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Farmakologi
Farmakologi
PR
3 mth to <1 yr 60-125
mg
1 to <5 yr 125-250
mg
5-12 yr 250-500 mg.
prn q4-6h. Max: 4
doses in 24 hr.
Post-immunization
Pyrexia
2-3 mth 60 mg
PO/PR. If necessary,
a 2nd dose may be
given after 4-6 hr.
- Slower absorption w/ food.
- Increased GI bleeding w/ alcohol.
Tablet (100mg,
200mg, 400mg, - Increased risk of GI bleeding w/
600mg, 800mg) warfarin, corticosteroids, SSRIs and
Capsule (200mg) aspirin.
PO
Tablet, chewable 4 10 mg/kg/dose - May reduce the natriuretic effects of
PO, 30
Ibuprofen (50mg, 100mg) PO q6-8h, not to 4-6 hr diuretics.
IV 60
Oral suspension exceed 40 mg/kg/day - Reduced antihypertensive effect of ACE
min
(100mg/5mL, 40 inhibitors and angiotensin II receptor
mg/mL) antagonists.
IV solution - May increase toxicity of lithium and
(100mg/mL) methotrexate.
- Increased nephrotoxicity w/ ciclosporin
and tacrolimus.
Tablet (30mg) PO
<2 yr: 7.5 mg bid
Elixir (30mg/5mL) 15
Ambroxol PO 2-5 yr: 7.5 mg bid/tid 6-8 hr Should be taken with food.
Syrup (15mg/5mL) 30
6-12 yr: 15 mg bid/tid
Drops (15mg/mL) min
Tablet, immediate As hydrochloride or PO Imme - Increased risk of hypertension and
Pseudoephedr release (30mg, sulfate: 2-6 yr: 15 15 diate arrhythmias if given with cardiac
PO
in 60mg, 120mg) mg/day q6-8h 30 releas glycosides, quinidine or TCAs.
Tablet, extended 6-12 yr: 30 mg/day min e : 4 - Increased risk of vasoconstrictor effects
release (120mg, q6-8h 6 hr if given with ergot alkaloids or oxytocin.
240 mg) - Co-admin with MAOIs may cause
Syrup (3mg/mL) Exten hypertensive crisis.
ded - Anaesthetics e.g. cyclopropane,
releas halothane and other halogenated
e : 12 anaesthestics; antihypertensive agents.
hr
REFERENSI
Lippincotts Pharmacology 6th Edition
Goodman & Gilmans The Pharmacological Basis of Therapeutics 11st Edition
Katzung Basic Clinical & Pharmacology 12th Edition
Monthly Index of Medical Specialties (MIMS)