Cellular Respiration

BIOL 110
Agenda

Review: Cellular Respiration

We are going to learn cellular respiration together in class. We

will watch some videos to help understand the whole process

In-class activity: Case Study

We will finish the case study together to check whether you

understand the class material well
How do we produce energy?
How do we produce energy?

Glycolysis
Glycolysis
Glycolysis:
Literally, splitting sugar (herein glucose)
Happens in both anaerobic and aerobic respiration
How do we produce energy?

2 Glycolysis
How do we produce energy?

2 Glycolysis

Fermentation
Fermentation
Fermentation:
Another part of anaerobic respiration
Doesnt produce energy
Vary in different organisms:
How do we produce energy?

2 Glycolysis

Krebs/TCA
Cycle
0 Fermentation
Krebs cycle / TCA cycle / Citric acid cycle
A series of chemical reactions used by all aerobic organisms to release stored
energy in the form of adenosine triphosphate (ATP).
How do we produce energy?

2 Glycolysis

Krebs/TCA
Cycle
0 Fermentation

e- transport
+ oxidative phs.
Electron transport chain
Transfer electrons from electron donors to electron acceptors via redox (both
reduction and oxidation occurring simultaneously) reactions, and couples this
electron transfer with the transfer of protons (H+ ions) across a membrane.
Oxidative phosphorylation
The metabolic pathway in which cells use enzymes to oxidize nutrients, thereby
releasing energy which is used to reform ATP.
Oxidative phosphorylation - Complex I
NADH-coenzyme Q oxidoreductase, also known as NADH dehydrogenase or
complex I, is the first protein in the electron transport chain.
Oxidative phosphorylation - Complex II
Succinate-Q oxidoreductase, also known as complex II or succinate
dehydrogenase, is a second entry point to the electron transport chain.
Oxidative phosphorylation - Complex III
Q-cytochrome c oxidoreductase is also known as cytochrome c reductase,
cytochrome bc1 complex, or simply complex III.
Oxidative phosphorylation - Complex IV
Cytochrome c oxidase, also known as complex IV, is the final protein complex in
the electron transport chain.
How do we produce energy?

2 Glycolysis

Krebs/TCA
Cycle
0 Fermentation

e- transport
+ oxidative phs.

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Aerobic Respiration
In-class Case Study

Part I Seven deaths

See handouts

Q1 Similarities? What more questions do you want to ask?

Q2 Are they connected? Why or why not?

In-class Case Study

Part II Autopsy reports

Immediate cause of death: hypoxia

Tissue sections: massive cell death in multiple organs
Histology: major mitochondrial damage
High oxygen level in victims blood

Q1 What functions of the cells was interrupted? Could it

be lethal? Why or why not?

Q2 Anything seemingly inconsistent in this report?

In-class Case Study

Part III Subcellular metabolite analysis

See handouts

Q1 What are their roles and main functions?

Q2 What are the abnormalities in the victims? Develop

your hypothesis.

Q3 Explain your hypothesis

In-class Case Study

Part I Cyanide

See handouts

Q1 What could it affect? Explain.

Q2 Explain the inconsistency.

Q3 Can artificial respiration save them? Why?

Q4 Possible source? How should public health officials and

police respond?
Summary

2 Glycolysis

Krebs/TCA
Cycle
0 Fermentation

e- transport
+ oxidative phs.

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