TUGAS INVIDU KULIAH FORENSIK ATA 2016/2017

Program Reguler/Paralel
Departemen Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam
Universitas Indonesia Depok.

: Larasati Denaputri
Tanggal : 19 Meii 2017 Nama S.

NPM :1406603176

Kelompok : Reguler/Paralel (Pilih dan hapus salah satu)

Dosen : DR.rer.nat. Budiawan

Dra. Sri Handayani M.Biomed
Dr. Ridla Bakri Msc
Tugas dikumpul ke Dr. rer.nat Budiawan (lembar terpisah), selambatnya tgl. 23 Mei 2017 ,
jam 17.00Wib .
=====================================================

Soal take home test Kimia Forensik dan hadir sesuai jadwal Ujian:

1. Pada suatu ketika ditemukan sesosok mayat wanita tak dikenal tergeletak di suatu
rumah kosong. Tidak ada dokumen identitas ditemukan di TKP. Dari mayat tersebut,
terlihat adanya tanda-tanda kekerasan. Ada dugaan bahwa wanita tersebut juga
merupakan korban kejahatan seksual. Jelaskan, langkah apa saja yang harus
dilakukan pihak investigator dalam melacak :
a. Siapa korban
b. Siapa pelaku kekerasan yang menyebabkan kematian tersebut

2. Case study Benzene and Acute Leukemia: Silahkan dijawab dengan bahasa Kita
(Indonesia), disarankan lembar jawaban terpisah!
Case study;
History of Present Illness
The case involves a 30-year old white male (Mr. JD) who had a long standing history
of obesity. In early 1989 Mr. JD started to experience weakness, and in July he
reported right shoulder and chest pain, and he was admitted to the hospital for 4 days.
Hypertension was identified and treated at that time. In September of the same year he
developed headache and malaise. In October he noted right shoulder pain subsequent
swelling. There were intermittent fevers, chills and night sweats. In November he was
admitted again to the hospital, and was found to have had a fall in his hemoglobin and
white blood count. He was subsequently transferred on 11/3/1989 to another hospital
that is specialized in these types of diseases.
This case was assigned to the author as subject expert for pursuing the case for work
compensation purposes. In an attempt to establish a cause-effect relationship between
the medical conditions Mr. JD developed and the chemicals he may have been
 exposed to during his work career, the subject expert was able to gather some facts
about his occupational and social history.

Occupational History
Mr. JD graduated from high school in 1977. While being in high school he worked as
a part-time basis bagging groceries at Krogers. During summer vacations he and a
friend would paint the exterior of homes. Following his graduation from high school,
Mr. JD worked for one year on an assembly line in an automobile parts plant that
made window sash mechanisms for automobiles. Mr. JD then got a job with Miracle
Co., Inc., where he worked for nine years as painter. His duties primarily involved
spray-painting metal parts in a spray booth. In this capacity he had opportunity for
exposure to benzene, toluene and xylene which were used as solvents in the painting
process. During the course of this employment his workplace was inspected by
Michigan OSHA in 1986 and again in 1988. Measurements of benzene concentration
in breathing air indicated 8-hour TWA levels of 10 ppm and 15 ppm, respectively,
with peak levels as high as 100 ppm. He frequently used a canister-type respirator
with cartridges rated for organic solvents, but he could not recall ever changing the
cartridges during his entire nine years at Miracle Co., Inc., and additionally, he was
never fit-tested. He also wore gloves and apron, but on most days he would end up
with some paint on his arms
Habits
Mr. JD used to smoke 1.5 packs of cigarettes per day for 14 years. He also reported
smoking marijuana almost daily for 10 years. His alcohol use consisted of two to four
beers per day.
Past Medical History
Mr. JD reported no surgeries or hospital admissions.
Hospital course
On admission to the specialist hospital, Mr. JD was noted to be 74 inches tall, and to
weigh 380 pounds. He was diagnosed with acute leukemia on the basis of his clinical
history, routine laboratory results (e.g. complete blood counts) and a bone marrow
biopsy procedure. Peripheral blood was subjected to cytogenetic analyses.

Questions to answer :
1. Why was Mr. JD diagnosed with acute leukemia? What proof was made to justify this
condition and what kind of Biomaker is caused of Benzene exposure?
2. What is the possible cause of Mr. JD sickness? Describe the exposure source,
potential exposure routes, and potential toxicity symptoms that supports your opinion.
1. How would you set a strategy to prove the cause of acute leukemia, by using toxicology
forensic (biomonitoring tools)?

* Good Luck and Success****

 Jawaban take home test Kimia Forensik 2017
1. a. Apabila terdapat sesosok wanita tanpa identitas ditemukan sebagai korban
pembunuhan, khususnya kekerasan seksual hal yang pertama dilakukan adalah meninjau
TKP (tempat kejadian perkara) apabila di tempat tersebut terdapat bukti-bukti yang
sekiranya dapat mendukung penyelesaian investigasi terutama dalam hal ini adalah
identifikasi korban. Hal yang dapat dilakukan selanjutnya adalah proses autopsi, Penyidik
dapat menganalisis bekas gigitan untuk karakteris untuk membantu mereka
mengidenfikasi korban atau tersangka serta untuk mengecualikan orang lain. Berikutnya
dilakukan identifikasi pada organ-organ seksual pada korban untuk memastikan adanya
kekerasan seksual, terutama apabila pada organ seksual korban masih terdapat sisa-sisa
kekerasan seksual (air mani pelaku) dapat diidentifikasi pelaku kekerasan seksual
tersebut.
b. Hampir sama dengan menentukan identitas korban, namun dalam hal pelaku dapat
dilakukan berbagai pendekatan, yaitu saksi mata, keterangan dari kerabat dan keluarga,
bukti yang ditinggalkan oleh pelaku (barang, sidik jari dan sebagainya) sehingga dapat
membantu jalannya investigasi penentuan pelaku.

2. a. identifikasi pertama Mr. JD divonis mengidap leukimia akut berdasarkan dari hasil
perhitugan haemoglobin darah yang sedikit dan kadar darah putih yang tinggi serta
didukung dengan faktor masa lalu Mr. JD yang sering berada dalam lingkungan
pekerjaan yang menggunakan zat-zat karsinogenik seperti benzena. Berikut merupakan
biomarker benzena.
b. Ditinjau dari berbagai latar belakang Mr. JD yang cenderung bergelut di bidang industri
cat, logam dan berbagai barang yang menggunakan zat-zat berbahaya, bahkan karsinogenik.
Karsinogen dapat bekerja dalam banyak cara, yaitu langsung merusak DNA dalam sel
sehingga menyebabkan kelainan pada sel normal, dan cara lainnya yaitu dengan
menyebabkan kerusakan sel yang menyebabkan sel-sel membelah lebih cepat, yang pada
akhirnya dapat mengakibatkan berkembangnya penyakit kanker. Kemampuan karsinogen
dalam menyebabkan kanker antar individu berbeda-beda, tergantung dari jumlah paparan,
lamanya paparan, kesehatan individu yang terpapar, dan faktor lainnya. Kerentanan tiap
orang yang terpapar karsinogen dalam menyebabkan kanker juga tergantung dari faktor
keturunan. Faktor keturunan memainkan peranan penting sebagai penyebab kanker. Hal ini
didukung dengan latar belakang pekerjaan Mr.JD yang bekerja dengan zat-zat berbahaya
seperti benzena, toluena, xylene dan logam berat didukung juga kebiasaan Mr.JD yang
menyukai kebiasaan merokok dimana dalam rokok mengandung zat-zat aditif seperti nikotin
dan tar, didukung dengan konsumsi alkohol yang dapat mengganggu metabolisme hati Mr.JD
itu sendiri.