MAHESH R.

BORKAR
M.Pharm. (Pharmaceutical Chemistry)
Bharati Vidyapeeth Deemed University & Research Centre
Poona College of Pharmacy
Kothrud, Pune-411038.
Maharashtra, INDIA
E-mail:mahesh.borkar@gmail.com

QUALIFICATIONS
 M.Pharm.Pharmaceutical Chemistry
Bharati Vidyapeeth Deemed University
Poona College of Pharmacy & Research Centre
Year of Passing: July 2006
First Year: 64.33%
Second Year: Dissertation & Viva: 74.33% (Grade A)

 Bachelor of Pharmacy
SGRS, Saswad, University of Pune
Year of Passing: July 2004
Final Year: 69 %

 Diploma of Pharmacy
LMCP, Gondia
Year of Passing: June 2001
Final Year: 74.55 %

 HSC, 1997-1999, Nagpur Board

 SSC, 1996-1997, Nagpur Board

MAJOR PROJECTS
 Worked on a project: Design, Synthesis, Pharmacological Testing and QSAR Study of
2, 4-thiazolidinedione as antidiabetic agents.
 Synthesis and QSAR study of N-substituted 2,4-Thiazolidinedione as antidiabetics
agents
 Synthesis of 5-substituted 2,4-Thiazolidinedione as antidiabetics agents

PUBLICATIONS

 Synthesis of N-substituted 2,4-Thiazolidinediones and their Hypoglycemic activity and

QSAR, Mahesh R.Borkar, N.Sachan, S.S.Kadam and Vithal M. Kulkarni, Indian
Journal of Heterocyclic Chemistry (2009), vol.18(1),295-200.
PAPER PRESENTATIONS

 New Drug Developments on Antibiotics.Presented at S.G.R.S. College of Pharmacy,

Saswad, Pune. (MS) 2004.
 Protien Tyrosine Phosphatases PTP-1B Inhibitors as Antidiabetics.BVDU Poona College
of Pharmacy, Pune,(MS) 2005.
 Synthesis and Pharmacological screening of some novel antidiabetics. BVDU Poona
College of Pharmacy, Pune. (MS) 2006.
 Synthesis, Antidiabetic activity and QSAR study of N-substituted 2, 4-
thiazolidinediones, 58thIndian Pharmaceutical Congress, Mumbai (MS) 2006.
 N-substituted 2, 4- thiazolidinediones: Synthesis, Antidiabetic Activity and QSAR
study, 12th International Conference On “The Interface of Chemistry-Biology in
Biomedical Research, BITS, Pilani Rajesthan, 2008.
 Dipeptidyl Peptidase-IV (DPP-IV) Inhibitors as New Target for Development of
Antidiabetic Drugs,1st National Convention on Recent Advances in Pharmaceutical
Sciences & Drug Discovery, Butibori, Nagpur (MS), 2009

 Role of Angiogenesis Inhibitors in Cancer Treatment, 1st National Convention on Recent

Advances in Pharmaceutical Sciences & Drug Discovery, Butibori, Nagpur (MS), 2009

 Novel Second Generation approaches in the treatment of Diabeties Mellitus, Sharad Pawar
College of Pharmacy, Nagpur, (MS) 2009.

ACHIEVEMENTS
Secured 85.87 percentile in GATE-2004

1st Runner up in State Level Pharma Quiz Competition, Pune, India, 2004

WORKSHOPS ATTENDED

 Indian Pharmaceutical Congress (IPC-2003), Pune, Dec, 2003

 Indian Pharmaceutical Congress (IPC-2005), Hydrabad, Dec, 2005
 New Trends in Drug Discovery, Pune 2005.
 Indian Pharmaceutical Congress (IPC-2006), Mumbai, Dec, 2006
 Workshop on Computer Aided Drug Design, Pune 2006
 Role of Biotechnology in Waste Water Management ,Gondia. 2007,
 C.M.E. on Pharmacovigilance, GMC, Nagpur, Sep.2007
 12th International Conference on “The Interface of Chemistry-Biology in Biomedical
Research, BITS, Pilani, Rajesthan Feb.2008
 1st National Convention on Recent Advances in Pharmaceutical Sciences & Drug Discovery,
Butibori, Nagpur, Nov.2009

 Staff development Programme on “Emerging trends in drug discovery and quality assurance”
Butibori, Nagpur, Nov2009
SKILLS
 Strong background in Organic chemistry (synthetic).
 Expertise in conventional as well as modern synthetic reagents and reactions.
 Experience in handling air sensitive, moisture sensitive, acid/base liable compounds and
explosives.
 Experience in all aspects of modern analytical techniques including separation,
purification and characterization of compounds using various analytical tools.
 Worked on Microwave induced synthesis.

RESEARCH INTERESTS
 Synthetic organic chemistry
 Medicinal chemistry
 Microwave induced synthesis
 Drug design
 Molecular modeling

TRAINING
Industrial In Plant Training at Alintosh Pharmaceutical Ltd.Nagpur.
Period: 1 Month.

ACADEMIC EXPERIENCE: 4 Years

PERSONAL DETAILS

Date of Birth: 29th Nov.1981 Permanent Address:

Nationality: Indian c/o Rameshrao P.Borkar
Sex: Male Hari Om Nivas, Gautambuddha
Ward, Shrinagar, Gondia-441601
Maharashtra .INDIA
REFERENCES

Prof. Dr.V. M. Kulkarni

Dept. of Pharmaceutical Chemistry
Bharati Vidyapeeth Deemed University
Poona College of Pharmacy & Research Centre
E-mail: vithal@biogate.com

Dr.K.R.Mahadik
Principal
Bharati Vidyapeeth Deemed University
Poona College of Pharmacy & Research Centre
Erandwane, Pune-411038
Maharashtra, India
M.Pharm. Research Topic:

Design,Synthesis, Pharmacological Testing and QSAR Study of 2,4thiazolidinedione as

Antidiabetic Agents.

Abstract:
Peroxisome proliferator activated receptor-gamma (PPARγ) is transducer proteins
belonging to nuclear receptor super family. Interest has been focused on PPARγ because it plays
an important role in type two diabetes mellitus. It has been reported that 2, 4-thiazolidinediones
causes activation of PPARγ receptor. Based on these findings a series of N-substituted 2, 4-
thiazolidinediones derivatives were synthesized and screened for antidiabetic activity.
Ten N-substituted 2, 4-thiazolidinediones derivatives were synthesized by reacting
thiourea with chloroacetic acid to obtain 2, 4-Thiazolidinedione which was then condensed with
substituted benzyl halide to get the title compounds. The structures of finally synthesized
compounds were confirmed by chromatographic and spectral analysis.
All the compounds were screened for antidiabetic activity using alloxan induced diabetes
mice model. 3-Benzyl-2,4-thiazolidinedione and 3-(4-methoxy-benzyl)-2,4-thiazolidinedione
showed hypoglycemic activity comparable to Pioglitazone. Other compounds showed moderate
activity.
QSAR analysis of these N-substituted 2, 4-thiazolidinediones was performed using
multiple linear regression (MLR) analysis. From the QSAR equation it was found that
thermodynamic and electronic parameters show good correlation with biological activity. This
series of N-substituted 2, 4-thiazolidinediones may be potent alternatives to some of the related
antidiabetic agents

Research Guide:
Dr.V.M.Kulkarni
Emeritus Professor
Pharmaceutical Chemistry,
BVDU’S Poona College of Pharmacy & Research Centre,
Pune.