RESEARCHHYPOTHESIS

SaharMahate
InternMentorIG/T
20172018

Title:T umorDormancyinOsteosarcoma

ResearchQuestion:
Howwillthediscoveryoftumordormancyaltercurrentcancertreatments?

Hypothesis:
Ifdormanttumorcellsarefoundinalivingorganism,drugsworkingtopreventangiogenesis
couldbeusedtopreventproliferationofthetumorcells.

Background/HistoryoftheIssue:
TumordormancyoccurswhentumorcellsenteranextendedG0phase(Naumov,Akslen&
Folkman,2006).Tumorsdependonangiogenesistogrow,andarethusareharmlesswheninthe
nonangiogenicdormantstate.Anearlydemonstrationoftumordormancywasseeninarabbit
eye,asthetumorintherabbiteyeremainedstagnantuntilthecellsweremovedclosertoiris
vessels,whichallowedthetumorcellstoformnewbloodvesselssothatitcouldspread.
Neovascularizationinirisvesselsdemonstratedthetumorsreleaseofangiogenicfactorswhich
causedthetumortogrowexponentially.

Rationale:
Thistopicishugelyimportantbecauseunderstandingtumordormancycanallowmoreeffective
treatmentstobeusedtopreventorstopcancermetastasis.

BasisofHypothesis:
Myhypothesisisbasedonresearchabouttumordormancyandtheprocessofangiogenesis.If
dormanttumorcellscanbefoundintheanimalmodels,treatmentstopreventthecellsfrom
undergoingangiogenesiscanberesearchedinordertofacilitatetumordormancyandprevent
cancer.

OperationalDefinitions:
Angiogenesistheformationofnewbloodvessels

DescriptorsUsedforLiteratureSearch:
Tumordormancy
Dormanttumorcells
G0phasetumorcells
Nonangiogenictumorcells
Angiogenesisincancercells

References

Naumov,G.N.,Akslen,L.A.,&Folkman,J.(2006,August15).Roleofangiogenesisinhuman
tumordormancy:Animalmodelsoftheangiogenicswitch.RetrievedOctober7,2017,
fromhttps://www.ncbi.nlm.nih.gov/pubmed/16931911