BI TP PEPTIT V PROTEIN

Dng 1. Cc cu hi l thuyt
Cu 1: Thy phn khng hon ton pentapeptit mch h: Gly-Ala-Gly-Ala-Gly c th thu c ti a bao
nhiu ipeptit? A. 1 B. 2 C. 3 D. 4
Cu 2: Thy phn khng hon ton mt pentapeptit X (mch h): Gly-Val-Gly-Val-Ala c th thu c ti
a bao nhiu tripetit? A. 2 B. 4 C. 3 D. 1
Cu 3 (H 2010-Khi B): Thy phn hon ton 1 mol pentapeptit X, thu c 2 mol glyxin (Gly), 1 mol
alanin (Ala), 1 mol valin (Val) v 1 mol phenylalanin (Phe). Thy phn khng hon ton X thu c ipeptit
Val-Phe v tripeptit Gly-Ala-Val nhng khng thu c ipeptit Gly-Gly. Cht X c cng thc l
A. Gly-Phe-Gly-Ala-Val. B. Gly-Ala-Val-Val-Phe.
C. Gly-Ala-Val-Phe-Gly. D. Val-Phe-Gly-Ala-Gly.
Cu 4: Thy phn hon ton 1 mol pentapeptit X, thu c 1 mol glyxin (Gly), 1 mol alanin (Ala), 1 mol
valin (Val), 1 mol axit glutamic (Glu) v 1 mol Lysin (Lys). Thy phn khng hon ton X thu c hn hp
cha: Gly-Lys; Val-Ala; Lys-Val; Ala-Glu v Lys-Val-Ala. Xc nh cu to ca X?
2. Bi tp v thy phn khng hon ton peptit: Phng php bo ton s mol gc a.a
Cu 5 (H 2011-Khi A): Thy phn ht m gam tetrapeptit Ala-Ala-Ala-Ala (mch h) thu c hn hp
gm 28,48 gam Ala, 32 gam Ala-Ala v 27,72 gam Ala-Ala-Ala. Gi tr ca m l
A. 90,6. B. 111,74. C. 81,54. D. 66,44.
Cu 6: Thy phn 101,17 gam mt tetrapeptit mch h: Ala-Ala-Ala-Ala thu c hn hp gm 42,72 gam
Ala; m gam Ala-Ala; 27,72 gam Ala-Ala-Ala. Gi tr ca m l:
A. 40,0 B. 59,2 C. 24,0 D. 48,0
Cu 7: Thy phn mt lng tetrapeptit X (mch h) ch thu c 14,6 gam Ala-Gly; 7,3 gam Gly-Ala;
6,125 gam Gly-Ala-Val; 1,875 gam Gly; 8,775 gam Val; m gam hn hp gm Ala-Val v Ala. Gi tr ca m l
A. 29,006. B. 38,675. C. 34,375. D. 29,925.
Cu 8: Cho bit X l tetrapeptit (mch h) to thnh t 1 amino axit (A) no, mch h (phn t cha 1 nhm
NH2 v 1 nhm COOH). Bit rng trong phn t A cha 15,73%N theo khi lng. Thy phn m gam X
trong mi trng axit thu c 41,58 gam tripeptit; 25,6 gam ipeptit v 92,56 gam A. Gi tr m l:
A. 149 gam B. 161 gam C. 143,45 gam D. 159,25 gam
Cu 9: Thy phn m gam pentapeptit A to bi phn t amino axit (glyxin) thu c 0,3 gam Glyxin; 0,792
gam ipeptit Gly-Gly; 1,701 gam tripeptit Gly-Gly-Gly; 0,738 gam tetrapeptit Gly-Gly-Gly-Gly v 0,303
gam A. Gi tr ca m l:A. 4,545 gam B. 3,636 gam C. 3,843 gam D. 3,672 gam
Cu 10: A l mt hexapeptit mch h to thnh t mt -amino axit X no, mch h (phn t cha 1 nhm
NH2 v 1 nhm COOH). Bit rng phn trm khi lng ca oxi trong X l 42,667%. Thy phn m gam A
thu c hn hp gm 90,9 gam pentapeptit; 147,6 gam tetrapeptit; 37,8 gam tripeptit; 39,6 gam ipeptit v
45 gam X. Gi tr ca m l: A. 342 gam B. 409,5 gam C. 360,9 gam D. 427,5 gam
Cu 11: Thy phn ht 1 lng pentapeptit X trong mi trng axit thu c 32,88 gam AlaGlyAlaGly;
10,85 gam AlaGlyAla; 16,24 gam AlaGlyGly; 26,28 gam AlaGly; 8,9 gam Alanin cn li l GlyGly
v Glyxin. T l s mol GlyGly:Gly l 10:1. Tng khi lng GlyGly v Glyxin trong hn hp sn phm
l: A. 27,9 gam B. 28,8 gam C. 29,7 gam D. 13,95 gam
Cu 12: Thy phn hon ton tetrapeptit X ch thu c aminoaxit Y (no, mch h, phn t cha 1 nhm
NH2 v 1 nhm COOH). Trong Y nguyn t N chim 18,67% theo khi lng. Khi thy phn khng hon
ton 25,83 gam X thu c 11,34 gam tripeptit; m gam ipeptit v 10,5 gam Y. Gi tr ca m l:
A. 2,64 gam B. 6,6 gam C. 3,3 gam D. 10,5 gam.
Cu 13: Tripeptit M v Tetrapeptit Q c to ra t mt aminoacid X mch h ( phn t ch cha 1 nhm
NH2 ). Phn trm khi lng Nito trong X bng 18,667%. Thy phn khng hon ton m gam hn hp M,Q
(c t l s mol 1:1) trong mi trng Axit thu c 0,945 gam M; 4,62 gam ipeptit v 3,75 gam X. Gi tr
ca m l:A. 4,1945. B. 8,389. C. 12,58. D. 25,167.
3. Bi ton thy phn hon ton peptit (axit hoc kim ch vi vai tr xt).
Cu 1: Cho 13,32 gam peptit X do n gc alalin to thnh, thy phn hon ton trong mi trng axit thu
c 16,02 gam alalin duy nht. X thuc loi no?
A. Tripeptit B. Tetrapeptit C. Hexapeptit D. ipeptit
Cu 2: Khi thy phn hon ton 65 gam mt oligopeptit X thu c 22,25 gam alalin v 56,25 gam glyxin.
X thuc loi no?A. Tripeptit B. Tetrapeptit C. Hexapeptit D. ipeptit
4. Bi ton thy phn hon ton peptit trong mi trng kim.
Cu 13 (C 2012): Thy phn hon ton m gam ipeptit Gly-Ala (mch h) bng dung dch KOH va ,
thu c dung dch X. C cn ton b dung dch X thu c 2,4 gam mui khan. Gi tr ca m l
 A. 1,46. B. 1,36. C. 1,64. D. 1,22.
Cu 14: Thy phn hon ton 32,55 gam tripeptit mch h (Ala-Gly-Ala) bng dung dch NaOH (va ),
sau phn ng thu c dung dch X. C cn X thu c m gam mui khan. Gi tr m l:
A. 47,85 gam B. 42,45 gam C. 35,85 gam D. 44,45 gam
Cu 15 (H 2012-Khi B): un nng m gam hn hp gm a mol tetrapeptit mch h X v 2a mol tripeptit
mch h Y vi 600 ml dung dch NaOH 1M (va ). Sau khi cc phn ng kt thc, c cn dung dch thu
c 72,48 gam mui khan ca cc amino axit u c mt nhm COOH v mt nhm NH 2 trong phn t.
Gi tr ca m l A. 54,30. B. 66,00. C. 44,48. D. 51,72.
Cu 16: un nng 32,9 gam mt peptit mch h X vi 200 gam dung dch NaOH 10% (va ). Sau phn
ng thu c dung dch Y. C cn dung dch Y thu c 52 gam mui khan. Bit rng X to thnh t cc -
amino axit m phn t cha 1 nhm NH2 v 1 nhm COOH. S lin kt peptit trong X l:
A. 10 B. 9 C. 5 D. 4
Cu 17: Thy phn hon ton 21,8 gam ipeptit mch h Glu-Ala trong NaOH (va ) thu c dung dch
X. C cn dung dch X thu c m gam mui khan. Gi tr ca m l:
A. 28,0 B. 24,0 C. 30,2 D. 26,2
Cu 18: Thy phn hon ton m gam hn hp X gm 2a mol tripeptit mch h X v a mol tetrapeptit mch
h Y (bit rng X, Y u c to thnh t cc -amino axit c cng 1 nhm NH 2 v 1 nhm COOH) cn
va 560 gam dung dch KOH 7%. Sau phn ng thu c dung dch cha 104,6 gam mui. Gi tr m l:
A. 69,18 gam B. 67,2 gam C. 82,0 gam D. 76,2 gam
Cu 19: Cho X l ipeptit mch h Gly-Ala; Y l tripeptit mch h Ala-Ala-Gly. un nng 36,3 gam hn
hp gm hai peptit X v Y (t l mol 1:1) vi lng dung dch NaOH va . Sau phn ng thu c dung
dch cha m gam mui khan. Gi tr ca m l:
A. 43,6 gam B. 52,7 gam C. 40,7 gam D. 41,1
Cu 20: X l tetrapeptit mch h: Ala-Gly-Val-Ala; Y l tripeptit mch h: Val-Gly-Val. un nng m (gam)
hn hp cha X v Y c t l s mol tng ng l 1:3 vi dung dch NaOH va . Sau khi phn ng hon
ton thu c dung dch T. C cn cn thn dung dch T thu c 23,745 gam cht rn khan. Gi tr ca m l
A. 68,1. B. 17,025. C. 19,455. D. 78,4
5. Bi ton thy phn hon ton peptit trong mi trng axit.
Cu 21: Cho 24,36 gam tripeptit mch h Gly-Ala-Gly tc dng vi lng dung dch HCl va , sau phn
ng thu c dung dch Y cha m gam mui. Gi tr m l:
A. 37,50 gam B. 41,82 gam C. 38,45 gam D. 40,42 gam
a
Cu 22: Thu phn hon ton 0,1 mol mt peptit X (mch h, c to bi cc - amino axit c 1 nhm
-NH2 v 1 nhm -COOH) bng dung dch HCl va thu c dung dch Y. C cn dung dch Y thu c
cht rn c khi lng ln hn khi lng ca X l 52,7 gam. S lin kt peptit trong X l
A. 14. B. 9. C. 11. D. 13.
Cu 23: Thy phn hon ton 143,45 gam hn hp A gm hai tetrapeptit thu c 159,74 gam hn hp X
gm cc Aminoaxit (Cc Aminoaxit ch cha 1nhm -COOH v 1 nhm -NH2). Cho tan b X tc dng vi
dung dch HCl d, sau c cn dung dch th nhn c m gam mui khan. Tnh khi lng nc phn ng
v gi tr ca m ln lt l:A. 8,145 gam v 203,78 gam. B. 32,58 gam v 10,15 gam.
C. 16,2 gam v 203,78 gam D. 16,29 gam v 203,78 gam.
6. Phn ng chy ca Peptit:
Cu 25: Tripeptit mch h X v Tetrapeptit mch h Y u c to ra t mt aminoacid no,mch h c 1
nhm COOH v 1 nhm NH2 .t chy hon ton 0,1 mol X thu c sn phm gm H2O,CO2 v N2
trong tng khi lng CO2 v H2O bng 36,3(g) .Nu t chy hon ton 0,2 mol Y th s mol O2 cn
phn ng l? a. 2,8(mol). b. 1,8(mol). c. 1,875(mol). d. 3,375 (mol)
Cu 26: t chy hon ton (a) mol 1 peptit X to thnh t aminoaxit mch h (1 nhm COOH v 1
nhm NH2) thu c (b) mol CO2 ;(c)mol H2O;(d) mol N2.THy phn hon ton 0,2 mol X bng dung
dch NaOH ( ly d gp i so vi lng cn thit) ri c cn dung dch sau phn ng thu c cht rn c
khi lng tng m gam so vi peptit ban u.Gi tr m l?( bit b-c=a)
A. 60,4 B.60,6 C.54,5 D.60
Cu 27: :(Khi B- 2010):ipeptit mch h X v mch h Y u c to ra t mt loi amino axit no, mch
h c mt nhm NH2 v mt nhm COOH. t chy hon ton 0,1 mol Y thu c sn phm gm CO2,
H2O, v N2 trong tng khi lng CO2 v H2O bng 54,9 gam. Nu t chy hon ton 0,2 mol X, sn
phm thu c cho li qua dung dch nc vi trong d th thu c m gam kt ta. Gi tr ca m l:
A. 45. B. 120. C. 30. D. 60.
7. Mt s cu Peptit kh v l:
Cu 28 : Hn hp A gm ba peptit mch h c t l mol tng ng l 1 : 1 : 2. Thy phn hon
ton m gam A thu c hn hp sn phm gm 52,5 gam Glyxin v 71,2 gam Alanin. Bit s lin
kt peptit trong phn t X nhiu hn trong Z v tng s lin kt peptit trong ba phn t X, Y, Z nh hn
10. Gi tr ca m l
A. 96,7. B. 101,74. C. 100,3. D. 103,9.
Cu 29 : Hn hp A gm ba peptit mch h X, Y, Z c t l mol tng ng l 2 : 3 : 4. Thy phn hon
ton m gam A thu c hn hp sn phm gm 21,75 gam Glyxin v 16,02 gam Alanin. Bit s lin
ktpeptit trong phn t X nhiu hn trong Z v tng s lin kt peptit trong ba phn t X, Y, Z nh hn
17. Gi tr ca m l
A. 30,93. B. 30,57. C. 30,21. D. 31,29.
Cu 30: un nng 0,4 mol hn hp E gm ipeptit X, tripeptit Y v tetrapeptit Z u mch h bng lng
va dung dch NaOH, thu c dung dch cha 0,5 mol mui ca glyxin v 0,4 mol mui ca alanin
v 0,2 mol mui ca valin. Mt khc t chy m gam E trong O2 va thu c hn hp CO2, H2O v
N2, trong tng khi lng ca CO2 v nc l 78,28 gam. Gi tr m gn nht vi
A. 50. B. 40. C. 45. D. 35.
Cu 31: Cho hn hp A cha hai peptit X v Y to bi cc amino axit no mch h, phn t cha 1 nhm
-COOH, 1 nhm -NH2 ,bit rng tng s nguyn t O trong 2 phn t X, Y l 13. Trong X hoc Y u c s
lin kt peptit khng nh hn 4. un nng 0,7 mol A trong KOH th thy 3,9 mol KOH phn ng v thu c
m gam mui. Mt khc t chyhon ton 66,075 gam A ri cho sn phm hp th vo bnh cha Ca(OH) 2
d thy khi lng bnh tng 147,825 gam. Gi tr ca m l
A. 490,6 B. 560,1 C. 470,1 D. 520,2
Cu 324: Hn hp M gm mt peptit mch h X v mt peptit mch h Y (mi peptit u c cu to t
mt loi -aminoaxit, tng s lin kt peptit trong 2 phn t X, Y l 5) vi t l mol l 1 : 3. Khi thy phn m
gam hn hp M thu c 81 gam Glyxin v 42,72 gam Alanin. Gi tr ca m l
A. 104,28. B. 116,28. C. 109,50. D. 110,28.
Cu 33: Ngi ta thy phn 15,26 gam hn hp X gm 3 peptit c s mol bng nhau, c to bi ala, gly,
Val trong dung dch NaOH d th thy c 0,18 mol NaOH phn ng ng thi dung dch sau phn ng cha
m gam mui. Mt khc t chy hon ton lng X trn ri cho sn phm hp th vo bnh cha Ba(OH)2 d
thy khi lng bnh tng 39,14 gam. Bit cc phn ng xay ra hon ton, gi tr ca m?
Cu 34: Thy phn hon ton m gam hn hp A gm peptit X v peptit Y (c trn theo t l 4:1) thu c
30 gam glyxin; 71,2 gam alanin v 70,2 gam valin. Bit tng s lin kt peptit c trong 2 phn t X v Y l 7.
Gi tr nh nht ca m c th l?
Cu 35: Thy phn hon ton 0.09 mol hn hp X gm Tripeptit, tetapeptit, pentapetit vi dung dch NaOH
va thu c 16.49 gam mui ca Glyxyl, 17.76 gam mui ca Alanin v 6.95 gam mui ca Valin. Nu
t chy hon ton m gam hn hp X th thu c CO2, H2O v N2 trong tng khi lng ca CO2 v
H2O l 46.5 gam. Gi tr gn ng ca m l:
Cu 36: Hn hp X gm peptit A mch h c cng thc CxHyN5O6 v hp cht B c cng thc phn t l
C4H9NO2. Ly 0,09 mol X tc dng va vi 0,21 mol NaOH ch thu c sn phm l dung dch gm
ancol etylic v a mol mui ca glyxin, b mol mui ca alanin. Nu t chy hon ton 41,325 gam hn
hp X bng lng oxi va th thu c N2 v 96,975 gam hn hp CO2 v H2O. Gi tr a : b gn nht
vi
A. 0,50. B. 0,76. C. 1,30. D. 2,60.
Cu 37: Hn hp X gm Ala-Ala, Ala-Gly-Ala, Ala-Gly-Ala-Gly v Ala-Gly-Ala-Gly-Gly. t 26,26 gam
hn hp X cn va 25,872 lt O2(ktc). Cho 0,25 mol hn hp X tc dng vi dung dch KOH va th
thu c m gam mui khan. Gi tr ca m l:
A. 25,08. B. 99,15. C. 54,62. D. 114,35.
Cu 38: Thu phn khng hon ton m gam hexapeptit Gly-Ala-Gly-Ala-Gly-Ala-Gly thu c 153,3 gam
hn hpX gm Ala, Ala-Gly, Gly-Ala, Gly-Val-Gly. t chy ton b X cn va 6,3 mol O 2. Ga tr m gn
gi tr no nht di y?
A.138,2 B. 145,7. C.160,82. D. 130,88
 BI TP T LUYN

Cu 1: Peptit X v peptit Y c tng lin kt peptit bng 8. Thy phn hon ton X cng nh Y u thu c
Gly v Val. t chy hon ton hn hp E cha X v Y c t l mol tng ng 1:3 cn dng 22,176 lit O2
(ktc). Sn phm chy gm CO2, H2O v N2. Dn ton b sn phm chy qua bnh ng dung dch
Ca(OH)2 d thy khi lng bnh tng 46,48 gam, kh thot ra khi bnh c th tch 2,464 lit (ktc).
a. Khi lng X em dng gn nht vi gi tr:
A. 3,23 gam B. 3,28 gam C. 4,24 gam D. 14,48 gam
b. Thy phn hon ton hn hp E thu c a mol Gly v b mol Val. T l a : b l
A. 1:1 B. 1:2 C. 2:1 D. 2:3
Goi CT chung ca amino axit to ra l CnH2n+1O2N c 0,22 mol;
k l s mol H2O cn thy phn E.
Bo ton khi lng 0,22(14n + 47)- 18k = 46,48 + 0,11. 28 0,99. 32 = 17,88; n = 3,5
Bo ton C, H 0,22. 44. n + 18. 0,11(2n +1) 18k = 46,48 => k = 0,18
s mol gly = s mol val = 0,11???
X l (gly)x; (val)y c amol (x + y) 1 + (z + t) 1 = 8) v (x + y) a + (z + t)3a = 0,22
Y l (gly)z; (val)t c 3a mol (x + y 1)a + (z + t -1 )3a = 0,18
a = 0,01 ; (x +y ) = 4; (z +t) = 6 x = y = 2; t = z = 3 mX = (75.2 + 117.2 18.3)0,01 = 3,24 g
Cu 2:Hn hp M gm 2 peptit X v Y u cu to t 2 loi amino axit c tng s lin kt peptit trong phn
t X v Y l 5 v c t l mol tng ng l 1:3 . Thy phn hon ton m gam M thu c 81 g Glyxin v
42,72 gam Alanin. Gi tr ca m l
A 115,28 B 104,28 C 109,5 D 110,28
Cu 3. un nng 0,16 mol hn hp E gm hai peptit X (C xHyOzN6) v Y (CnHmO6Nt) cn dng 600 ml dung
dch NaOH 1,5M ch thu c dung dch cha a mol mui ca glyxin v b mol mui ca alanin. Mt khc
t chy 30,73 gam E trong O 2 va thu c hn hp CO 2, H2O v N2, trong tng khi lng ca CO 2
v nc l 69,31 gam. Gi tr a : b gn nht vi
A. 0,730. B. 0,810. C. 0,756. D. 0,962.
Cu 4:Thy phn hon ton m gam hn hp gm peptit X v peptit Y bng dung dch NaOH thu c 151,2
gam hn hp gm cc mui natri ca Gly,Ala v Val.Mt khc, t chy hon ton m gam hn hp X,Y
trn cn 107,52 lt kh O2 (ktc) v thu c 64,8 gam H2O. Gi tr ca m l
A.102,4. B.97,0. C.92,5. D.107,8.
Cu 5/H2014:Hn hp X gm ba peptit u mch h c t l mol tng ng l 1 : 1 : 3. Thy phn hon
ton m gam X, thu c hn hp sn phm gm 14,24 gam alanin v 8,19 gam valin. Bit tng s lin kt
peptit trong phn t ca ba peptit trong X nh hn 13. Gi tr ca m l
A. 18,83 B. 18,29 C. 19,19 D. 18,47
Cu 6: Hn hp M gm peptit X v peptit Y chng cu to t cng mt loi a-amino axit v c tng s
nhm
-CO-NH- trong hai phn t l 5, t l s mol X : s mol Y = 1: 2. Thy phn hon ton m gam M thu c 12
gam glyxin v 5,34 gam alanin. Gi tr ca m v loi peptit ca X l
A. 14,61v tripeptit. B. 14,61 v tetrapeptit.
C. 14,46 v tripeptit . D. 14,46 v tetrapeptit.
Cu 7: Tripeptit X v tetrapeptit Y u mch h (c to nn t cc -amino axit c cng thc dng H2N-
CxHy-COOH). Tng phn trm khi lng oxi v nit trong X l 45,88%; trong Y l 55,28%. Thy phn
hon ton 32,3 gam hn hp X v Y cn va 400 ml dung dch KOH 1,25M, sau phn ng thu c dung
dch Z cha ba mui. Khi lng mui ca -aminoaxit c phn t khi nh nht trong Z gn vi gi tr no
nht sau y? A: 48,97 gam. B: 38,80 gam C: 45,20 gam. D: 42,03 gam.
Cu 8: Cho hn hp A cha hai peptit X v Y to bi cc amino acid no mch h, phn t cha 1 nhm
-COOH, 1 nhm -NH2 ,bit rng tng s nguyn t O trong 2 phn t X, Y l 13. Trong X hoc Y u c s
lin kt peptit khng nh hn 4. un nng 0,7 mol A trong KOH th thy 3,9 mol KOH phn ng v thu c
m gam mui. Mt khc t chyhon ton 66,075 gam A ri cho sn phm hp th vo bnh cha Ca(OH) 2
d thy khi lng bnh tng 147,825 gam. Gi tr ca m l
A. 490,6 B. 560,1 C. 470,1 D. 520,2
Goi cng thc cc mui to ra t thy phn hh A l CnH2nO2NK
O,7 mol hhA + 3,9 mol KOH 3,9 mol CnH2nO2NK + 0,7 mol H2O.
Bo ton C, H ta c, Khi t chy 0,7 mol hh A cho
3,9n mol CO2 v (3,9n+ 0,7 - 3,9 :2)
Bo ton khi lng ta c khi lng ca 0,7 mol hh A l
[3,9(14n + 85) + 0,7 . 18 3,9. 56]=(54,6n + 125,7)
 54, 6n + 125, 7 44.3,9n + 18(3,9n - 1, 25)
=
66, 075 147,825
n =2,53846... m =3,9(14n +85) = 470,1
Cu 9: X v Y l cc tripeptit v tetrapeptit c to thnh t cng mt amino axit no mch h, c 1 nhm
-COOH v mt nhm -NH2. t chy hon ton 0,1 mol Y thu c sn phm gm C02, H20,N2, trong
tng khi lng ca C02 v H20 l 47,8g. Nu t chy hon ton 0,3 mol X cn bn mol 0xi?
s: 2,025 mol.
Cu 10: Hn hp M gm peptit X v 1 peptit Y, chng cu to t cng mt loi amino axit v c tng s
nhm -C0-NH- trong 2 phn t l 5. Vi t l mol nX:nY=1:2, thy phn hon ton m g M thu c 12g
glixin v 5,34g alanin. m c gi tr l?s: 14,46g.
Cu 11: Thy phn ht m g tetrapeptit Ala-Ala-Ala-Ala( mch h)thu c hn hp gm 5,696g Ala, 6,4 g Ala-
Ala v 5,544g Ala-Ala-Ala. Gi tr m l?
S: 16,308g.
Cu 12: Hn hp X gm 3 peptit u mch h c t l s mol tng ng l 1:2:1 . Thy phn hon ton m g
X thu c hn hp sn phm gm 13,5 g Glyxin v 7,12 g Alanin . Bit tng s lin kt peptit trong phn t
ca 3 peptit trong X nh hn 10 . Gi tr ca m l????
Cu 13: Hn hp X gm 3 peptit u mch h c t l mol tng ng l 1 : 1 : 3. Thy phn hon ton m
gam X, thu c hn hp sn phm gm 6,23 gam alanin; 6,00 gam glyxin v 9,36 gam valin. Bit tng s
lin kt peptit trong phn t ca ba peptit trong X khng qu 8. Gi tr ca m l:
A. 18,35 B. 18,80 C. 18,89 D. 19,07
Trong 1 peptit c N mt xch th c (N-1) lin kt peptit. Tnh hung bi cho 3 peptit m tng s lk peptit lko
qu 8 mnh din t theo tng s mt xch trong 3 peptit khng qu 8 + 3.
nAla = 0,07 mol ; nGly = 0,08 mol ; nVal = 0,08 mol
Goi s mt xch trong 3 peptit ln lt l:
A1, G1, V1
A2, G2, V2
A3, G3, V3
Bo ton mol( mt xch) ta c: x(A1 + A2 + 3A3) = 0,07 (1) ; x(G1 + G2 + 3G3) = 0,08 (2)
Ly (1)/ (2) = 7n / 8n (K : n thuc N*)
A1 + A2 + 3A3 = 7n ; G1 + G2 + 3G3 = 8n ; V1 + V2 + 3V3 = 8n Vy 3(A1 + A2 + A3 + G1 + G2 + G3
+V1 + V2 + V3) > 7n + 8n + 8n.
<-> 3*11 > 7n + 8n + 8n
n < 1,4. Vy n=1 x = 0,01.
n(peptit) + nH2O = n(a.a)
Bo ton khi lng: m(a.a) - mH2O = m(peptit) = m
Cu 14: Hn hp M gm 1 peptit X v 1 peptit Y(chng cu to t 1 loi amino axit) tng s nhm peptit
trong 2 phn t l 5 vi t l s mol :nX :nY=1:3 Khi thu phn hon ton m (g) hn hp M thu c 81 g
Glixin v 42,72g alanin. m c gi tr l ?
A.104,28 g B.109,25g C.102,28 g
Cu 15: Hn hp X gm tripeptit A v tetrapeptit B u c cu to bi glyxin v alanin. Thnh phn phn
trm khi lng nit trong A v B theo th t l 19,36% v 19,44%. Thy phn hon 0,1 mol hn hp X
bng mt lng dung dch NaOH va , thu c dung dch Y. C cn dung dch Y thu c 36,34 gam hn
hp mui. T l mol gia A v B trong hn hp X l
A. 2:3 B. 3:7 C. 3:2 D. 7:3
Cu 16: Thu phn hon ton m gam mt pentapeptit mch h M thu c hn hp gm hai amino axit X 1,
X2 (u no, mch h, phn t cha mt nhm -NH 2 v mt nhm -COOH). t chy ton b lng X 1, X2
trn cn dng va 0,255 mol O2, ch thu c N2, H2O v 0,22 mol CO2. Gi tr ca m l
A. 6,34. B. 7,78. C. 8,62. D. 7,18.
Cu 17: Cho 9,3 gam cht X c cng thc phn t C 3H12N2O3 un nng vi 2 lt dung dch KOH 0,1M. Sau
khi phn ng hon ton thu c mt cht kh lm qu tm m i thnh xanh v dung dch Y ch cha cht
v c. C cn dung dch Y thu c khi lng cht rn khan l
A. 10,375 gam. B. 9,950 gam. C. 13,150 gam D. 10,350 gam.
Cu 18: X v Y ln lt l tripeptit v hexapeptit c to thnh t cng mt aminoaxit no mch h, c mt
nhm -COOH v mt nhm -NH2. t chy hon ton 0,1 mol X bng O2 va thu c sn phm gm
CO2, H2O v N2 c tng khi lng l 40,5 gam. Nu cho 0,15 mol Y tc dng hon ton vi dung dch
NaOH (ly d 20% so vi lng cn thit), sau phn ng c cn dung dch thu c khi lng cht rn
khan l
A. 98,9 gam. B. 94,5 gam C. 87,3 gam. D. 107,1 gam.
Cu 19: Thy phn ht mt lng pentapeptit T thu c 32,88 gam Ala-Gly-Ala-Gly; 10,85 gam Ala-Gly-
Ala; 16,24 gam Ala-Gly-Gly; 26,28 gam Ala-Gly; 8,9 gam Alanin; cn li l Glyxin v Gly-Gly vi t l mol
tng ng l 1:10. Tng khi lng Gly-Gly v Glyxin trong hn hp sn phm l
A. 27,9 gam. B. 29,70 gam C. 34,875 gam. D. 28,80 gam.
Cu 20: Thy phn hon ton 143,45 gam hn hp A gm hai tetrapeptit thu c 159,74 gam hn hp X
gm cc Aminoaxit (Cc Aminoaxit ch cha 1nhm -COOH v 1 nhm -NH2 ) . Cho tan b X tc dng vi
dung dch HCl d,sau c cn dung dch th nhn c m(gam) mui khan. Tnh khi lng nc phn
ng v gi tr ca m ln lt bng?
A. 8,145(g) v 203,78(g). B. 32,58(g) v 10,15(g).
C. 16,2(g) v 203,78(g) D. 16,29(g) v 203,78(g).
Cu 21: Tripeptit M v Tetrapeptit Q c to ra t mt aminoaxit X mch h ( phn t ch cha 1 nhm
NH2 ). Phn trm khi lng Nito trong X bng 18,667%. Thy phn khng hon ton m(g) hn hp M,Q(c
t l s mol 1:1) trong mi trng Axit thu c 0,945(g) M; 4,62(g) ipeptit v 3,75 (g) X.Gi tr ca m?
A. 4,1945(g). B. 8,389(g). C. 12,58(g). D. 25,167(g).
Cu 22: Tripeptit mch h X v Tetrapeptit mch h Y u c to ra t mt aminoaxit no,mch h c 1
nhm COOH v 1 nhm NH2 .t chy hon ton 0,1 mol X thu c sn phm gm H2O,CO2 v N2
trong tng khi lng CO2 v H2O bng 36,3(g) .Nu t chy hon ton 0,2 mol Y th s mol O2 cn
phn ng l?
A. 2,8(mol). B. 1,8(mol). C. 1,875(mol). D. 3,375 (mol)
Cu 23: X l mt Hexapeptit cu to t mt Aminoacid H2N-CnH2n-COOH(Y). Y c tng % khi lng Oxi
v Nito l 61,33%. Thy phn ht m(g) X trong mi trng acid thu c 30,3(g) pentapeptit, 19,8(g) ieptit
v 37,5(g) Y. Gi tr ca m l?
A. 69 gam. B. 84 gam. C. 100 gam. D. 78 gam.
Cu 24: Tripeptit X c cng thc sau :
H2NCH2CONHCH(CH3)CONHCH(CH3)COOH
Thy phn hon ton 0,1 mol X trong 400 ml dung dch NaOH 1M. Khi lng cht rn thu c khi c cn
dung dch sau phn ng l :
A. 28,6 gam. B. 22,2 gam. C. 35,9 gam. D. 31,9 gam.
Cu 25: Thu phn hon ton 500 gam mt oligopeptit X (cha t 2 n 10 gc -amino axit) thu c
178 gam amino axit Y v 412 gam amino axit Z. Bit phn t khi ca Y l 89. Phn t khi ca Z l :
A. 103. B. 75. C. 117 D. 147.
Cu 26: X l mt tetrapeptit cu to t mt amino axit (A) no, mch h c 1 nhm COOH ; 1 nhm
NH2. Trong A %N = 15,73% (v khi lng). Thy phn m gam X trong mi trng axit thu c 41,58
gam tripeptit ; 25,6 gam ipeptit v 92,56 gam A. Gi tr ca m l :
A. 149 gam. B. 161 gam. C. 143,45 gam. D. 159 gam.
Cu 267: A l mt hexapeptit mch h to thnh t mt -amino axit X no, mch h (phn t cha 1 nhm
NH2 v 1 nhm COOH). Bit rng phn trm khi lng ca oxi trong X l 42,667%. Thy phn m gam A
thu c hn hp gm 90,9 gam pentapeptit; 147,6 gam tetrapeptit; 37,8 gam tripeptit; 39,6 gam ipeptit v
45 gam X. Gi tr ca m l:
A. 342 gam B. 409,5 gam C. 360,9 gam D. 427,5 gam
Cu 28: Thy phn hon ton tetrapeptit X ch thu c aminoaxit Y (no, mch h, phn t cha 1 nhm
NH2 v 1 nhm COOH). Trong Y nguyn t N chim 18,67% theo khi lng. Khi thy phn khng hon
ton 25,83 gam X thu c 11,34 gam tripeptit; m gam ipeptit v 10,5 gam Y. Gi tr ca m l:
A. 2,64 gam B. 6,6 gam C. 3,3 gam D. 10,5 gam.
Cu 29: Thy phn hon ton m gam ipeptit Gly-Ala (mch h) bng dung dch KOH va , thu c
dung dch X. C cn ton b dung dch X thu c 2,4 gam mui khan. Gi tr ca m l
A. 1,46. B. 1,36. C. 1,64. D. 1,22.
Cu 30: un nng 32,9 gam mt peptit mch h X vi 200 gam dung dch NaOH 10% (va ). Sau phn
ng thu c dung dch Y. C cn dung dch Y thu c 52 gam mui khan. Bit rng X to thnh t cc -
amino axit m phn t cha 1 nhm NH2 v 1 nhm COOH. S lin kt peptit trong X l:
A. 10 B. 9 C. 5 D. 4
Cu 31: X l tetrapeptit mch h: Ala-Gly-Val-Ala; Y l tripeptit mch h: Val-Gly-Val. un nng m (gam)
hn hp cha X v Y c t l s mol tng ng l 1:3 vi dung dch NaOH va . Sau khi phn ng hon
ton thu c dung dch T. C cn cn thn dung dch T thu c 23,745 gam cht rn khan. Gi tr ca m l
A. 68,1. B. 17,025. C. 19,455. D. 78,4
Cu 32: Thu phn hon ton 0,1 mol mt peptit X (mch h, c to bi cc a - amino axit c 1 nhm
-NH2 v 1 nhm -COOH) bng dung dch HCl va thu c dung dch Y. C cn dung dch Y thu c
cht rn c khi lng ln hn khi lng ca X l 52,7 gam. S lin kt peptit trong X l
A. 14. B. 9. C. 11. D. 13.
Cu 33: X l mt tetrapeptit cu to t mt amino axit (A) no, mch h c 1 nhm COOH; 1 nhm NH2. Trong X
th khi lng Nit v Oxi chim 55,28 %. Thy phn 116,85 gam X trong mi trng axit thu c 34,02 gam
tripeptit; m gam ipeptit v 78 gam A. Gi tr ca m l:
A. 184,4. B. 105,6. C. 92,4. D. 52,8.
Cu 34: Thy phn ht m gam Tetrapeptit X (mch h) thu c hn hp gm 2,67 gam Ala, 7,3 gam Gly-
Ala, 6,75 gam Glyxin v 13,02 gam Gly-Ala-Ala. Gi tr ca m l
A. 29,20. B. 27,40. C. 29,74. D. 37,24.
Cu 35: Hn hp M gm mt peptit X v mt peptit Y (chng cu to t 1 loi aminoaxit, tng s nhm
CONH trong 2 phn t l 5) vi t l s mol n X:nY=1:3.Khi thy phn hon ton m gam M thu c 81
gam glixin v 42,72 gam alanin. m c gi tr l
A. 104,28 gam B. 109,5 gam C. 116,28 gam D. 110,28 gam
Cu 36: Cho 20,3 gam Gly-Al-Gly tc dng vi 500ml dung dch KOH 1M. C cn dung dch thu c sau
phn ng thu c m gam mui cht rn. Gi tr ca m l
A. 11,2. B. 48,3. C. 35,3. D. 46,5.
Cu 37: X l tetrapeptit c cng thc Gly-Ala-Val-Gly. Y l tripeptit c cng thc Gly-Val-Ala. un nng A
gm X v Y c t l mol tng ng l 4 : 3 vi dung dch KOH va sau khi phn ng xy ra hon ton c
cn dung dch thu c 257,36 gam cht rn khan. Gi tr ca m l
A. 167,38. B. 150,88. C. 212,12. D. 155,44.
Cu 38: X l tetrapeptit Ala-Gly-Val-Ala, Y l tripeptit Val-Gly-Val. un nng m (gam) hn hp cha X v
Y c t l s mol ca X v Y tng ng l 1:3 vi dung dch NaOH va . Phn ng hon ton thu c
dung dch T. C cn cn thn dung dch T thu c 23,745 gam cht rn khan. Gi tr ca m l
A. 68,1. B. 17,025. C. 19,455. D. 78,4
Cu 39: Hn hp X gm mt s aminoaxit no (ch c cha nhm chc COOH v NH2, khng c nhm
chc khc) c t l khi lng mO : mN = 48 : 19. tc dng va vi 39,9 gam hn hp X cn 380ml
dung dch HCl1M. Mt khc t chy 39,9 gam hn hp X cn 41,776 lit O2 (ktc) thu c m gam CO2.
Gi tr m l
A. 66. B. 59,84. C. 61,60. D. 63,36.
Cu 40: HKA-11 Thy phn ht m gam tetrapeptit Ala-Ala-Ala-Ala (mch h) thu c hn hp gm
28,48 gam Ala, 32 gam Ala-Ala v 27,72 gam Ala-Ala-Ala. Gi tr ca m l
A. 81,54. B. 66,44. C. 111,74. D. 90,6.
Cu 41: X l mt tetrapeptit cu to t mt amino axit (A) no, mch h c 1 nhm COOH; 1 nhm NH 2. Trong A
%N = 15,73% (v khi lng). Thy phn m gam X trong mi trng axit thu c 41,58 gam tripeptit; 25,6 gam
ipeptit v 92,56 gam A. Gi tr ca m l:
A. 149,00. B. 161,00. C. 143,45. D. 159,00.
Cu 42: Hn hp X gm bn peptit u mch h c t l mol tng ng l 1 : 1 : 2 : 3. Thy phn hon ton
m gam X, thu c hn hp sn phm ch gm 13,884 gam alanin v 13,5 gam glyxin. Bit tng s lin kt
peptit trong phn t ca bn peptit trong X nh hn 11. Gi tr ca m l
A. 27,384. B. 22,416. C. 22,848. D. 22,632.

Cu 43: C x tetrapeptit l ng phn vi nhau. Thy phn khng hon ton mi tetrapeptit u to thnh
mt tripeptit trong phn t c 2 gc glyxin hoc 2 gc alanin. Nu thy phn khng hon ton x ng phn
tretrapeptit trn thnh cc ipeptit th trong s c y ng phn ipeptit u c cha gc alanin. Gi tr ca
x v y ln lt l
A. 4 v 3. B. 6 v 3. C. 5 v 4. D. 3 v 3.
Cu 44: Hn hp X gm cc cht Y (C5H14N2O4) v cht Z (C4H8N2O3); trong Y l mui ca axit a chc,
Z l ipeptit mch h. Cho 21,5 gam X tc dng vi dung dch NaOH d, un nng, thu c 0,1 mol hn
hp kh u lm xanh qu tm m, t khi ca mi kh so vi khng kh u ln hn 1. Mt khc 21,5 gam X
tc dng vi dung dch HCl d un nng thu c m gam cht hu c. Gi tr ca m l
 A. 32,45. B. 28,80. C. 34,25. D. 37,90.
Cu 45: Thy phn hon ton m gam hn hp M gm tetrapeptit X v pentapeptit Y (u mch h) bng
dung dch KOH va , ri c cn cn thn th thu c (m + 11,42) gam hn hp mui khan ca Val v Ala.
t chy hon ton mui sinh ra bng mt lng oxi va thu c K 2CO3; 2,464 lt N2 (ktc) v 50,96
gam hn hp gm CO2 v H2O. Phn trm khi lng ca Y trong hn hp M c th l
A. 55,24%. B. 54,54%. C. 45,98%. D. 64,59%.
Cu 46. Thc hin tng hp tetrapeptit mch h t 5 mol glyxin 4 mol alanin v 7 mol axit 2-aminobutanoic.
Bit cc phn ng xy ra hon ton, sn phm ca phn ng ch c tetrapeptit. Khi lng tetrapeptit
thu c l
A. 1164 gam. B. 1452 gam. C. 1236 gam. D. 1308 gam.

Gii
4aa (aa)4 + 3H2O
16 12 (mol)
1452 m 216 (gam)
m = 1236 (gam) Chon C
Ch : naa = 5 + 4 + 7 = 16 (mol); maa = 5.75 + 4.89 + 7.103 = 1452 (gam)
Cu 47: Cho hn hp A cha hai peptit X v Y to bi cc amino axit no mch h, phn t cha 1 nhm
-COOH, 1 nhm -NH2 ,bit rng tng s nguyn t O trong 2 phn t X, Y l 13. Trong X hoc Y u c s
lin kt peptit khng nh hn 4. un nng 0,7 mol A trong KOH th thy 3,9 mol KOH phn ng v thu c
m gam mui. Mt khc t chy hon ton 66,075 gam A ri cho sn phm hp th vo bnh cha Ca(OH)2
d thy khi lng bnh tng 147,825 gam. Gi tr ca m l
A. 490,6 B. 560,1 C. 470,1 D. 520,2
Goi cng thc cc mui to ra t thy phn hh A l CnH2nO2NK
O,7 mol hhA + 3,9 mol KOH 3,9 mol CnH2nO2NK + 0,7 mol H2O.
Bo ton C, H ta c, Khi t chy 0,7 mol hh A cho
3,9n mol CO2 v (3,9n+ 0,7 - 3,9 :2)
Bo ton khi lng ta c khi lng ca 0,7 mol hh A l
[3,9(14n + 85) + 0,7 . 18 3,9. 56]=(54,6n + 125,7)
54, 6n + 125, 7 44.3,9n + 18(3,9n - 1, 25)
=
66, 075 147,825
n =2,53846... m =3,9(14n +85) = 470,1
Cu 48: Thy phn hon ton m gam hn hp A gm peptit X v peptit Y (c trn theo t l mol 4:1) thu
c 30 gam glyxin; 71,2 gam alanin v 70,2 gam valin. Bit tng s lin kt peptit c trong 2 phn t X v
Y l 7. Gi tr nh nht ca m c th l:
A. 146,8. B. 145. C. 151,6. D. 148.
Cu 49: X l mt peptit mch h, thy phn khng hon ton m gam X ch thu c cc tripeptit th tng
khi lng ca tripeptit l 56,7 gam. Nu thy phn khng hon ton m gam X ch thu c cc ipeptit th
tng khi lng ca ipeptit l 59,4 gam. Nu thy phn hon ton m gam X th thu c a gam aminoaxit Y
(ch c mt nhm COOH v mt nhm NH2). Gi tr ca a l :
A. 62,1 B. 64,8 C. 67,5D. 70,2
Cu 50: Mt oligopeptit c to thnh t glyxin, alanin, valin. Thy phn X trong 500ml dung dch H 2SO4
1M th thu c dung dch Y, c cn dung dch Y th thu c hn hp Z c cha cc ipeptit, tripeptit,
tetrapeptit, pentapeptit v cc aminoaxit tng ng. t mt na hn hp Z bng mt lng khng kh va
, hp th sn phm chy vo bnh Ba(OH)2 d th thy khi lng bnh tng 74,225 gam, khi lng dung
dch gim 161,19 gam ng thi thot ra 139,608 lt kh tr. Cho dung dch Y tc dng ht vi V lt dung
dch KOH 2M un nng (dng d 20% so vi lng cn thit), c cn dung dch sau phn ng th khi lng
cht rn c gi tr gn ng l :
A. 198 B. 111 C. 106 D. 184