FINAL BODY WT(G) 354. LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 863 of 4796
ANIMAL NO. 23213 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 08/26/08 DATE OF DEATH: 08/26/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 18.36 5.368 8,8
KIDNEYS 2.67 0.781 KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1
FINAL BODY WT(G) 342. LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 864 of 4796
ANIMAL NO. 23203 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 08/27/08 DATE OF DEATH: 08/27/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 17.36 4.989 9,8
KIDNEYS 2.55 0.733 LIVER MICRO: INFILTRATE, MONONUCLEAR 2
FINAL BODY WT(G) 348. NECROSIS 2
MULTIFOCAL
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 865 of 4796
MICRO:KIDNEYS
ANIMAL NO. 23207 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 08/26/08 DATE OF DEATH: 08/26/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 17.36 5.408 5,10
KIDNEYS 2.62 0.816 KIDNEYS MICRO: MINERALIZATION 2
FINAL BODY WT(G) 321. AT CORTICOMEDULLARY JUNCTION
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 866 of 4796
ANIMAL NO. 23226 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 08/27/08 DATE OF DEATH: 08/27/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 17.72 5.555 7,8
KIDNEYS 2.72 0.853 NO SIGNIFICANT
FINAL BODY WT(G) 319. CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS LIVER
ANIMAL NO. 23242 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 08/27/08 DATE OF DEATH: 08/27/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 19.81 5.644 6,12
KIDNEYS 2.73 0.778 KIDNEYS MICRO: MINERALIZATION 1
FINAL BODY WT(G) 351. AT CORTICOMEDULLARY JUNCTION
INFILTRATE, MONONUCLEAR 1
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
Page 868 of 4796
ANIMAL NO. 23209 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 08/28/08 DATE OF DEATH: 08/28/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 16.24 4.819 6,12
KIDNEYS 2.70 0.801 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 337. NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS
Page 869 of 4796
ANIMAL NO. 23178 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 08/28/08 DATE OF DEATH: 08/28/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.54 4.690 5,12
KIDNEYS 2.40 0.774 KIDNEYS MICRO: MINERALIZATION 1
FINAL BODY WT(G) 310. AT CORTICOMEDULLARY JUNCTION
INFILTRATE, MONONUCLEAR 1
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
Page 870 of 4796
ANIMAL NO. 23186 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 08/27/08 DATE OF DEATH: 08/27/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 18.14 5.011 9,6
KIDNEYS 2.73 0.754 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 362. NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS
Page 871 of 4796
ANIMAL NO. 23194 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 08/28/08 DATE OF DEATH: 08/28/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 15.68 4.380 8,9
KIDNEYS 2.90 0.810 KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1
FINAL BODY WT(G) 358. MINERALIZATION 1
AT CORTICOMEDULLARY JUNCTION
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 872 of 4796
MICRO:LIVER
ANIMAL NO. 23182 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 08/29/08 DATE OF DEATH: 08/29/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 13.93 4.436 7,9
KIDNEYS 2.63 0.838 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 314. NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS
Page 873 of 4796
ANIMAL NO. 23240 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 08/29/08 DATE OF DEATH: 08/29/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.47 4.729 8,8
KIDNEYS 2.63 0.859 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 306. STOMACH GROSS: CONTENTS, YELLOW P
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN THYMUS
THYROID GLANDS TRACHEA URINARY BLADDER UTERUS
CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS
Page 874 of 4796
ANIMAL NO. 26521 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 09/24/08 DATE OF DEATH: 09/24/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 17.33 4.646 10,8
KIDNEYS 2.55 0.684 KIDNEYS MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 373. LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 875 of 4796
ANIMAL NO. 26449 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 09/24/08 DATE OF DEATH: 09/24/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.48 4.401 8,9
KIDNEYS 2.54 0.772 KIDNEYS MICRO: MINERALIZATION 1
FINAL BODY WT(G) 329. AT CORTICOMEDULLARY JUNCTION
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 876 of 4796
ANIMAL NO. 26473 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 09/24/08 DATE OF DEATH: 09/24/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 16.04 4.531 6,9
KIDNEYS 2.60 0.734 KIDNEYS MICRO: MINERALIZATION 1
FINAL BODY WT(G) 354. AT CORTICOMEDULLARY JUNCTION
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 877 of 4796
ANIMAL NO. 26452 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 09/25/08 DATE OF DEATH: 09/25/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 13.11 4.034 9,8
KIDNEYS 2.35 0.723 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 325. NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS
Page 878 of 4796
ANIMAL NO. 26491 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 09/25/08 DATE OF DEATH: 09/25/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.56 4.282 7,7
KIDNEYS 2.49 0.732 KIDNEYS MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 340. LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 879 of 4796
ANIMAL NO. 26512 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 09/25/08 DATE OF DEATH: 09/25/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 15.67 4.609 6,8
KIDNEYS 2.41 0.709 KIDNEYS MICRO: MINERALIZATION 1
FINAL BODY WT(G) 340. AT CORTICOMEDULLARY JUNCTION
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 880 of 4796
ANIMAL NO. 26454 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 09/25/08 DATE OF DEATH: 09/25/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.39 4.220 11,5
KIDNEYS 2.38 0.698 KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1
FINAL BODY WT(G) 341. NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:LIVER
Page 881 of 4796
ANIMAL NO. 26529 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 09/25/08 DATE OF DEATH: 09/25/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 18.28 5.064 8,9
KIDNEYS 3.23 0.895 KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1
FINAL BODY WT(G) 361. LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 882 of 4796
ANIMAL NO. 26453 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 09/25/08 DATE OF DEATH: 09/25/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 15.43 4.286 8,10
KIDNEYS 2.81 0.781 KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1
FINAL BODY WT(G) 360. LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 883 of 4796
ANIMAL NO. 26527 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 09/25/08 DATE OF DEATH: 09/25/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 15.01 4.313 10,7
KIDNEYS 2.42 0.695 KIDNEYS MICRO: MINERALIZATION 1
FINAL BODY WT(G) 348. AT CORTICOMEDULLARY JUNCTION
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 884 of 4796
ANIMAL NO. 26489 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 09/26/08 DATE OF DEATH: 09/26/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 11.90 3.940 8,11
KIDNEYS 2.20 0.728 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 302. NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS
Page 885 of 4796
ANIMAL NO. 23195 GROUP 2: 0.15 PPM FEMALE SCHEDULED EUTH 08/26/08 DATE OF DEATH: 08/26/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 17.62 5.137 6,8
KIDNEYS 2.68 0.781 KIDNEYS GROSS: PALE P
FINAL BODY WT(G) 343. BILATERAL
KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1
NO CORRELATE TO GROSS PALLOR
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE LIVER LYMPH NODE, MES
LUNGS MAMMARY GLAND OVIDUCTS OVARIES
PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND
SKIN SPLEEN STOMACH THYMUS
Page 886 of 4796
ANIMAL NO. 23180 GROUP 2: 0.15 PPM FEMALE SCHEDULED EUTH 08/27/08 DATE OF DEATH: 08/27/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 16.74 4.797 8,9
KIDNEYS 3.05 0.874 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 349. NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS
Page 887 of 4796
ANIMAL NO. 23176 GROUP 2: 0.15 PPM FEMALE SCHEDULED EUTH 08/26/08 DATE OF DEATH: 08/26/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 16.78 4.794 9,7
KIDNEYS 2.77 0.791 KIDNEYS GROSS: AREA(S), DEPRESSED P
FINAL BODY WT(G) 350. FEW, PINPOINT, IN CORTEX, BILATERAL
KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 2
CORRELATES WITH GROSS DEPRESSED AREA(S)
MINERALIZATION 1
AT CORTICOMEDULLARY JUNCTION
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE LIVER LYMPH NODE, MES
LUNGS MAMMARY GLAND OVIDUCTS OVARIES
Page 888 of 4796
ANIMAL NO. 23251 GROUP 2: 0.15 PPM FEMALE SCHEDULED EUTH 08/27/08 DATE OF DEATH: 08/27/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 19.92 5.518 8,7
KIDNEYS 2.90 0.803 KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1
FINAL BODY WT(G) 361. MINERALIZATION 1
AT CORTICOMEDULLARY JUNCTION
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
Page 889 of 4796
ANIMAL NO. 23235 GROUP 2: 0.15 PPM FEMALE SCHEDULED EUTH 08/27/08 DATE OF DEATH: 08/27/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 17.12 5.050 7,8
KIDNEYS 2.40 0.708 KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1
FINAL BODY WT(G) 339. MINERALIZATION 1
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 890 of 4796
ANIMAL NO. 23231 GROUP 2: 0.15 PPM FEMALE SCHEDULED EUTH 08/27/08 DATE OF DEATH: 08/27/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 19.28 5.621 8,6
KIDNEYS 2.69 0.784 KIDNEYS MICRO: BASOPHILIC TUBULES 1
FINAL BODY WT(G) 343. LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 891 of 4796
ANIMAL NO. 23216 GROUP 2: 0.15 PPM FEMALE SCHEDULED EUTH 08/28/08 DATE OF DEATH: 08/28/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 16.08 4.647 7,11
KIDNEYS 2.73 0.789 KIDNEYS MICRO: MINERALIZATION, PAPILLARY TUBULAR 1
FINAL BODY WT(G) 346. LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 892 of 4796
ANIMAL NO. 23261 GROUP 2: 0.15 PPM FEMALE SCHEDULED EUTH 08/28/08 DATE OF DEATH: 08/28/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 15.07 4.394 7,8
KIDNEYS 2.70 0.787 KIDNEYS MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 343. LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 893 of 4796
ANIMAL NO. 23205 GROUP 2: 0.15 PPM FEMALE SCHEDULED EUTH 08/28/08 DATE OF DEATH: 08/28/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 20.72 5.382 10,8
KIDNEYS 3.20 0.831 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 385. NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS
Page 894 of 4796
ANIMAL NO. 23181 GROUP 2: 0.15 PPM FEMALE SCHEDULED EUTH 08/29/08 DATE OF DEATH: 08/29/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.65 4.334 6,11
KIDNEYS 2.93 0.867 KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1
FINAL BODY WT(G) 338. LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 895 of 4796
ANIMAL NO. 23264 GROUP 2: 0.15 PPM FEMALE SCHEDULED EUTH 08/28/08 DATE OF DEATH: 08/28/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.58 3.962 6,8
KIDNEYS 2.53 0.688 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 368. NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS
Page 896 of 4796
ANIMAL NO. 26474 GROUP 2: 0.15 PPM FEMALE SCHEDULED EUTH 09/24/08 DATE OF DEATH: 09/24/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 15.37 4.055 8,12
KIDNEYS 2.80 0.739 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 379. NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS
Page 897 of 4796
ANIMAL NO. 26476 GROUP 2: 0.15 PPM FEMALE SCHEDULED EUTH 09/24/08 DATE OF DEATH: 09/24/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.74 4.248 5,12
KIDNEYS 2.43 0.700 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 347. NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS
Page 898 of 4796
ANIMAL NO. 26496 GROUP 2: 0.15 PPM FEMALE SCHEDULED EUTH 09/24/08 DATE OF DEATH: 09/24/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.91 4.505 8,6
KIDNEYS 2.50 0.755 KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1
FINAL BODY WT(G) 331. MINERALIZATION 1
AT CORTICOMEDULLARY JUNCTION
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
Page 899 of 4796
ANIMAL NO. 26505 GROUP 2: 0.15 PPM FEMALE SCHEDULED EUTH 09/25/08 DATE OF DEATH: 09/25/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 15.12 4.370 6,6
KIDNEYS 2.52 0.728 KIDNEYS GROSS: AREA(S), DEPRESSED P
FINAL BODY WT(G) 346. FEW, PINPOINT TO 1 MM IN DIAMETER, IN CORTEX, BILATERAL
KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1
NO CORRELATE TO GROSS DEPRESSED AREA(S)
MINERALIZATION 1
AT CORTICOMEDULLARY JUNCTION
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE LIVER LYMPH NODE, MES
LUNGS MAMMARY GLAND OVIDUCTS OVARIES
Page 900 of 4796
ANIMAL NO. 26483 GROUP 2: 0.15 PPM FEMALE SCHEDULED EUTH 09/25/08 DATE OF DEATH: 09/25/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.14 4.405 7,9
KIDNEYS 2.40 0.748 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 321. NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS
Page 901 of 4796
ANIMAL NO. 26479 GROUP 2: 0.15 PPM FEMALE SCHEDULED EUTH 09/25/08 DATE OF DEATH: 09/25/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 13.84 4.339 7,8
KIDNEYS 2.53 0.793 KIDNEYS MICRO: MINERALIZATION 1
FINAL BODY WT(G) 319. AT CORTICOMEDULLARY JUNCTION
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 902 of 4796
ANIMAL NO. 26450 GROUP 2: 0.15 PPM FEMALE SCHEDULED EUTH 09/25/08 DATE OF DEATH: 09/25/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.59 4.254 10,9
KIDNEYS 2.24 0.653 KIDNEYS MICRO: MINERALIZATION 1
FINAL BODY WT(G) 343. AT CORTICOMEDULLARY JUNCTION
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:LIVER
Page 903 of 4796
ANIMAL NO. 26457 GROUP 2: 0.15 PPM FEMALE SCHEDULED EUTH 09/24/08 DATE OF DEATH: 09/24/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 15.90 4.556 10,9
KIDNEYS 3.06 0.877 KIDNEYS MICRO: MINERALIZATION 1
FINAL BODY WT(G) 349. AT CORTICOMEDULLARY JUNCTION
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 904 of 4796
ANIMAL NO. 26492 GROUP 2: 0.15 PPM FEMALE SCHEDULED EUTH 09/24/08 DATE OF DEATH: 09/24/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.77 4.232 7,10
KIDNEYS 2.47 0.708 KIDNEYS MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 349. LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 905 of 4796
ANIMAL NO. 26493 GROUP 2: 0.15 PPM FEMALE SCHEDULED EUTH 09/25/08 DATE OF DEATH: 09/25/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 17.01 4.712 11,10
KIDNEYS 2.99 0.828 KIDNEYS MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 361. LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 906 of 4796
ANIMAL NO. 26488 GROUP 2: 0.15 PPM FEMALE SCHEDULED EUTH 09/26/08 DATE OF DEATH: 09/26/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.40 4.557 4,11
KIDNEYS 2.59 0.820 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 316. NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS
Page 907 of 4796
ANIMAL NO. 26520 GROUP 2: 0.15 PPM FEMALE SCHEDULED EUTH 09/26/08 DATE OF DEATH: 09/26/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 16.04 4.997 6,10
KIDNEYS 2.51 0.782 KIDNEYS MICRO: MINERALIZATION 1
FINAL BODY WT(G) 321. AT CORTICOMEDULLARY JUNCTION
INFILTRATE, MONONUCLEAR 1
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
Page 908 of 4796
ANIMAL NO. 23248 GROUP 3: 1.5 PPM FEMALE SCHEDULED EUTH 08/25/08 DATE OF DEATH: 08/25/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 20.24 5.271 7,10
KIDNEYS 3.31 0.862 KIDNEYS GROSS: AREA(S), DEPRESSED P
FINAL BODY WT(G) 384. ONE, 3 X 1 X 1 MM, IN CORTEX, LEFT; ONE, PINPOINT, IN
CORTEX, RIGHT
KIDNEYS MICRO: MINERALIZATION 1
NO CORRELATE TO GROSS DEPRESSED AREA(S)
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE LIVER LYMPH NODE, MES
LUNGS MAMMARY GLAND OVIDUCTS OVARIES
PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND
Page 909 of 4796
ANIMAL NO. 23217 GROUP 3: 1.5 PPM FEMALE SCHEDULED EUTH 08/26/08 DATE OF DEATH: 08/26/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 17.69 4.668 11,10
KIDNEYS 2.74 0.723 KIDNEYS MICRO: MINERALIZATION 1
FINAL BODY WT(G) 379. AT CORTICOMEDULLARY JUNCTION
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 910 of 4796
ANIMAL NO. 23190 GROUP 3: 1.5 PPM FEMALE SCHEDULED EUTH 08/26/08 DATE OF DEATH: 08/26/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 16.96 5.003 6,11
KIDNEYS 2.63 0.776 KIDNEYS MICRO: MINERALIZATION 2
FINAL BODY WT(G) 339. AT CORTICOMEDULLARY JUNCTION
INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 911 of 4796
MICRO:LIVER
ANIMAL NO. 23236 GROUP 3: 1.5 PPM FEMALE SCHEDULED EUTH 08/27/08 DATE OF DEATH: 08/27/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 18.02 5.347 8,7
KIDNEYS 2.41 0.715 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 337. NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS
Page 912 of 4796
ANIMAL NO. 23260 GROUP 3: 1.5 PPM FEMALE SCHEDULED EUTH 08/27/08 DATE OF DEATH: 08/27/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 17.04 4.800 8,6
KIDNEYS 2.89 0.814 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 355. NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS
Page 913 of 4796
ANIMAL NO. 23221 GROUP 3: 1.5 PPM FEMALE SCHEDULED EUTH 08/28/08 DATE OF DEATH: 08/28/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.47 4.594 6,9
KIDNEYS 2.58 0.819 KIDNEYS MICRO: MINERALIZATION 1
FINAL BODY WT(G) 315. INFILTRATE, MONONUCLEAR 1
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 914 of 4796
ANIMAL NO. 23263 GROUP 3: 1.5 PPM FEMALE SCHEDULED EUTH 08/28/08 DATE OF DEATH: 08/28/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 13.11 4.202 7,8
KIDNEYS 2.18 0.699 KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1
FINAL BODY WT(G) 312. MINERALIZATION 1
AT CORTICOMEDULLARY JUNCTION
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
Page 915 of 4796
ANIMAL NO. 23253 GROUP 3: 1.5 PPM FEMALE SCHEDULED EUTH 08/28/08 DATE OF DEATH: 08/28/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 16.88 4.865 5,12
KIDNEYS 2.75 0.793 KIDNEYS MICRO: MINERALIZATION 1
FINAL BODY WT(G) 347. AT CORTICOMEDULLARY JUNCTION
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 916 of 4796
ANIMAL NO. 23244 GROUP 3: 1.5 PPM FEMALE SCHEDULED EUTH 08/28/08 DATE OF DEATH: 08/28/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 16.66 4.602 11,7
KIDNEYS 2.71 0.749 KIDNEYS MICRO: MINERALIZATION 1
FINAL BODY WT(G) 362. AT CORTICOMEDULLARY JUNCTION
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:LIVER
Page 917 of 4796
ANIMAL NO. 23218 GROUP 3: 1.5 PPM FEMALE SCHEDULED EUTH 08/28/08 DATE OF DEATH: 08/28/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 15.36 4.339 12,6
KIDNEYS 3.10 0.876 KIDNEYS MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 354. LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 918 of 4796
ANIMAL NO. 23208 GROUP 3: 1.5 PPM FEMALE SCHEDULED EUTH 08/28/08 DATE OF DEATH: 08/28/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 18.27 4.614 5,10
KIDNEYS 3.06 0.773 KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1
FINAL BODY WT(G) 396. MINERALIZATION 2
AT CORTICOMEDULLARY JUNCTION
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
Page 919 of 4796
ANIMAL NO. 23252 GROUP 3: 1.5 PPM FEMALE SCHEDULED EUTH 08/29/08 DATE OF DEATH: 08/29/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 16.85 4.720 10,7
KIDNEYS 2.73 0.765 KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1
FINAL BODY WT(G) 357. LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 920 of 4796
ANIMAL NO. 26510 GROUP 3: 1.5 PPM FEMALE SCHEDULED EUTH 09/23/08 DATE OF DEATH: 09/23/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 18.76 5.453 5,11
KIDNEYS 2.98 0.866 KIDNEYS MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 344. LIVER MICRO: INFILTRATE, MONONUCLEAR 2
HYPERPLASIA, BILE DUCT 1
NECROSIS 1
FOCAL
SPLEEN GROSS: NODULE(S) P
MULTIPLE, 1 TO 3 MM IN DIAMETER
SPLEEN GROSS: AREA(S), WHITE P
FEW, IRREGULARLY SHAPED
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
Page 921 of 4796
ANIMAL NO. 26519 GROUP 3: 1.5 PPM FEMALE SCHEDULED EUTH 09/23/08 DATE OF DEATH: 09/23/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.74 4.285 10,8
KIDNEYS 2.57 0.747 KIDNEYS MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 344. LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 922 of 4796
ANIMAL NO. 26468 GROUP 3: 1.5 PPM FEMALE SCHEDULED EUTH 09/24/08 DATE OF DEATH: 09/24/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.06 4.210 8,7
KIDNEYS 2.28 0.683 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 334. NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS
Page 923 of 4796
ANIMAL NO. 26475 GROUP 3: 1.5 PPM FEMALE SCHEDULED EUTH 09/25/08 DATE OF DEATH: 09/25/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.48 4.511 11,3
KIDNEYS 2.66 0.829 KIDNEYS MICRO: MINERALIZATION 1
FINAL BODY WT(G) 321. AT CORTICOMEDULLARY JUNCTION
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 924 of 4796
ANIMAL NO. 26532 GROUP 3: 1.5 PPM FEMALE SCHEDULED EUTH 09/24/08 DATE OF DEATH: 09/24/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.64 4.561 7,10
KIDNEYS 2.47 0.769 KIDNEYS MICRO: DILATATION, TUBULAR 1
FINAL BODY WT(G) 321. MEDULLA; UNILATERAL
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 925 of 4796
ANIMAL NO. 26507 GROUP 3: 1.5 PPM FEMALE SCHEDULED EUTH 09/24/08 DATE OF DEATH: 09/24/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 15.45 4.465 10,10
KIDNEYS 2.96 0.855 KIDNEYS MICRO: MINERALIZATION 1
FINAL BODY WT(G) 346. AT CORTICOMEDULLARY JUNCTION
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 926 of 4796
ANIMAL NO. 26480 GROUP 3: 1.5 PPM FEMALE SCHEDULED EUTH 09/25/08 DATE OF DEATH: 09/25/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 18.26 5.115 11,7
KIDNEYS 2.38 0.667 KIDNEYS MICRO: MINERALIZATION 1
FINAL BODY WT(G) 357. INFILTRATE, MONONUCLEAR 1
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 927 of 4796
ANIMAL NO. 26482 GROUP 3: 1.5 PPM FEMALE SCHEDULED EUTH 09/25/08 DATE OF DEATH: 09/25/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 13.37 4.139 9,4
KIDNEYS 2.38 0.737 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 323. NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS
Page 928 of 4796
ANIMAL NO. 26522 GROUP 3: 1.5 PPM FEMALE SCHEDULED EUTH 09/25/08 DATE OF DEATH: 09/25/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 13.86 3.872 9,6
KIDNEYS 2.37 0.662 KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1
FINAL BODY WT(G) 358. MINERALIZATION 1
AT CORTICOMEDULLARY JUNCTION
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
Page 929 of 4796
ANIMAL NO. 26517 GROUP 3: 1.5 PPM FEMALE SCHEDULED EUTH 09/26/08 DATE OF DEATH: 09/26/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 13.38 3.901 6,11
KIDNEYS 2.50 0.729 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 343. NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS
Page 930 of 4796
ANIMAL NO. 26514 GROUP 3: 1.5 PPM FEMALE SCHEDULED EUTH 09/26/08 DATE OF DEATH: 09/26/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.90 4.730 10,7
KIDNEYS 2.42 0.768 KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1
FINAL BODY WT(G) 315. LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 931 of 4796
ANIMAL NO. 26534 GROUP 3: 1.5 PPM FEMALE SCHEDULED EUTH 09/26/08 DATE OF DEATH: 09/26/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.60 4.756 5,11
KIDNEYS 2.61 0.850 KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1
FINAL BODY WT(G) 307. LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 932 of 4796
ANIMAL NO. 23179 GROUP 4: 75 PPM FEMALE SCHEDULED EUTH 08/26/08 DATE OF DEATH: 08/26/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 17.32 5.170 7,3
KIDNEYS 2.86 0.854 KIDNEYS GROSS: PALE P
FINAL BODY WT(G) 335. BILATERAL
KIDNEYS MICRO: INFILTRATE, MONONUCLEAR 1
NO CORRELATE TO GROSS PALLOR
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE LIVER LYMPH NODE, MES
LUNGS MAMMARY GLAND OVIDUCTS OVARIES
PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND
SKIN SPLEEN STOMACH THYMUS
Page 933 of 4796
ANIMAL NO. 23212 GROUP 4: 75 PPM FEMALE SCHEDULED EUTH 08/27/08 DATE OF DEATH: 08/27/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 17.30 5.044 11,7
KIDNEYS 2.81 0.819 KIDNEYS MICRO: MINERALIZATION 1
FINAL BODY WT(G) 343. AT CORTICOMEDULLARY JUNCTION
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 934 of 4796
ANIMAL NO. 23201 GROUP 4: 75 PPM FEMALE SCHEDULED EUTH 08/27/08 DATE OF DEATH: 08/27/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 17.99 5.170 6,9
KIDNEYS 2.72 0.782 KIDNEYS GROSS: AREA(S), DEPRESSED P
FINAL BODY WT(G) 348. FEW, PINPOINT, IN CORTEX, RIGHT
KIDNEYS MICRO: MINERALIZATION 1
NO CORRELATE TO GROSS DEPRESSED AREA(S)
INFILTRATE, MONONUCLEAR 1
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE LIVER LYMPH NODE, MES
LUNGS MAMMARY GLAND OVIDUCTS OVARIES
PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND
Page 935 of 4796
ANIMAL NO. 23259 GROUP 4: 75 PPM FEMALE SCHEDULED EUTH 08/28/08 DATE OF DEATH: 08/28/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.86 4.748 5,9
KIDNEYS 2.35 0.751 KIDNEYS MICRO: MINERALIZATION 1
FINAL BODY WT(G) 313. AT CORTICOMEDULLARY JUNCTION
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 936 of 4796
ANIMAL NO. 23210 GROUP 4: 75 PPM FEMALE SCHEDULED EUTH 08/28/08 DATE OF DEATH: 08/28/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.45 4.676 8,9
KIDNEYS 2.78 0.900 KIDNEYS MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 309. LIVER MICRO: INFILTRATE, MONONUCLEAR 1
THYMUS GROSS: AREA(S), DARK RED P
MULTIPLE, PINPOINT
^==> THYMUS: HEMORRHAGE
THYMUS MICRO: HEMORRHAGE 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
Page 937 of 4796
ANIMAL NO. 23256 GROUP 4: 75 PPM FEMALE SCHEDULED EUTH 08/28/08 DATE OF DEATH: 08/28/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.07 4.138 10,6
KIDNEYS 2.59 0.762 KIDNEYS MICRO: MINERALIZATION 1
FINAL BODY WT(G) 340. AT CORTICOMEDULLARY JUNCTION
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 938 of 4796
ANIMAL NO. 23238 GROUP 4: 75 PPM FEMALE SCHEDULED EUTH 08/28/08 DATE OF DEATH: 08/28/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.30 4.181 8,11
KIDNEYS 3.39 0.991 KIDNEYS MICRO: MINERALIZATION 1
FINAL BODY WT(G) 342. AT CORTICOMEDULLARY JUNCTION
INFILTRATE, MONONUCLEAR 1
#M NEPHROBLASTOMA P
UNILATERAL
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
Page 939 of 4796
ANIMAL NO. 23228 GROUP 4: 75 PPM FEMALE SCHEDULED EUTH 08/28/08 DATE OF DEATH: 08/28/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 13.38 4.387 9,9
KIDNEYS 2.64 0.866 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 305. NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS
Page 940 of 4796
ANIMAL NO. 23220 GROUP 4: 75 PPM FEMALE SCHEDULED EUTH 08/28/08 DATE OF DEATH: 08/28/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 17.36 4.863 7,11
KIDNEYS 2.67 0.748 KIDNEYS MICRO: MINERALIZATION 1
FINAL BODY WT(G) 357. AT CORTICOMEDULLARY JUNCTION
INFILTRATE, MONONUCLEAR 1
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
Page 941 of 4796
ANIMAL NO. 23183 GROUP 4: 75 PPM FEMALE SCHEDULED EUTH 08/29/08 DATE OF DEATH: 08/29/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 13.79 4.960 4,9
KIDNEYS 2.44 0.878 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 278. NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS
Page 942 of 4796
ANIMAL NO. 23184 GROUP 4: 75 PPM FEMALE SCHEDULED EUTH 08/29/08 DATE OF DEATH: 08/29/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 13.88 4.870 8,10
KIDNEYS 2.48 0.870 KIDNEYS MICRO: MINERALIZATION, PAPILLARY TUBULAR 1
FINAL BODY WT(G) 285. STOMACH GROSS: AREA(S), DARK RED P
MULTIPLE, IRREGULARLY SHAPED, GLANDULAR PORTION
^==> STOMACH: EROSION
STOMACH MICRO: EROSION 1
FOCAL; GLANDULAR STOMACH
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
Page 943 of 4796
ANIMAL NO. 26497 GROUP 4: 75 PPM FEMALE SCHEDULED EUTH 09/24/08 DATE OF DEATH: 09/24/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 15.33 4.469 4,12
KIDNEYS 2.45 0.714 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 343. NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS
Page 944 of 4796
ANIMAL NO. 26495 GROUP 4: 75 PPM FEMALE SCHEDULED EUTH 09/24/08 DATE OF DEATH: 09/24/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.55 4.396 6,9
KIDNEYS 2.48 0.749 KIDNEYS MICRO: MINERALIZATION 1
FINAL BODY WT(G) 331. AT CORTICOMEDULLARY JUNCTION
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 945 of 4796
ANIMAL NO. 26499 GROUP 4: 75 PPM FEMALE SCHEDULED EUTH 09/25/08 DATE OF DEATH: 09/25/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 15.46 4.786 7,10
KIDNEYS 2.70 0.836 KIDNEYS MICRO: MINERALIZATION 1
FINAL BODY WT(G) 323. AT CORTICOMEDULLARY JUNCTION
INFILTRATE, MONONUCLEAR 1
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
Page 946 of 4796
ANIMAL NO. 26494 GROUP 4: 75 PPM FEMALE SCHEDULED EUTH 09/24/08 DATE OF DEATH: 09/24/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.24 4.302 4,8
KIDNEYS 2.05 0.619 KIDNEYS MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 331. LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 947 of 4796
ANIMAL NO. 26533 GROUP 4: 75 PPM FEMALE SCHEDULED EUTH 09/25/08 DATE OF DEATH: 09/25/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 13.95 4.387 10,6
KIDNEYS 2.36 0.742 KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1
FINAL BODY WT(G) 318. MINERALIZATION 1
AT CORTICOMEDULLARY JUNCTION
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
Page 948 of 4796
ANIMAL NO. 26502 GROUP 4: 75 PPM FEMALE SCHEDULED EUTH 09/25/08 DATE OF DEATH: 09/25/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 15.08 4.346 11,7
KIDNEYS 2.69 0.775 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 347. NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS
Page 949 of 4796
ANIMAL NO. 26451 GROUP 4: 75 PPM FEMALE SCHEDULED EUTH 09/25/08 DATE OF DEATH: 09/25/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 15.15 4.417 5,12
KIDNEYS 2.34 0.682 KIDNEYS MICRO: MINERALIZATION 1
FINAL BODY WT(G) 343. AT CORTICOMEDULLARY JUNCTION
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 950 of 4796
ANIMAL NO. 26535 GROUP 4: 75 PPM FEMALE SCHEDULED EUTH 09/25/08 DATE OF DEATH: 09/25/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 13.59 4.274 7,11
KIDNEYS 2.25 0.708 KIDNEYS GROSS: AREA(S), DEPRESSED P
FINAL BODY WT(G) 318. MULTIPLE, PINPOINT, IN CORTEX, RIGHT
KIDNEYS MICRO: INFILTRATE, MONONUCLEAR 1
NO CORRELATE TO GROSS DEPRESSED AREA(S)
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE LIVER LYMPH NODE, MES
LUNGS MAMMARY GLAND OVIDUCTS OVARIES
PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND
SKIN SPLEEN STOMACH THYMUS
Page 951 of 4796
ANIMAL NO. 26456 GROUP 4: 75 PPM FEMALE SCHEDULED EUTH 09/25/08 DATE OF DEATH: 09/25/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.03 4.126 8,11
KIDNEYS 2.35 0.691 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 340. NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS
Page 952 of 4796
ANIMAL NO. 26518 GROUP 4: 75 PPM FEMALE SCHEDULED EUTH 09/26/08 DATE OF DEATH: 09/26/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 13.81 4.329 6,7
KIDNEYS 2.72 0.853 KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1
FINAL BODY WT(G) 319. LIVER MICRO: INFILTRATE, MONONUCLEAR 1
THYMUS GROSS: AREA(S), DARK RED P
MULTIPLE, 1 MM IN DIAMETER
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYROID GLANDS TRACHEA URINARY BLADDER UTERUS
Page 953 of 4796
ANIMAL NO. 26459 GROUP 4: 75 PPM FEMALE SCHEDULED EUTH 09/26/08 DATE OF DEATH: 09/26/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.35 4.362 3,11
KIDNEYS 2.54 0.772 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 329. STOMACH GROSS: AREA(S), DARK RED P
FEW, PINPOINT TO 1 MM IN DIAMETER, NONGLANDULAR PORTION
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN THYMUS
THYROID GLANDS TRACHEA URINARY BLADDER UTERUS
CERVIX VAGINA DIAPHRAGM
Page 954 of 4796
MICRO:KIDNEYS
ANIMAL NO. 23198 GROUP 5: 750 PPM FEMALE SCHEDULED EUTH 08/26/08 DATE OF DEATH: 08/26/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 16.95 5.313 10,5
KIDNEYS 2.35 0.737 KIDNEYS GROSS: AREA(S), DEPRESSED P
FINAL BODY WT(G) 319. ONE, PINPOINT, IN CORTEX, LEFT
KIDNEYS GROSS: PALE P
BILATERAL
KIDNEYS MICRO: NO SIGNIFICANT CHANGES OBSERVED
NO CORRELATES TO GROSS PALLOR OR DEPRESSED AREA(S)
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE LIVER LYMPH NODE, MES
LUNGS MAMMARY GLAND OVIDUCTS OVARIES
Page 955 of 4796
ANIMAL NO. 23233 GROUP 5: 750 PPM FEMALE SCHEDULED EUTH 08/26/08 DATE OF DEATH: 08/26/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 15.69 4.432 7,6
KIDNEYS 2.62 0.740 KIDNEYS MICRO: MINERALIZATION 2
FINAL BODY WT(G) 354. AT CORTICOMEDULLARY JUNCTION
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 956 of 4796
ANIMAL NO. 23241 GROUP 5: 750 PPM FEMALE SCHEDULED EUTH 08/27/08 DATE OF DEATH: 08/27/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 17.35 5.014 8,7
KIDNEYS 2.70 0.780 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 346. NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS
Page 957 of 4796
ANIMAL NO. 23239 GROUP 5: 750 PPM FEMALE SCHEDULED EUTH 08/28/08 DATE OF DEATH: 08/28/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 17.17 4.977 7,7
KIDNEYS 2.73 0.791 KIDNEYS MICRO: MINERALIZATION 1
FINAL BODY WT(G) 345. AT CORTICOMEDULLARY JUNCTION
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 958 of 4796
ANIMAL NO. 23245 GROUP 5: 750 PPM FEMALE SCHEDULED EUTH 08/27/08 DATE OF DEATH: 08/27/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 15.45 5.133 9,8
KIDNEYS 2.64 0.877 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 301. NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS
Page 959 of 4796
ANIMAL NO. 23223 GROUP 5: 750 PPM FEMALE SCHEDULED EUTH 08/28/08 DATE OF DEATH: 08/28/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 16.22 4.595 9,8
KIDNEYS 2.97 0.841 KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1
FINAL BODY WT(G) 353. LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 960 of 4796
ANIMAL NO. 23191 GROUP 5: 750 PPM FEMALE SCHEDULED EUTH 08/28/08 DATE OF DEATH: 08/28/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 18.21 5.603 6,10
KIDNEYS 2.29 0.705 KIDNEYS MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 325. LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 961 of 4796
ANIMAL NO. 23247 GROUP 5: 750 PPM FEMALE SCHEDULED EUTH 08/28/08 DATE OF DEATH: 08/28/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.41 4.129 11,7
KIDNEYS 2.76 0.791 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 349. NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS
Page 962 of 4796
ANIMAL NO. 23230 GROUP 5: 750 PPM FEMALE SCHEDULED EUTH 08/27/08 DATE OF DEATH: 08/27/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 18.18 5.022 7,9
KIDNEYS 3.01 0.831 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 362. NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS
Page 963 of 4796
ANIMAL NO. 23249 GROUP 5: 750 PPM FEMALE SCHEDULED EUTH 08/29/08 DATE OF DEATH: 08/29/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 12.91 3.912 6,10
KIDNEYS 2.47 0.748 KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1
FINAL BODY WT(G) 330. MINERALIZATION, PAPILLARY TUBULAR 1
CYST P
MEDULLA; UNILATERAL
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
Page 964 of 4796
ANIMAL NO. 23258 GROUP 5: 750 PPM FEMALE SCHEDULED EUTH 08/29/08 DATE OF DEATH: 08/29/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 12.01 3.837 4,8
KIDNEYS 2.09 0.668 KIDNEYS MICRO: MINERALIZATION 2
FINAL BODY WT(G) 313. AT CORTICOMEDULLARY JUNCTION
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 965 of 4796
ANIMAL NO. 26478 GROUP 5: 750 PPM FEMALE SCHEDULED EUTH 09/24/08 DATE OF DEATH: 09/24/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 13.71 4.056 9,4
KIDNEYS 2.41 0.713 KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1
FINAL BODY WT(G) 338. LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 966 of 4796
ANIMAL NO. 26501 GROUP 5: 750 PPM FEMALE SCHEDULED EUTH 09/24/08 DATE OF DEATH: 09/24/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.88 4.769 7,10
KIDNEYS 2.44 0.782 KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1
FINAL BODY WT(G) 312. LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 967 of 4796
ANIMAL NO. 26486 GROUP 5: 750 PPM FEMALE SCHEDULED EUTH 09/25/08 DATE OF DEATH: 09/25/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 12.47 4.375 6,9
KIDNEYS 2.24 0.786 KIDNEYS MICRO: MINERALIZATION 1
FINAL BODY WT(G) 285. AT CORTICOMEDULLARY JUNCTION
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
HEMATOPOIESIS, EXTRAMEDULLARY 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
Page 968 of 4796
ANIMAL NO. 26464 GROUP 5: 750 PPM FEMALE SCHEDULED EUTH 09/25/08 DATE OF DEATH: 09/25/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.44 4.336 7,6
KIDNEYS 2.52 0.757 KIDNEYS MICRO: BASOPHILIC TUBULES 1
FINAL BODY WT(G) 333. LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 969 of 4796
ANIMAL NO. 26498 GROUP 5: 750 PPM FEMALE SCHEDULED EUTH 09/24/08 DATE OF DEATH: 09/24/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.20 4.201 7,12
KIDNEYS 2.64 0.781 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 338. HEMATOPOIESIS, EXTRAMEDULLARY 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS
Page 970 of 4796
ANIMAL NO. 26481 GROUP 5: 750 PPM FEMALE SCHEDULED EUTH 09/25/08 DATE OF DEATH: 09/25/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1
LIVER 16.72 4.710 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
KIDNEYS 2.53 0.713 NO SIGNIFICANT
FINAL BODY WT(G) 355. CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
ANIMAL NO. 26472 GROUP 5: 750 PPM FEMALE SCHEDULED EUTH 09/24/08 DATE OF DEATH: 09/24/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.15 4.262 8,10
KIDNEYS 2.46 0.741 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 332. NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS
Page 972 of 4796
ANIMAL NO. 26537 GROUP 5: 750 PPM FEMALE SCHEDULED EUTH 09/25/08 DATE OF DEATH: 09/25/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 15.36 4.327 10,8
KIDNEYS 2.91 0.820 KIDNEYS MICRO: MINERALIZATION 1
FINAL BODY WT(G) 355. LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NECROSIS 1
FOCAL
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
Page 973 of 4796
ANIMAL NO. 26506 GROUP 5: 750 PPM FEMALE SCHEDULED EUTH 09/24/08 DATE OF DEATH: 09/24/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 15.04 4.398 6,11
KIDNEYS 2.46 0.719 KIDNEYS MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 342. LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 974 of 4796
ANIMAL NO. 26471 GROUP 5: 750 PPM FEMALE SCHEDULED EUTH 09/26/08 DATE OF DEATH: 09/26/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.64 4.618 6,9
KIDNEYS 2.36 0.744 KIDNEYS MICRO: MINERALIZATION 1
FINAL BODY WT(G) 317. AT CORTICOMEDULLARY JUNCTION
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 975 of 4796
ANIMAL NO. 26455 GROUP 5: 750 PPM FEMALE SCHEDULED EUTH 09/26/08 DATE OF DEATH: 09/26/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 12.92 4.336 9,6
KIDNEYS 2.12 0.711 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 298. NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS
Page 976 of 4796
ANIMAL NO. 23255 GROUP 6: 2250 PPM FEMALE SCHEDULED EUTH 08/26/08 DATE OF DEATH: 08/26/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.73 4.960 8,8
KIDNEYS 2.30 0.774 SKIN GROSS: HAIR LOSS P
FINAL BODY WT(G) 297. ALL EXTERNAL SURFACES
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SPLEEN STOMACH THYMUS
THYROID GLANDS TRACHEA URINARY BLADDER UTERUS
CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS LIVER
Page 977 of 4796
ANIMAL NO. 23215 GROUP 6: 2250 PPM FEMALE SCHEDULED EUTH 08/27/08 DATE OF DEATH: 08/27/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 17.62 5.356 9,8
KIDNEYS 2.46 0.748 KIDNEYS MICRO: MINERALIZATION 1
FINAL BODY WT(G) 329. AT CORTICOMEDULLARY JUNCTION
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:LIVER
Page 978 of 4796
ANIMAL NO. 23214 GROUP 6: 2250 PPM FEMALE SCHEDULED EUTH 08/27/08 DATE OF DEATH: 08/27/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 17.23 5.318 5,9
KIDNEYS 2.54 0.784 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 324. NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS
Page 979 of 4796
ANIMAL NO. 23192 GROUP 6: 2250 PPM FEMALE SCHEDULED EUTH 08/27/08 DATE OF DEATH: 08/27/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 13.58 4.867 8,7
KIDNEYS 2.39 0.857 KIDNEYS GROSS: AREA(S), DEPRESSED P
FINAL BODY WT(G) 279. ONE, IRREGULARLY SHAPED, IN CORTEX, RIGHT
KIDNEYS MICRO: MINERALIZATION 2
NO CORRELATE TO GROSS DEPRESSED AREA(S)
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE LIVER LYMPH NODE, MES
LUNGS MAMMARY GLAND OVIDUCTS OVARIES
PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND
SKIN SPLEEN STOMACH THYMUS
THYROID GLANDS TRACHEA URINARY BLADDER UTERUS
Page 980 of 4796
ANIMAL NO. 23219 GROUP 6: 2250 PPM FEMALE SCHEDULED EUTH 08/28/08 DATE OF DEATH: 08/28/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.60 4.479 7,9
KIDNEYS 2.34 0.718 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 326. NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS
Page 981 of 4796
ANIMAL NO. 23211 GROUP 6: 2250 PPM FEMALE SCHEDULED EUTH 08/28/08 DATE OF DEATH: 08/28/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.08 4.319 9,5
KIDNEYS 2.55 0.782 KIDNEYS MICRO: MINERALIZATION 1
FINAL BODY WT(G) 326. AT CORTICOMEDULLARY JUNCTION
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:LIVER
Page 982 of 4796
ANIMAL NO. 23189 GROUP 6: 2250 PPM FEMALE SCHEDULED EUTH 08/28/08 DATE OF DEATH: 08/28/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 13.51 4.235 11,7
KIDNEYS 2.50 0.784 KIDNEYS MICRO: CYST P
FINAL BODY WT(G) 319. MEDULLA; UNILATERAL
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 983 of 4796
ANIMAL NO. 23204 GROUP 6: 2250 PPM FEMALE SCHEDULED EUTH 08/28/08 DATE OF DEATH: 08/28/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.48 4.611 8,10
KIDNEYS 2.42 0.771 NO SIGNIFICANT
FINAL BODY WT(G) 314. CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS LIVER
ANIMAL NO. 23257 GROUP 6: 2250 PPM FEMALE SCHEDULED EUTH 08/27/08 DATE OF DEATH: 08/27/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 18.94 5.037 9,9
KIDNEYS 2.68 0.713 KIDNEYS MICRO: MINERALIZATION 2
FINAL BODY WT(G) 376. AT CORTICOMEDULLARY JUNCTION
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 985 of 4796
ANIMAL NO. 23234 GROUP 6: 2250 PPM FEMALE SCHEDULED EUTH 08/28/08 DATE OF DEATH: 08/28/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 13.76 3.977 12,4
KIDNEYS 2.77 0.801 KIDNEYS GROSS: DILATED PELVIS 2
FINAL BODY WT(G) 346. RIGHT
^==> KIDNEYS: HYDRONEPHROSIS
KIDNEYS MICRO: BASOPHILIC TUBULES 3
IN HYDRONEPHROTIC KIDNEY
HYDRONEPHROSIS 2
UNILATERAL
LIVER GROSS: DISCOLORATION, DARK RED P
CAUDATE LOBE
^==> LIVER: HEMORRHAGE
^==> LIVER: PIGMENT, BROWN
Page 986 of 4796
ANIMAL NO. 23234 GROUP 6: 2250 PPM FEMALE SCHEDULED EUTH 08/28/08 DATE OF DEATH: 08/28/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
URETERS GROSS: DISTENDED 1
BILATERAL
^==> URETERS: DILATATION, LUMEN
URETERS MICRO: DILATATION, LUMEN 2
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE LYMPH NODE, MES LUNGS
MAMMARY GLAND OVIDUCTS OVARIES PANCREAS
PITUITARY SPINAL CORD SAL. GLAND MAND SKIN
SPLEEN STOMACH THYMUS THYROID GLANDS
TRACHEA URINARY BLADDER UTERUS CERVIX
VAGINA
Page 987 of 4796
ANIMAL NO. 23227 GROUP 6: 2250 PPM FEMALE SCHEDULED EUTH 08/28/08 DATE OF DEATH: 08/28/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 15.17 4.347 7,9
KIDNEYS 3.02 0.865 KIDNEYS MICRO: MINERALIZATION 2
FINAL BODY WT(G) 349. AT CORTICOMEDULLARY JUNCTION
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 988 of 4796
ANIMAL NO. 26509 GROUP 6: 2250 PPM FEMALE SCHEDULED EUTH 09/23/08 DATE OF DEATH: 09/23/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 15.20 4.343 8,8
KIDNEYS 2.63 0.751 KIDNEYS MICRO: MINERALIZATION 1
FINAL BODY WT(G) 350. AT CORTICOMEDULLARY JUNCTION AND IN URINARY SPACE
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 989 of 4796
ANIMAL NO. 26448 GROUP 6: 2250 PPM FEMALE SCHEDULED EUTH 09/24/08 DATE OF DEATH: 09/24/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 16.26 4.418 7,8
KIDNEYS 2.74 0.745 KIDNEYS MICRO: MINERALIZATION 1
FINAL BODY WT(G) 368. AT CORTICOMEDULLARY JUNCTION
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 990 of 4796
ANIMAL NO. 26508 GROUP 6: 2250 PPM FEMALE SCHEDULED EUTH 09/24/08 DATE OF DEATH: 09/24/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.56 4.245 9,7
KIDNEYS 2.77 0.808 KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1
FINAL BODY WT(G) 343. LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 991 of 4796
ANIMAL NO. 26463 GROUP 6: 2250 PPM FEMALE SCHEDULED EUTH 09/25/08 DATE OF DEATH: 09/25/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 12.88 3.963 7,8
KIDNEYS 2.44 0.751 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 325. NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS
Page 992 of 4796
ANIMAL NO. 26504 GROUP 6: 2250 PPM FEMALE SCHEDULED EUTH 09/24/08 DATE OF DEATH: 09/24/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.56 4.439 8,8
KIDNEYS 2.51 0.765 KIDNEYS MICRO: MINERALIZATION 1
FINAL BODY WT(G) 328. AT CORTICOMEDULLARY JUNCTION
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 993 of 4796
ANIMAL NO. 26465 GROUP 6: 2250 PPM FEMALE SCHEDULED EUTH 09/25/08 DATE OF DEATH: 09/25/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.18 4.727 4,12
KIDNEYS 2.35 0.783 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 300. NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS
Page 994 of 4796
ANIMAL NO. 26477 GROUP 6: 2250 PPM FEMALE SCHEDULED EUTH 09/25/08 DATE OF DEATH: 09/25/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 13.43 4.107 7,7
KIDNEYS 2.34 0.716 KIDNEYS GROSS: DILATED PELVIS 3
FINAL BODY WT(G) 327. RIGHT
^==> KIDNEYS: HYDRONEPHROSIS
KIDNEYS MICRO: MINERALIZATION 1
AT CORTICOMEDULLARY JUNCTION
HYDRONEPHROSIS 2
UNILATERAL
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE LIVER LYMPH NODE, MES
Page 995 of 4796
ANIMAL NO. 26511 GROUP 6: 2250 PPM FEMALE SCHEDULED EUTH 09/25/08 DATE OF DEATH: 09/25/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.71 4.326 6,8
KIDNEYS 2.39 0.703 KIDNEYS MICRO: MINERALIZATION 1
FINAL BODY WT(G) 340. AT CORTICOMEDULLARY JUNCTION
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 996 of 4796
ANIMAL NO. 26466 GROUP 6: 2250 PPM FEMALE SCHEDULED EUTH 09/25/08 DATE OF DEATH: 09/25/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.77 4.294 11,7
KIDNEYS 2.53 0.735 KIDNEYS MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 344. LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 997 of 4796
ANIMAL NO. 26462 GROUP 6: 2250 PPM FEMALE SCHEDULED EUTH 09/25/08 DATE OF DEATH: 09/25/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 15.62 4.567 9,9
KIDNEYS 2.64 0.772 KIDNEYS MICRO: DILATATION, TUBULAR 1
FINAL BODY WT(G) 342. CORTEX; FOCAL
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
Page 998 of 4796
ANIMAL NO. 26523 GROUP 6: 2250 PPM FEMALE SCHEDULED EUTH 09/25/08 DATE OF DEATH: 09/25/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 14.69 4.258 7,12
KIDNEYS 2.38 0.690 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
FINAL BODY WT(G) 345. NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS
Page 999 of 4796
ANIMAL NO. 26470 GROUP 6: 2250 PPM FEMALE SCHEDULED EUTH 09/26/08 DATE OF DEATH: 09/26/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 15.33 5.026 9,9
KIDNEYS 2.18 0.715 KIDNEYS MICRO: MINERALIZATION 1
FINAL BODY WT(G) 305. AT CORTICOMEDULLARY JUNCTION
MINERALIZATION, PAPILLARY TUBULAR 1
UNILATERAL
INFILTRATE, MONONUCLEAR 1
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
LUNGS GROSS: AREA(S), DARK RED P
MULTIPLE, IRREGULARLY SHAPED, ALL LOBES
SKIN GROSS: MATTING, RED P
NASAL
NO SIGNIFICANT
Page 1000 of 4796
Volume 4 of 16
(Appendix A [Tables A18-A24])
STUDY TITLE
A DIETARY DEVELOPMENTAL
NEUROTOXICITY STUDY OF BISPHENOL A IN RATS
STUDY NUMBER
WIL-186056
DATA REQUIREMENT
STUDY DIRECTOR
26 June 2008
30 September 2009
PERFORMING LABORATORY
SPONSOR
APPENDIX A
TABLES A18-A24
0 PPM
DAM IMPLANTATION PUPS UNACCOUNTED
NO. SITES BORN SITES
-----------------------------------------------------------------------------------------------------------------------------------
23243 15 15 0
23213 16 15 1
23203 17 17 0
23207 15 14 1
23226 15 15 0
23242 18 17 1
23209 18 16 2
23178 17 15 2
23186 15 14 1
23194 17 17 0
23182 16 16 0
23240 16 15 1
26521 18 17 1
Page 1003 of 4796
26449 17 17 0
26473 15 15 0
26452 17 17 0
26491 14 14 0
26512 14 13 1
26454 16 15 1
26529 17 16 1
26453 18 17 1
26527 17 14 3
26489 19-A 20 A
-----------------------------------------------------------------------------------------------------------------------------------
MEAN 16.3 15.7 0.8
S.D. 1.28 1.55 0.81
S.E. 0.27 0.32 0.17
N 22 23 22
NOTE: ONLY DAMS THAT HAVE DELIVERED ONE OR MORE PUPS ARE INCLUDED IN CALCULATION OF MEAN.
A = NUMBER OF PUPS BORN EXCEEDED NUMBER OF IMPLANTATION SITES; VALUE NOT INCLUDED IN CALCULATION OF MEAN
TABLE A18 (F0)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC INDIVIDUAL IMPLANTATION SITES
0.15 PPM
DAM IMPLANTATION PUPS UNACCOUNTED
NO. SITES BORN SITES
-----------------------------------------------------------------------------------------------------------------------------------
23195 14 12 2
23180 17 16 1
23176 16 16 0
23251 15 15 0
23235 15 15 0
23231 14 13 1
23216 18 17 1
23261 15 13 2
23205 18 16 2
23181 17 14 3
23264 14 14 0
26474 20 17 3
26476 17 16 1
Page 1004 of 4796
26496 14 12 2
26505 12 12 0
26483 16 14 2
26479 15 14 1
26450 19 18 1
26457 19 17 2
26492 17 17 0
26493 21 21 0
26488 15 14 1
26520 16 16 0
-----------------------------------------------------------------------------------------------------------------------------------
MEAN 16.3 15.2 1.1
S.D. 2.20 2.19 1.00
S.E. 0.46 0.46 0.21
N 23 23 23
NOTE: ONLY DAMS THAT HAVE DELIVERED ONE OR MORE PUPS ARE INCLUDED IN CALCULATION OF MEAN.
TABLE A18 (F0)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 3
SPONSOR:ACC INDIVIDUAL IMPLANTATION SITES
1.5 PPM
DAM IMPLANTATION PUPS UNACCOUNTED
NO. SITES BORN SITES
-----------------------------------------------------------------------------------------------------------------------------------
23248 17 17 0
23217 21 21 0
23190 17 17 0
23236 15-A 16 A
23260 14 14 0
23221 15 14 1
23263 15 15 0
23253 17 17 0
23244 18 17 1
23218 18 17 1
23208 15 14 1
23252 17 17 0
26510 16 15 1
Page 1005 of 4796
26519 18 15 3
26468 15 13 2
26475 14 14 0
26532 17 16 1
26507 20 18 2
26480 18 18 0
26482 13 13 0
26522 15 14 1
26517 17 16 1
26514 17 16 1
26534 16 16 0
-----------------------------------------------------------------------------------------------------------------------------------
MEAN 16.5 15.8 0.7
S.D. 1.90 1.86 0.82
S.E. 0.40 0.38 0.17
N 23 24 23
NOTE: ONLY DAMS THAT HAVE DELIVERED ONE OR MORE PUPS ARE INCLUDED IN CALCULATION OF MEAN.
A = NUMBER OF PUPS BORN EXCEEDED NUMBER OF IMPLANTATION SITES; VALUE NOT INCLUDED IN CALCULATION OF MEAN
TABLE A18 (F0)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 4
SPONSOR:ACC INDIVIDUAL IMPLANTATION SITES
75 PPM
DAM IMPLANTATION PUPS UNACCOUNTED
NO. SITES BORN SITES
-----------------------------------------------------------------------------------------------------------------------------------
23179 10 10 0
23212 18 18 0
23201 15 14 1
23259 14 13 1
23210 17 16 1
23256 16 16 0
23238 19 19 0
23228 18 16 2
23246 17 7 10
23220 18 18 0
23183 13 12 1
23184 18 16 2
26516 15 15 0
Page 1006 of 4796
26497 16 16 0
26495 15 14 1
26499 17 17 0
26494 12 12 0
26533 16 15 1
26502 18 17 1
26451 17 17 0
26535 18 17 1
26456 19 18 1
26518 13 12 1
26459 14 13 1
-----------------------------------------------------------------------------------------------------------------------------------
MEAN 16.0 14.9 1.0
S.D. 2.35 2.87 2.01
S.E. 0.48 0.59 0.41
N 24 24 24
NOTE: ONLY DAMS THAT HAVE DELIVERED ONE OR MORE PUPS ARE INCLUDED IN CALCULATION OF MEAN.
TABLE A18 (F0)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 5
SPONSOR:ACC INDIVIDUAL IMPLANTATION SITES
750 PPM
DAM IMPLANTATION PUPS UNACCOUNTED
NO. SITES BORN SITES
-----------------------------------------------------------------------------------------------------------------------------------
23198 15 15 0
23233 13 12 1
23241 15 13 2
23254 17 11 6
23239 14 13 1
23245 17 14 3
23223 17 16 1
23191 16 16 0
23247 18 16 2
23230 16 16 0
23249 16 13 3
23258 12 12 0
26485 16 14 2
Page 1007 of 4796
26478 13 12 1
26501 17 17 0
26486 15 14 1
26464 13 13 0
26498 19 16 3
26472 18 18 0
26537 18 16 2
26506 17 17 0
26471 15 14 1
26455 15 14 1
-----------------------------------------------------------------------------------------------------------------------------------
MEAN 15.7 14.4 1.3
S.D. 1.86 1.90 1.46
S.E. 0.39 0.40 0.30
N 23 23 23
NOTE: ONLY DAMS THAT HAVE DELIVERED ONE OR MORE PUPS ARE INCLUDED IN CALCULATION OF MEAN.
TABLE A18 (F0)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 6
SPONSOR:ACC INDIVIDUAL IMPLANTATION SITES
2250 PPM
DAM IMPLANTATION PUPS UNACCOUNTED
NO. SITES BORN SITES
-----------------------------------------------------------------------------------------------------------------------------------
23255 16 16 0
23237 16 12 4-B
23215 17 16 1
23214 14 14 0
23192 15 13 2
23219 16 16 0
23211 14 14 0
23189 18 18 0
23204 18 18 0
23257 18 17 1
23234 16 15 1
23227 16 16 0
26509 16 13 3
Page 1008 of 4796
26448 15 15 0
26508 16 16 0
26463 15 15 0
26504 16 14 2
26465 16 15 1
26477 14 13 1
26511 14 14 0
26466 18 17 1
26462 18 17 1
26523 19 17 2
26470 18 17 1
-----------------------------------------------------------------------------------------------------------------------------------
MEAN 16.2 15.3 0.7
S.D. 1.50 1.69 0.86
S.E. 0.31 0.34 0.18
N 24 24 23
NOTE: ONLY DAMS THAT HAVE DELIVERED ONE OR MORE PUPS ARE INCLUDED IN CALCULATION OF MEAN.
B = FEMALE WAS FOUND DEAD ON LACTATION DAY 0 WITH 3 FETUSES AND 1 EARLY RESORPTION RETAINED IN UTERO; NOT INCLUDED IN
CALCULATION OF MEAN
PIISv4.09
12/17/2008
R:02/05/2009
TABLE A19 (F0 - LACTATION DAY 21)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G]
POFBWv4.14
12/17/2008
R:01/12/2009
TABLE A20 (F0 - LACTATION DAY 21)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G]
POFBWv4.14
12/17/2008
R:01/12/2009
TABLE A21 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC INDIVIDUAL LITTER VIABILITY
GROUP: 0 PPM
-----------------------------------------------------------------------------------------------------------------------------------
DAM # PND 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23243 ALIVE 15 15 15 15 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 7
SELECTE...ESTING 4
23213 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
23203 ALIVE 17 17 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
Page 1021 of 4796
CULLED 8
MISSING 1
SELECTE...ESTING 4
23207 ALIVE 14 14 14 14 8 8 8 8 7 7 7 7 7 7 7 7 7 7 7 7 7 0
SCHED. EUTH. 3
CULLED 6
MISSING 1
SELECTE...ESTING 4
23226 ALIVE 15 15 15 15 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
23242 ALIVE 17 17 17 17 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 9
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
SCHED. EUTH.= SCHEDULED EUTHANASIA, CULLED= CULLED ON SCHEDULED DAY
SELECTE...ESTING= SELECTED FOR POST-WEANING BEHAVIORAL TESTING
SCHEDULED CULL DAY IS PND 4
TABLE A21 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC INDIVIDUAL LITTER VIABILITY
GROUP: 0 PPM
-----------------------------------------------------------------------------------------------------------------------------------
DAM # PND 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23209 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
23178 ALIVE 15 15 15 15 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 7
SELECTE...ESTING 4
23186 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 6
Page 1022 of 4796
SELECTE...ESTING 4
23194 ALIVE 17 17 17 17 8 8 8 8 7 7 7 7 7 7 7 7 7 7 7 7 7 0
FOUND DEAD 1
SCHED. EUTH. 3
CULLED 8
MISSING 1
SELECTE...ESTING 4
23182 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
23240 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
SCHED. EUTH.= SCHEDULED EUTHANASIA, CULLED= CULLED ON SCHEDULED DAY
SELECTE...ESTING= SELECTED FOR POST-WEANING BEHAVIORAL TESTING
SCHEDULED CULL DAY IS PND 4
TABLE A21 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 3
SPONSOR:ACC INDIVIDUAL LITTER VIABILITY
GROUP: 0 PPM
-----------------------------------------------------------------------------------------------------------------------------------
DAM # PND 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
26521 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
26449 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
26473 ALIVE 15 15 15 15 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
Page 1023 of 4796
SCHED. EUTH. 4
CULLED 7
SELECTE...ESTING 4
26452 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
26491 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
26512 ALIVE 13 13 13 13 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 5
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
SCHED. EUTH.= SCHEDULED EUTHANASIA, CULLED= CULLED ON SCHEDULED DAY
SELECTE...ESTING= SELECTED FOR POST-WEANING BEHAVIORAL TESTING
SCHEDULED CULL DAY IS PND 4
TABLE A21 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 4
SPONSOR:ACC INDIVIDUAL LITTER VIABILITY
GROUP: 0 PPM
-----------------------------------------------------------------------------------------------------------------------------------
DAM # PND 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
26454 ALIVE 15 15 15 15 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 7
SELECTE...ESTING 4
26529 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
26453 ALIVE 17 17 17 17 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 9
Page 1024 of 4796
SELECTE...ESTING 4
26527 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
26489 ALIVE 18 17 17 17 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 2
SCHED. EUTH. 4
CULLED 9
MISSING 1
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
SCHED. EUTH.= SCHEDULED EUTHANASIA, CULLED= CULLED ON SCHEDULED DAY
SELECTE...ESTING= SELECTED FOR POST-WEANING BEHAVIORAL TESTING
SCHEDULED CULL DAY IS PND 4
TABLE A21 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 5
SPONSOR:ACC INDIVIDUAL LITTER VIABILITY
23180 ALIVE 16 16 15 15 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 7
SELECTE...ESTING 4
23176 ALIVE 16 16 15 15 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
Page 1025 of 4796
SCHED. EUTH. 4
CULLED 7
SELECTE...ESTING 4
23251 ALIVE 15 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 6
MISSING 1
SELECTE...ESTING 4
23235 ALIVE 13 13 13 13 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 2 1
SCHED. EUTH. 4
CULLED 4
SELECTE...ESTING 4
23231 ALIVE 13 13 13 13 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 5
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
SCHED. EUTH.= SCHEDULED EUTHANASIA, CULLED= CULLED ON SCHEDULED DAY
SELECTE...ESTING= SELECTED FOR POST-WEANING BEHAVIORAL TESTING
SCHEDULED CULL DAY IS PND 4
TABLE A21 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 6
SPONSOR:ACC INDIVIDUAL LITTER VIABILITY
23261 ALIVE 13 13 13 13 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 5
SELECTE...ESTING 4
23205 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
Page 1026 of 4796
CULLED 8
SELECTE...ESTING 4
23181 ALIVE 14 13 13 13 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 5
MISSING 1
SELECTE...ESTING 4
23264 ALIVE 13 13 13 13 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 5
SELECTE...ESTING 4
26474 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
SCHED. EUTH.= SCHEDULED EUTHANASIA, CULLED= CULLED ON SCHEDULED DAY
SELECTE...ESTING= SELECTED FOR POST-WEANING BEHAVIORAL TESTING
SCHEDULED CULL DAY IS PND 4
TABLE A21 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 7
SPONSOR:ACC INDIVIDUAL LITTER VIABILITY
26496 ALIVE 12 12 12 12 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 4
SELECTE...ESTING 4
26505 ALIVE 12 12 12 12 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
Page 1027 of 4796
CULLED 4
SELECTE...ESTING 4
26483 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
26479 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
26450 ALIVE 18 18 18 18 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 10
SELECTE...ESTING 4
26457 ALIVE 17 17 17 17 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 9
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
SCHED. EUTH.= SCHEDULED EUTHANASIA, CULLED= CULLED ON SCHEDULED DAY
SELECTE...ESTING= SELECTED FOR POST-WEANING BEHAVIORAL TESTING
SCHEDULED CULL DAY IS PND 4
TABLE A21 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 8
SPONSOR:ACC INDIVIDUAL LITTER VIABILITY
26493 ALIVE 21 21 21 20 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1 1
SCHED. EUTH. 4
CULLED 11
SELECTE...ESTING 4
26488 ALIVE 11 11 11 11 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 3
Page 1028 of 4796
SCHED. EUTH. 4
CULLED 3
SELECTE...ESTING 4
26520 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
SCHED. EUTH.= SCHEDULED EUTHANASIA, CULLED= CULLED ON SCHEDULED DAY
SELECTE...ESTING= SELECTED FOR POST-WEANING BEHAVIORAL TESTING
SCHEDULED CULL DAY IS PND 4
TABLE A21 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 9
SPONSOR:ACC INDIVIDUAL LITTER VIABILITY
23217 ALIVE 21 21 21 21 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 13
SELECTE...ESTING 4
23190 ALIVE 17 17 17 17 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
Page 1029 of 4796
CULLED 9
SELECTE...ESTING 4
23236 ALIVE 16 16 16 15 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1 1
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
23260 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
23221 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
23263 ALIVE 15 15 15 15 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 7
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
SCHED. EUTH.= SCHEDULED EUTHANASIA, CULLED= CULLED ON SCHEDULED DAY
SELECTE...ESTING= SELECTED FOR POST-WEANING BEHAVIORAL TESTING
SCHEDULED CULL DAY IS PND 4
TABLE A21 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 10
SPONSOR:ACC INDIVIDUAL LITTER VIABILITY
23244 ALIVE 17 17 17 17 8 8 7 7 7 7 7 7 7 6 6 6 6 6 6 6 6 0
FOUND DEAD 1 1
SCHED. EUTH. 2
CULLED 9
SELECTE...ESTING 4
23218 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
Page 1030 of 4796
FOUND DEAD 1 1
SCHED. EUTH. 4
CULLED 7
SELECTE...ESTING 4
23208 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
23252 ALIVE 17 17 16 16 8 8 8 8 7 7 7 7 7 7 7 7 7 7 7 7 7 0
FOUND DEAD 1 1
SCHED. EUTH. 3
CULLED 8
SELECTE...ESTING 4
26510 ALIVE 15 15 15 15 8 8 8 7 7 7 7 7 7 6 6 6 6 6 6 6 4 0
FOUND DEAD 1 1 2
SCHED. EUTH. 1
CULLED 7
SELECTE...ESTING 3
-----------------------------------------------------------------------------------------------------------------------------------
SCHED. EUTH.= SCHEDULED EUTHANASIA, CULLED= CULLED ON SCHEDULED DAY
SELECTE...ESTING= SELECTED FOR POST-WEANING BEHAVIORAL TESTING
SCHEDULED CULL DAY IS PND 4
TABLE A21 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 11
SPONSOR:ACC INDIVIDUAL LITTER VIABILITY
26468 ALIVE 12 12 12 12 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 4
SELECTE...ESTING 4
26475 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
Page 1031 of 4796
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
26532 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
26507 ALIVE 18 18 18 18 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 10
SELECTE...ESTING 4
26480 ALIVE 18 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
MISSING 2
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
SCHED. EUTH.= SCHEDULED EUTHANASIA, CULLED= CULLED ON SCHEDULED DAY
SELECTE...ESTING= SELECTED FOR POST-WEANING BEHAVIORAL TESTING
SCHEDULED CULL DAY IS PND 4
TABLE A21 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 12
SPONSOR:ACC INDIVIDUAL LITTER VIABILITY
26522 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
26517 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
Page 1032 of 4796
SELECTE...ESTING 4
26514 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
26534 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
SCHED. EUTH.= SCHEDULED EUTHANASIA, CULLED= CULLED ON SCHEDULED DAY
SELECTE...ESTING= SELECTED FOR POST-WEANING BEHAVIORAL TESTING
SCHEDULED CULL DAY IS PND 4
TABLE A21 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 13
SPONSOR:ACC INDIVIDUAL LITTER VIABILITY
GROUP: 75 PPM
-----------------------------------------------------------------------------------------------------------------------------------
DAM # PND 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23179 ALIVE 10 10 10 10 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 2
SELECTE...ESTING 4
23212 ALIVE 18 17 17 17 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 9
SELECTE...ESTING 4
23201 ALIVE 13 13 13 13 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1 1
Page 1033 of 4796
SCHED. EUTH. 4
CULLED 4
SELECTE...ESTING 4
23259 ALIVE 13 12 12 12 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 4
MISSING 1
SELECTE...ESTING 4
23210 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
23256 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
SCHED. EUTH.= SCHEDULED EUTHANASIA, CULLED= CULLED ON SCHEDULED DAY
SELECTE...ESTING= SELECTED FOR POST-WEANING BEHAVIORAL TESTING
SCHEDULED CULL DAY IS PND 4
TABLE A21 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 14
SPONSOR:ACC INDIVIDUAL LITTER VIABILITY
GROUP: 75 PPM
-----------------------------------------------------------------------------------------------------------------------------------
DAM # PND 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23238 ALIVE 19 18 18 18 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 10
MISSING 1
SELECTE...ESTING 4
23228 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
23246 ALIVE 7 7 7 7 0
SCHEDUL...OT MET 7
Page 1034 of 4796
23220 ALIVE 18 18 18 18 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 10
SELECTE...ESTING 4
23183 ALIVE 12 12 12 12 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 3
SELECTE...ESTING 4
23184 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
26516 ALIVE 10 5 5 5 0
FOUND DEAD 5 5
SCHEDUL...OT MET 5
-----------------------------------------------------------------------------------------------------------------------------------
SCHED. EUTH.= SCHEDULED EUTHANASIA, CULLED= CULLED ON SCHEDULED DAY
SCHEDUL...OT MET= SCHEDULED EUTHANASIA; SEX RATIO CRITERIA NOT MET
SELECTE...ESTING= SELECTED FOR POST-WEANING BEHAVIORAL TESTING
SCHEDULED CULL DAY IS PND 4
TABLE A21 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 15
SPONSOR:ACC INDIVIDUAL LITTER VIABILITY
GROUP: 75 PPM
-----------------------------------------------------------------------------------------------------------------------------------
DAM # PND 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
26497 ALIVE 16 16 15 15 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 7
MISSING 1
SELECTE...ESTING 4
26495 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
26499 ALIVE 17 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
Page 1035 of 4796
CULLED 8
MISSING 1
SELECTE...ESTING 4
26494 ALIVE 12 12 12 12 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 4
SELECTE...ESTING 4
26533 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
26502 ALIVE 14 14 14 13 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 3
SCHED. EUTH. 4
CULLED 5
MISSING 1
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
SCHED. EUTH.= SCHEDULED EUTHANASIA, CULLED= CULLED ON SCHEDULED DAY
SELECTE...ESTING= SELECTED FOR POST-WEANING BEHAVIORAL TESTING
SCHEDULED CULL DAY IS PND 4
TABLE A21 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 16
SPONSOR:ACC INDIVIDUAL LITTER VIABILITY
GROUP: 75 PPM
-----------------------------------------------------------------------------------------------------------------------------------
DAM # PND 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
26451 ALIVE 16 15 15 15 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 7
MISSING 1
SELECTE...ESTING 4
26535 ALIVE 17 17 17 17 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 9
SELECTE...ESTING 4
26456 ALIVE 18 18 18 18 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
Page 1036 of 4796
SCHED. EUTH. 4
CULLED 10
SELECTE...ESTING 4
26518 ALIVE 12 12 12 12 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 4
SELECTE...ESTING 4
26459 ALIVE 10 10 10 10 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 3
SCHED. EUTH. 4
CULLED 2
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
SCHED. EUTH.= SCHEDULED EUTHANASIA, CULLED= CULLED ON SCHEDULED DAY
SELECTE...ESTING= SELECTED FOR POST-WEANING BEHAVIORAL TESTING
SCHEDULED CULL DAY IS PND 4
TABLE A21 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 17
SPONSOR:ACC INDIVIDUAL LITTER VIABILITY
23233 ALIVE 9 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 0
FOUND DEAD 3 1
SCHED. EUTH. 3
MISSING 1
SELECTE...ESTING 4
23241 ALIVE 13 13 13 13 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
Page 1037 of 4796
CULLED 5
SELECTE...ESTING 4
23254 ALIVE 11 11 11 11 0
CULLED 3
SCHEDUL...OT MET 8
23239 ALIVE 12 12 12 12 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 4
SELECTE...ESTING 4
23245 ALIVE 13 13 13 13 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 5
SELECTE...ESTING 4
23223 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
SCHED. EUTH.= SCHEDULED EUTHANASIA, CULLED= CULLED ON SCHEDULED DAY
SCHEDUL...OT MET= SCHEDULED EUTHANASIA; SEX RATIO CRITERIA NOT MET
SELECTE...ESTING= SELECTED FOR POST-WEANING BEHAVIORAL TESTING
SCHEDULED CULL DAY IS PND 4
TABLE A21 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 18
SPONSOR:ACC INDIVIDUAL LITTER VIABILITY
23247 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
23230 ALIVE 16 16 16 15 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
Page 1038 of 4796
CULLED 7
MISSING 1
SELECTE...ESTING 4
23249 ALIVE 11 11 11 11 8 8 8 8 8 8 8 7 5 5 4 4 4 4 4 4 4 0
FOUND DEAD 2 1 2 1
SCHED. EUTH. 2
CULLED 3
SELECTE...ESTING 2
23258 ALIVE 12 12 12 12 8 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 0
EUTH. EXTREMIS 1
SCHED. EUTH. 3
CULLED 4
SELECTE...ESTING 4
26485 ALIVE 14 14 14 14 0
CULLED 6
SCHEDUL...OT MET 8
-----------------------------------------------------------------------------------------------------------------------------------
EUTH. EXTREMIS= EUTHANIZED IN EXTREMIS, SCHED. EUTH.= SCHEDULED EUTHANASIA, CULLED= CULLED ON SCHEDULED DAY
SCHEDUL...OT MET= SCHEDULED EUTHANASIA; SEX RATIO CRITERIA NOT MET
SELECTE...ESTING= SELECTED FOR POST-WEANING BEHAVIORAL TESTING
SCHEDULED CULL DAY IS PND 4
TABLE A21 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 19
SPONSOR:ACC INDIVIDUAL LITTER VIABILITY
26501 ALIVE 17 17 17 17 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 9
SELECTE...ESTING 4
26486 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 6
Page 1039 of 4796
SELECTE...ESTING 4
26464 ALIVE 13 13 13 13 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 5
SELECTE...ESTING 4
26498 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
26481 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
26472 ALIVE 18 17 17 17 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 9
MISSING 1
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
SCHED. EUTH.= SCHEDULED EUTHANASIA, CULLED= CULLED ON SCHEDULED DAY
SELECTE...ESTING= SELECTED FOR POST-WEANING BEHAVIORAL TESTING
SCHEDULED CULL DAY IS PND 4
TABLE A21 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 20
SPONSOR:ACC INDIVIDUAL LITTER VIABILITY
26506 ALIVE 17 17 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
MISSING 1
SELECTE...ESTING 4
26471 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
Page 1040 of 4796
CULLED 6
SELECTE...ESTING 4
26455 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
SCHED. EUTH.= SCHEDULED EUTHANASIA, CULLED= CULLED ON SCHEDULED DAY
SELECTE...ESTING= SELECTED FOR POST-WEANING BEHAVIORAL TESTING
SCHEDULED CULL DAY IS PND 4
TABLE A21 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 21
SPONSOR:ACC INDIVIDUAL LITTER VIABILITY
23237 ALIVE 0
DEATH OF DAM 12
23215 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
Page 1041 of 4796
23214 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
23192 ALIVE 13 12 12 12 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 4
SELECTE...ESTING 4
23219 ALIVE 15 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 6
MISSING 1
SELECTE...ESTING 4
23211 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
SCHED. EUTH.= SCHEDULED EUTHANASIA, CULLED= CULLED ON SCHEDULED DAY, DEATH OF DAM= SENT TO NECROPSY DUE TO DEATH OF DAM
SELECTE...ESTING= SELECTED FOR POST-WEANING BEHAVIORAL TESTING
SCHEDULED CULL DAY IS PND 4
TABLE A21 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 22
SPONSOR:ACC INDIVIDUAL LITTER VIABILITY
23204 ALIVE 18 17 15 15 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1 2
SCHED. EUTH. 4
CULLED 7
SELECTE...ESTING 4
23257 ALIVE 17 17 17 16 8 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 0
FOUND DEAD 1 1
Page 1042 of 4796
SCHED. EUTH. 3
CULLED 8
SELECTE...ESTING 4
23234 ALIVE 15 15 15 15 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 7
SELECTE...ESTING 4
23227 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
26509 ALIVE 13 13 13 13 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 5
SELECTE...ESTING 4
26448 ALIVE 15 15 15 15 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 7
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
SCHED. EUTH.= SCHEDULED EUTHANASIA, CULLED= CULLED ON SCHEDULED DAY
SELECTE...ESTING= SELECTED FOR POST-WEANING BEHAVIORAL TESTING
SCHEDULED CULL DAY IS PND 4
TABLE A21 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 23
SPONSOR:ACC INDIVIDUAL LITTER VIABILITY
26463 ALIVE 15 15 15 15 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 7
SELECTE...ESTING 4
26504 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 6
Page 1043 of 4796
SELECTE...ESTING 4
26465 ALIVE 15 14 13 13 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 5
MISSING 1 1
SELECTE...ESTING 4
26477 ALIVE 13 13 13 13 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 5
SELECTE...ESTING 4
26511 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
26466 ALIVE 17 17 17 17 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 9
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
SCHED. EUTH.= SCHEDULED EUTHANASIA, CULLED= CULLED ON SCHEDULED DAY
SELECTE...ESTING= SELECTED FOR POST-WEANING BEHAVIORAL TESTING
SCHEDULED CULL DAY IS PND 4
TABLE A21 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 24
SPONSOR:ACC INDIVIDUAL LITTER VIABILITY
26523 ALIVE 17 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
Page 1044 of 4796
26470 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
SCHED. EUTH.= SCHEDULED EUTHANASIA, CULLED= CULLED ON SCHEDULED DAY
SELECTE...ESTING= SELECTED FOR POST-WEANING BEHAVIORAL TESTING
SCHEDULED CULL DAY IS PND 4
PPVIAv4.02
12/17/2008
TABLE A22 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC INDIVIDUAL PUP VIABILITY
--------------------------------------------------------
LITTERS FROM GROUP 1: 0 PPM
--------------------------------------------------------
DAY OF
DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23243 04-AUG-08 a21 e21 a21 C e21 C C C C a21 C e21 C e21 a21
M M M M M M M M M F F F F F F
23213 05-AUG-08 0 e21 e21 a21 C C C a21 a21 e21 C C e21 C a21
M M M M F F F F F F F F F F F
23203 06-AUG-08 a21 C C a21 e21 C 2 e21 a21 C C e21 e21 C a21 C C
M M M M M M M M F F F F F F F F F
23226 06-AUG-08 a21 e21 e21 a21 a21 C C e21 C a21 C C e21 4 C
M M M M F F F F F F F F F F F
23242 06-AUG-08 C C C e21 a21 e21 C a21 C C a21 C C C e21 e21 a21
M M M M M M M M F F F F F F F F F
23209 07-AUG-08 C C e21 C a21 e21 C a21 C C C a21 C e21 e21 a21
M M M M M M M M M F F F F F F F
23178 07-AUG-08 a21 C e21 a21 C C e21 C C C e21 a21 e21 a21 C
M M M M M M M M F F F F F F F
23186 06-AUG-08 e21 e21 a21 C a21 C e21 e21 a21 C a21 C C C
M M M M M M F F F F F F F F
-----------------------------------------------------------------------------------------------------------------------------------
A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4
M = MALE, F = FEMALE, U = UNDETERMINED
a=SCHEDULED EUTHANASIA
e=SELECTED FOR POST-WEANING BEHAVIORAL TESTING
TABLE A22 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC INDIVIDUAL PUP VIABILITY
--------------------------------------------------------
LITTERS FROM GROUP 1: 0 PPM
--------------------------------------------------------
DAY OF
DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23194 07-AUG-08 e21 C 8 a21 C e21 C C C a21 C C e21 C a21 4 e21
M M M M M M M M F F F F F F F F F
23182 08-AUG-08 C C e21 a21 a21 C e21 C C a21 e21 a21 C C e21 C
M M M M M M M F F F F F F F F F
23240 08-AUG-08 0 a21 C C e21 e21 C a21 C C C e21 e21 a21 a21
M M M M M M M M M M M F F F F
26521 03-SEP-08 0 e21 e21 C a21 C C a21 C C C e21 C a21 C e21 a21
F M M M M M M M M M F F F F F F F
Page 1046 of 4796
26449 03-SEP-08 0 C C C e21 C e21 a21 a21 C C a21 C a21 e21 C e21
M M M M M M M M M M F F F F F F F
26473 03-SEP-08 C C e21 a21 a21 e21 C C a21 a21 e21 C e21 C C
M M M M M M M F F F F F F F F
26452 04-SEP-08 0 e21 a21 C a21 C C C C C e21 C a21 C e21 e21 a21
M M M M M M M M M M M F F F F F F
26491 04-SEP-08 C e21 a21 a21 e21 C a21 C e21 a21 C C C e21
M M M M M M F F F F F F F F
26512 04-SEP-08 e21 a21 e21 C e21 a21 a21 C C C a21 C e21
M M M F F F F F F F F F F
-----------------------------------------------------------------------------------------------------------------------------------
A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4
M = MALE, F = FEMALE, U = UNDETERMINED
a=SCHEDULED EUTHANASIA
e=SELECTED FOR POST-WEANING BEHAVIORAL TESTING
TABLE A22 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 3
SPONSOR:ACC INDIVIDUAL PUP VIABILITY
--------------------------------------------------------
LITTERS FROM GROUP 1: 0 PPM
--------------------------------------------------------
DAY OF
DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
26454 04-SEP-08 e21 e21 C a21 a21 C C a21 C C e21 C C a21 e21
M M M M M F F F F F F F F F F
26529 04-SEP-08 a21 e21 a21 e21 C C C C C a21 C a21 C e21 C e21
M M M M M F F F F F F F F F F F
26453 04-SEP-08 C C C C e21 C C C a21 C a21 C e21 a21 a21 e21 e21
M M M M M M M M M M M M M F F F F
26527 04-SEP-08 C C e21 C a21 a21 e21 C C C e21 a21 a21 e21
M M M M M M M M F F F F F F
Page 1047 of 4796
26489 05-SEP-08 0 0 C C C C e21 e21 a21 C a21 C a21 C e21 a21 e21 C C 1
F F M M M M M M M M M F F F F F F F F F
-----------------------------------------------------------------------------------------------------------------------------------
A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4
M = MALE, F = FEMALE, U = UNDETERMINED
a=SCHEDULED EUTHANASIA
e=SELECTED FOR POST-WEANING BEHAVIORAL TESTING
TABLE A22 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 4
SPONSOR:ACC INDIVIDUAL PUP VIABILITY
--------------------------------------------------------
LITTERS FROM GROUP 2: 0.15 PPM
--------------------------------------------------------
DAY OF
DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23195 05-AUG-08 a21 C C e21 a21 e21 C a21 C e21 a21 e21
M M M M M M M M M F F F
23180 06-AUG-08 C a21 e21 2 C a21 e21 C C a21 e21 e21 C C a21 C
M M M M M M M M F F F F F F F F
23176 05-AUG-08 e21 e21 a21 C C a21 C C C a21 C e21 a21 e21 2 C
M M M M M M M M M F F F F F F F
23251 06-AUG-08 e21 e21 C C a21 C C C C a21 a21 a21 e21 1 e21
M M M M M M M M M M F F F F F
Page 1048 of 4796
23235 06-AUG-08 0 0 4 a21 a21 e21 a21 e21 a21 e21 C C C e21 C
F F M M M M F M F F F F F F F
23231 06-AUG-08 C C e21 a21 C a21 e21 C C a21 a21 e21 e21
M M M M M M M M M F F F F
23216 07-AUG-08 0 e21 a21 C e21 C C a21 C C e21 C C C a21 a21 e21
F M M M M M M M M M F F F F F F F
23261 07-AUG-08 e21 a21 C e21 a21 C a21 C a21 e21 C e21 C
M M M M M M F F F F F F F
23205 07-AUG-08 a21 e21 C e21 a21 C a21 C C a21 C C C e21 C e21
M M M M M M F F F F F F F F F F
-----------------------------------------------------------------------------------------------------------------------------------
A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4
M = MALE, F = FEMALE, U = UNDETERMINED
a=SCHEDULED EUTHANASIA
e=SELECTED FOR POST-WEANING BEHAVIORAL TESTING
TABLE A22 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 5
SPONSOR:ACC INDIVIDUAL PUP VIABILITY
--------------------------------------------------------
LITTERS FROM GROUP 2: 0.15 PPM
--------------------------------------------------------
DAY OF
DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23181 08-AUG-08 C C e21 e21 a21 1 a21 a21 C C e21 e21 C a21
M M M M M M M F F F F F F F
23264 07-AUG-08 0 a21 a21 e21 e21 C e21 C C a21 a21 C e21 C
F M M M M M F F F F F F F F
26474 03-SEP-08 0 e21 a21 C e21 C C a21 C C C a21 e21 e21 C C a21
M M M M M M M M F F F F F F F F F
26476 03-SEP-08 0 C a21 C a21 e21 C e21 e21 C e21 C a21 C C a21
F M M M M M M M F F F F F F F F
Page 1049 of 4796
26496 03-SEP-08 a21 e21 a21 C e21 e21 e21 a21 C a21 C C
M M M M M F F F F F F F
26505 04-SEP-08 e21 C C a21 e21 C a21 C a21 e21 a21 e21
M M M M M M M M F F F F
26483 04-SEP-08 a21 e21 C e21 C C C a21 e21 C a21 a21 e21 C
M M M M M M M M F F F F F F
26479 04-SEP-08 a21 e21 e21 C a21 a21 e21 C C a21 C e21 C C
M M M M M F F F F F F F F F
26450 04-SEP-08 C e21 C C a21 e21 C a21 C C C C C C e21 e21 a21 a21
M M M M M M M M M F F F F F F F F F
-----------------------------------------------------------------------------------------------------------------------------------
A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4
M = MALE, F = FEMALE, U = UNDETERMINED
a=SCHEDULED EUTHANASIA
e=SELECTED FOR POST-WEANING BEHAVIORAL TESTING
TABLE A22 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 6
SPONSOR:ACC INDIVIDUAL PUP VIABILITY
--------------------------------------------------------
LITTERS FROM GROUP 2: 0.15 PPM
--------------------------------------------------------
DAY OF
DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
26457 03-SEP-08 C C e21 e21 C C C C a21 C a21 e21 C a21 e21 a21 C
M M M M M M M M M F F F F F F M F
26492 03-SEP-08 C C e21 C C a21 a21 C C a21 C e21 e21 a21 C C e21
M M M M M M M M M F F F F F F F M
26493 04-SEP-08 4 C C e21 C a21 a21 C C 3 e21 C C a21 C e21 C a21 C e21 C
M M M M M M M M M M M M F F F F F F F F F
26488 05-SEP-08 0 0 0 C a21 e21 e21 a21 a21 C a21 e21 C e21
F M F M M M M M F F F F F F
Page 1050 of 4796
26520 05-SEP-08 e21 a21 e21 a21 a21 C C e21 C C e21 C a21 C C C
M M M M F F F F F F F F F F F F
-----------------------------------------------------------------------------------------------------------------------------------
A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4
M = MALE, F = FEMALE, U = UNDETERMINED
a=SCHEDULED EUTHANASIA
e=SELECTED FOR POST-WEANING BEHAVIORAL TESTING
TABLE A22 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 7
SPONSOR:ACC INDIVIDUAL PUP VIABILITY
--------------------------------------------------------
LITTERS FROM GROUP 3: 1.5 PPM
--------------------------------------------------------
DAY OF
DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23248 04-AUG-08 1 C C C e21 a21 C e21 a21 a21 C C e21 e21 C a21 C
F M M M M M M M M F F F F F F F F
23217 05-AUG-08 C C a21 e21 C C C e21 a21 e21 a21 C C C C C C a21 C C e21
M M M M M M M M M F F F F F F F F F F F F
23190 05-AUG-08 a21 C e21 e21 a21 C C a21 C C C e21 C C a21 C e21
M M M M M M M F F F F F F F F F F
23236 06-AUG-08 a21 C C C C e21 a21 C e21 3 C e21 a21 e21 a21 4
M M M M M M M M M M F F F F F F
Page 1051 of 4796
23260 06-AUG-08 e21 C C e21 C a21 a21 C C e21 e21 a21 C a21
M M M M M M M F F F F F F F
23221 07-AUG-08 a21 C C a21 C e21 e21 C C e21 a21 a21 C e21
M M M M M M M M F F F F F F
23263 07-AUG-08 C a21 C C C e21 C e21 a21 e21 C C a21 e21 a21
M M M M M M M M M F F F F F F
23253 07-AUG-08 0 C e21 e21 a21 C C a21 C C C C C e21 a21 e21 a21
M M M M M M M M M M M M F F F F F
-----------------------------------------------------------------------------------------------------------------------------------
A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4
M = MALE, F = FEMALE, U = UNDETERMINED
a=SCHEDULED EUTHANASIA
e=SELECTED FOR POST-WEANING BEHAVIORAL TESTING
TABLE A22 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 8
SPONSOR:ACC INDIVIDUAL PUP VIABILITY
--------------------------------------------------------
LITTERS FROM GROUP 3: 1.5 PPM
--------------------------------------------------------
DAY OF
DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23218 07-AUG-08 0 C e21 C a21 4 C a21 C C a21 C C e21 e21 e21 a21
F M M M M M M M M F F F F M F F F
23208 07-AUG-08 a21 C C a21 e21 C C e21 C C a21 a21 e21 e21
M M M M M M M M F F F F F F
26519 02-SEP-08 C 2 a21 e21 C a21 e21 e21 a21 C a21 C C C e21
F M M M M M M F F F F F F F F
26468 03-SEP-08 0 a21 e21 e21 a21 C C C e21 a21 C a21 e21
F M M M M M M M F F F F F
26475 04-SEP-08 a21 a21 e21 C e21 a21 C C e21 C C C a21 e21
M M M F M F F F F F F F F F
26532 03-SEP-08 C C e21 e21 C a21 C a21 C e21 C C a21 a21 C e21
M M M M M M M M F F F F F F F F
26507 03-SEP-08 C a21 e21 e21 C C C a21 C C C C a21 e21 C e21 C a21
F M M M M M M M M F F F F F F F F F
-----------------------------------------------------------------------------------------------------------------------------------
A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4
M = MALE, F = FEMALE, U = UNDETERMINED
a=SCHEDULED EUTHANASIA
e=SELECTED FOR POST-WEANING BEHAVIORAL TESTING
TABLE A22 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 9
SPONSOR:ACC INDIVIDUAL PUP VIABILITY
--------------------------------------------------------
LITTERS FROM GROUP 3: 1.5 PPM
--------------------------------------------------------
DAY OF
DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
26480 04-SEP-08 C a21 a21 e21 e21 C C 1 C C e21 C e21 C a21 a21 1 C
M M M M M M M M M F F F F F F F F F
26482 04-SEP-08 e21 C a21 C e21 a21 a21 C C C a21 e21 e21
M M M M M M F F F F F F F
26522 04-SEP-08 e21 a21 a21 e21 a21 a21 C C C e21 C e21 C C
M M M M F F F F F F F F F F
26517 05-SEP-08 C a21 e21 e21 a21 C C a21 C C C e21 C e21 C a21
M M M M M M M F F F F F F F F F
Page 1053 of 4796
26514 05-SEP-08 a21 C C C C e21 e21 a21 C C C C a21 e21 e21 a21
M M M M M M M M M F F F F F F F
26534 05-SEP-08 e21 C C a21 a21 e21 C a21 C a21 C C e21 C C e21
M M M M M M F F F F F F F F F F
-----------------------------------------------------------------------------------------------------------------------------------
A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4
M = MALE, F = FEMALE, U = UNDETERMINED
a=SCHEDULED EUTHANASIA
e=SELECTED FOR POST-WEANING BEHAVIORAL TESTING
TABLE A22 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 10
SPONSOR:ACC INDIVIDUAL PUP VIABILITY
--------------------------------------------------------
LITTERS FROM GROUP 4: 75 PPM
--------------------------------------------------------
DAY OF
DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23179 05-AUG-08 a21 a21 e21 e21 C e21 C e21 a21 a21
M M M M F F F F F F
23212 06-AUG-08 1 e21 C C C C e21 a21 a21 C e21 C C C e21 a21 a21 C
F M M M M M M M M F F F F F F F F F
23201 06-AUG-08 0 e21 a21 e21 C e21 C e21 a21 C a21 4 C a21
F M M M F F F F F F F F F F
23259 07-AUG-08 1 e21 a21 C e21 a21 C C e21 a21 e21 C a21
F M M M M M F F F F F F F
Page 1054 of 4796
23210 07-AUG-08 a21 C e21 C C a21 C C e21 C C a21 C e21 a21 e21
M M M M M M M M M M F F F F F F
23256 07-AUG-08 C C C a21 C C a21 e21 e21 C e21 C e21 a21 C a21
M M M M M M M M M F F F F F F F
23238 07-AUG-08 C a21 e21 e21 C C a21 e21 a21 C C C e21 C C a21 C C 1
M M M M M M M F F F F F F F F F F F F
23228 07-AUG-08 C C a21 e21 a21 C e21 a21 C e21 a21 e21 C C C C
M M M M M M M F F F F F F F F F
23246 07-AUG-08 b4 b4 b4 b4 b4 b4 b4
M M M M M F F
-----------------------------------------------------------------------------------------------------------------------------------
A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4
M = MALE, F = FEMALE, U = UNDETERMINED
a=SCHEDULED EUTHANASIA
b=SCHEDULED EUTHANASIA; SEX RATIO CRITERIA NOT MET
e=SELECTED FOR POST-WEANING BEHAVIORAL TESTING
TABLE A22 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 11
SPONSOR:ACC INDIVIDUAL PUP VIABILITY
--------------------------------------------------------
LITTERS FROM GROUP 4: 75 PPM
--------------------------------------------------------
DAY OF
DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23220 07-AUG-08 C C C C C C a21 a21 e21 C e21 C a21 a21 e21 C C e21
M M M M M M M M M M M M F F F F F F
23183 08-AUG-08 a21 C C e21 4 e21 a21 e21 C a21 a21 e21
M M M M M M M F F F F F
23184 08-AUG-08 e21 C a21 C C e21 a21 e21 C C C C C a21 e21 a21
M M M M M M M F F F F F F F F F
26516 02-SEP-08 0 0 1 1 b4 0 0 0 1 1 b4 b4 b4 b4 1
M M M M M F F F F F M M F F F
Page 1055 of 4796
26497 03-SEP-08 e21 C 2 C C e21 C C a21 a21 a21 C e21 C a21 e21
M M M M M M M M M M F F F F F F
26495 03-SEP-08 e21 C e21 C a21 a21 C C a21 a21 C e21 C e21
M M M M M M M F F F F F F F
26499 04-SEP-08 C 1 C a21 C e21 e21 a21 C e21 a21 e21 C a21 C C C
M M M M M M M M F F F F F F F F F
26494 03-SEP-08 e21 C a21 e21 C a21 C a21 e21 a21 C e21
M M M M M M F F F F F F
26533 04-SEP-08 0 C a21 C e21 e21 a21 e21 e21 C C a21 C a21 C
U M M M M M M F F F F F F F F
-----------------------------------------------------------------------------------------------------------------------------------
A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4
M = MALE, F = FEMALE, U = UNDETERMINED
a=SCHEDULED EUTHANASIA
b=SCHEDULED EUTHANASIA; SEX RATIO CRITERIA NOT MET
e=SELECTED FOR POST-WEANING BEHAVIORAL TESTING
TABLE A22 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 12
SPONSOR:ACC INDIVIDUAL PUP VIABILITY
--------------------------------------------------------
LITTERS FROM GROUP 4: 75 PPM
--------------------------------------------------------
DAY OF
DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
26502 04-SEP-08 0 0 0 a21 e21 C C C e21 a21 e21 a21 e21 3 a21 C C
M M F M M M M M M M F F F F F F F
26451 04-SEP-08 0 e21 C e21 C a21 a21 1 C a21 a21 e21 e21 C C C C
F M M M M M M F F F F F F F F F F
26535 04-SEP-08 C C e21 a21 e21 C C a21 C C e21 C a21 e21 C a21 C
M M M M M M M M M F F F F F F F M
26456 04-SEP-08 e21 C C C a21 C C a21 C C e21 C C a21 a21 e21 C e21
M M M M M M M M M M M M F F F F F F
Page 1056 of 4796
26518 05-SEP-08 C a21 a21 e21 C e21 a21 e21 C a21 C e21
M M M M M M F F F F F F
26459 05-SEP-08 0 0 0 a21 e21 e21 a21 C a21 a21 e21 e21 C
M M F M M M M F F F F F F
-----------------------------------------------------------------------------------------------------------------------------------
A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4
M = MALE, F = FEMALE, U = UNDETERMINED
a=SCHEDULED EUTHANASIA
e=SELECTED FOR POST-WEANING BEHAVIORAL TESTING
TABLE A22 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 13
SPONSOR:ACC INDIVIDUAL PUP VIABILITY
--------------------------------------------------------
LITTERS FROM GROUP 5: 750 PPM
--------------------------------------------------------
DAY OF
DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23198 05-AUG-08 a21 C C C C e21 a21 e21 C C a21 e21 C a21 e21
M M M M M M M M F F F F F F F
23241 06-AUG-08 C C a21 a21 e21 e21 C a21 e21 e21 a21 C C
M M M M M M M F F F F F F
23254 08-AUG-08 b4 b4 b4 C C b4 b4 C b4 b4 b4
M M F F F F F F F F F
Page 1057 of 4796
23239 07-AUG-08 0 e21 e21 a21 a21 C C a21 e21 a21 C C e21
F M M M M F F F F F F F F
23245 06-AUG-08 0 a21 a21 e21 e21 C a21 C C a21 e21 C C e21
M M M M M F F F F F F F F F
23223 07-AUG-08 C a21 C C e21 a21 C e21 C C e21 C a21 C e21 a21
M M M M M M M M M M F F F F F F
23191 07-AUG-08 e21 1 C a21 C e21 C C a21 C a21 a21 C e21 e21 C
M M M M M M M M M F F F F F F F
23247 07-AUG-08 C a21 C C e21 a21 e21 C C C C a21 e21 C a21 e21
M M M M M M M M F F F F F F F F
-----------------------------------------------------------------------------------------------------------------------------------
A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4
M = MALE, F = FEMALE, U = UNDETERMINED
a=SCHEDULED EUTHANASIA
b=SCHEDULED EUTHANASIA; SEX RATIO CRITERIA NOT MET
e=SELECTED FOR POST-WEANING BEHAVIORAL TESTING
TABLE A22 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 14
SPONSOR:ACC INDIVIDUAL PUP VIABILITY
--------------------------------------------------------
LITTERS FROM GROUP 5: 750 PPM
--------------------------------------------------------
DAY OF
DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23230 06-AUG-08 C C a21 C a21 e21 e21 C 3 e21 a21 e21 C C a21 C
M M M M M M M M F F F F F F F F
26485 02-SEP-08 C b4 b4 b4 C C C C b4 b4 b4 C b4 b4
M M M M M M M M M M M M F F
Page 1058 of 4796
26478 03-SEP-08 a21 a21 e21 e21 C C e21 a21 e21 a21 C C
M M M M F F F F F F F F
26501 03-SEP-08 C C a21 C C e21 a21 e21 C e21 C C C C a21 e21 a21
M M M M M M M M M F F F F F F F F
26486 04-SEP-08 e21 e21 a21 C a21 C C a21 C e21 C C a21 e21
M M M M M M M F F F F F F F
26464 04-SEP-08 C a21 e21 C a21 e21 C e21 a21 e21 a21 C C
M M M M M M M F F F F F F
26498 03-SEP-08 C C e21 e21 a21 a21 C C a21 C C a21 C e21 e21 C
M M M M M M F F F F F F F F F F
-----------------------------------------------------------------------------------------------------------------------------------
A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4
M = MALE, F = FEMALE, U = UNDETERMINED
a=SCHEDULED EUTHANASIA
b=SCHEDULED EUTHANASIA; SEX RATIO CRITERIA NOT MET
e=SELECTED FOR POST-WEANING BEHAVIORAL TESTING
TABLE A22 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 15
SPONSOR:ACC INDIVIDUAL PUP VIABILITY
--------------------------------------------------------
LITTERS FROM GROUP 5: 750 PPM
--------------------------------------------------------
DAY OF
DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
26481 04-SEP-08 a21 C a21 C C e21 e21 e21 C C a21 C e21 C C a21
M M M M M M M F F F F F F F F F
26472 03-SEP-08 1 e21 C C C a21 C a21 C e21 C e21 a21 e21 a21 C C C
F F M M M M M M M M M M F F F F F F
26537 04-SEP-08 e21 C C a21 C C C a21 a21 e21 a21 C e21 C e21 C
M M M M M M M M F F F F M F F F
26506 03-SEP-08 C a21 e21 a21 e21 C C C e21 2 C e21 a21 C C C a21
M M M M M F F F F F F F F F F F F
Page 1059 of 4796
26471 05-SEP-08 C e21 C C C C a21 a21 e21 e21 e21 C a21 a21
M M M M M M M M M F F F F F
26455 05-SEP-08 e21 a21 C C e21 a21 C C e21 e21 a21 a21 C C
M M M M M M F F F F F F F F
-----------------------------------------------------------------------------------------------------------------------------------
A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4
M = MALE, F = FEMALE, U = UNDETERMINED
a=SCHEDULED EUTHANASIA
e=SELECTED FOR POST-WEANING BEHAVIORAL TESTING
TABLE A22 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 16
SPONSOR:ACC INDIVIDUAL PUP VIABILITY
--------------------------------------------------------
LITTERS FROM GROUP 6: 2250 PPM
--------------------------------------------------------
DAY OF
DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23255 05-AUG-08 C a21 C e21 e21 C C a21 C C e21 a21 C e21 C a21
M M M M M M M M M M F F F F F F
23237 06-AUG-08 d0 d0 d0 d0 d0 d0 d0 d0 d0 d0 d0 d0
M M M M F F F F F F F F
23215 06-AUG-08 C e21 a21 C e21 a21 C C C C a21 a21 e21 C e21 C
M M M M M M M M M F F F F F F F
23214 06-AUG-08 C a21 C C e21 C e21 a21 C a21 e21 e21 C a21
M M M M M M M M M F F F F F
Page 1060 of 4796
23192 06-AUG-08 a21 C e21 C 1 C C e21 a21 e21 a21 a21 e21
M M M M M M M M M F F F F
23219 07-AUG-08 0 C C 1 e21 e21 C C C a21 a21 e21 a21 a21 e21 C
F M M M M M M M M M M F F F F F
23211 07-AUG-08 a21 e21 C e21 a21 C C C C C e21 a21 a21 e21
M M M M M M M M M M F F F F
23189 07-AUG-08 e21 C e21 C C a21 a21 C C a21 C a21 C C e21 C C e21
M M M M M M M F F F F F F F F F F F
23204 07-AUG-08 C 2 1 C C C C e21 C a21 a21 e21 2 e21 C a21 e21 a21
M M M M M M M M M M M M M F F F F F
-----------------------------------------------------------------------------------------------------------------------------------
A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4
M = MALE, F = FEMALE, U = UNDETERMINED
a=SCHEDULED EUTHANASIA
d=SENT TO NECROPSY DUE TO DEATH OF DAM
e=SELECTED FOR POST-WEANING BEHAVIORAL TESTING
TABLE A22 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 17
SPONSOR:ACC INDIVIDUAL PUP VIABILITY
--------------------------------------------------------
LITTERS FROM GROUP 6: 2250 PPM
--------------------------------------------------------
DAY OF
DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23257 06-AUG-08 3 C C e21 a21 a21 C C e21 C e21 a21 C C e21 5 C
M M M M M M M M M M F F F F F F F
23234 07-AUG-08 a21 e21 e21 a21 C a21 C e21 e21 C C C C a21 C
M M M M F F F F F F F F F F F
23227 07-AUG-08 C a21 C C e21 C e21 C a21 C e21 e21 C a21 a21 C
M M M M M M M M M M F F F F F F
26509 02-SEP-08 C a21 a21 e21 e21 C C e21 C a21 a21 C e21
M M M M M M M F F F F F F
Page 1061 of 4796
26448 03-SEP-08 C e21 C a21 a21 C C e21 C C e21 a21 e21 a21 C
F M M M M M M M M M F F F F F
26508 03-SEP-08 C C a21 e21 C C a21 e21 e21 C a21 C a21 e21 C C
M M M M M M M M F F F F F F F F
26463 04-SEP-08 C a21 C e21 C e21 a21 e21 e21 C C a21 C a21 C
M M M M M M M F F F F F F F F
26504 03-SEP-08 a21 e21 a21 e21 C C a21 e21 C e21 a21 C C C
M M M M M F F F F F F F F F
26465 04-SEP-08 C a21 1 e21 C C C e21 a21 a21 C e21 e21 a21 2
M M M M M M M M M M M F F F F
-----------------------------------------------------------------------------------------------------------------------------------
A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4
M = MALE, F = FEMALE, U = UNDETERMINED
a=SCHEDULED EUTHANASIA
e=SELECTED FOR POST-WEANING BEHAVIORAL TESTING
TABLE A22 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 18
SPONSOR:ACC INDIVIDUAL PUP VIABILITY
--------------------------------------------------------
LITTERS FROM GROUP 6: 2250 PPM
--------------------------------------------------------
DAY OF
DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
26477 04-SEP-08 C e21 e21 C a21 a21 C e21 C e21 a21 C a21
M M M M M M F F F F F F F
26511 04-SEP-08 e21 a21 C C e21 a21 e21 C C C a21 a21 C e21
M M M M M M F F F F F F F F
26466 04-SEP-08 C a21 a21 C C C C e21 e21 C a21 a21 e21 C C e21 C
M M M M M M M M M M F F F F F F F
26523 04-SEP-08 e21 C 1 C a21 e21 C C a21 C a21 C C e21 C a21 e21
M M M M M M M M M F F F F F F F F
26470 05-SEP-08 0 C C a21 e21 e21 a21 a21 e21 a21 e21 C C C C C C
F M M M M M M F F F F F F F F F F
-----------------------------------------------------------------------------------------------------------------------------------
A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4
M = MALE, F = FEMALE, U = UNDETERMINED
a=SCHEDULED EUTHANASIA
e=SELECTED FOR POST-WEANING BEHAVIORAL TESTING
PLITRv4.02
12/17/2008
TABLE A23 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC INDIVIDUAL POSTNATAL SURVIVAL [% PER LITTER]
--------------------------------------------
LITTERS FROM GROUP 1: 0 PPM
--------------------------------------------
ANIMAL 0 0- 1 1- 4 4- 7 7-14 14-21 B- 4 4-21
-----------------------------------------------------------------------------------------------------------------------------------
23243 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23213 93.3 100.0 100.0 100.0 100.0 100.0 93.3 100.0
23203 100.0 100.0 94.1 100.0 100.0 100.0 94.1 100.0
23207 100.0 100.0 100.0 100.0 87.5 100.0 100.0 87.5
23226 100.0 100.0 93.3 100.0 100.0 100.0 93.3 100.0
23242 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23209 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23178 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23186 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23194 100.0 100.0 94.1 100.0 87.5 100.0 94.1 87.5
23182 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23240 93.3 100.0 100.0 100.0 100.0 100.0 93.3 100.0
Page 1063 of 4796
--------------------------------------------
LITTERS FROM GROUP 2: 0.15 PPM
--------------------------------------------
ANIMAL 0 0- 1 1- 4 4- 7 7-14 14-21 B- 4 4-21
-----------------------------------------------------------------------------------------------------------------------------------
23195 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23180 100.0 100.0 93.8 100.0 100.0 100.0 93.8 100.0
23176 100.0 100.0 93.8 100.0 100.0 100.0 93.8 100.0
23251 100.0 93.3 100.0 100.0 100.0 100.0 93.3 100.0
23235 86.7 100.0 92.3 100.0 100.0 100.0 80.0 100.0
23231 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23216 94.1 100.0 100.0 100.0 100.0 100.0 94.1 100.0
23261 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23205 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23181 100.0 92.9 100.0 100.0 100.0 100.0 92.9 100.0
23264 92.9 100.0 100.0 100.0 100.0 100.0 92.9 100.0
26474 94.1 100.0 100.0 100.0 100.0 100.0 94.1 100.0
Page 1064 of 4796
--------------------------------------------
LITTERS FROM GROUP 3: 1.5 PPM
--------------------------------------------
ANIMAL 0 0- 1 1- 4 4- 7 7-14 14-21 B- 4 4-21
-----------------------------------------------------------------------------------------------------------------------------------
23248 100.0 94.1 100.0 100.0 100.0 100.0 94.1 100.0
23217 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23190 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23236 100.0 100.0 87.5 100.0 100.0 100.0 87.5 100.0
23260 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23221 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23263 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23253 94.1 100.0 100.0 100.0 100.0 100.0 94.1 100.0
23244 100.0 100.0 100.0 87.5 85.7 100.0 100.0 75.0
23218 94.1 100.0 93.8 100.0 100.0 100.0 88.2 100.0
23208 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23252 100.0 100.0 94.1 100.0 87.5 100.0 94.1 87.5
Page 1065 of 4796
--------------------------------------------
LITTERS FROM GROUP 4: 75 PPM
--------------------------------------------
ANIMAL 0 0- 1 1- 4 4- 7 7-14 14-21 B- 4 4-21
-----------------------------------------------------------------------------------------------------------------------------------
23179 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23212 100.0 94.4 100.0 100.0 100.0 100.0 94.4 100.0
23201 92.9 100.0 92.3 100.0 100.0 100.0 85.7 100.0
23259 100.0 92.3 100.0 100.0 100.0 100.0 92.3 100.0
23210 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23256 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23238 100.0 94.7 100.0 100.0 100.0 100.0 94.7 100.0
23228 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23246 100.0 100.0 100.0 NA NA NA 100.0 NA
23220 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23183 100.0 100.0 91.7 100.0 100.0 100.0 91.7 100.0
23184 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
Page 1066 of 4796
--------------------------------------------
LITTERS FROM GROUP 5: 750 PPM
--------------------------------------------
ANIMAL 0 0- 1 1- 4 4- 7 7-14 14-21 B- 4 4-21
-----------------------------------------------------------------------------------------------------------------------------------
23198 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23233 75.0 77.8 100.0 100.0 100.0 100.0 58.3 100.0
23241 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23254 100.0 100.0 100.0 NA NA NA 100.0 NA
23239 92.3 100.0 100.0 100.0 100.0 100.0 92.3 100.0
23245 92.9 100.0 100.0 100.0 100.0 100.0 92.9 100.0
23223 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23191 100.0 93.8 100.0 100.0 100.0 100.0 93.8 100.0
23247 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23230 100.0 100.0 93.8 100.0 100.0 100.0 93.8 100.0
23249 84.6 100.0 100.0 100.0 50.0 100.0 84.6 50.0
23258 100.0 100.0 100.0 87.5 100.0 100.0 100.0 87.5
Page 1067 of 4796
--------------------------------------------
LITTERS FROM GROUP 6: 2250 PPM
--------------------------------------------
ANIMAL 0 0- 1 1- 4 4- 7 7-14 14-21 B- 4 4-21
-----------------------------------------------------------------------------------------------------------------------------------
23255 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23237 100.0 NA NA NA NA NA NA NA
23215 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23214 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23192 100.0 92.3 100.0 100.0 100.0 100.0 92.3 100.0
23219 93.8 93.3 100.0 100.0 100.0 100.0 87.5 100.0
23211 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23189 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23204 100.0 94.4 88.2 100.0 100.0 100.0 83.3 100.0
23257 100.0 100.0 94.1 87.5 100.0 100.0 94.1 87.5
23234 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23227 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
Page 1068 of 4796
SCHEDULED EUTHANASIA 21
9 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
10 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
11 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
12 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
13 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 4
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
2 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
3 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
4 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
5 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
6 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
7 M MISSING 2
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 5
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
13 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
14 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
15 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
16 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 6
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
4 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
5 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
6 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
7 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
8 F NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 7
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
14 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
5 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
6 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
7 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
8 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
9 M NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 12
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
15 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
16 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
9 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
10 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
11 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
12 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
13 F NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 16
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
FOUND DEAD 8
4 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
5 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
6 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
7 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
8 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 17
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
SCHEDULED EUTHANASIA 21
6 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
7 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
8 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
9 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
10 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 19
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
16 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
SCHEDULED EUTHANASIA 21
9 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
10 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
11 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
12 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
13 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 21
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
SCHEDULED EUTHANASIA 21
15 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
16 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
17 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
6 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
7 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
8 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
9 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
10 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 26
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
15 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
11 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
12 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
13 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
14 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
15 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 28
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
3 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
4 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
5 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 29
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
11 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
12 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
13 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
14 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
5 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
6 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
7 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
8 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
9 F NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 31
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
3 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
4 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
5 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
6 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
7 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
8 F NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 34
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
13 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
14 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
15 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
16 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
17 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
8 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
9 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
10 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
11 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
12 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 38
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
14 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
15 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
16 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
17 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 40
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
6 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
7 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
8 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
9 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 42
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
SCHEDULED EUTHANASIA 21
11 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
12 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
13 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
14 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
15 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 44
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
3 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
4 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
5 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
6 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
7 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
8 M NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 45
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
13 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
14 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
15 F FOUND DEAD 2
16 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
6 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
7 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
8 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
9 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
10 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
11 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 47
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
SCHEDULED EUTHANASIA 21
10 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
11 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
12 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
13 F BODY PALE 4
BODY COOL 4
CULLED ON SCHEDULED DAY 4
14 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 49
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
5 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
6 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
7 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
8 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 50
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
SCHEDULED EUTHANASIA 21
9 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
10 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
11 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
12 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
13 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
14 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 52
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
10 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
11 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
12 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
13 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 54
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
SCHEDULED EUTHANASIA 21
8 F BODY PALE 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
9 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
10 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
11 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
12 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 57
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
SCHEDULED EUTHANASIA 21
3 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
4 M SMALL STATURE 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
5 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
6 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 58
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
12 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
13 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
14 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
2 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
3 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
4 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
5 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 63
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
9 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
10 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
11 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
12 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
2 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
3 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
4 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
5 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
6 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
7 M NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 66
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
12 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
13 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
14 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
6 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
7 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
8 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
9 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 68
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
10 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
11 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
12 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
13 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
14 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
15 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
16 F NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 70
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
SCHEDULED EUTHANASIA 21
12 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
13 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
14 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
15 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 72
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
4 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
5 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
6 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
7 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
8 M NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 73
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
3 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
4 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
5 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
6 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
7 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 75
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
3 F FOUND DEAD 0
4 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
5 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
6 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
7 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 77
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
SCHEDULED EUTHANASIA 21
12 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
13 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
14 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
5 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
6 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
7 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
8 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
9 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
10 F NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 79
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
BODY PALE 6
SCABBING 11
FACIAL AREA
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
14 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
15 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
16 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 80
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
7 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
8 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
9 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
10 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 81
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
8 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
9 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
10 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
11 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 83
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
18 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
19 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
20 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
21 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
6 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
7 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
8 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
9 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
10 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 85
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
SCHEDULED EUTHANASIA 21
16 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
17 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
8 M SMALL STATURE 4
CULLED ON SCHEDULED DAY 4
9 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
10 M FOUND DEAD 3
11 F SMALL STATURE 4
CULLED ON SCHEDULED DAY 4
12 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
13 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 87
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
2 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
3 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
4 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
5 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
6 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 88
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
10 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
11 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
12 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
13 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
14 F NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 92
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
4 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
5 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
6 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
7 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
8 M NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 93
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
14 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
15 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
16 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
17 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 94
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
5 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
6 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
7 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
8 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
9 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
10 M NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 95
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
16 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
17 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
SCHEDULED EUTHANASIA 21
9 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
10 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
11 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
12 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
13 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
14 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 97
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
SCHEDULED EUTHANASIA 21
10 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
11 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
12 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
13 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
14 F NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 99
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
4 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
5 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
6 M NO REMARKABLE OBSERVATIONS 4
FOUND DEAD 8
7 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
8 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
9 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
10 M NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 100
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
15 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
16 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
17 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
26519 1 F GASPING 0
NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
2 M MISSING 2
3 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
4 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
5 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
6 M NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 103
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
10 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
11 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
12 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
13 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
14 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
15 F NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 104
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
4 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
5 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
6 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
7 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
8 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
9 F NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 105
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
13 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
4 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
5 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
6 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
7 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
8 M NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 108
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
13 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
14 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
15 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
16 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 109
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
5 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
6 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
7 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
8 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
9 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
10 F NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 110
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
15 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
16 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
17 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
18 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
6 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
7 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
8 M MISSING 1
9 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
10 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
11 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 112
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
16 F SMALL STATURE 4
SMALL STATURE 11
SMALL STATURE 21
SCHEDULED EUTHANASIA 21
17 F MISSING 1
18 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
7 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
8 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
9 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
10 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
11 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
12 F NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 114
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
3 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
4 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
5 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 115
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
6 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
7 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
8 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
9 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
10 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
11 F NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 117
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
16 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
SCHEDULED EUTHANASIA 21
9 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
10 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
11 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
12 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
13 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
14 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 119
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
2 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
3 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
4 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
5 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
6 M NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 120
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
11 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
12 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
13 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
14 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
15 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
16 F NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 121
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
5 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
6 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
7 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
8 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 123
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
SCHEDULED EUTHANASIA 21
4 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
5 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
6 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
7 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
8 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 126
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
13 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
14 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
3 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
4 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
5 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
6 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
7 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
8 M NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 129
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
13 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
14 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
15 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
16 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 130
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
SCHEDULED EUTHANASIA 21
15 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
16 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
8 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
9 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
10 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
11 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
12 F NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 133
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
17 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
18 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
19 F MISSING 1
8 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
9 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
10 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
11 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
12 F NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 135
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
8 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
9 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
10 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
11 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 137
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
16 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
17 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
18 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
7 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
8 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
9 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
10 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
11 F NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 139
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
FOUND DEAD 1
10 F FOUND DEAD 1
11 M NO REMARKABLE OBSERVATIONS 4
SCHEDULED EUTHANASIA; SEX RATIO CRITERIA NOT MET 4
12 M NO REMARKABLE OBSERVATIONS 4
SCHEDULED EUTHANASIA; SEX RATIO CRITERIA NOT MET 4
13 F NO REMARKABLE OBSERVATIONS 4
SCHEDULED EUTHANASIA; SEX RATIO CRITERIA NOT MET 4
14 F NO REMARKABLE OBSERVATIONS 4
SCHEDULED EUTHANASIA; SEX RATIO CRITERIA NOT MET 4
15 F FOUND DEAD 1
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
9 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
10 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
11 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
12 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
13 F NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 145
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
5 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
6 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
7 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
8 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 146
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
13 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
14 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
15 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
16 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
17 F LACERATION 4
RIGHT AXILLARY AREA
VENTRAL NECK
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 147
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
4 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
5 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
6 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
7 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
8 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 148
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
SCHEDULED EUTHANASIA 21
5 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
6 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
7 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
8 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
9 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 151
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
14 F MISSING 3
15 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
16 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
17 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
7 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
8 F MISSING 1
9 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
10 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
11 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 153
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
9 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
10 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
11 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
12 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
13 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 155
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
12 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
13 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
14 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
15 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 157
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
2 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
3 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
4 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
5 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
6 M NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 158
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
10 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
11 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
12 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
8 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
9 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
10 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
11 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 160
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
7 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
8 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
9 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
10 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 162
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
SCHEDULED EUTHANASIA 21
15 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
10 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
11 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
12 F FOUND DEAD 1
6 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
7 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
8 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
9 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
10 F NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 165
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
4 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
5 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
6 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
7 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 167
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
8 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
9 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
10 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
11 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 169
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
3 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
4 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
5 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
6 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
7 M NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 170
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
12 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
13 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
14 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
15 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
16 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 171
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
5 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
6 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
7 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
8 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
9 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
10 F NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 172
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
15 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
16 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
8 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
9 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
10 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
11 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
12 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 174
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
11 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
12 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
13 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
14 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 176
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
4 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
FOUND DEAD 14
REDDENED PLANTAR SURFACE OF LEFT HINDLIMB 14
REDDENED PLANTAR SURFACE OF RIGHT HINDLIMB 14
5 M NO REMARKABLE OBSERVATIONS 4
FOUND DEAD 11
6 M NO REMARKABLE OBSERVATIONS 4
BODY COOL 11
REDDENED PLANTAR SURFACE OF LEFT HINDLIMB 11
REDDENED PLANTAR SURFACE OF RIGHT HINDLIMB 11
REDDENED PALMAR SURFACE OF RIGHT FORELIMB 11
REDDENED PALMAR SURFACE OF LEFT FORELIMB 11
FOUND DEAD 12
7 M NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 177
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
12 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
13 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
3 M NO REMARKABLE OBSERVATIONS 4
SCHEDULED EUTHANASIA; SEX RATIO CRITERIA NOT MET 4
4 M NO REMARKABLE OBSERVATIONS 4
SCHEDULED EUTHANASIA; SEX RATIO CRITERIA NOT MET 4
5 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
6 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
7 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
8 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
9 M NO REMARKABLE OBSERVATIONS 4
SCHEDULED EUTHANASIA; SEX RATIO CRITERIA NOT MET 4
10 M NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 180
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
SCHEDULED EUTHANASIA 21
2 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
3 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
4 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
5 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 181
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
8 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
9 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
10 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
11 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
12 F NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 183
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
17 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
9 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
10 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
11 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
12 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
13 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 185
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
3 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
4 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
5 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
6 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
7 M NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 186
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
11 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
12 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
13 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
SCHEDULED EUTHANASIA 21
7 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
8 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
9 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
10 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
11 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
12 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 188
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
9 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
10 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
11 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
12 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
13 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
14 F NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 190
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
26472 1 F GASPING 0
MISSING 1
2 F SUBCUTANEOUS HEMORRHAGE(S) 1
DORSAL ABDOMINAL AREA
VENTRAL ABDOMINAL AREA
Page 1258 of 4796
NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
3 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
4 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
5 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
6 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
7 M NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 191
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
12 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
13 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
14 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
15 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 192
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
4 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
5 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
6 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
7 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
8 F NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 195
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
14 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
15 F SMALL STATURE 4
CULLED ON SCHEDULED DAY 4
16 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
17 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
7 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
8 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
9 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
10 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 197
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
10 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
11 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
12 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 199
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
6 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
7 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
8 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
9 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
10 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 201
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
23237 1 M LACERATION 0
VENTRAL ABDOMINAL AREA
SENT TO NECROPSY DUE TO DEATH OF DAM 0
2 M SENT TO NECROPSY DUE TO DEATH OF DAM 0
3 M SENT TO NECROPSY DUE TO DEATH OF DAM 0
4 M SENT TO NECROPSY DUE TO DEATH OF DAM 0
5 F SENT TO NECROPSY DUE TO DEATH OF DAM 0
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 202
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
13 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
14 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
15 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
16 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 204
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
SCHEDULED EUTHANASIA 21
10 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
11 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
12 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
13 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 207
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
6 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
7 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
8 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
9 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
10 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
11 M NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 208
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
15 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
16 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
2 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
3 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
4 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
5 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
6 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 211
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
11 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
12 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
13 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
14 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
15 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
16 F NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 212
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
15 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
16 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
17 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
18 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 214
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
6 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
7 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
8 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
9 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
10 M NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 215
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
15 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
16 F NO REMARKABLE OBSERVATIONS 4
FOUND DEAD 5
17 F SMALL STATURE 4
BODY PALE 4
CULLED ON SCHEDULED DAY 4
6 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
7 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
8 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
9 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
10 F NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 217
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
3 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
4 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
5 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
6 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
7 M NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 220
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
12 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
13 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
10 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
11 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
12 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
13 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
14 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 224
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
13 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
14 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
15 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
5 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
6 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
7 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
8 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
9 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
10 F NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 227
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
11 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
12 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
13 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
14 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 229
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
4 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
5 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
6 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
7 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
8 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 230
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
13 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
3 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
4 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
5 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
6 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
7 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
8 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 233
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
13 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
14 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
15 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
16 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
17 F NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 234
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
FOUND DEAD 8
5 M NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
6 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
7 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
8 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
9 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 235
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
16 F FOUND DEAD 3
17 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
10 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SCHEDULED EUTHANASIA 21
11 F NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
NO REMARKABLE OBSERVATIONS 21
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
12 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
13 F NO REMARKABLE OBSERVATIONS 4
CULLED ON SCHEDULED DAY 4
TABLE A24 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 239
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS
PPOBSv4.06
02/04/2009
Page 1307 of 4796
FINAL REPORT
Volume 5 of 16
(Appendix A [Tables A25-A32])
STUDY TITLE
A DIETARY DEVELOPMENTAL
NEUROTOXICITY STUDY OF BISPHENOL A IN RATS
STUDY NUMBER
WIL-186056
DATA REQUIREMENT
STUDY DIRECTOR
26 June 2008
30 September 2009
PERFORMING LABORATORY
SPONSOR
APPENDIX A
TABLES A25-A32
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
23243-01 M 6.9 9.5 15.4 25.5 33.3 40.5 48.9
23243-02 M 6.7 9.1 16.0 25.7 32.7 41.7 52.6
23243-03 M 6.8 9.5 15.8 26.1 33.5 42.4 50.2
23243-04 M 7.5 10.4 NA NA NA NA NA
23243-05 M 6.8 9.6 15.6 25.6 33.5 40.2 49.1
23243-06 M 6.1 8.6 NA NA NA NA NA
23243-07 M 6.5 8.9 NA NA NA NA NA
23243-08 M 7.0 9.5 NA NA NA NA NA
23243-09 M 6.9 9.8 NA NA NA NA NA
23243-10 F 6.6 9.5 15.6 25.4 33.3 40.7 50.5
Page 1310 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
23213-09 F 6.7 9.1 14.7 23.1 31.7 39.3 48.2
23213-10 F 7.6 10.6 16.6 26.6 35.1 41.5 52.1
23213-11 F 7.3 9.4 NA NA NA NA NA
23213-12 F 7.2 9.2 NA NA NA NA NA
23213-13 F 8.2 10.8 16.8 27.2 36.3 43.4 54.2
23213-14 F 6.6 8.2 NA NA NA NA NA
23213-15 F 7.3 9.7 15.6 24.6 33.1 39.5 49.7
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 3
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
23203-16 F 6.2 7.4 NA NA NA NA NA
23203-17 F 6.9 8.5 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 4
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
23226-03 M 5.4 6.7 10.5 19.2 28.1 36.0 43.8
23226-04 M 6.4 8.4 13.0 23.1 32.6 41.2 52.5
23226-05 F 5.6 7.6 11.9 20.8 30.1 36.8 45.9
23226-06 F 6.1 7.5 NA NA NA NA NA
23226-07 F 5.3 6.4 NA NA NA NA NA
23226-08 F 5.4 6.5 10.3 18.8 27.7 34.5 41.1
23226-09 F 5.8 7.2 NA NA NA NA NA
23226-10 F 5.9 8.4 12.6 22.3 30.8 38.3 48.7
23226-11 F 5.8 7.2 NA NA NA NA NA
23226-12 F 6.1 7.3 NA NA NA NA NA
Page 1313 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 5
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
23242-10 F 5.9 8.3 NA NA NA NA NA
23242-11 F 5.9 7.9 13.7 23.1 32.8 40.5 51.6
23242-12 F 6.4 8.5 NA NA NA NA NA
23242-13 F 6.2 8.2 NA NA NA NA NA
23242-14 F 5.8 7.6 NA NA NA NA NA
23242-15 F 6.0 8.2 13.3 22.2 30.8 36.8 47.2
23242-16 F 6.1 8.0 13.7 22.3 30.9 37.4 47.1
23242-17 F 5.3 7.9 13.3 22.3 30.9 38.3 46.9
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 6
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
23209-15 F 7.7 10.8 17.4 26.7 35.1 40.0 52.2
23209-16 F 7.0 9.3 15.7 24.2 32.2 36.7 49.4
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 7
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
23186-02 M 6.1 8.0 13.8 23.9 30.8 37.7 46.2
23186-03 M 5.9 8.0 13.2 22.2 30.8 37.2 44.6
23186-04 M 6.0 8.2 NA NA NA NA NA
23186-05 M 5.6 7.3 12.0 20.1 28.2 35.4 42.8
23186-06 M 6.2 8.4 NA NA NA NA NA
23186-07 F 5.8 7.4 12.2 20.0 27.3 33.0 40.6
23186-08 F 5.4 7.5 12.7 20.9 28.0 35.4 43.3
23186-09 F 5.9 7.5 13.2 21.1 28.9 35.9 44.1
23186-10 F 5.9 7.9 NA NA NA NA NA
23186-11 F 5.8 7.6 13.4 22.4 31.6 38.4 46.0
Page 1316 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 8
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
23194-10 F 6.2 7.5 12.9 21.5 29.2 38.0 46.9
23194-11 F 5.9 8.2 NA NA NA NA NA
23194-12 F 5.5 7.2 NA NA NA NA NA
23194-13 F 4.7 6.5 10.7 19.6 28.7 38.3 46.6
23194-14 F 6.0 8.2 NA NA NA NA NA
23194-15 F 6.0 7.9 12.9 22.8 33.2 42.5 53.1
23194-16 F 4.2 NA NA NA NA NA NA
23194-17 F 5.9 8.0 13.1 21.9 30.3 38.6 48.8
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 9
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
23182-15 F 7.4 9.1 16.0 27.6 35.5 45.4 54.7
23182-16 F 7.0 9.2 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 10
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
26521-04 M 6.9 9.8 NA NA NA NA NA
26521-05 M 7.2 10.0 17.1 27.2 36.9 46.3 58.7
26521-06 M 7.1 10.3 NA NA NA NA NA
26521-07 M 7.1 10.6 NA NA NA NA NA
26521-08 M 6.8 9.5 15.7 25.4 35.0 42.2 52.5
26521-09 M 7.4 10.0 NA NA NA NA NA
26521-10 M 6.8 9.3 NA NA NA NA NA
26521-11 F 7.0 9.5 NA NA NA NA NA
26521-12 F 6.5 9.1 15.2 24.8 32.9 39.4 49.9
26521-13 F 7.2 9.8 NA NA NA NA NA
Page 1319 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 11
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
26449-10 M 6.9 9.0 NA NA NA NA NA
26449-11 F 6.5 9.2 NA NA NA NA NA
26449-12 F 6.8 9.4 15.2 24.5 33.1 40.9 57.4
26449-13 F 6.8 9.1 NA NA NA NA NA
26449-14 F 6.5 8.9 14.7 24.0 31.6 39.7 53.5
26449-15 F 6.5 9.1 15.1 24.3 31.7 39.8 56.2
26449-16 F 6.8 8.6 NA NA NA NA NA
26449-17 F 6.2 8.7 14.7 24.0 29.6 36.7 50.9
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 12
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
26473-15 F 7.4 9.8 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 13
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
26491-02 M 8.3 11.2 18.0 27.6 33.5 41.0 60.2
26491-03 M 8.0 10.6 17.6 27.8 33.9 41.2 60.5
26491-04 M 7.7 10.1 16.5 25.8 30.5 36.9 51.1
26491-05 M 7.5 10.1 16.1 25.8 30.7 37.4 55.1
26491-06 M 8.5 11.1 NA NA NA NA NA
26491-07 F 7.5 10.0 16.5 25.4 31.3 37.4 50.5
26491-08 F 7.5 10.0 NA NA NA NA NA
26491-09 F 7.3 9.8 16.5 26.0 30.9 37.2 49.8
26491-10 F 7.6 10.5 17.2 26.3 32.2 40.9 60.1
26491-11 F 7.8 10.1 NA NA NA NA NA
Page 1322 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 14
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
26512-10 F 7.2 10.2 NA NA NA NA NA
26512-11 F 7.6 10.7 17.0 24.9 31.1 38.5 53.1
26512-12 F 7.3 9.7 NA NA NA NA NA
26512-13 F 7.2 10.6 16.0 24.4 31.7 38.3 51.4
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 15
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
26454-15 F 7.1 10.5 16.4 25.2 32.0 36.6 51.8
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 16
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
26453-02 M 7.6 9.6 NA NA NA NA NA
26453-03 M 7.9 9.9 NA NA NA NA NA
26453-04 M 7.5 10.2 NA NA NA NA NA
26453-05 M 7.6 9.7 15.8 25.1 34.4 40.7 53.4
26453-06 M 6.9 9.2 NA NA NA NA NA
26453-07 M 6.4 8.6 NA NA NA NA NA
26453-08 M 7.4 9.9 NA NA NA NA NA
26453-09 M 6.6 8.3 13.3 20.7 27.9 32.7 41.2
26453-10 M 7.3 9.7 NA NA NA NA NA
26453-11 M 6.8 8.9 14.5 23.2 32.0 39.3 51.4
Page 1325 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 17
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
26527-07 M 6.4 8.9 14.9 24.5 34.4 42.2 53.2
26527-08 M 6.3 8.6 NA NA NA NA NA
26527-09 F 5.8 8.1 NA NA NA NA NA
26527-10 F 6.6 9.1 NA NA NA NA NA
26527-11 F 5.9 8.2 13.5 23.2 31.2 38.0 47.1
26527-12 F 6.2 8.7 14.3 24.0 32.8 41.1 51.2
26527-13 F 6.2 8.4 14.0 23.6 31.8 39.0 46.5
26527-14 F 5.7 8.2 13.2 22.4 30.6 35.7 44.7
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 18
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
26489-17 F 5.5 6.9 10.7 20.3 26.9 33.5 40.0
26489-18 F 6.1 7.8 NA NA NA NA NA
26489-19 F 5.8 6.3 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 19
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
23195-01 M 9.0 11.8 17.6 29.3 38.0 45.1 61.6
23195-02 M 8.2 10.6 NA NA NA NA NA
23195-03 M 8.4 10.5 NA NA NA NA NA
23195-04 M 8.3 11.0 16.6 27.8 37.0 45.2 61.3
23195-05 M 8.9 11.6 17.8 29.5 38.8 48.1 61.3
23195-06 M 9.0 12.1 18.1 29.2 37.4 43.8 58.6
23195-07 M 8.8 11.9 NA NA NA NA NA
23195-08 M 8.1 10.7 17.3 27.1 35.9 42.3 53.2
23195-09 M 8.2 10.8 NA NA NA NA NA
23195-10 F 8.3 11.1 17.8 28.7 36.6 43.2 57.1
Page 1328 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 20
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
23180-11 F 6.3 8.6 15.1 22.3 30.5 36.5 48.6
23180-12 F 6.8 8.8 15.4 25.3 32.0 40.2 54.9
23180-13 F 6.8 8.4 NA NA NA NA NA
23180-14 F 6.7 8.2 NA NA NA NA NA
23180-15 F 7.3 9.3 15.5 24.4 33.3 39.8 52.5
23180-16 F 7.2 9.1 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 21
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
23176-16 F 6.5 7.6 NA NA NA NA NA
23235-03 M 6.5 NA NA NA NA NA NA
23235-04 M 6.2 7.7 12.3 20.5 27.8 34.5 42.4
23235-05 M 5.9 7.4 11.3 18.7 24.7 30.2 37.9
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 22
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
23235-06 M 6.5 8.5 12.7 19.3 24.9 30.4 34.8
23235-07 F 6.1 8.2 13.9 18.2 29.4 35.6 43.2
23235-08 M 6.1 7.7 11.4 22.1 25.4 31.0 36.3
23235-09 F 6.2 8.1 12.8 20.6 27.7 34.1 43.3
23235-10 F 6.0 8.3 13.9 22.4 28.9 33.9 42.4
23235-11 F 6.6 8.7 NA NA NA NA NA
23235-12 F 6.2 8.8 NA NA NA NA NA
23235-13 F 6.7 7.1 NA NA NA NA NA
23235-14 F 6.2 8.3 13.2 21.3 28.3 33.9 43.9
23235-15 F 6.5 8.2 NA NA NA NA NA
Page 1331 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 23
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
23231-13 F 6.6 9.1 14.8 25.6 34.2 41.4 53.8
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 24
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
23261-02 M 7.2 10.1 16.6 25.6 33.8 41.5 52.2
23261-03 M 7.5 9.9 NA NA NA NA NA
23261-04 M 7.8 10.4 16.6 25.0 32.0 38.1 52.6
23261-05 M 7.3 10.4 16.8 26.4 34.2 42.0 52.5
23261-06 M 7.3 9.9 NA NA NA NA NA
23261-07 F 7.2 8.9 14.8 23.6 31.9 38.7 49.4
23261-08 F 7.3 10.0 NA NA NA NA NA
23261-09 F 6.8 9.0 15.7 25.8 34.5 42.6 52.0
23261-10 F 7.3 9.3 16.1 24.1 31.5 37.6 44.2
23261-11 F 6.6 8.5 NA NA NA NA NA
Page 1333 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 25
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
23205-11 F 7.6 9.7 NA NA NA NA NA
23205-12 F 7.2 9.0 NA NA NA NA NA
23205-13 F 7.3 9.4 NA NA NA NA NA
23205-14 F 6.5 8.0 12.5 19.6 28.1 34.5 48.4
23205-15 F 7.4 9.8 NA NA NA NA NA
23205-16 F 7.6 9.7 16.3 23.8 34.4 43.3 58.0
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 26
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
23181-14 F 7.9 10.0 16.7 28.5 35.6 42.4 52.8
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 27
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
26474-06 M 8.1 10.6 NA NA NA NA NA
26474-07 M 8.3 10.8 NA NA NA NA NA
26474-08 M 7.1 9.5 15.5 24.3 32.0 40.0 52.2
26474-09 F 7.2 9.1 NA NA NA NA NA
26474-10 F 6.9 9.6 NA NA NA NA NA
26474-11 F 7.8 10.4 NA NA NA NA NA
26474-12 F 6.9 9.4 15.2 25.1 34.3 41.4 52.0
26474-13 F 5.5 7.5 12.4 20.4 27.1 34.4 44.5
26474-14 F 7.0 8.7 15.2 23.2 29.9 35.8 49.2
26474-15 F 7.1 9.5 NA NA NA NA NA
Page 1336 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 28
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
26476-12 F 7.1 10.2 NA NA NA NA NA
26476-13 F 7.0 9.9 16.9 26.7 35.5 43.0 60.0
26476-14 F 7.0 10.1 NA NA NA NA NA
26476-15 F 6.9 10.1 NA NA NA NA NA
26476-16 F 7.1 9.5 16.2 25.9 33.6 39.7 56.7
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 29
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
26505-02 M 7.2 9.9 NA NA NA NA NA
26505-03 M 7.3 9.9 NA NA NA NA NA
26505-04 M 7.8 11.4 17.9 27.6 35.4 43.1 61.9
26505-05 M 7.6 10.9 17.1 27.1 35.0 43.6 59.0
26505-06 M 6.9 9.8 NA NA NA NA NA
26505-07 M 7.5 11.7 18.8 29.4 37.9 48.5 65.0
26505-08 M 6.9 10.3 NA NA NA NA NA
26505-09 F 7.0 10.0 16.3 25.3 31.3 40.5 53.5
26505-10 F 7.1 10.2 16.6 25.6 32.6 40.5 52.7
26505-11 F 5.9 8.5 13.7 21.5 28.9 35.7 46.4
Page 1338 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 30
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
26483-12 F 7.0 10.2 17.0 28.4 36.2 43.9 56.8
26483-13 F 6.8 9.6 16.6 27.5 34.5 42.0 53.1
26483-14 F 7.3 11.2 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 31
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
26450-02 M 5.7 8.2 14.1 22.8 29.7 37.3 50.1
26450-03 M 7.8 10.5 NA NA NA NA NA
26450-04 M 5.8 10.3 NA NA NA NA NA
26450-05 M 7.3 8.0 13.8 23.0 30.6 39.3 47.4
26450-06 M 5.8 8.4 14.6 25.2 33.2 41.2 54.0
26450-07 M 6.7 9.7 NA NA NA NA NA
26450-08 M 6.7 9.5 16.3 26.6 35.7 45.1 53.4
26450-09 M 7.3 10.6 NA NA NA NA NA
26450-10 F 7.0 10.2 NA NA NA NA NA
26450-11 F 6.0 8.3 NA NA NA NA NA
Page 1340 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 32
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
26457-06 M 6.7 9.2 NA NA NA NA NA
26457-07 M 6.6 8.8 NA NA NA NA NA
26457-08 M 6.6 8.6 NA NA NA NA NA
26457-09 M 6.7 8.1 14.4 24.7 32.8 41.6 50.8
26457-10 F 6.3 7.8 NA NA NA NA NA
26457-11 F 5.2 6.5 11.2 20.0 27.7 35.9 45.2
26457-12 F 5.8 7.1 12.0 21.2 29.1 37.5 48.1
26457-13 F 5.8 7.4 NA NA NA NA NA
26457-14 F 5.9 7.7 12.7 21.9 29.9 39.0 50.0
26457-15 F 6.1 7.4 12.4 21.7 28.8 34.8 45.8
Page 1341 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 33
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
26492-11 F 5.7 8.0 NA NA NA NA NA
26492-12 F 6.0 7.8 12.2 21.7 28.9 35.9 48.4
26492-13 F 5.9 8.1 13.8 23.0 29.9 39.7 51.1
26492-14 F 6.2 7.7 13.3 22.6 30.1 39.9 50.5
26492-15 F 6.3 8.5 NA NA NA NA NA
26492-16 F 6.0 8.1 NA NA NA NA NA
26492-17 M 5.8 7.8 12.9 22.2 29.2 37.6 47.0
26493-01 M 6.3 NA NA NA NA NA NA
26493-02 M 6.8 9.0 NA NA NA NA NA
26493-03 M 6.9 8.8 NA NA NA NA NA
26493-04 M 6.2 8.1 12.6 20.5 27.6 33.5 45.2
26493-05 M 7.1 10.5 NA NA NA NA NA
26493-06 M 6.7 8.3 14.9 24.0 33.7 40.6 55.4
26493-07 M 7.2 10.7 17.4 26.6 36.2 43.5 60.5
26493-08 M 6.7 8.2 NA NA NA NA NA
26493-09 M 6.5 8.1 NA NA NA NA NA
26493-10 M 6.6 NA NA NA NA NA NA
26493-11 M 7.0 9.3 13.9 23.4 32.9 40.7 56.5
26493-12 M 7.8 10.4 NA NA NA NA NA
26493-13 F 5.9 8.0 NA NA NA NA NA
26493-14 F 6.3 8.4 13.6 21.6 29.7 37.4 49.0
26493-15 F 6.6 7.9 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 34
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
26493-16 F 6.0 8.8 14.6 24.3 32.6 41.1 57.6
26493-17 F 6.5 9.4 NA NA NA NA NA
26493-18 F 5.9 7.8 13.0 21.6 29.4 37.1 50.5
26493-19 F 6.1 7.3 NA NA NA NA NA
26493-20 F 5.7 7.3 11.4 19.2 27.2 34.9 44.8
26493-21 F 6.1 7.8 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 35
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
26520-02 M 7.7 9.6 16.8 27.4 36.3 45.5 59.5
26520-03 M 7.2 8.6 14.7 25.0 34.1 42.8 55.4
26520-04 M 7.2 8.8 14.9 25.1 33.7 42.4 55.6
26520-05 F 6.5 8.5 14.9 24.9 32.6 41.3 50.5
26520-06 F 6.2 8.2 NA NA NA NA NA
26520-07 F 6.7 7.9 NA NA NA NA NA
26520-08 F 6.9 8.8 15.4 25.9 33.6 41.5 51.4
26520-09 F 6.5 8.1 NA NA NA NA NA
26520-10 F 6.8 8.5 NA NA NA NA NA
26520-11 F 7.3 8.6 15.4 26.2 34.6 41.5 56.4
Page 1344 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 36
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
23248-02 M 7.4 9.9 NA NA NA NA NA
23248-03 M 7.6 10.4 NA NA NA NA NA
23248-04 M 7.4 10.0 NA NA NA NA NA
23248-05 M 7.9 11.4 18.3 27.6 34.2 41.6 49.7
23248-06 M 7.2 10.6 17.3 27.9 35.9 46.1 53.5
23248-07 M 7.6 9.6 NA NA NA NA NA
23248-08 M 6.9 9.6 15.3 23.9 31.9 40.6 49.2
23248-09 M 8.0 10.4 17.9 26.2 33.7 41.4 49.6
23248-10 F 6.5 8.3 13.8 22.3 30.2 38.9 47.2
23248-11 F 7.0 9.4 NA NA NA NA NA
Page 1345 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 37
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
23217-07 M 6.4 8.4 NA NA NA NA NA
23217-08 M 5.7 6.6 10.8 18.3 25.2 30.9 36.3
23217-09 M 6.2 8.1 14.0 23.4 31.2 38.2 44.4
23217-10 F 5.6 7.7 13.1 22.0 29.0 34.8 44.0
23217-11 F 5.0 6.2 9.9 16.5 23.5 29.2 36.9
23217-12 F 5.3 7.1 NA NA NA NA NA
23217-13 F 5.6 7.0 NA NA NA NA NA
23217-14 F 5.8 7.0 NA NA NA NA NA
23217-15 F 5.6 7.5 NA NA NA NA NA
23217-16 F 5.9 8.0 NA NA NA NA NA
Page 1346 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 38
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
23190-08 F 6.0 8.3 14.5 24.3 32.3 39.8 51.9
23190-09 F 6.3 8.7 NA NA NA NA NA
23190-10 F 6.1 8.6 NA NA NA NA NA
23190-11 F 5.7 7.5 NA NA NA NA NA
23190-12 F 5.5 7.2 12.5 21.3 28.5 35.5 46.0
23190-13 F 5.9 8.1 NA NA NA NA NA
23190-14 F 5.8 8.6 NA NA NA NA NA
23190-15 F 5.9 8.6 14.3 23.1 31.9 38.5 52.5
23190-16 F 6.0 8.6 NA NA NA NA NA
23190-17 F 5.9 8.3 14.5 23.4 31.5 37.9 51.0
Page 1347 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 39
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
23236-13 F 5.4 6.2 9.7 17.2 24.7 31.7 36.6
23236-14 F 6.1 7.7 12.3 20.7 28.0 35.2 45.4
23236-15 F 5.8 6.4 10.6 19.3 27.0 33.9 41.5
23236-16 F 4.8 NA NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 40
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
23260-14 F 5.8 7.1 11.9 19.9 26.5 33.8 41.5
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 41
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
23263-04 M 6.3 9.0 NA NA NA NA NA
23263-05 M 6.2 8.3 NA NA NA NA NA
23263-06 M 7.5 10.0 16.1 25.2 31.8 39.0 52.0
23263-07 M 6.6 9.2 NA NA NA NA NA
23263-08 M 7.0 9.6 16.1 25.5 34.2 42.4 52.6
23263-09 M 6.7 9.3 15.8 25.8 34.9 43.2 53.9
23263-10 F 6.2 8.3 13.8 22.9 29.7 36.0 45.1
23263-11 F 6.5 8.4 NA NA NA NA NA
23263-12 F 6.4 8.5 NA NA NA NA NA
23263-13 F 6.2 8.3 13.7 21.7 29.4 36.6 49.0
Page 1350 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 42
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
23253-12 M 6.8 9.6 NA NA NA NA NA
23253-13 F 7.3 9.7 NA NA NA NA NA
23253-14 F 6.8 8.4 13.3 20.5 28.7 40.5 45.1
23253-15 F 6.9 9.1 14.9 23.5 32.1 40.0 49.7
23253-16 F 7.4 10.1 16.3 25.7 33.8 41.3 53.9
23253-17 F 6.9 9.6 15.8 24.4 33.6 41.1 52.8
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 43
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
23244-17 F 5.6 7.6 12.9 22.5 32.4 41.5 50.6
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 44
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
23208-02 M 8.3 11.4 NA NA NA NA NA
23208-03 M 8.8 11.8 NA NA NA NA NA
23208-04 M 8.1 11.3 19.3 27.2 37.4 42.0 65.4
23208-05 M 8.7 11.1 17.8 25.4 36.2 44.9 58.2
23208-06 M 8.3 10.7 NA NA NA NA NA
23208-07 M 8.7 11.0 NA NA NA NA NA
23208-08 M 8.6 11.5 18.7 25.5 33.2 41.1 54.8
23208-09 F 8.3 11.6 NA NA NA NA NA
23208-10 F 8.6 10.8 NA NA NA NA NA
23208-11 F 6.5 8.6 15.1 21.6 30.1 45.1 48.7
Page 1353 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 45
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
23252-10 M 6.3 7.4 NA NA NA NA NA
23252-11 F 5.6 6.5 NA NA NA NA NA
23252-12 F 6.4 7.8 12.8 24.4 32.0 37.8 48.3
23252-13 F 6.1 7.6 12.6 24.1 32.4 40.6 47.8
23252-14 F 6.1 7.3 NA NA NA NA NA
23252-15 F 6.3 7.6 13.8 25.3 33.8 41.4 51.6
23252-16 F 5.4 6.7 11.2 19.3 26.5 33.9 41.6
23252-17 F 6.1 7.3 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 46
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
26510-15 F 6.7 9.2 15.8 22.5 28.1 35.2 NA
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 47
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
26468-04 M 7.8 11.4 18.4 27.8 34.9 41.4 57.8
26468-05 M 7.8 11.7 18.6 28.0 35.9 44.7 60.2
26468-06 M 6.9 10.3 NA NA NA NA NA
26468-07 M 7.0 10.5 NA NA NA NA NA
26468-08 M 7.8 11.1 NA NA NA NA NA
26468-09 F 7.1 10.3 17.3 25.8 33.0 38.5 54.6
26468-10 F 7.4 10.2 16.9 25.5 33.7 41.2 56.2
26468-11 F 7.0 10.3 NA NA NA NA NA
26468-12 F 7.4 11.0 17.6 25.9 32.5 40.0 50.6
26468-13 F 7.5 10.7 17.5 26.1 33.1 40.1 53.8
Page 1356 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 48
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
26475-13 F 7.0 9.5 15.6 25.5 31.8 38.2 50.3
26475-14 F 7.0 10.4 16.3 25.4 33.6 39.6 51.8
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 49
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
26532-16 F 5.9 8.5 14.4 23.7 31.3 37.3 49.9
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 50
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
26507-18 F 5.6 7.8 14.6 24.3 33.4 38.9 50.0
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 51
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
26482-02 M 7.1 11.1 NA NA NA NA NA
26482-03 M 7.6 11.2 18.4 27.8 35.5 43.2 59.8
26482-04 M 7.0 10.9 NA NA NA NA NA
26482-05 M 7.4 11.0 17.8 27.0 32.6 39.6 58.2
26482-06 M 7.7 11.3 17.6 26.4 33.2 41.0 57.7
26482-07 F 7.4 10.8 17.5 26.4 33.4 40.1 55.7
26482-08 F 7.3 10.2 NA NA NA NA NA
26482-09 F 6.7 9.9 NA NA NA NA NA
26482-10 F 6.4 9.6 NA NA NA NA NA
26482-11 F 7.4 10.8 17.4 26.7 33.4 41.6 57.0
Page 1360 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 52
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
26522-11 F 7.1 9.8 NA NA NA NA NA
26522-12 F 7.5 10.8 17.8 27.7 34.7 40.8 52.3
26522-13 F 7.7 10.5 NA NA NA NA NA
26522-14 F 7.8 8.8 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 53
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
26517-16 F 7.0 10.0 17.2 28.5 36.2 44.6 55.0
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 54
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
26534-02 M 6.9 9.7 NA NA NA NA NA
26534-03 M 7.1 10.1 NA NA NA NA NA
26534-04 M 7.7 11.8 19.3 30.5 37.9 45.7 59.6
26534-05 M 7.9 11.6 18.8 29.8 37.8 46.4 57.5
26534-06 M 7.0 10.3 17.3 28.0 36.1 43.9 53.9
26534-07 F 7.3 9.3 NA NA NA NA NA
26534-08 F 7.2 10.3 16.6 27.9 35.4 42.8 53.1
26534-09 F 6.8 10.5 NA NA NA NA NA
26534-10 F 7.3 9.9 16.2 27.1 35.7 42.8 53.3
26534-11 F 6.7 9.5 NA NA NA NA NA
Page 1363 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 55
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 4: 75 PPM
---------------------------------------
23179-01 M 8.4 11.2 17.1 27.2 34.5 41.2 51.0
23179-02 M 7.7 9.6 15.1 26.2 35.9 43.1 54.6
23179-03 M 8.4 11.7 17.9 29.7 37.9 46.0 58.7
23179-04 M 7.8 11.4 18.0 27.7 33.1 39.9 50.6
23179-05 F 7.1 9.6 NA NA NA NA NA
23179-06 F 6.7 9.0 13.6 21.5 26.7 32.4 42.3
23179-07 F 7.3 10.1 NA NA NA NA NA
23179-08 F 7.3 10.7 16.9 26.9 34.0 40.7 55.6
23179-09 F 7.9 10.2 15.5 25.7 32.7 38.5 50.3
23179-10 F 7.5 10.4 15.8 25.8 32.3 38.5 52.2
Page 1364 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 56
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 4: 75 PPM
---------------------------------------
23212-14 F 7.5 9.1 NA NA NA NA NA
23212-15 F 7.0 8.9 14.9 25.5 34.9 44.7 57.4
23212-16 F 7.0 9.4 15.4 26.6 35.6 43.2 53.2
23212-17 F 7.0 8.9 14.4 24.3 33.9 42.2 53.3
23212-18 F 7.4 9.5 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 57
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 4: 75 PPM
---------------------------------------
23201-14 F 6.5 8.2 11.9 17.7 25.8 31.9 40.0
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 58
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 4: 75 PPM
---------------------------------------
23210-06 M 7.5 10.4 17.6 25.9 33.0 39.5 50.4
23210-07 M 7.7 9.9 NA NA NA NA NA
23210-08 M 7.8 11.3 NA NA NA NA NA
23210-09 M 7.1 9.6 16.2 25.3 32.8 37.4 47.9
23210-10 M 6.9 9.8 NA NA NA NA NA
23210-11 F 7.1 9.8 NA NA NA NA NA
23210-12 F 6.4 9.0 14.8 22.0 29.2 35.7 43.8
23210-13 F 6.9 9.2 NA NA NA NA NA
23210-14 F 6.7 9.7 15.8 24.8 31.9 38.7 49.9
23210-15 F 6.6 8.7 14.4 22.9 30.2 36.9 46.3
Page 1367 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 59
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 4: 75 PPM
---------------------------------------
23256-12 F 6.5 8.9 NA NA NA NA NA
23256-13 F 7.0 9.6 11.2 24.6 30.3 36.2 45.2
23256-14 F 6.7 8.3 16.4 20.6 28.1 35.4 44.9
23256-15 F 6.8 8.9 NA NA NA NA NA
23256-16 F 5.4 7.3 14.2 18.3 25.9 31.4 39.3
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 60
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 4: 75 PPM
---------------------------------------
23238-18 F 5.9 7.5 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 61
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 4: 75 PPM
---------------------------------------
23246-02 M 8.8 13.2 NA NA NA NA NA
23246-03 M 8.6 12.1 NA NA NA NA NA
23246-04 M 8.9 12.6 NA NA NA NA NA
23246-05 M 8.0 11.9 NA NA NA NA NA
23246-06 F 8.5 12.0 NA NA NA NA NA
23246-07 F 8.5 11.9 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 62
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 4: 75 PPM
---------------------------------------
23220-17 F 7.1 9.9 NA NA NA NA NA
23220-18 F 6.7 9.2 14.3 24.6 32.0 40.9 51.3
23183-05 M 8.2 NA NA NA NA NA NA
23183-06 M 8.8 12.2 18.1 29.5 36.8 46.4 57.2
23183-07 M 9.4 11.3 18.7 29.9 37.4 46.1 54.8
23183-08 F 7.4 9.9 15.2 25.8 31.1 37.6 48.0
23183-09 F 8.9 11.4 NA NA NA NA NA
23183-10 F 8.6 11.0 17.2 29.0 36.3 45.6 51.9
23183-11 F 8.4 11.3 17.5 30.1 37.1 46.1 54.4
23183-12 F 8.4 10.8 18.5 29.6 36.9 46.2 53.9
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 63
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 4: 75 PPM
---------------------------------------
23184-05 M 8.2 10.0 NA NA NA NA NA
23184-06 M 7.2 9.1 15.9 25.5 33.1 39.4 51.8
23184-07 M 7.9 9.9 17.0 28.5 36.5 44.3 55.2
23184-08 F 7.0 8.8 15.0 24.9 31.7 36.8 48.2
23184-09 F 7.6 9.9 NA NA NA NA NA
23184-10 F 6.7 9.0 NA NA NA NA NA
23184-11 F 7.3 10.4 NA NA NA NA NA
23184-12 F 7.4 9.1 NA NA NA NA NA
23184-13 F 7.5 9.4 NA NA NA NA NA
23184-14 F 7.4 9.8 16.7 27.4 34.6 42.3 49.1
Page 1372 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 64
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 4: 75 PPM
---------------------------------------
26497-02 M 8.2 11.6 NA NA NA NA NA
26497-03 M 7.8 NA NA NA NA NA NA
26497-04 M 8.3 10.4 NA NA NA NA NA
26497-05 M 7.2 9.8 NA NA NA NA NA
26497-06 M 7.3 9.5 16.1 25.4 35.3 43.3 59.1
26497-07 M 7.2 9.3 NA NA NA NA NA
26497-08 M 8.5 11.2 NA NA NA NA NA
26497-09 M 7.4 10.0 16.7 27.1 36.5 44.5 60.4
26497-10 M 6.9 9.2 16.1 26.0 34.8 41.6 60.0
26497-11 F 6.7 9.5 17.0 27.6 36.5 43.9 57.1
Page 1373 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 65
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 4: 75 PPM
---------------------------------------
26495-08 F 5.9 6.6 NA NA NA NA NA
26495-09 F 7.0 8.9 15.3 24.8 31.8 39.1 47.9
26495-10 F 7.5 9.8 16.5 26.0 34.1 41.9 53.6
26495-11 F 7.4 10.3 NA NA NA NA NA
26495-12 F 7.3 9.7 16.0 25.5 33.6 40.0 49.4
26495-13 F 7.0 9.2 NA NA NA NA NA
26495-14 F 7.3 9.9 16.6 26.0 33.6 40.8 50.9
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 66
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 4: 75 PPM
---------------------------------------
26499-17 F 7.1 7.1 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 67
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 4: 75 PPM
---------------------------------------
26533-07 M 7.3 10.8 17.6 27.2 35.4 42.8 60.3
26533-08 F 6.9 10.3 17.0 27.4 34.7 41.8 60.7
26533-09 F 7.2 9.9 16.6 26.6 35.2 43.5 62.1
26533-10 F 7.4 10.9 NA NA NA NA NA
26533-11 F 6.3 9.2 NA NA NA NA NA
26533-12 F 7.4 11.2 18.0 27.9 36.6 44.1 61.4
26533-13 F 7.1 10.6 NA NA NA NA NA
26533-14 F 7.1 10.4 16.9 26.9 35.3 43.7 59.8
26533-15 F 6.9 10.4 NA NA NA NA NA
Page 1376 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 68
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 4: 75 PPM
---------------------------------------
26502-17 F 6.9 10.0 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 69
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 4: 75 PPM
---------------------------------------
26535-03 M 7.1 9.8 15.8 24.2 31.9 39.3 49.2
26535-04 M 6.2 9.1 15.0 22.4 30.6 36.6 48.3
26535-05 M 6.7 9.5 15.4 21.9 29.7 34.2 43.2
26535-06 M 6.5 9.1 NA NA NA NA NA
26535-07 M 7.1 10.1 NA NA NA NA NA
26535-08 M 7.0 8.9 15.1 24.2 31.5 37.3 51.0
26535-09 M 5.5 8.2 NA NA NA NA NA
26535-10 F 6.2 8.9 NA NA NA NA NA
26535-11 F 6.4 9.3 14.4 21.3 29.6 34.6 42.0
26535-12 F 6.0 8.0 NA NA NA NA NA
Page 1378 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 70
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 4: 75 PPM
---------------------------------------
26456-08 M 7.0 9.7 16.5 25.7 33.7 39.9 52.6
26456-09 M 6.5 9.8 NA NA NA NA NA
26456-10 M 6.8 9.2 NA NA NA NA NA
26456-11 M 6.1 8.4 13.7 21.8 28.7 34.0 43.7
26456-12 M 7.0 8.6 NA NA NA NA NA
26456-13 F 6.1 8.3 NA NA NA NA NA
26456-14 F 6.8 9.2 15.5 23.9 31.4 40.4 53.3
26456-15 F 6.7 9.4 16.0 25.0 32.7 41.7 55.4
26456-16 F 6.3 8.7 15.1 24.6 32.5 40.5 54.4
26456-17 F 6.9 9.8 NA NA NA NA NA
Page 1379 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 71
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 4: 75 PPM
---------------------------------------
26518-12 F 7.9 11.0 16.5 27.4 35.6 43.1 55.7
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 72
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 5: 750 PPM
---------------------------------------
23198-01 M 7.5 10.8 17.5 27.0 34.6 42.4 56.3
23198-02 M 7.9 10.6 NA NA NA NA NA
23198-03 M 7.5 9.7 NA NA NA NA NA
23198-04 M 8.1 11.4 NA NA NA NA NA
23198-05 M 8.2 10.9 NA NA NA NA NA
23198-06 M 8.5 11.8 18.5 27.9 35.5 44.3 61.3
23198-07 M 7.1 9.9 16.4 25.3 32.8 39.5 51.1
23198-08 M 7.7 10.9 17.9 27.2 34.4 40.4 56.0
23198-09 F 7.1 9.4 NA NA NA NA NA
23198-10 F 8.3 10.6 NA NA NA NA NA
Page 1381 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 73
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 5: 750 PPM
---------------------------------------
23241-01 M 7.8 10.5 NA NA NA NA NA
23241-02 M 7.5 10.5 NA NA NA NA NA
23241-03 M 7.3 10.1 16.2 24.2 29.3 35.4 47.0
23241-04 M 7.7 10.9 17.3 26.1 30.7 35.9 49.4
23241-05 M 7.5 10.1 16.2 24.1 29.3 35.2 45.3
23241-06 M 7.6 10.5 17.1 25.1 29.5 34.4 45.8
23241-07 M 8.3 11.8 NA NA NA NA NA
23241-08 F 7.2 10.3 16.5 24.5 28.3 33.4 45.5
23241-09 F 7.3 10.2 16.4 24.9 29.3 34.5 46.9
23241-10 F 7.2 10.6 17.1 25.3 29.9 34.9 46.6
Page 1382 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 74
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 5: 750 PPM
---------------------------------------
23254-10 F 7.9 10.4 NA NA NA NA NA
23254-11 F 7.8 10.0 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 75
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 5: 750 PPM
---------------------------------------
23245-06 F 5.9 8.5 NA NA NA NA NA
23245-07 F 6.2 8.8 14.1 22.0 29.5 35.9 46.9
23245-08 F 6.3 8.7 NA NA NA NA NA
23245-09 F 6.1 8.6 NA NA NA NA NA
23245-10 F 5.9 8.5 13.9 21.8 28.2 34.5 42.9
23245-11 F 6.0 8.6 13.8 21.2 27.7 33.4 42.6
23245-12 F 5.6 8.1 NA NA NA NA NA
23245-13 F 6.4 9.2 NA NA NA NA NA
23245-14 F 5.9 8.4 13.1 20.7 27.2 35.6 42.3
Page 1384 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 76
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 5: 750 PPM
---------------------------------------
23223-14 F 7.8 10.0 NA NA NA NA NA
23223-15 F 7.0 9.8 15.1 26.8 33.2 40.5 50.9
23223-16 F 7.3 9.1 15.1 23.1 32.0 39.5 49.9
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 77
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 5: 750 PPM
---------------------------------------
23191-16 F 5.6 7.9 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 78
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 5: 750 PPM
---------------------------------------
23230-02 M 5.9 7.2 NA NA NA NA NA
23230-03 M 5.4 6.1 9.4 16.1 21.7 25.0 30.7
23230-04 M 5.2 6.2 NA NA NA NA NA
23230-05 M 6.0 7.1 11.3 17.9 25.2 31.2 36.9
23230-06 M 5.3 6.1 9.2 15.4 22.0 27.0 32.4
23230-07 M 5.7 6.7 10.5 17.4 25.2 32.2 39.0
23230-08 M 5.6 6.1 NA NA NA NA NA
23230-09 F 5.9 NA NA NA NA NA NA
23230-10 F 5.9 7.1 10.8 17.4 23.1 27.9 34.8
23230-11 F 5.5 6.1 8.8 12.5 18.4 23.8 30.5
Page 1387 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 79
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 5: 750 PPM
---------------------------------------
23249-10 M 7.9 10.7 16.4 16.9 NA NA NA
23249-11 F 7.3 10.0 15.5 17.3 19.3 24.8 29.7
23249-12 F 7.6 10.6 16.0 20.1 22.5 27.7 37.5
23249-13 F 7.7 10.3 15.6 18.3 21.7 26.4 35.7
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 80
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 5: 750 PPM
---------------------------------------
26485-03 M 6.3 9.5 NA NA NA NA NA
26485-04 M 6.4 9.6 NA NA NA NA NA
26485-05 M 6.5 9.8 NA NA NA NA NA
26485-06 M 6.5 9.7 NA NA NA NA NA
26485-07 M 6.5 9.6 NA NA NA NA NA
26485-08 M 6.7 9.8 NA NA NA NA NA
26485-09 M 7.0 10.5 NA NA NA NA NA
26485-10 M 6.8 10.3 NA NA NA NA NA
26485-11 M 6.9 10.6 NA NA NA NA NA
26485-12 M 6.3 9.8 NA NA NA NA NA
Page 1389 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 81
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 5: 750 PPM
---------------------------------------
26478-11 F 8.3 11.4 NA NA NA NA NA
26478-12 F 7.8 11.5 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 82
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 5: 750 PPM
---------------------------------------
26501-17 F 5.9 8.8 14.1 21.7 30.0 37.1 50.5
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 83
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 5: 750 PPM
---------------------------------------
26464-04 M 7.7 9.2 NA NA NA NA NA
26464-05 M 8.0 10.8 17.6 27.9 35.9 44.4 56.7
26464-06 M 8.4 10.4 16.2 25.9 32.9 39.9 49.6
26464-07 M 7.8 10.2 NA NA NA NA NA
26464-08 F 7.2 9.3 14.4 23.3 29.7 38.9 46.0
26464-09 F 7.3 9.4 15.1 24.3 31.7 41.2 51.6
26464-10 F 7.5 9.5 15.2 24.2 32.0 38.7 47.9
26464-11 F 7.5 10.5 15.9 26.0 33.9 42.4 54.4
26464-12 F 6.9 9.1 NA NA NA NA NA
26464-13 F 6.8 8.9 NA NA NA NA NA
Page 1392 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 84
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 5: 750 PPM
---------------------------------------
26498-13 F 6.3 8.1 NA NA NA NA NA
26498-14 F 6.2 8.0 14.7 22.4 30.9 37.6 48.8
26498-15 F 5.8 7.6 13.4 20.6 28.7 34.5 47.2
26498-16 F 5.9 7.8 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 85
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 5: 750 PPM
---------------------------------------
26481-16 F 6.4 8.4 14.3 22.4 29.3 37.0 51.9
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 86
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 5: 750 PPM
---------------------------------------
26472-18 F 5.8 8.1 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 87
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 5: 750 PPM
---------------------------------------
26506-02 M 6.9 9.6 16.3 27.9 38.1 45.8 58.5
26506-03 M 6.1 8.5 15.0 24.2 34.1 41.4 52.6
26506-04 M 6.4 9.0 15.3 25.0 34.1 43.3 54.5
26506-05 M 6.6 9.2 15.2 26.9 35.6 43.8 51.7
26506-06 F 6.1 8.1 NA NA NA NA NA
26506-07 F 6.3 8.8 NA NA NA NA NA
26506-08 F 5.8 8.3 NA NA NA NA NA
26506-09 F 6.6 9.4 15.2 26.8 35.7 42.6 54.7
26506-10 F 5.7 NA NA NA NA NA NA
26506-11 F 5.6 7.4 NA NA NA NA NA
Page 1396 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 88
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 5: 750 PPM
---------------------------------------
26471-07 M 7.0 9.9 16.4 25.8 33.8 42.5 56.2
26471-08 M 7.4 10.4 17.2 27.5 35.9 43.5 56.2
26471-09 M 6.5 9.0 15.6 25.6 33.3 39.9 50.6
26471-10 F 7.0 9.8 16.4 26.4 34.0 39.9 52.1
26471-11 F 6.7 9.6 15.8 24.6 33.3 40.0 53.2
26471-12 F 6.9 9.6 NA NA NA NA NA
26471-13 F 6.7 9.3 15.7 25.8 33.7 40.9 52.2
26471-14 F 6.4 9.0 15.3 24.5 31.8 40.1 49.5
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 89
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 5: 750 PPM
---------------------------------------
26455-14 F 7.2 8.7 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 90
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 6: 2250 PPM
---------------------------------------
23255-01 M 6.2 7.4 NA NA NA NA NA
23255-02 M 6.0 6.9 11.0 18.8 24.8 32.6 40.9
23255-03 M 5.7 6.7 NA NA NA NA NA
23255-04 M 5.9 7.1 11.0 18.4 25.7 32.0 40.2
23255-05 M 5.3 6.3 10.2 17.1 23.1 29.8 37.3
23255-06 M 6.1 7.2 NA NA NA NA NA
23255-07 M 5.8 7.0 NA NA NA NA NA
23255-08 M 6.1 7.4 11.9 19.0 27.0 32.8 41.9
23255-09 M 5.7 6.4 NA NA NA NA NA
23255-10 M 6.2 7.0 NA NA NA NA NA
Page 1399 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 91
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 6: 2250 PPM
---------------------------------------
23215-07 M 7.4 9.7 NA NA NA NA NA
23215-08 M 8.7 11.2 NA NA NA NA NA
23215-09 M 8.3 10.8 NA NA NA NA NA
23215-10 F 7.3 9.3 NA NA NA NA NA
23215-11 F 7.2 9.2 15.5 23.8 32.2 39.1 51.2
23215-12 F 7.8 9.5 16.1 25.1 33.5 41.6 51.0
23215-13 F 8.6 10.4 17.3 26.0 33.4 39.7 51.2
23215-14 F 6.9 8.6 NA NA NA NA NA
23215-15 F 8.3 9.8 16.6 25.5 34.3 44.2 51.8
23215-16 F 7.2 9.6 NA NA NA NA NA
Page 1400 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 92
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 6: 2250 PPM
---------------------------------------
23214-13 F 6.9 9.5 NA NA NA NA NA
23214-14 F 6.8 8.8 14.5 23.1 30.9 37.3 49.6
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 93
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 6: 2250 PPM
---------------------------------------
23219-07 M 7.3 10.9 NA NA NA NA NA
23219-08 M 7.5 10.5 NA NA NA NA NA
23219-09 M 7.1 10.3 NA NA NA NA NA
23219-10 M 7.5 10.8 19.2 27.4 35.0 43.4 56.5
23219-11 M 7.8 11.2 18.5 27.2 36.1 44.9 59.5
23219-12 F 6.7 9.4 16.4 24.4 31.9 37.8 50.0
23219-13 F 7.0 10.2 17.9 26.6 34.6 42.9 53.8
23219-14 F 7.4 10.3 17.3 25.9 34.1 42.7 54.8
23219-15 F 7.3 10.0 17.2 25.3 33.3 40.4 48.5
23219-16 F 7.1 10.2 NA NA NA NA NA
Page 1402 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 94
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 6: 2250 PPM
---------------------------------------
23211-13 F 6.5 8.3 13.5 19.1 26.7 33.3 43.5
23211-14 F 7.2 8.9 15.2 21.8 29.8 36.1 49.1
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 95
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 6: 2250 PPM
---------------------------------------
23189-18 F 4.9 6.4 11.1 17.4 24.6 31.1 38.5
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 96
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 6: 2250 PPM
---------------------------------------
23204-18 F 6.0 7.2 11.2 17.6 25.0 31.9 40.8
23257-01 M 3.8 NA NA NA NA NA NA
23257-02 M 4.8 5.6 NA NA NA NA NA
23257-03 M 4.9 6.0 NA NA NA NA NA
23257-04 M 6.7 9.4 15.1 22.8 30.1 34.2 48.8
23257-05 M 6.3 8.9 15.2 24.0 33.5 41.8 51.5
Page 1405 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 97
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 6: 2250 PPM
---------------------------------------
23257-17 F 4.9 5.6 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 98
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 6: 2250 PPM
---------------------------------------
23227-03 M 6.2 8.2 NA NA NA NA NA
23227-04 M 6.1 7.8 NA NA NA NA NA
23227-05 M 6.5 8.4 14.4 22.7 30.4 35.6 46.5
23227-06 M 6.2 8.1 NA NA NA NA NA
23227-07 M 6.7 8.6 14.6 23.2 31.5 38.5 48.4
23227-08 M 7.1 8.8 NA NA NA NA NA
23227-09 M 6.3 8.7 14.3 22.3 30.7 37.6 47.2
23227-10 M 6.4 8.5 NA NA NA NA NA
23227-11 F 6.1 8.1 13.4 20.9 28.9 35.5 43.4
23227-12 F 6.4 8.0 13.7 21.5 28.8 38.4 42.2
Page 1407 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 99
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 6: 2250 PPM
---------------------------------------
26509-09 F 6.5 9.0 NA NA NA NA NA
26509-10 F 6.3 8.0 13.6 20.9 28.3 34.5 46.5
26509-11 F 6.9 9.6 16.5 25.4 32.5 39.6 52.6
26509-12 F 6.5 8.8 NA NA NA NA NA
26509-13 F 6.9 9.0 14.3 22.8 29.7 36.4 49.2
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 100
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 6: 2250 PPM
---------------------------------------
26448-15 F 7.0 10.2 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 101
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 6: 2250 PPM
---------------------------------------
26463-02 M 6.6 9.0 15.9 25.4 33.3 41.3 53.8
26463-03 M 6.6 9.1 NA NA NA NA NA
26463-04 M 4.9 6.7 10.9 19.5 28.1 35.7 43.4
26463-05 M 5.6 7.8 NA NA NA NA NA
26463-06 M 6.3 8.9 15.5 25.3 33.2 40.7 52.0
26463-07 M 6.7 9.1 14.5 23.1 30.7 38.3 46.5
26463-08 F 6.2 8.0 13.3 22.4 30.1 36.2 43.2
26463-09 F 6.6 8.8 15.3 25.3 33.9 42.0 49.7
26463-10 F 6.3 8.4 NA NA NA NA NA
26463-11 F 6.0 8.0 NA NA NA NA NA
Page 1410 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 102
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 6: 2250 PPM
---------------------------------------
26504-09 F 6.6 9.3 NA NA NA NA NA
26504-10 F 6.5 8.8 15.1 21.9 29.1 35.6 44.6
26504-11 F 5.1 6.8 11.1 16.7 22.0 28.8 37.2
26504-12 F 6.5 9.1 NA NA NA NA NA
26504-13 F 6.2 7.7 NA NA NA NA NA
26504-14 F 6.3 8.9 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 103
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 6: 2250 PPM
---------------------------------------
26465-15 F 2.6 NA NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 104
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 6: 2250 PPM
---------------------------------------
26511-05 M 8.0 11.1 17.9 27.9 35.1 42.2 57.4
26511-06 M 7.4 10.4 16.6 26.9 34.9 43.4 55.8
26511-07 F 7.1 10.9 17.5 26.5 33.8 42.6 53.2
26511-08 F 6.4 9.6 NA NA NA NA NA
26511-09 F 6.8 10.0 NA NA NA NA NA
26511-10 F 7.4 10.2 NA NA NA NA NA
26511-11 F 6.8 9.9 16.2 25.4 32.9 39.8 53.6
26511-12 F 7.2 10.4 16.4 25.7 33.2 40.8 51.5
26511-13 F 7.1 10.6 NA NA NA NA NA
26511-14 F 6.2 9.6 15.6 26.2 33.0 40.3 50.9
Page 1413 of 4796
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 105
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 6: 2250 PPM
---------------------------------------
26466-13 F 5.9 7.5 13.4 22.0 29.2 35.2 46.8
26466-14 F 6.0 8.5 NA NA NA NA NA
26466-15 F 6.3 8.6 NA NA NA NA NA
26466-16 F 6.8 8.5 14.2 22.7 30.9 38.4 52.8
26466-17 F 7.1 9.2 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 106
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 6: 2250 PPM
---------------------------------------
26462-17 F 5.7 5.5 9.1 16.3 24.6 33.7 41.2
NA = NOT APPLICABLE
TABLE A25 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 107
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 6: 2250 PPM
---------------------------------------
26470-03 M 6.3 8.9 NA NA NA NA NA
26470-04 M 6.1 8.7 13.7 22.0 28.7 35.5 44.8
26470-05 M 6.7 9.4 15.7 25.2 31.1 36.9 51.5
26470-06 M 6.5 9.0 14.7 23.5 30.8 38.2 49.5
26470-07 M 6.4 9.3 15.9 25.0 32.3 40.0 52.1
26470-08 F 6.1 8.7 15.2 23.6 30.0 37.5 49.3
26470-09 F 5.6 7.6 12.9 20.9 27.0 31.9 42.1
26470-10 F 6.1 9.3 13.2 24.2 31.2 38.5 50.9
26470-11 F 5.9 8.2 14.6 21.4 28.5 34.4 45.1
26470-12 F 5.8 8.0 NA NA NA NA NA
Page 1416 of 4796
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
23243-01 M 2.6 5.9 10.1 7.8 7.2 8.4
23243-02 M 2.4 6.9 9.7 7.0 9.0 10.9
23243-03 M 2.7 6.3 10.3 7.4 8.9 7.8
23243-04 M 2.9 NA NA NA NA NA
23243-05 M 2.8 6.0 10.0 7.9 6.7 8.9
23243-06 M 2.5 NA NA NA NA NA
23243-07 M 2.4 NA NA NA NA NA
23243-08 M 2.5 NA NA NA NA NA
23243-09 M 2.9 NA NA NA NA NA
23243-10 F 2.9 6.1 9.8 7.9 7.4 9.8
Page 1417 of 4796
23243-11 F 2.5 NA NA NA NA NA
23243-12 F 2.9 6.4 9.5 7.8 7.6 8.0
23243-13 F 2.2 NA NA NA NA NA
23243-14 F 2.4 6.7 10.5 8.7 7.1 7.8
23243-15 F 1.2 5.4 9.6 8.1 7.7 10.2
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 2
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
23213-09 F 2.4 5.6 8.4 8.6 7.6 8.9
23213-10 F 3.0 6.0 10.0 8.5 6.4 10.6
23213-11 F 2.1 NA NA NA NA NA
23213-12 F 2.0 NA NA NA NA NA
23213-13 F 2.6 6.0 10.4 9.1 7.1 10.8
23213-14 F 1.6 NA NA NA NA NA
23213-15 F 2.4 5.9 9.0 8.5 6.4 10.2
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 3
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
23203-17 F 1.6 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 4
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
23226-04 M 2.0 4.6 10.1 9.5 8.6 11.3
23226-05 F 2.0 4.3 8.9 9.3 6.7 9.1
23226-06 F 1.4 NA NA NA NA NA
23226-07 F 1.1 NA NA NA NA NA
23226-08 F 1.1 3.8 8.5 8.9 6.8 6.6
23226-09 F 1.4 NA NA NA NA NA
23226-10 F 2.5 4.2 9.7 8.5 7.5 10.4
23226-11 F 1.4 NA NA NA NA NA
23226-12 F 1.2 NA NA NA NA NA
23226-13 F 0.9 4.1 8.3 9.3 6.7 8.9
Page 1420 of 4796
23226-15 F 1.8 NA NA NA NA NA
23242-01 M 2.6 NA NA NA NA NA
23242-02 M 1.9 NA NA NA NA NA
23242-03 M 2.1 NA NA NA NA NA
23242-04 M 2.5 5.3 9.3 7.0 6.9 11.6
23242-05 M 2.5 5.8 9.2 8.8 7.4 11.6
23242-06 M 2.3 6.3 10.5 9.3 7.5 12.9
23242-07 M 2.0 NA NA NA NA NA
23242-08 M 1.9 5.9 10.1 8.8 8.6 11.3
23242-09 F 2.3 NA NA NA NA NA
23242-10 F 2.4 NA NA NA NA NA
23242-11 F 2.0 5.8 9.4 9.7 7.7 11.1
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 5
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
23242-12 F 2.1 NA NA NA NA NA
23242-13 F 2.0 NA NA NA NA NA
23242-14 F 1.8 NA NA NA NA NA
23242-15 F 2.2 5.1 8.9 8.6 6.0 10.4
23242-16 F 1.9 5.7 8.6 8.6 6.5 9.7
23242-17 F 2.6 5.4 9.0 8.6 7.4 8.6
23209-01 M 3.3 NA NA NA NA NA
23209-02 M 2.9 NA NA NA NA NA
23209-03 M 3.0 6.7 7.8 7.4 6.2 12.0
23209-04 M 1.9 NA NA NA NA NA
23209-05 M 2.9 6.2 7.6 7.6 6.0 10.1
23209-06 M 2.2 5.8 8.2 9.1 5.4 11.9
23209-07 M 2.2 NA NA NA NA NA
23209-08 M 2.7 4.7 9.7 8.3 7.5 12.5
23209-09 M 2.3 NA NA NA NA NA
23209-10 F 2.4 NA NA NA NA NA
23209-11 F 3.0 NA NA NA NA NA
23209-12 F 3.6 6.4 9.0 9.2 5.9 10.1
23209-13 F 1.7 NA NA NA NA NA
23209-14 F 2.5 5.2 8.4 7.4 6.4 11.7
23209-15 F 3.1 6.6 9.3 8.4 4.9 12.2
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 6
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
23209-16 F 2.3 6.4 8.5 8.0 4.5 12.7
23178-06 M 2.4 NA NA NA NA NA
23178-07 M 2.8 6.3 9.0 7.5 7.7 14.4
23178-08 M 2.1 NA NA NA NA NA
23178-09 F 2.6 NA NA NA NA NA
23178-10 F 1.8 NA NA NA NA NA
23178-11 F 2.1 4.9 8.0 8.3 7.2 11.4
23178-12 F 2.1 5.4 8.1 8.5 7.3 7.5
23178-13 F 2.1 5.2 7.8 6.3 6.4 11.3
23178-14 F 2.5 5.7 9.1 7.7 6.8 11.4
23178-15 F 2.5 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 7
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
23186-03 M 2.1 5.2 9.0 8.6 6.4 7.4
23186-04 M 2.2 NA NA NA NA NA
23186-05 M 1.7 4.7 8.1 8.1 7.2 7.4
23186-06 M 2.2 NA NA NA NA NA
23186-07 F 1.6 4.8 7.8 7.3 5.7 7.6
23186-08 F 2.1 5.2 8.2 7.1 7.4 7.9
23186-09 F 1.6 5.7 7.9 7.8 7.0 8.2
23186-10 F 2.0 NA NA NA NA NA
23186-11 F 1.8 5.8 9.0 9.2 6.8 7.6
23186-12 F 2.1 NA NA NA NA NA
Page 1423 of 4796
23186-13 F 1.7 NA NA NA NA NA
23186-14 F 2.2 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 8
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
23194-11 F 2.3 NA NA NA NA NA
23194-12 F 1.7 NA NA NA NA NA
23194-13 F 1.8 4.2 8.9 9.1 9.6 8.3
23194-14 F 2.2 NA NA NA NA NA
23194-15 F 1.9 5.0 9.9 10.4 9.3 10.6
23194-17 F 2.1 5.1 8.8 8.4 8.3 10.2
23182-01 M 2.1 NA NA NA NA NA
23182-02 M 2.9 NA NA NA NA NA
23182-03 M 3.3 6.9 12.9 7.2 7.9 11.2
23182-04 M 1.9 6.7 11.1 8.1 9.0 3.9
23182-05 M 2.4 6.7 12.3 10.1 8.9 8.3
23182-06 M 2.6 NA NA NA NA NA
23182-07 M 2.5 7.0 12.1 8.4 8.2 11.0
23182-08 F 2.0 NA NA NA NA NA
23182-09 F 2.7 NA NA NA NA NA
23182-10 F 2.2 6.9 10.8 10.2 9.0 8.1
23182-11 F 2.4 5.6 12.4 6.5 7.1 9.1
23182-12 F 1.7 5.5 10.4 7.9 9.0 8.0
23182-13 F 2.1 NA NA NA NA NA
23182-14 F 2.3 NA NA NA NA NA
23182-15 F 1.7 6.9 11.6 7.9 9.9 9.3
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 9
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
23182-16 F 2.2 NA NA NA NA NA
23240-07 M 2.4 NA NA NA NA NA
23240-08 M 2.5 7.2 9.2 7.1 7.4 8.2
23240-09 M 3.1 NA NA NA NA NA
23240-10 M 2.4 NA NA NA NA NA
23240-11 M 2.8 NA NA NA NA NA
23240-12 F 1.9 7.2 9.3 6.4 5.2 7.7
23240-13 F 2.5 7.2 9.9 7.0 6.6 8.7
23240-14 F 2.5 6.6 9.5 7.4 6.6 10.2
23240-15 F 3.1 5.9 9.8 6.9 7.2 8.1
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 10
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
26521-05 M 2.8 7.1 10.1 9.7 9.4 12.4
26521-06 M 3.2 NA NA NA NA NA
26521-07 M 3.5 NA NA NA NA NA
26521-08 M 2.7 6.2 9.7 9.6 7.2 10.3
26521-09 M 2.6 NA NA NA NA NA
26521-10 M 2.5 NA NA NA NA NA
26521-11 F 2.5 NA NA NA NA NA
26521-12 F 2.6 6.1 9.6 8.1 6.5 10.5
26521-13 F 2.6 NA NA NA NA NA
26521-14 F 2.8 7.5 9.7 9.1 7.3 13.8
Page 1426 of 4796
26521-15 F 2.1 NA NA NA NA NA
26521-16 F 2.5 6.0 9.4 9.3 7.2 12.7
26521-17 F 3.0 6.5 9.4 10.2 7.4 12.3
26449-02 M 2.2 NA NA NA NA NA
26449-03 M 2.6 NA NA NA NA NA
26449-04 M 2.2 NA NA NA NA NA
26449-05 M 2.2 5.8 8.6 7.8 8.4 14.7
26449-06 M 2.7 NA NA NA NA NA
26449-07 M 2.2 6.3 7.7 8.6 6.7 17.7
26449-08 M 2.3 5.8 9.3 8.1 8.6 16.1
26449-09 M 2.8 6.1 9.2 7.8 9.3 15.8
26449-10 M 2.1 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 11
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
26449-11 F 2.7 NA NA NA NA NA
26449-12 F 2.6 5.8 9.3 8.6 7.8 16.5
26449-13 F 2.3 NA NA NA NA NA
26449-14 F 2.4 5.8 9.3 7.6 8.1 13.8
26449-15 F 2.6 6.0 9.2 7.4 8.1 16.4
26449-16 F 1.8 NA NA NA NA NA
26449-17 F 2.5 6.0 9.3 5.6 7.1 14.2
26473-01 M 2.3 NA NA NA NA NA
26473-02 M 2.5 NA NA NA NA NA
26473-03 M 2.2 6.2 9.3 8.3 8.2 16.5
26473-04 M 2.6 6.4 9.2 6.5 6.2 17.9
26473-05 M 2.5 6.2 8.9 7.0 6.7 11.2
26473-06 M 2.7 6.1 9.3 5.7 5.4 15.6
26473-07 M 2.9 NA NA NA NA NA
26473-08 F 2.1 NA NA NA NA NA
26473-09 F 2.0 5.4 8.5 6.8 6.4 15.4
26473-10 F 2.6 5.9 9.1 7.5 6.0 13.4
26473-11 F 2.1 5.8 9.7 7.0 5.5 13.6
26473-12 F 3.1 NA NA NA NA NA
26473-13 F 2.8 6.0 9.1 6.7 6.3 16.3
26473-14 F 2.8 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 12
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
26473-15 F 2.4 NA NA NA NA NA
26452-07 M 1.9 NA NA NA NA NA
26452-08 M 2.7 NA NA NA NA NA
26452-09 M 2.4 NA NA NA NA NA
26452-10 M 2.5 NA NA NA NA NA
26452-11 M 2.8 6.8 9.6 10.1 9.1 13.9
26452-12 F 2.9 NA NA NA NA NA
26452-13 F 2.4 5.9 9.2 9.3 10.1 14.0
26452-14 F 2.6 NA NA NA NA NA
26452-15 F 2.4 5.8 7.4 11.1 7.5 12.3
26452-16 F 2.4 5.0 10.6 5.9 7.3 11.6
26452-17 F 2.5 5.6 8.2 8.2 8.6 9.9
26491-01 M 2.8 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 13
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
26491-02 M 2.9 6.8 9.6 5.9 7.5 19.2
26491-03 M 2.6 7.0 10.2 6.1 7.3 19.3
26491-04 M 2.4 6.4 9.3 4.7 6.4 14.2
26491-05 M 2.6 6.0 9.7 4.9 6.7 17.7
26491-06 M 2.6 NA NA NA NA NA
26491-07 F 2.5 6.5 8.9 5.9 6.1 13.1
26491-08 F 2.5 NA NA NA NA NA
26491-09 F 2.5 6.7 9.5 4.9 6.3 12.6
26491-10 F 2.9 6.7 9.1 5.9 8.7 19.2
26491-11 F 2.3 NA NA NA NA NA
Page 1429 of 4796
26491-12 F 2.2 NA NA NA NA NA
26491-13 F 2.7 NA NA NA NA NA
26491-14 F 3.0 7.5 9.7 4.7 6.6 14.8
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 14
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
26512-10 F 3.0 NA NA NA NA NA
26512-11 F 3.1 6.3 7.9 6.2 7.4 14.6
26512-12 F 2.4 NA NA NA NA NA
26512-13 F 3.4 5.4 8.4 7.3 6.6 13.1
26454-03 M 3.9 NA NA NA NA NA
26454-04 M 3.2 6.7 9.5 7.7 5.9 16.2
26454-05 M 3.8 6.9 11.0 7.9 4.3 12.8
26454-06 F 3.4 NA NA NA NA NA
26454-07 F 3.7 NA NA NA NA NA
26454-08 F 2.9 6.6 9.9 6.4 5.0 16.5
26454-09 F 3.1 NA NA NA NA NA
26454-10 F 3.0 NA NA NA NA NA
26454-11 F 4.1 6.6 10.8 5.5 5.2 16.8
26454-12 F 3.5 NA NA NA NA NA
26454-13 F 2.8 NA NA NA NA NA
26454-14 F 3.1 6.5 8.6 7.9 5.7 15.9
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 15
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
26454-15 F 3.4 5.9 8.8 6.8 4.6 15.2
26529-06 F 2.7 NA NA NA NA NA
26529-07 F 1.7 NA NA NA NA NA
26529-08 F 2.7 NA NA NA NA NA
26529-09 F 2.2 NA NA NA NA NA
26529-10 F 2.7 6.7 10.0 7.7 8.1 12.9
26529-11 F 2.9 NA NA NA NA NA
26529-12 F 3.4 7.4 10.7 7.1 7.4 14.9
26529-13 F 2.3 NA NA NA NA NA
26529-14 F 2.4 7.1 10.1 6.7 7.4 14.3
26529-15 F 2.3 NA NA NA NA NA
26529-16 F 3.1 6.5 10.9 8.0 8.2 13.9
26453-01 M 2.1 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 16
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
26453-02 M 2.0 NA NA NA NA NA
26453-03 M 2.0 NA NA NA NA NA
26453-04 M 2.7 NA NA NA NA NA
26453-05 M 2.1 6.1 9.3 9.3 6.3 12.7
26453-06 M 2.3 NA NA NA NA NA
26453-07 M 2.2 NA NA NA NA NA
26453-08 M 2.5 NA NA NA NA NA
26453-09 M 1.7 5.0 7.4 7.2 4.8 8.5
26453-10 M 2.4 NA NA NA NA NA
26453-11 M 2.1 5.6 8.7 8.8 7.3 12.1
Page 1432 of 4796
26453-12 M 0.6 NA NA NA NA NA
26453-13 M 1.5 5.7 6.5 9.2 8.0 14.0
26453-14 F 2.2 6.3 8.6 8.5 7.6 10.8
26453-15 F 1.8 6.7 8.5 7.7 7.8 12.4
26453-16 F 2.0 5.5 9.0 8.4 7.6 11.0
26453-17 F 3.0 6.8 9.0 7.6 7.2 16.1
26527-01 M 2.6 NA NA NA NA NA
26527-02 M 2.5 NA NA NA NA NA
26527-03 M 3.2 5.1 10.0 8.2 5.3 10.1
26527-04 M 2.7 NA NA NA NA NA
26527-05 M 2.8 6.6 10.1 7.9 6.9 9.2
26527-06 M 2.3 5.2 10.0 8.4 7.1 8.0
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 17
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
26527-07 M 2.5 6.0 9.6 9.9 7.8 11.0
26527-08 M 2.3 NA NA NA NA NA
26527-09 F 2.3 NA NA NA NA NA
26527-10 F 2.5 NA NA NA NA NA
26527-11 F 2.3 5.3 9.7 8.0 6.8 9.1
26527-12 F 2.5 5.6 9.7 8.8 8.3 10.1
26527-13 F 2.2 5.6 9.6 8.2 7.2 7.5
26527-14 F 2.5 5.0 9.2 8.2 5.1 9.0
26489-03 M 2.1 NA NA NA NA NA
26489-04 M 1.6 NA NA NA NA NA
26489-05 M 1.8 NA NA NA NA NA
26489-06 M 1.6 NA NA NA NA NA
26489-07 M 1.9 6.1 11.1 8.5 8.3 7.7
26489-08 M 1.6 4.5 10.4 6.9 7.2 8.8
26489-09 M 1.4 4.4 9.8 6.8 7.5 5.9
26489-10 M 2.5 NA NA NA NA NA
26489-11 M 2.1 5.2 12.3 7.7 7.3 8.7
26489-12 F 2.2 NA NA NA NA NA
26489-13 F 1.9 4.3 11.0 7.2 7.2 7.0
26489-14 F 1.9 NA NA NA NA NA
26489-15 F 1.5 5.8 11.5 8.8 8.4 6.4
26489-16 F 1.5 5.4 9.6 9.1 7.7 8.4
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 18
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
26489-17 F 1.4 3.8 9.6 6.6 6.6 6.5
26489-18 F 1.7 NA NA NA NA NA
26489-19 F 0.5 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 19
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
23195-01 M 2.8 5.8 11.7 8.7 7.1 16.5
23195-02 M 2.4 NA NA NA NA NA
23195-03 M 2.1 NA NA NA NA NA
23195-04 M 2.7 5.6 11.2 9.2 8.2 16.1
23195-05 M 2.7 6.2 11.7 9.3 9.3 13.2
23195-06 M 3.1 6.0 11.1 8.2 6.4 14.8
23195-07 M 3.1 NA NA NA NA NA
23195-08 M 2.6 6.6 9.8 8.8 6.4 10.9
23195-09 M 2.6 NA NA NA NA NA
23195-10 F 2.8 6.7 10.9 7.9 6.6 13.9
Page 1435 of 4796
23180-01 M 1.7 NA NA NA NA NA
23180-02 M 2.2 6.8 9.6 8.2 8.1 13.8
23180-03 M 1.6 5.9 7.8 5.0 5.0 12.8
23180-05 M 1.4 NA NA NA NA NA
23180-06 M 2.8 6.3 8.8 7.8 7.9 13.1
23180-07 M 2.1 6.0 10.0 8.5 8.1 14.0
23180-08 M 2.0 NA NA NA NA NA
23180-09 F 2.4 NA NA NA NA NA
23180-10 F 2.2 6.2 8.9 9.1 5.3 12.8
23180-11 F 2.3 6.5 7.2 8.2 6.0 12.1
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 20
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
23180-12 F 2.0 6.6 9.9 6.7 8.2 14.7
23180-13 F 1.6 NA NA NA NA NA
23180-14 F 1.5 NA NA NA NA NA
23180-15 F 2.0 6.2 8.9 8.9 6.5 12.7
23180-16 F 1.9 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 21
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
23176-16 F 1.1 NA NA NA NA NA
23251-06 M 2.9 NA NA NA NA NA
23251-07 M 4.2 NA NA NA NA NA
23251-08 M 3.4 NA NA NA NA NA
23251-09 M 3.2 NA NA NA NA NA
23251-10 M 3.5 6.9 9.7 9.0 8.7 14.5
23251-11 F 2.7 6.7 9.7 9.0 8.6 12.7
23251-12 F 2.7 7.1 10.7 10.4 8.9 10.9
23251-13 F 3.7 7.3 9.4 7.8 6.8 12.6
23251-15 F 3.0 6.5 10.0 9.9 8.8 12.3
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 22
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
23235-07 F 2.1 5.7 4.3 11.2 6.2 7.6
23235-08 M 1.6 3.7 10.7 3.3 5.6 5.3
23235-09 F 1.9 4.7 7.8 7.1 6.4 9.2
23235-10 F 2.3 5.6 8.5 6.5 5.0 8.5
23235-11 F 2.1 NA NA NA NA NA
23235-12 F 2.6 NA NA NA NA NA
23235-13 F 0.4 NA NA NA NA NA
23235-14 F 2.1 4.9 8.1 7.0 5.6 10.0
23235-15 F 1.7 NA NA NA NA NA
Page 1438 of 4796
23231-01 M 3.6 NA NA NA NA NA
23231-02 M 2.5 NA NA NA NA NA
23231-03 M 3.1 6.4 9.7 6.7 6.7 10.4
23231-04 M 2.5 6.6 9.6 8.7 6.9 11.1
23231-05 M 3.2 NA NA NA NA NA
23231-06 M 2.7 6.0 9.9 8.0 8.2 11.1
23231-07 M 3.0 6.1 10.4 8.0 8.3 10.3
23231-08 M 2.7 NA NA NA NA NA
23231-09 M 2.4 NA NA NA NA NA
23231-10 F 2.6 6.2 10.0 8.0 6.8 11.4
23231-11 F 2.5 6.1 10.5 8.3 6.8 9.9
23231-12 F 2.9 6.1 10.0 7.7 7.1 10.5
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 23
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
23231-13 F 2.5 5.7 10.8 8.6 7.2 12.4
23216-07 M 3.6 NA NA NA NA NA
23216-08 M 2.3 6.3 10.5 10.7 9.0 14.9
23216-09 M 2.7 NA NA NA NA NA
23216-10 M 3.3 NA NA NA NA NA
23216-11 F 2.6 6.2 9.1 9.5 5.8 13.0
23216-12 F 3.1 NA NA NA NA NA
23216-13 F 2.6 NA NA NA NA NA
23216-14 F 3.2 NA NA NA NA NA
23216-15 F 3.0 6.3 8.7 11.9 9.3 15.1
23216-16 F 3.5 5.6 9.3 10.0 7.9 11.5
23216-17 F 2.3 5.4 10.7 10.0 9.4 14.4
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 24
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
23261-02 M 2.9 6.5 9.0 8.2 7.7 10.7
23261-03 M 2.4 NA NA NA NA NA
23261-04 M 2.6 6.2 8.4 7.0 6.1 14.5
23261-05 M 3.1 6.4 9.6 7.8 7.8 10.5
23261-06 M 2.6 NA NA NA NA NA
23261-07 F 1.7 5.9 8.8 8.3 6.8 10.7
23261-08 F 2.7 NA NA NA NA NA
23261-09 F 2.2 6.7 10.1 8.7 8.1 9.4
23261-10 F 2.0 6.8 8.0 7.4 6.1 6.6
23261-11 F 1.9 NA NA NA NA NA
Page 1440 of 4796
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 25
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
23205-11 F 2.1 NA NA NA NA NA
23205-12 F 1.8 NA NA NA NA NA
23205-13 F 2.1 NA NA NA NA NA
23205-14 F 1.5 4.5 7.1 8.5 6.4 13.9
23205-15 F 2.4 NA NA NA NA NA
23205-16 F 2.1 6.6 7.5 10.6 8.9 14.7
23181-01 M 2.8 NA NA NA NA NA
23181-02 M 2.7 NA NA NA NA NA
23181-03 M 2.9 6.2 11.9 5.2 8.8 12.8
23181-04 M 2.7 5.6 11.7 7.6 7.1 11.1
23181-05 M 2.4 6.7 11.4 8.1 9.2 12.4
23181-07 M 3.3 6.5 13.2 7.5 5.0 12.2
23181-08 F 2.0 4.5 10.2 6.0 6.4 8.7
23181-09 F 2.9 NA NA NA NA NA
23181-10 F 2.0 NA NA NA NA NA
23181-11 F 2.5 5.7 10.1 8.1 9.2 9.6
23181-12 F 2.4 6.3 11.7 6.3 4.8 9.4
23181-13 F 2.4 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 26
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
23181-14 F 2.1 6.7 11.8 7.1 6.8 10.4
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 27
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
26474-06 M 2.5 NA NA NA NA NA
26474-07 M 2.5 NA NA NA NA NA
26474-08 M 2.4 6.0 8.8 7.7 8.0 12.2
26474-09 F 1.9 NA NA NA NA NA
26474-10 F 2.7 NA NA NA NA NA
26474-11 F 2.6 NA NA NA NA NA
26474-12 F 2.5 5.8 9.9 9.2 7.1 10.6
26474-13 F 2.0 4.9 8.0 6.7 7.3 10.1
26474-14 F 1.7 6.5 8.0 6.7 5.9 13.4
26474-15 F 2.4 NA NA NA NA NA
Page 1443 of 4796
26474-16 F 2.4 NA NA NA NA NA
26474-17 F 2.3 4.9 8.6 7.7 7.2 11.4
26476-02 M 3.0 NA NA NA NA NA
26476-03 M 3.5 7.7 11.1 8.1 9.8 20.6
26476-04 M 3.2 NA NA NA NA NA
26476-05 M 3.2 6.7 9.8 7.9 6.8 18.1
26476-06 M 2.2 6.3 9.6 7.5 8.0 14.4
26476-07 M 3.4 NA NA NA NA NA
26476-08 M 3.5 6.9 10.7 8.1 6.8 17.3
26476-09 F 3.0 6.2 9.8 6.4 5.0 14.9
26476-10 F 2.8 NA NA NA NA NA
26476-11 F 2.8 6.6 10.3 7.4 6.9 14.5
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 28
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
26476-12 F 3.1 NA NA NA NA NA
26476-13 F 2.9 7.0 9.8 8.8 7.5 17.0
26476-14 F 3.1 NA NA NA NA NA
26476-15 F 3.2 NA NA NA NA NA
26476-16 F 2.4 6.7 9.7 7.7 6.1 17.0
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 29
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
26505-02 M 2.7 NA NA NA NA NA
26505-03 M 2.6 NA NA NA NA NA
26505-04 M 3.6 6.5 9.7 7.8 7.7 18.8
26505-05 M 3.3 6.2 10.0 7.9 8.6 15.4
26505-06 M 2.9 NA NA NA NA NA
26505-07 M 4.2 7.1 10.6 8.5 10.6 16.5
26505-08 M 3.4 NA NA NA NA NA
26505-09 F 3.0 6.3 9.0 6.0 9.2 13.0
26505-10 F 3.1 6.4 9.0 7.0 7.9 12.2
26505-11 F 2.6 5.2 7.8 7.4 6.8 10.7
Page 1445 of 4796
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 30
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
26483-12 F 3.2 6.8 11.4 7.8 7.7 12.9
26483-13 F 2.8 7.0 10.9 7.0 7.5 11.1
26483-14 F 3.9 NA NA NA NA NA
26479-04 M 2.9 NA NA NA NA NA
26479-05 M 2.9 5.9 9.9 8.0 8.3 12.3
26479-06 F 1.5 4.2 7.8 6.6 7.7 8.9
26479-07 F 2.8 4.5 8.7 6.8 6.2 11.5
26479-08 F 2.5 NA NA NA NA NA
26479-09 F 2.7 NA NA NA NA NA
26479-10 F 2.9 4.5 8.6 7.4 8.1 10.0
26479-11 F 2.4 NA NA NA NA NA
26479-12 F 2.5 5.3 8.6 7.9 7.6 12.8
26479-13 F 2.3 NA NA NA NA NA
26479-14 F 2.5 NA NA NA NA NA
26450-01 M 2.7 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 31
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
26450-02 M 2.5 5.9 8.7 6.9 7.6 12.8
26450-03 M 2.7 NA NA NA NA NA
26450-04 M 4.5 NA NA NA NA NA
26450-05 M 0.7 5.8 9.2 7.6 8.7 8.1
26450-06 M 2.6 6.2 10.6 8.0 8.0 12.8
26450-07 M 3.0 NA NA NA NA NA
26450-08 M 2.8 6.8 10.3 9.1 9.4 8.3
26450-09 M 3.3 NA NA NA NA NA
26450-10 F 3.2 NA NA NA NA NA
26450-11 F 2.3 NA NA NA NA NA
Page 1447 of 4796
26450-12 F 3.1 NA NA NA NA NA
26450-13 F 2.9 NA NA NA NA NA
26450-14 F 3.1 NA NA NA NA NA
26450-15 F 1.9 5.6 9.5 8.2 6.9 11.1
26450-16 F 2.1 6.6 10.4 7.2 8.4 11.5
26450-17 F 2.3 6.4 9.8 7.8 8.5 13.0
26450-18 F 2.8 7.2 9.7 9.8 9.4 12.9
26457-01 M 2.2 NA NA NA NA NA
26457-02 M 1.6 NA NA NA NA NA
26457-03 M 1.4 6.8 10.3 8.2 10.4 11.8
26457-04 M 1.7 6.3 10.1 7.5 7.0 12.8
26457-05 M 2.3 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 32
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
26457-06 M 2.5 NA NA NA NA NA
26457-07 M 2.2 NA NA NA NA NA
26457-08 M 2.0 NA NA NA NA NA
26457-09 M 1.4 6.3 10.3 8.1 8.8 9.2
26457-10 F 1.5 NA NA NA NA NA
26457-11 F 1.3 4.7 8.8 7.7 8.2 9.3
26457-12 F 1.3 4.9 9.2 7.9 8.4 10.6
26457-13 F 1.6 NA NA NA NA NA
26457-14 F 1.8 5.0 9.2 8.0 9.1 11.0
26457-15 F 1.3 5.0 9.3 7.1 6.0 11.0
Page 1448 of 4796
26492-01 M 2.1 NA NA NA NA NA
26492-02 M 1.6 NA NA NA NA NA
26492-03 M 1.9 5.2 9.6 4.0 6.1 8.3
26492-04 M 2.1 NA NA NA NA NA
26492-05 M 1.6 NA NA NA NA NA
26492-06 M 1.4 5.2 8.7 8.0 8.5 9.5
26492-07 M 2.4 6.1 9.6 8.6 9.8 11.3
26492-08 M 2.0 NA NA NA NA NA
26492-09 M 1.4 NA NA NA NA NA
26492-10 F 2.4 6.8 9.6 7.8 7.5 7.2
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 33
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
26492-11 F 2.3 NA NA NA NA NA
26492-12 F 1.8 4.4 9.5 7.2 7.0 12.5
26492-13 F 2.2 5.7 9.2 6.9 9.8 11.4
26492-14 F 1.5 5.6 9.3 7.5 9.8 10.6
26492-15 F 2.2 NA NA NA NA NA
26492-16 F 2.1 NA NA NA NA NA
26492-17 M 2.0 5.1 9.3 7.0 8.4 9.4
26493-02 M 2.2 NA NA NA NA NA
26493-03 M 1.9 NA NA NA NA NA
26493-04 M 1.9 4.5 7.9 7.1 5.9 11.7
26493-05 M 3.4 NA NA NA NA NA
26493-06 M 1.6 6.6 9.1 9.7 6.9 14.8
26493-07 M 3.5 6.7 9.2 9.6 7.3 17.0
26493-08 M 1.5 NA NA NA NA NA
26493-09 M 1.6 NA NA NA NA NA
26493-11 M 2.3 4.6 9.5 9.5 7.8 15.8
26493-12 M 2.6 NA NA NA NA NA
26493-13 F 2.1 NA NA NA NA NA
26493-14 F 2.1 5.2 8.0 8.1 7.7 11.6
26493-15 F 1.3 NA NA NA NA NA
26493-16 F 2.8 5.8 9.7 8.3 8.5 16.5
26493-17 F 2.9 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 34
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
26493-18 F 1.9 5.2 8.6 7.8 7.7 13.4
26493-19 F 1.2 NA NA NA NA NA
26493-20 F 1.6 4.1 7.8 8.0 7.7 9.9
26493-21 F 1.7 NA NA NA NA NA
26488-04 M 4.1 NA NA NA NA NA
26488-05 M 4.2 7.5 12.2 7.3 6.9 15.7
Page 1450 of 4796
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 35
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
26520-04 M 1.6 6.1 10.2 8.6 8.7 13.2
26520-05 F 2.0 6.4 10.0 7.7 8.7 9.2
26520-06 F 2.0 NA NA NA NA NA
26520-07 F 1.2 NA NA NA NA NA
26520-08 F 1.9 6.6 10.5 7.7 7.9 9.9
26520-09 F 1.6 NA NA NA NA NA
26520-10 F 1.7 NA NA NA NA NA
26520-11 F 1.3 6.8 10.8 8.4 6.9 14.9
26520-12 F 2.2 NA NA NA NA NA
26520-13 F 2.2 2.1 6.5 8.1 6.9 9.3
Page 1451 of 4796
26520-14 F 2.0 NA NA NA NA NA
26520-15 F 1.9 NA NA NA NA NA
26520-16 F 2.1 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 36
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
23248-02 M 2.5 NA NA NA NA NA
23248-03 M 2.8 NA NA NA NA NA
23248-04 M 2.6 NA NA NA NA NA
23248-05 M 3.5 6.9 9.3 6.6 7.4 8.1
23248-06 M 3.4 6.7 10.6 8.0 10.2 7.4
23248-07 M 2.0 NA NA NA NA NA
23248-08 M 2.7 5.7 8.6 8.0 8.7 8.6
23248-09 M 2.4 7.5 8.3 7.5 7.7 8.2
23248-10 F 1.8 5.5 8.5 7.9 8.7 8.3
23248-11 F 2.4 NA NA NA NA NA
Page 1452 of 4796
23248-12 F 2.7 NA NA NA NA NA
23248-13 F 2.2 6.0 8.4 8.4 7.7 9.1
23248-14 F 2.1 5.9 9.4 7.6 7.0 6.8
23248-15 F 2.2 NA NA NA NA NA
23248-16 F 2.2 5.0 8.3 8.3 8.6 7.3
23248-17 F 2.0 NA NA NA NA NA
23217-01 M 1.6 NA NA NA NA NA
23217-02 M 1.9 NA NA NA NA NA
23217-03 M 2.6 4.8 9.4 8.5 6.2 6.8
23217-04 M 1.3 5.7 8.5 6.5 5.4 7.5
23217-05 M 2.4 NA NA NA NA NA
23217-06 M 1.6 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 37
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
23217-07 M 2.0 NA NA NA NA NA
23217-08 M 0.9 4.2 7.5 6.9 5.7 5.4
23217-09 M 1.9 5.9 9.4 7.8 7.0 6.2
23217-10 F 2.1 5.4 8.9 7.0 5.8 9.2
23217-11 F 1.2 3.7 6.6 7.0 5.7 7.7
23217-12 F 1.8 NA NA NA NA NA
23217-13 F 1.4 NA NA NA NA NA
23217-14 F 1.2 NA NA NA NA NA
23217-15 F 1.9 NA NA NA NA NA
23217-16 F 2.1 NA NA NA NA NA
Page 1453 of 4796
23217-17 F 1.8 NA NA NA NA NA
23217-18 F 2.2 5.7 8.5 9.0 6.4 6.3
23217-19 F 2.6 NA NA NA NA NA
23217-20 F 2.1 NA NA NA NA NA
23217-21 F 1.7 5.4 8.7 8.5 8.0 7.8
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 38
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
23190-08 F 2.3 6.2 9.8 8.0 7.5 12.1
23190-09 F 2.4 NA NA NA NA NA
23190-10 F 2.5 NA NA NA NA NA
23190-11 F 1.8 NA NA NA NA NA
23190-12 F 1.7 5.3 8.8 7.2 7.0 10.5
23190-13 F 2.2 NA NA NA NA NA
23190-14 F 2.8 NA NA NA NA NA
23190-15 F 2.7 5.7 8.8 8.8 6.6 14.0
23190-16 F 2.6 NA NA NA NA NA
23190-17 F 2.4 6.2 8.9 8.1 6.4 13.1
Page 1454 of 4796
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 39
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
23236-14 F 1.6 4.6 8.4 7.3 7.2 10.2
23236-15 F 0.6 4.2 8.7 7.7 6.9 7.6
23260-05 M 1.8 NA NA NA NA NA
23260-06 M 1.0 4.6 7.4 6.9 7.2 8.5
23260-07 M 0.8 3.9 6.6 8.2 4.8 10.3
23260-08 F 1.2 NA NA NA NA NA
23260-09 F 1.7 NA NA NA NA NA
23260-10 F 1.1 4.2 6.6 8.6 6.9 10.4
23260-11 F 1.2 3.9 7.0 8.4 6.0 7.7
23260-12 F 1.5 5.1 7.2 5.2 2.4 11.1
23260-13 F 0.8 NA NA NA NA NA
23260-14 F 1.3 4.8 8.0 6.6 7.3 7.7
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 40
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
23221-03 M 2.4 NA NA NA NA NA
23221-04 M 2.7 6.5 8.5 8.0 8.3 11.7
23221-05 M 3.1 NA NA NA NA NA
23221-06 M 2.4 6.3 9.7 7.8 5.9 14.8
23221-07 M 3.2 5.4 9.6 7.0 8.9 14.5
23221-08 M 2.8 NA NA NA NA NA
23221-09 F 2.5 NA NA NA NA NA
23221-10 F 2.7 6.3 8.6 8.1 8.0 11.9
23221-11 F 2.5 6.1 8.2 7.5 7.9 14.0
23221-12 F 2.5 6.4 8.0 7.2 8.1 14.2
Page 1456 of 4796
23221-13 F 2.5 NA NA NA NA NA
23221-14 F 3.0 6.2 8.3 6.9 5.0 12.1
23263-01 M 2.1 NA NA NA NA NA
23263-02 M 2.6 5.9 9.1 7.8 7.3 7.9
23263-03 M 1.9 NA NA NA NA NA
23263-04 M 2.7 NA NA NA NA NA
23263-05 M 2.1 NA NA NA NA NA
23263-06 M 2.5 6.1 9.1 6.6 7.2 13.0
23263-07 M 2.6 NA NA NA NA NA
23263-08 M 2.6 6.5 9.4 8.7 8.2 10.2
23263-09 M 2.6 6.5 10.0 9.1 8.3 10.7
23263-10 F 2.1 5.5 9.1 6.8 6.3 9.1
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 41
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
23263-11 F 1.9 NA NA NA NA NA
23263-12 F 2.1 NA NA NA NA NA
23263-13 F 2.1 5.4 8.0 7.7 7.2 12.4
23263-14 F 1.6 4.8 8.7 6.8 7.8 11.9
23263-15 F 2.6 5.2 8.1 7.8 8.4 11.5
23253-02 M 1.5 NA NA NA NA NA
Page 1457 of 4796
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 42
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
23253-17 F 2.7 6.2 8.6 9.2 7.5 11.7
23244-06 M 2.3 NA NA NA NA NA
23244-07 M 2.1 4.8 9.3 8.6 9.6 11.1
23244-08 M 1.5 NA NA NA NA NA
23244-09 M 1.7 3.7 8.3 8.6 9.2 10.2
23244-10 M 1.9 NA NA NA NA NA
23244-11 F 2.2 NA NA NA NA NA
23244-12 F 1.8 NA NA NA NA NA
23244-13 F 3.0 5.9 9.3 9.2 10.1 12.0
23244-14 F 0.9 NA NA NA NA NA
23244-15 F 2.4 NA NA NA NA NA
23244-16 F 1.9 6.3 9.3 8.0 9.2 8.1
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 43
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
23244-17 F 2.0 5.3 9.6 9.9 9.1 9.1
23218-02 M 2.7 NA NA NA NA NA
23218-03 M 2.4 6.2 7.8 9.1 6.8 13.0
23218-04 M 2.9 NA NA NA NA NA
23218-05 M 2.9 6.6 9.1 10.0 9.5 12.2
23218-07 M 2.3 NA NA NA NA NA
Page 1459 of 4796
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 44
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
23208-03 M 3.0 NA NA NA NA NA
23208-04 M 3.2 8.0 7.9 10.2 4.6 23.4
23208-05 M 2.4 6.7 7.6 10.8 8.7 13.3
23208-06 M 2.4 NA NA NA NA NA
23208-07 M 2.3 NA NA NA NA NA
23208-08 M 2.9 7.2 6.8 7.7 7.9 13.7
23208-09 F 3.3 NA NA NA NA NA
23208-10 F 2.2 NA NA NA NA NA
23208-11 F 2.1 6.5 6.5 8.5 15.0 3.6
23208-12 F 2.5 6.8 6.7 8.1 11.3 10.6
Page 1460 of 4796
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 45
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
23252-12 F 1.4 5.0 11.6 7.6 5.8 10.5
23252-13 F 1.5 5.0 11.5 8.3 8.2 7.2
23252-14 F 1.2 NA NA NA NA NA
23252-15 F 1.3 6.2 11.5 8.5 7.6 10.2
23252-16 F 1.3 4.5 8.1 7.2 7.4 7.7
23252-17 F 1.2 NA NA NA NA NA
26510-01 M 2.3 NA NA NA NA NA
26510-02 M 2.2 7.5 8.2 6.1 6.9 10.9
26510-03 M 2.8 7.0 8.5 6.0 7.6 11.0
26510-04 M 2.9 NA NA NA NA NA
26510-05 M 2.3 NA NA NA NA NA
26510-06 M 2.8 NA NA NA NA NA
26510-07 M 2.4 NA NA NA NA NA
26510-08 M 2.7 NA NA NA NA NA
26510-09 M 2.1 6.5 7.3 6.0 7.8 7.3
26510-10 M 3.0 NA NA NA NA NA
26510-11 F 2.6 NA NA NA NA NA
26510-12 F 1.9 6.5 8.6 4.4 7.9 10.5
26510-13 F 0.8 3.5 4.8 NA NA NA
26510-14 F 2.5 6.2 7.7 5.3 8.2 NA
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 46
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
26510-15 F 2.5 6.6 6.7 5.6 7.1 NA
26519-01 F 2.6 NA NA NA NA NA
26519-03 M 3.0 7.0 9.5 9.7 8.2 14.0
26519-04 M 3.3 7.5 11.3 8.8 8.8 16.1
26519-05 M 2.8 NA NA NA NA NA
26519-06 M 3.0 7.6 11.8 9.3 8.6 13.6
Page 1462 of 4796
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 47
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
26468-05 M 3.9 6.9 9.4 7.9 8.8 15.5
26468-06 M 3.4 NA NA NA NA NA
26468-07 M 3.5 NA NA NA NA NA
26468-08 M 3.3 NA NA NA NA NA
26468-09 F 3.2 7.0 8.5 7.2 5.5 16.1
26468-10 F 2.8 6.7 8.6 8.2 7.5 15.0
26468-11 F 3.3 NA NA NA NA NA
26468-12 F 3.6 6.6 8.3 6.6 7.5 10.6
26468-13 F 3.2 6.8 8.6 7.0 7.0 13.7
Page 1463 of 4796
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 48
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
26475-14 F 3.4 5.9 9.1 8.2 6.0 12.2
26532-01 M 2.0 NA NA NA NA NA
26532-02 M 2.6 NA NA NA NA NA
26532-03 M 2.6 6.6 9.8 8.2 8.4 12.6
26532-04 M 2.4 5.7 9.2 8.4 7.5 12.8
26532-05 M 2.5 NA NA NA NA NA
Page 1464 of 4796
26507-01 F 2.4 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 49
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
26507-02 M 2.8 7.0 9.8 7.8 6.8 13.8
26507-03 M 2.5 6.4 10.1 9.4 7.6 12.6
26507-04 M 2.8 6.5 9.3 7.5 6.2 11.9
26507-05 M 2.7 NA NA NA NA NA
26507-06 M 2.3 NA NA NA NA NA
26507-07 M 2.6 NA NA NA NA NA
26507-08 M 3.0 7.7 10.5 8.2 8.3 10.4
26507-09 M 1.6 NA NA NA NA NA
26507-10 F 2.6 NA NA NA NA NA
26507-11 F 2.6 NA NA NA NA NA
Page 1465 of 4796
26507-12 F 2.7 NA NA NA NA NA
26507-13 F 2.5 6.2 9.7 7.7 6.5 11.7
26507-14 F 2.4 6.8 10.4 7.5 5.9 11.5
26507-15 F 2.6 NA NA NA NA NA
26507-16 F 2.9 7.4 9.8 8.6 8.3 12.2
26507-17 F 2.3 NA NA NA NA NA
26507-18 F 2.2 6.8 9.7 9.1 5.5 11.1
26480-01 M 2.7 NA NA NA NA NA
26480-02 M 4.3 5.8 10.1 9.0 9.7 12.1
26480-03 M 3.8 6.5 10.3 9.4 10.3 11.9
26480-04 M 3.4 6.3 10.3 9.5 10.0 13.3
26480-05 M 3.6 4.9 10.1 8.6 6.8 12.1
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 50
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
26480-06 M 2.7 NA NA NA NA NA
26480-07 M 3.1 NA NA NA NA NA
26480-09 M 3.9 NA NA NA NA NA
26480-10 F 2.1 NA NA NA NA NA
26480-11 F 3.6 5.9 10.2 9.2 7.1 14.3
26480-12 F 3.9 NA NA NA NA NA
26480-13 F 2.7 4.8 8.2 8.7 9.7 9.5
26480-14 F 3.0 NA NA NA NA NA
26480-15 F 2.3 4.7 9.0 9.2 8.1 9.7
26480-16 F 0.5 1.6 4.1 5.9 6.1 5.8
Page 1466 of 4796
26480-18 F 3.7 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 51
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
26482-12 F 2.9 5.6 9.3 7.5 7.5 13.5
26482-13 F 2.9 6.0 9.2 6.2 6.6 15.5
26517-01 M 2.9 NA NA NA NA NA
26517-02 M 2.4 7.4 8.7 7.3 7.7 13.6
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 52
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
26517-03 M 3.9 7.2 11.0 7.1 8.6 14.7
26517-04 M 3.7 8.0 10.5 6.3 6.7 16.1
26517-05 M 3.0 7.3 9.5 8.1 7.4 14.7
26517-06 M 2.7 NA NA NA NA NA
26517-07 M 3.0 NA NA NA NA NA
26517-08 F 3.0 7.2 8.4 7.3 7.2 10.9
26517-09 F 3.0 NA NA NA NA NA
26517-10 F 2.7 NA NA NA NA NA
26517-11 F 3.0 NA NA NA NA NA
26517-12 F 3.2 7.1 10.3 8.5 7.8 10.3
Page 1468 of 4796
26517-13 F 3.0 NA NA NA NA NA
26517-14 F 3.3 7.1 11.2 7.5 6.1 15.7
26517-15 F 3.2 NA NA NA NA NA
26517-16 F 3.0 7.2 11.3 7.7 8.4 10.4
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 53
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
26514-09 M 3.1 NA NA NA NA NA
26514-10 F 2.9 NA NA NA NA NA
26514-11 F 2.2 NA NA NA NA NA
26514-12 F 2.3 NA NA NA NA NA
26514-13 F 2.0 4.6 8.9 8.1 6.8 11.4
26514-14 F 2.2 5.3 9.7 7.5 4.9 14.0
26514-15 F 2.5 6.3 9.5 8.3 6.3 14.5
26514-16 F 2.9 5.3 11.5 7.7 7.9 13.7
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 54
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 3: 1.5 PPM
---------------------------------------
26534-15 F 2.5 NA NA NA NA NA
26534-16 F 2.8 7.8 11.1 7.2 6.3 9.4
N 24 24 24 24 24 24
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 55
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 4: 75 PPM
---------------------------------------
23179-01 M 2.8 5.9 10.1 7.3 6.7 9.8
23179-02 M 1.9 5.5 11.1 9.7 7.2 11.5
23179-03 M 3.3 6.2 11.8 8.2 8.1 12.7
23179-04 M 3.6 6.6 9.7 5.4 6.8 10.7
23179-05 F 2.5 NA NA NA NA NA
23179-06 F 2.3 4.6 7.9 5.2 5.7 9.9
23179-07 F 2.8 NA NA NA NA NA
23179-08 F 3.4 6.2 10.0 7.1 6.7 14.9
23179-09 F 2.3 5.3 10.2 7.0 5.8 11.8
23179-10 F 2.9 5.4 10.0 6.5 6.2 13.7
Page 1471 of 4796
NA = NOT APPLICABLE
TABLE A26 (F1)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 56
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 4: 75 PPM
---------------------------------------
23212-14 F 1.6 NA NA NA NA NA
23212-15 F 1.9 6.0 10.6 9.4 9.8 12.7
23212-16 F 2.4 6.0 11.2 9.0 7.6 10.0
23212-17 F 1.9 5.5 9.9 9.6 8.3 11.1
23212-18 F 2.1 NA NA NA NA NA