TITLE PAGE NO.

ACKNOWLEDGEMENT 2
OBJECTIVE 3
INTRODUCTION 4
CHEMISTRY OF ANTACID 5
EXPERIMENT 6
DIAGRAM 7
OBSERVATION 9-11
CONCLUSION 12
BIBLIOGRAPHY 13
TEACHERS REMARKS 14
Presenting the project on Foaming Capacity of Soap gave me
immense pleasure and valuable experience.

I am indebted to my chemistry teacher Mr. ASHOK for his

valuable guidance, constant support and encouragement. He
has helped greatly to bring the project to this stage. My sincere
thanks to my paraents for his whole hearted support and
cooperation.

Last but not the least I appreciate the spirit among our group
which has resulted in the accomplishment towards this project.

ROHIT PRAKASH SINGH

The Project aims at analyzing the effectiveness of some
commercial antacid on the basis of the volume of HCl
neutralized by them.

ANTACIDS

Na2CO3 CHEMICAL HCl

PROCESS

NaoH
It is a well known that the food we take undergoes a series of
complex reactions within the body which constitutes the digestion
and metabolism. These reactions are catalyzed by enzymes which
are specjfjc in their action and can function properly only when
the Ph of the medium is within a specific range.

The stomach wall secretes gastric juices which chiefly contain

HCl, mucin and pepsin. The main purpose of HCl is to provide
acidic medium for the functioning of pepsin. It also suppresses
the growth of the bacteria and provides aid in hydrolysis.
However, sometimes stomach begins to secrete an excess of HCl
resulting in Gastric hyperacidity. This interferes in the normal
process of digestion and leads to acute discomfort.

Now a days, we find many commercial antacid which

neutralize extra HCl. The action of antacid is based on the fact
that a base can neutralize an acid forming salt and water. An
essential requirement of the antacids is that it must supply an
excess of alkali which may lead to alkaline conditions and thus
making the enzymes ineffective. This is achieved in the
commercial antacids by incorporating other constituents which
help to keep the pH within an alkaline range. These drugs
counteract the acid secreted in the stomach mainly to provide
symptomatic relief and lessen the extent of effort needed to
promote heating. The stomach keeps an emptying itself and the
action of the antacid is lost after a short interval. Commonly used
antacid are GELUSIL, DIGENE, DIVOL, PEPFIZ etc.

Antacids may be defined as : The chemical substances which

can neutralize the acidity.

The role of antacids is to neutralize the acidity and raise the Ph

level. They may also act as buffers i.e. they may not allow the
pH to fall when extra acid is released.

Mg(OH)2, MgCO3, MgSiO3, Al(OH)3, NaHCO3 and AlPO4 are

commonly used antacids.

In recent years, omeprazole and lansoprazole also marketed as

antacids in order to give quick relief from acidity.

REACTION OF THE ANTACIDS WITH HCl :

Al(OH)3 + 3HCl AlCl3 + 3H2O

AIM OF THE EXPERIMENT :

To analyze the given sample of commercial antacid by

determining the amount of HCl they neutralize.

APPARATUS REQUIRED :

Burette, Conical Flask, Pipette, Beaker, Weight box, NaOH,

Na2CO3, HCl, Phenolphthalein.

PROCEDURE :

0.1N HCl solution is prepared by adding 10ml of acid to 1 L water.

Similarly, 1 L of 1 N NaOH solution prepared by dissolving 4gm
of NaOH to water to prepare 1 L of solution. 0.1N Na2CO3 solution
is prepared by weighing 1.325 gm of anhydrous Na2CO3 and
dissolving it in water prepares 0.25ml of solution.

The HCl solution is standardized by titrating it against the

standard Na2CO3 solution using Methyl Orange as indicator.
Similarly, NaOH solution is standardized by titrating it against the
standard Na2CO3 solution using phenolphthalein as an indicator.

The various samples of antacid are powdered and 1gm of each is

weighted. A specific volume 50ml of standardized HCl is added to
each of the sample. 2-3 drops of phenolphthalein is added in flash
and is stirred till the powder dissolves.
The solution thus prepared is titrated against standardized NaOH
solution, till permanent pinkish colour is obtained.
Observation table for DIGENE :

Indicator used: Phenolphthalein

SL. No. Volume of Initial Final Difference

HCL Taken Reading Reading (ml)
1 10 0 4.4 4.4
2 10 4.4 9.3 4.9
3 10 9.3 14.9 5.6
4 10 14.9 20.6 5.7
5 10 20.6 26.4 5.8

Mean Reading = 5.2 ml.

Observation table for GELUSIL :

Indicator used : Phenolphthalein

SL. No. Volume of Initial Final Difference

HCL Taken Reading Reading (ml)
1 10 0 1.5 1.5
2 10 1.5 3.2 1.7
3 10 3.2 4.8 1.6
4 10 4.8 6.4 1.6
5 10 6.4 8 1.6

Mean Reading = 1.6 ml

Observation table for PEPFIZ :

Indicator used : Phenolphthalein

SL. No. Volume of Initial Final Difference

HCL Taken Reading Reading (ml)
1 10 0 3.4 3.4
2 10 3.4 6.6 3.2
3 10 6.6 9.9 3.3
4 10 9.9 13.2 3.3
5 10 13.2 16.5 3.3

Mean Reading = 3.3 ml.

PEPFIZ :

CONTENT :

Ranitidine 160 mg
Papain 60 mg
Simethine (Dimethicone) 25 mg
Diastase (amylase) 20 mg
COLOUR : Sunset Yellow

DIGENE :

CONTENT :

Dried aluminum hydroxide gel IP 300 mg

Magnesium aluminum silicate 50 mg
hydrate
Magnesium hydroxide IP 25 mg
Simethicone IP 25 mg
COLOUR : Sunset yellow, qinoline yellow, Erythrosine & Ponceau

GELUSIL MPS :

CONTENT :

Aluminum hydroxide dried gel 200 mg

Magnesium hydroxide 200 mg
Simethicone 25 mg

COLOUR : Erythrosine & ponceau

After performing the experiment we found that Gelusil acts as
the best antacid while Digene is the latest effective and hence
the order of effectiveness of antacid is as follows :

GELUSIL > PEPFIZ > DIGENE

I would like to mention the names of the books and website I
sought for help while making this project.

NCERT Chemistry (Part 2) class 12 comprehensive practical

chemistry class 12.

www.antacidpurifhow.com

www.gelusilcontents.com

www.answers.com
TEACHERS SIGNATURE :

EXAMINERS SIGNATAURE :

DATE :

SCHOOL STAMP :