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Лекция № 1
Лекция № 1
pharmacology
By Satarkulova A.M.
Pharmacology
Pharmacology is the science of drugs, including
their ingredients, preparation, uses, and actions on
the body.
Clinical pharmacology is the study of drugs in
human patients
Toxicology is the study of harmful rather than
therapeutic effects
Pharmacy involves manufacture, preparation,
and dispensing of drugs
Drug:
A substance that is used in the prevention, diagnosis, or
treatment of disease
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What is Pharmacology ?
Pharmacokinetics Pharmacodynamics
What the body does to drug What the drug does to body
Pharmacology
Pharmacotherapeutics Pharmacocognosy
The study of the use of drugs Identifying crude materials as drugs
Toxicology
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PHARMACOKINETICS
ABSORBTION,
DISTRIBUTION,
METABOLISM (BIOTRANSFORMATION)
AND EXCRETION OF DRUGS
IT INCLUDES:
THE DOSE-EFFECT RELATIONSHIP,
FACTORS MODIFYING DRUG EFFECTS,
DOSAGE,
DRUG TOXICITY
Enteral
Parenteral
Advantages:
1. Rapid absorption
2. Drug stability
3. Avoid first-pass effect
Disadvantages:
1. inconvenient
2. small doses
3. unpleasant taste of some drugs
Advantages
1. Convenient - can be self- administered, pain
free, easy to take
2. Absorption - takes place along the whole
length of the GI tract
3. Cheap - compared to most other parenteral
routes
Advantages:
Disadvantages:
3. Concurrent administration of
vasoconstrictor will slow absorption
Disadvantages
1. Needs special apparatus
2. Drugs may be irritants to the mucus membrane
3. For local effect in the bronchi, the bronchial tree should not
be obstructed with mucous plugs as in case of asthma
Contact or
Transdermal:
1 to 2 days
NB:
No single route of drug administration is ideal
for all drugs in all circumstances
2- Liquids
Solutions prepared by dissolving one or more solutes in a solvent
Emulsions
consisting of two immiscible liquids
o/w or w/o
cloudy appearance
Suspensions
Solid particles are dispersed in liquid
Not intended for systemic administration of drugs with high potency
Shaped
Suppositories
Shaped
- Tablets
- Capsules
- Transdermal patches
1- solid
Pills
Capsules
Tablets
2- Effervescent tablets
Not a final dosage form (drug is administered as
the solution)
- Rapid absorption rapid on-set of action
- Avoids potential tablet adhesion to mucosa and
local irritation
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Dosage forms for systemic administration
ORAL (p.o.)
2- Liquid dosage forms
Solutions (drops) aqueous, oils
Syrups aqueous sol. with sugar
(or sugar substitute) with/without
flavouring agents
Emulsions
Suspension
Advantages: easier for administration
(children, elderly people), good
compliance (can be flavoured), rapid
absorption, flexible dosing
Disadvantages: stability (chemical,
microbial - a need for preservatives),
accurate dosing??
Injections (available as
ampoules, vials with rubber
head)
Solutions, emulsions or
suspensions which MUST BE
- STERILE
- PYROGEN-FREE
- ISOTONIC
1- lntravenous ( I.V.)
injections
2- intramuscular (I.M.) and
subcutaneous ( S.C.)
3- Infusions
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Sample Documentation