Professional Documents
Culture Documents
BIO20 - Nucleic Acids
BIO20 - Nucleic Acids
NUCLEIC ACIDS
BIO20-Introduction
to Biomimetics Prof. Ureah Thea A. Sevilla
Nucleic Acids
1
5/1/2016
Nucleotides
Nucleotide
A small organic molecule consisting of a sugar with a
five-carbon ring, a nitrogen-containing base, and one
or more phosphate groups
ATP
A nucleotide with three phosphate groups
Important in phosphate-group (energy) transfer
Sugar
Phosphate
2
5/1/2016
3
5/1/2016
ATP
4
5/1/2016
Polynucleotides
PHOSPHODIESTER
BOND
5 3 Polynucleotide Chain
5
5/1/2016
Nucleic Acids
Nucleic acids
Polymers of nucleotides in which the sugar of one
nucleotide is attached to the phosphate group of the
next
RNA and DNA are nucleic acids
RNA
RNA (ribonucleic acid)
RNAs are single-stranded polynucleotides that are used
to express genetic information.
Important in protein synthesis
6
5/1/2016
DNA
RNA DNA
A, G, C, U type of bases A G, C, T
used
ribose sugar used Deoxyribose
single polynucleotide double
strand
7
5/1/2016
Fig. 3-21, p. 48
The DNA
Molecule
Double-stranded
polynucleotide
covalent
bonding in
sugar
phosphate
backbone
hydrogen bonding
between bases
Fig. 3-22, p. 49
8
5/1/2016
BASE-PAIRS OF DNA
CYTOSINE GUANINE
base pair
H
N CH
N H O
C
CH C N
C
N H N
N
R THYMINE ADENINE
N C base pair
O H
H N
H3C
R O H N N
H CH
C
3 hydrogen bonds formed N H N NH
C
N C
CH N
O
9
5/1/2016
10
5/1/2016
11
5/1/2016
Summary of Biomolecules
Summary of Biomolecules
12
5/1/2016
References:
Yosef Bar Cohen, Biomimetics Biologically
Inspired Technologies, CRC press, 2006.
Voet, Voet and Pratt. Principles of Biochemistry,
13