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FinalReport Studenti
Study Title
Objectives:
Primary:
To evaluate the prevalence of Peripheral Arterial Disease (PAD) in patients admitted
in hospital with diagnosis of ACS or outpatients after an ACS (within last 6 months),
ambulatory checked.
Secondary:
To identify the Main Clinical Variables associated with a higher risk of PAD among this
population
To evaluate the therapeutic management of these patients
To train Cardiologists to measure Ankle / Brachial Index (ABI) in order to improve diagnosis
of PAD
Evaluated:
ABI (Cut-off for PAD 0,9)
Epidemiological data:
atherothrombotic risk factors
cardiovascular previous events
treatments prescribed at visit 1 (by therapeutic class)
Population studied: 100 patients, with the following gender distribution: 70% male and
40% female and with mean age of 63,03 years (62,7571 years in male group, respective
63,6667 years in female one).
100% of the major cardiovascular events (vascular death, myocardial infarction and
stroke/TIA) occurred during the 6 months of follow up in the group of patients with ABI values
< 0.9 and only 0% in those with normal ABI values.
Conclusions:
The prevalence of Peripheral Arterial Disease (PAD) based on ABI measurement in the
cohort of 100 patients admitted to hospital with diagnostic of ACS or outpatients after an ACS
(within last 6 months), ambulatory checked was of 69% ( 69 patients with ABI values < 0.9).
ABI measurement is also considered as a generalized atherosclerotic marker that may allow
identifying patients at high risk for developing cardio or cerebrovascular events: on top of the
patients with ABI values lower than 0.9 there were those ones with ABI values > 1.4 (0 %)
indicating arterial stiffness and, as already mentioned, risk of major cardiovascular events.
The main variables associated with a higher risk of PAD that have been identified among this
population were the following risk factors: hypertension, diabetes mellitus, present smoking
or history of smoking and history of cardiovascular diseases (p values of statistical
significance are illustrated below):
The logistic regression calculation (taking into account all these risk factors simultaneously)
identified that hypertension, diabetes mellitus, present smoking or history of smoking,
dyslipemia as well as history of cardiovascular disease are all risk factors with major impact
on Peripheral Arterial Disease induction.
100% of the major cardiovascular events (vascular death, myocardial infarction and
stroke/TIA) occurred during the 6 months of follow up in the group of patients with ABI values
< 0.9 and only 0% in those with normal ABI values.
99% of the patients were on antiplatelet treatment at the inclusion visit: 73%
acetylsalicylicacid, 27% thienopyridine and 3% others, as monotherapy or in combinations.