STUDIES

Lobelia (Lobelia inflata) is being promoted as a tool to help fight the effects of nicotine withdrawal, and
is found in many anti-smoking products. The active ingredient, is believed to have a similar effect on the
body as nicotine.

However, in 1993 the Office for the Supervision of the US Food and Drug Administration (FDA)
temporarily banned the sale of products containing lobelia and help to quit smoking. According to the
report, the reason was the lack of effectiveness.

Later studies showed that lobeline may increase the level of dopamine in the brain similar to the effect
of cigarettes. Dopamine affects mood and is responsible for the sensation of pleasure. However, there is
still no evidence that supplementation with lobelia to help people quit smoking.

Lobelia - a potentially toxic herb and should be used only under the supervision of a qualified medical
practitioner. Its use can cause dry mouth, sweating, nausea, vomiting, diarrhea, tremors, palpitations,
confusion, convulsions, coma, and in large doses, even to death. People with heart failure, high blood
pressure, sensitivity to tobacco, paralysis, epilepsy, shortness of breath or recover after the shock
should not use this plant. Pregnant and lactating women and children also should not take lobelia.

http://bezsigaret.com/prirodnye-sredstva-pomogayushhie-brosit-kurit.html

Multiple drug resistance (MDR) can limit the effectiveness of chemotherapy. Best studied the
mechanism includes a P-gp (P-glycoprotein) drug indirect measure.

This study focuses on MDR reversal agents from medicinal plants, which can interfere with P-gp.
Rhodamine 123 accumulation, analysis and flow cytometric analysis were employed to screen for the P-
gp inhibitors is dependent measure.

Alkaloids of Lobelia inflata and a few other species, inhibits P-gp activity. MDR reversal potential
lobeline may be demonstrated in cells treated with doxorubicin in that lobeline may inform resistant
tumor cells in non-toxic concentrations.

However, lobeline can not block BCRP (Breast Cancer Resistance Protein) mitoxantrone-dependent
measure. Lobeline might be a good candidate for the development of new MDR reversal agents.

http://www.onkonature.ru/2014/10/17/%D0%BB%D0%BE%D0%B1%D0%B5%D0%BB%D0%B8%D1%8F-
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Initially, scientists were very excited about the opportunity lobelia against epilepsy.

In July 2012, the Asian Journal of Tropical Biomedicine (Asian Pacific Journal of Tropical
Biomedicine) published clinical research in electronic form about lobelia on epileptic mice.

It observed that lobelia stops convulsions and seizures, increasing GABA release mechanism in
the brain.

Moreover, lobelia save lives mice in the test group. Of course, more research is needed,
including tests on humans, but at the moment as a cure for epilepsy lobelia looks promising.

http://healthyflower.ru/print-449