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JOMO KENYATTA UNIVERSITY

OF
AGRICULTURE AND TECHNOLOGY
UNIVERSITY EXAMINATIONS 2016/2017
YEAR 4 SEMESTER I EXAMINATION FOR THE DEGREE OF BACHELOR OF
SCIENCE IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
HBB 2400: METABOLIC REGULATION AND INTEGRATED METABOLISM
DATE: December 2016 TIME: 2 HOURS
INSTRUCTIONS: Answer question one (compulsory) and any other two questions.

QUESTION ONE (30 MARKS)

Explain the following terms and entities (3 marks each)
a) Signal transduction
b) Covalent modification
c) Regulatory cascade
d) Rate limiting step
e) Control of enzyme activity
f) Second messengers
g) Metabolic regulation
h) Allosteric control of enzymes
i) The control by the following enzymes;
i) Phosphofructokinase
ii) dCTP deaminase

QUESTION TWO (20 marks)

Referring to a named enzyme, discuss the following aspects:

a) Cumulative feedback inhibition (10marks)

b) Regulatory by adenylylation (10marks)

QUESTION THREE (20 marks)

Using clear diagrams, describe the hierarchial nature of hormonal regulation in vertebrates
(20marks)

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QUESTION FOUR (20 marks)

a) Using diagrams, explain the regulation of aspartate carbamoyl transferase

(10marks)
b) Discuss glucose homeostasis (10marks)

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