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Amniotic Fluid Embolism
Amniotic Fluid Embolism
Amniotic Fluid Embolism
Definition: Amniotic fluid and fetal debris entering the systemic maternal circulation, with an
anaphylactic reaction causing sudden cardiovascular collapse, altered mental status, and DIC.
Pathogenesis: A breech in the physical barriers between maternal and fetal environment,
mainly at the level of the endocervical veins, uterine trauma sites, and the placental
attachment site. A pressure gradient that favors the entry of amniotic fluid from the uterus
into the maternal circulation must be present.
Incidence: Approximately 1 in 15,000 deliveries. Accounts for 14% of maternal deaths. The
second leading cause of maternal deaths. Maternal mortality rate has declined from an initial
rate of about 80% to a current level of 22% with improved recognition and immediate
treatment.
Risk factors:
Maternal age >35 Cesarean delivery Operative vaginal delivery
Placenta previa Preeclampsia/Eclampsia Polyhydramnios
Cervical laceration Uterine rupture Induction of labor
Coagulopathy: The presence of tissue factor in amniotic fluid potentially activates the
extrinsic pathway by binding with factor VII and this triggers clotting by activating factor X,
with the subsequent development of a consumptive coagulopathy. The activation of the
clotting cascade in the pulmonary vasculature may cause generation of microvascular
thrombosis, which could then cause vasoconstriction. DIC results from a consumption
coagulopathy.
Clinical manifestations:
Occurrence: AFE typically occurs during labor and delivery or in the immediate postpartum
period, although it can occur as late as 48 hours postpartum. 70% of cases occur before
delivery.
These symptoms may indicate hypoxia and might give the first clue to the diagnosis of AFE
before collapse and hemorrhage occur.
Diagnosis: There is at present no test that can reliably confirm AFE in suspected cases.
AFE should be suspected in a woman experiencing 1 or more of the following findings during
pregnancy, labor and delivery, or up to 48 hours postpartum:
Tests:
Laboratory: CBC, coagulation profile, arterial blood gases, cardiac enzymes, electrolytes. Type
and cross match for blood products.
EKG: Look for tachycardia with right ventricular strain, ST and T wave abnormalities, cardiac
arrhythmias or asystole.
Pulse oxymetry: Look for sudden drop in oxygen saturation.
Chest X-ray: Look for diffuse bilateral heterogeneous and homogeneous areas of increased
opacity (indistinguishable from acute pulmonary edema from other causes).
Transesophageal echocardiography: Look for severe pulmonary hypertension, acute right
ventricular failure with a leftward deviation of the interatrial and interventruicular septum,
and a cavity-obliterated left ventricle during the early phase of AFE.
Differential diagnosis:
Pulmonary thromboembolism Air embolism
Drug-induced allergic anaphylaxis Myocardial infarction
Cardiac arrhythmia Anesthetic complications (total spinal/epidural)
Peripartum cardiomyopathy Aortic dissection
Aspiration of gastric contents Reaction to local anesthetic drugs
Blood transfusion reaction Sepsis
Postpartum hemorrhage Uterine rupture
Placental abruption Eclampsia
Prognosis:
The national registry showed that among survivors, persisting neurological impairment was
reported in 61% of women and 50% of infants.
Recurrence:
No instances of recurrent AFE have been reported in the literature.
Treatment:
Management goal: Maintenance of oxygenation, cardiac output and blood pressure, and
correction of the coagulopathy.
Initial management:
Rapid correction of maternal hemodynamic instability, which includes correction of hypoxia
and hypotension to prevent additional hypoxia and subsequent end-organ failure.
Administration of blood components: First line treatment for correcting the coagulopathy and
potential severe hemorrhage associated with AFE.
Packed red blood cells: To maintain oxygen delivery to the tissues
Fresh frozen plasma
Platelets
Cryoprecipitate: Particularly useful to replenish clotting factors in lieu of FFP in
volume-restricted patients. Contains fibronectin which could
facilitate the removal of cellular and particulate matter from the
blood.
Recombinant activated factor VIIa: For severe DIC, resistant to conventional blood
product replacement.
Management of postpartum hemorrhage: Look for the usual causes of PPH such as atony
retained POC, or cervical or uterine lacerations. If bleeding is profuse and pharmacological
intervention is unsuccessful, a hysterectomy may be necessary.