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- ' 2

________________ ._________________

.1 . '
( ,)helicase ' ,DNA polymerase I- '
( )topoisomerase ' (.)ligase

DNA- .

.2 ):(Meselson & Stahl


) (N15 .
) (N14 ( ) .
( ,
) DNA .

,
? .

.3 5X1010 - .
)Origin of replication( DNA - .2X104 -

. leading strand ?

. 1111 - .
Okazaki fragments Origin of replication
?

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