Hydatidiform Mole - Management - UpToDate

You might also like

Download as pdf or txt
Download as pdf or txt
You are on page 1of 15

0120023405 6789

8  99
 9

&''()(*+,-./-(01,'-23,4/526*1.,
77789/12:*1.8)23,;<=>?,4/526*1.@,A0)8,*0:B2-,(1C,*''(+(*1.C8,D++,E(FG1C,E.C.-H.:8

IJKLMNKNOPQRSRPTUVSWLXLYURUXM
Z
 [ \]^ 
_`` 98a
b 8
 ``c \6  
_`
\!
d8
[ e
f]9e  ``]9e99b `

7d8
\987gh9^``hZijb`\989[k 9`
Z
 !989
89l 8!e! 9l9 9e98 l  ! ! 

mNMUQLMnQUSQUoNUpSqnQQUXMSMrQPnYrVj!
3405strNuSMPvNqSTLuMSnvKLMUKVZ0w`3405
xytz{|}~tx{y6789
8  6 9
 9  8 9!9 89
9
9

  e9
!8 9b` !   9
 
9!
9989l


9
 !97 l98


98
9
9 _9
   b  e!9 
9
9
 9   

9
99

99
9
0
6 98 
 8 
!


`! 
789
8  989
9789
8  8 

e9  !   99

` 98 ! !  ! 


9
  7`98!  !9
9
98

! 3w 99! `9
 e `9!  88
e9 9
e!9 
79l

!99e 
7 8l   
99 9!79 9
8 9  8
9
9
9
  e9
!
 9 9bc
 
  !

 !88 
  9
l9 l 
i  !9!  9
a9!
9

  e9
!
 
d
 8
  e9
!
 
99
 6 el 89
  7 b` 8  7988 9   6`
98
 !98 bc98 !899
7
\b
9
9
  e9
!8 9a9
  7
\6789
8  d 8  7`!  !9 9
`988 9  
\b
9
9
  e9
! 9 9d 8  7`!  !9 9
`8 9  `
9 `98 ^

9
!9
`!
  
98 9  
\
999
   ^
9
9
  e9
! 9 9
\
999
   ^
9
9
  e9
! 9 9
\99
  
9
 !

9
9
  e9
! 9 9
WyWyt\  !9
 l9!9
9  8
98 9
98l9!9
 8 9
98
!

9 
9 
97 99
 789
8  6`
! 
 9
9 
67
!
7 9 
   9l! 
8! 8e9 
}MUQNXUSUoLqnLMNPX\ !
!

9 
 8
!  
 l9!9
`98

  _%
h  
6`

 l9!9

!
!

99

98 !9
 7

 8 8 !9
 7
 8 
 l9!9
   
`  
` 7
!  


22
89
! 2! 

2789
8  99
2 
" !# 
7$ 8
020%
0120023405 6789
8  99
 9

! 
 & 9'98 
8 9&&99
8
 !9!7 9 
7 
 9 9!(%)* !9+
9 8
9
 8 ! 
 ! 
9!



 !, -7
! ' 
998 .  !9
 /

  +9
!+  09


  
9
9
!8 91988
' +
9  9!  
9
  7&99
 !! 9 !   
8 9   698 8
7 ! 
&9
9
 1
  8 !

 +
9 9! 
! 
8 !9
 7&9!9

 7
87
9
&99
88 !9
 7&9!9
 6,#23%5. 
8
9
9  
 8
8 !9
 7&9!9
,9 7
 
998 .'34 55,33!
.+4 
7
4 8
 !

9'98&
9
8
!
97,5!
! 98
2
3
!
9

 !

9.(3)6 

87 
   88
  !
&9!9
'8 
 
998  !& !9  '+98 

87!
8
9+ &(3)7
9
9


 9
 9 8 !
'8 98  
9 -7
!    ,04
 08
9 9!
9
 
9
%48 2 .
 !97 
 9
98 9! 
9
! 
9!
'98
 
8!9+ 8 
 !8  !
&9!9
!  
 !9 !98 9
 
!& -'  8+7!

&9!9
98
!

9
! 4  
99  
9   8 !89+ 
,7
:7 
9 9+ 
99
:'!
 ;7  !9&9!9
;98:7  !9
 9

9!76 

 
:'!
 ;* 

9;.
!9 !98 9
 
!& - 8+ 898 97
9!!  89
9!9 98 9

9  9
 

  07 !  ! 998& !9

 9 9 9 
8 
& 897 
  99
 9! 
9
8 9
  8 9
9
'+ /+8 97+! 
88 
99 !  
9 
 + 8
9 8 
8 
 9!9&
7<&9!9
 

 ! 

 99 8'7
 9

  989  9 '8 ! &9+ 8 =

 
9
 !
&9!9
'


97 /9 87'98+8  ! 
 81 

 9
902/ 0'

 97 8999& 9
9+8 
 9! 
9

 ! 
9!
>!
&9!9


 

+! 
'9
9!

 8+8
 &97 8 9!   !

7   
 
9 9
&  97
 

 !8 
8
 
&9!9
 ! 
>9!  9
 
8 9   ! 
  97  +  
!
 
!

'
999! 9
9   4 
7 ! !?8   9 9
&9!9
97++
9
97 
9  9 
9 ' 8'  ! 
9+ 
* 

 9
 979&9/878 9
8&  
9
99 /9!
!9 9
9
 997 +
'989
9 97 7+!
8 8 9 8+98 

 ! !  ! 8 
@ABCDEBFGABGHCIHGJCFKGLMJGNOPQR9

9
9  / 
9
9
  +9
! 9 9,ST.97
+
  7
!
7  79!
!!
976  / 9
98 !8+ ,7
;S
9
9
  +9
! 9 9;+ .
UVFBDJDWBMXVQ>
7
!
7  
6 9Y2479989&! 
8
! 8+9 ST   /7 
 9 * 98

 &9!9
'7
!
799

8!9'+

  9
'
 / ST,7;S
9
9
  +9
! 9 9;+ .
+
 7
!
7 
 9 9 
9
8 9  Z3 9824
25

! 
 [ST8& 8 15 3Z,%2!
. 
9
8
8 9
98&9!9
9 
98   
 -9


9
8
7
!
79 (5)9/87&9
8 9!   !
 98
  ,*S.&\05%'444128998
! 

9:
9  /:   
 79!
!!
97 7
!
7 8+! 97!  88<&,Z%!
. 
 

9


&9!9
*S&\05%'4441288& 8ST7  97'9

87
9

!8833 98%4  8


! 
  8
9
ST8& 8 5 0%9

,34
!
.
9
8
8 9
98&9!9
9 98   
&9

 8
 97
7
!
7(Z)


22
89
! 2! 

2789
8  99
2 
" !# 
7$ 8
320%
0120023405 6789
8  99
 9

&!  9

9'

9

 
(
   
9

  
9


9
7
!
7
  9
 !9 )9 988 !
!9! 8)   


  '9
!8 9('

8 

)
9!9 
9
9
!8 98 
 !!

9
9*+,& 
9
8
7
!
7

-  
 ( !8  9./)*%,
9
9
!/08)  1!
 9

9


 )9!9
 9! 
789
8  *0,2345  4' 6
7

 7
!
7(
 )9 97')8 ! )9 9
9
9997! 
88
  
 )9 9
!9
 !7
9
(
7!9'9 9
8
8 !
) 989


8 !  
 

 7)9!99
 
9) 8
(9!) !97
!
7  - 
7
 8
8 !' 8 989) 8
9 97
67
!
7979 ' 8 
!799
 9!
 99



 9)9!9
(9
 
 
 9
7'  :9
9' 
'!!  
99 
 !  !9
*04,
;<=>?@ABCDECFC?GH=D?G<B>@I7
  

( !
97  - 
79
)9!9

9! 
789
8  
  J 24/
9
9
  '9
! 9 94' 6('




8
97'9
!97  9


  J! 
   9   

9)9 9'  9'(997'
!9
98 !
  !
9  !  (
!9 9
 7 9987  !9*%,8 
9
7(!  79K 8 
99
 9!




7

9*00(03,L


K9
989!
 7! 9)'8 
 

(98
9
 89
9


  8'
 89
7
 !
(9798  

9!
 7! 
  J9


 9!
!2
 J 9 79!
!!
97 !  79K 6  
8'789
9
9

!  

7 
9
!
97!98 !
 J '- 
   
8 9   /0

9

*0305,5  9
  J(8 
 !8
 79!
!!
97('

9
 
9
  2345  4' 6
98  
9
  79!
!!
97  
8'793403
9997 
9
 !88

98  :8
 92#M019

(98 9 8
! 
 6*01,  79!
!
!
9799 ! 9
8
9M1!
8 !
 
 J /029
) J*NN,415(+%O.8
4314%56

  8 ( 9
8


 8   !9- 9
7 

 9( !8 
9
 : 

87  9
 !88( 

 89!!
9! 
 ! 89
8988
(9

8 
 
9997 (
'
  79!
!!
97 

7!9'!9 
89
9


9
9

 8
 79!
!!
9798'- 
78 9 8

/0K !89897 '- 
8 9  98- 8 ! 
9! )  *01,
7

0P98  '9
!.
(9)
9
8+19

 
  9 (98 704200
!
6F8) 8 

8 9*03,Q 
(  
9

98
9
9
!8 99



 

8 998
!
83 K9


9
8


K9
  


 (98

( )- 8 7 !  

K9

9

9   
R?STUFEHHVWGFXA=YVAEWIZ9

 9N269
) 8! )9
   '  9



 
9

'!9 
N26 9!
 K8 
  '9
23[Z)
 N26
9   :9
 9!7[6
\]^]_`\`^aFbcFdb\;efd]afb^g
h@>G<D?@<=EiEjHI 99!79 ! 9
87
7 8   )

9

 


9
9
  '9
!8 92/63 9

 - 9

7 8
97
/
9

 
! 
L
998 !' !J 9
97'- 8' 
 8 !
 9
 9
)
 
9 87)97 

9'  !98!98 )9!9!  !9
 9
7 8
*0k,

22
89
! 2! 

2789
8  99
2 
" !# 
7$ 8
120%
0120023405 6789
8  99
 9

!
 9 
9

989 9!

979
99 
 9!   ! 98
  
'()*8 9
87
7 8 '+,67
7 8 8  9!79

,*
-./01/234567/389461237:;4;<!9
 !7
97 7 =
 
  
   
=9!9

8!  ()=> 
797
9
!?
7!9@9 9
8
99@8  978

9 8 89!!9
 !7
97!9 98A9
  ?97?
7
 
9 7>
!!9?
7!9@99899 !  !97B0CD'+,E=9 998 9  9
@
 ,98
,F=99
9899
 
8 =9 9!7
,*
G06678/HI;1/<J!9 99 ! 9
8
! 
 99!7 = 
79
 9
=9!9
98978 
K 8 !999

L/0M1NI98HN2/0:3;:HI4NH;<> 
9
8 
 

 
?!98   977
99
B34?30DO

 =9!9
 ! 
789
8   
! 8
 
?9 A 9
73
!
 9

8
8= !98   977
? !8 !
9 ?879?
9!79?
98
9!7!98 9B34DO !
9
 
!
97=98 9?98
!
98 9

8 
9
@ 9
9  97  
9
 987
97 =
 53 9

=9!9

!98   97 

P 9
78 
 979

 @
8

  @9
!@  Q9
?@
!99 @8 


!98   97!  !9
 
7 8
?
A 9?989 =  89!
!
  97  
9
!9 
@  

89
9
9?  !!
97 
9  9
798  
8> 
!9?
  
9
  = =%R
53 9
()=
8!9B33D!   97 8 '*9
 9=9!9
 
 9!  9 ()=
8 
K !
97  @9
!@  97 = 
9 79 9
()=

9
7 9 Q
S-TT-UVWG<X   
9

 789
8  '6*!  
 9
  9
 9!   ! 98
  '()*=?
98
!
9@= 9!898 9 
9 8 
=9 
'9 
0*
J !  9!
 
 9= 9!98
9


!  9 ! 9
8
 
! 
8 
98=9!88 9>

8+
9
? 8 
 
9
89
@9? @ ! 
99

  
 Y7
 9 
! 7

9898
!  9 @ 9 ? !8 ! 
?

9 
9
 ?98! 8!9K 
B31DJ9

8 !9
 !! 9
9



8
9898! 7
= 9!
! 
Z601/835L[<O9


6 8@ 
8
 9()

=99

=9!9

=99
  
 9
9
9
  @9
! 9 9')\*
Z90.6188/2763I0N4N7N8<) 8   
O !9(  E@

 ! 998)7!   

98= 
   
! B3%D
a F=7Y
 8
!
9@ 
Y?

a F=7 
  A 
b> 
()9 8
!
9@  A 
?

9

97

7 
@! 9
?  
Z5N04603M90/41N23N]3HN214N012^<979

 8
 A 
 8   8 !


! 
_ 97 
@ 9


9
9!7 ?9
!97
  =91&
X 
 ?Y7  
7()

 9A 
7 = Y  97 ?A =?98
! = 
?9Y  !  9!!  
O 
 8 () 
 99
@9 B3&11D Y )\ `0!
9
9
8
!
9@()= 9

9 8?@98 89
9  =9
 98    
 

?
!8 
(9 ( 6 
9? =
7 A9+

?\F98  @9
! 9


22
89
! 2! 

2789
8  99
2 
" !# 
7$ 8
%20&
0120023405 6789
8  99
 9

&
'()&*+98!
 6 97+, 
9 9+-9. +98
(
98/30111 9 
9
8
99   
 99!7'#33+4%1*  &9 & 6 
9 )982
9    
&3 9 .8+ 70 50484 83(/1516 
&3 9 .8
 
%08979
49!9
+
 7 3(90 0%10! 98
0 505&3 9 .8 
9

9%08979

 
9 8&349
 9 .9
955898503897 

9%098:%0897 +!
47 

  
49

&3 9
 9 .9
+
 
  ;
9
  
!9 9! !
<  97/301+ 9  04389



! 
 
9
8
49!9
+ 9

84 83(9

&34;!9
8
!
9; 9997
4
9%62=
>9


9
9 97;9
!97
9;  
88 9
 &34 9!;!9 

   7  
!/141,9?9/131+ 9 !
4!  

87'#344@* 9


 
89

A!  ;9
! 9&
+
 7  
 93(9
&3 9 .9

9415!
9
! 
 +4!
9
9
9 +98410!
9
9 

9!7
! ? 
 <  97+ 9
87 4 4 3@5 
9
9 +  

9

84 83(    
9 8! 98 9 .9
 
&34/3@1
B
;9  
89
9+
97;9 9;
9;;4 9
&3    
;
! 

 989
9 

9! 9;7 !9 
 7 89788 9   3(6
 
!

  !79
 !
+
()&+
9 9

   
9! 
 9
9 
;! 
9
9
9! 4 
! !
477  8;7
! !
4 
78
!
9;&3
4
6
   ;

 .&3 !4
8 !
99

C 7 84  3(9
 9
49!9
/1%1516 
87+9&34 :08862= 

 8
  
7   
9
9 49!9
99 ! 9
8
9
9
91%!
 7 3(/1@1<  97+9

87
 
8
9
 9
9! 
  &34934462= 
 
79

49!9
 904462= 
 ?
79
49!9
989 7  
!; 8!
,
&34:344462= 
 
79
49!9
99 ! 9
8
901@!
 7
84   

8 9/351
DEFGHIJEJKILKMNOPA   49!9
 9! 
 9
9 99!7+ &34  
9 49
8 4497+
9

 !9 8994 3(8 9    
 9
3( ;98 
   6
9
9A89
 37!  798B;

 !'A63B*!
 9/18
501
S &349
9 '9 
 R04!
 
4 
*9!  9
 49

7 8'+8970+5+05+9830*
S &34 !9:04!
9! 
49 49
 78 9
'+9
 
8970+5+9805+ !9 :04!
  8970
89705*
S > 
! 8
!
9;&3  
9 ? 
9
 949!9

9 
9
979!!
8!
 9
97
8 9   3(   989  9
9!76 4+A63B9 9!!

8 9   3(;98 9 
  !8 9  
!  !9!  9  49 4 '+98;7?9 9
 
 !

*982 
 8
!9

!  !9 98   !94 8! 
9
9
,
 A63B 8 ! 8
9

 9


 

&34 ? 
9
 9
9!7+9   &9 & 6 
9 
8 509

  9!  
 01+804
6
 98 

749
8;
8!  &34 ? 
9
49!9
6
 
87+00'@5
!
*9


9
8?!
9
7+98 701!
Q 8!
97
9

/531
<  97+9 03+%30-9.  99


 99!7+80'4@!
*98 

;
 9 
&39
 ? 
9
49!9
/511)?!
9
99
9  8 @09

980%'@43


22
89
! 2! 

2789
8  99
2 
" !# 
7$ 8
%20%
0120023405 6789
8  99
 9

!
'9! (8 
9   )98 0% 8( 89
*+
78 8
9(97
   
 ,

 8 9
(99
988 9   *+ 8 !8 8
9 99
7-./*
9
9
  09
!
 9 91 8  7)!  !9 9
)8 9  )
9 )98 2
9
!9
/)!
 3 9 
!
(99
398/*
9
9
  09
! 9 91 8  7)!  !9 9
)8 9  )
9 )98
 2
9
!9
/)!
 3 9  3'
45678795:9;<=>;?@A;BCD857E5:9;AFGHIJ9 !!9     9(9!9
)
K*(
  9 
 9 L989 (9
89
 (-M344N2O'J!9   

-
 9

9

 
' (K* P !
*+)9  8
9 9!
(*+
Q !
*+ 9 

7 ( K* 
90! 97!  !9 98   !9( 8!
*+R P !
*+ 
!  7 !!9
9! 
 )
978( 9
9
9 )
(9 ( ) !  !9!  9 ! 8
 
 

08 

! 99 !
 78 
9
8)  (9 (7!7

  09
!
9
 8 !9
909 
 K*98
978 
 
 (9 (8 99 9!7

  09
  
8 9
!990
STTU
Q !
*+ !99!
 L807
   -0' !  8 99
98 7 8
90!  !97)98
-3'K*(   (

97)9070!9 
 
!7! 
!  98
! 990
 9!V9


P !
*+ 8
0
9
8
!
97)0
! 
   8 !9
80!9 %
04!
 (
978( 9!
(*+)P  
9

ST&
T5U
9
 77! 79
8K*-K*6'90  8 ( 9! 9



P !
*+ST%)TWUK*6 97! 
  8 !807!7

  09
!98 9 ! 9
8


  09
 (9 ) 
 !7

  09
!)98 (9 
 9!
9 9
9
N
 

 

09 
 !  !9!  9 
98
   )98 
9   K*
 8 !8 9!
(*+
!  ( K*6 8 !9

! P !
*+N!9 ( K*6
8 !9

8( 
 9!
(*+
9
P 
9

STT)T&U
V9


P !
*+ 80 
8
 
7K*

9898( 8
9( 89!7
STXUY!
(*+ 808 9 8)98
9
89  9
7) K*6 
9

934!



9K*  

9K*9
 8 0 STW)&4)&0U-./N
999
   2
9
9

  09
! 9 9/'
9(9

   9 

 (K*) !8 

9798K* 8 !

9
!97   9 9 8 
98 9    

 K* 8 !8 8
9 
99
7-./6 9!   ! 98
  
 9!798
9
9
  09
!8 9
98!9    

(/)!
 3K9 98(99
  

 ( K*3'
@=:96ZE5[98=:IR 
 99!7 
098( 8
 90! 
9!
8  


 
(9 K* 
 Y9!78  
  8 892
8 !
    0



K*
98 8!  !9
99
J
 !8  9! 
9!
 09 

 8
8 ,7 
  9 
   9(8 !
7! 7 

! 
9!
(S31UY 
9
 8( ! 8
080 
K* 9 L0!9  

 2 
  9
8 
0 ( 
 

  (9 ( 
6 
 !97) 98( 8
 709 ! 
9!
098 9! !
9
  9
! 
9!
(97 !9
 2 *+S&3U. 89
9

9

  !98 299 ! 9
8


 8  &4!    8 9! 
9!
(S&1U6 ()
9 
7  
 9
  9! 
9!
(908 
9
8 
 
) !8 
 98  L8
 9S&T&%U
9
99*7!   !J!  7* 98  L8
 9-#3%%'
9
9 89


 9


22
89
! 2! 

2789
8  99
2 
" !# 
7$ 8
%20&
0120023405 6789
8  99
 9

! 
9!
& '9 ! 
9!
9
&9!9
 96(%%)*   !9
8 ! 
9

 
 9
  '9
!8 99 8'

 +  9!
,
 9! 
9!
& 989
 9
-31&11!
.8 9

 
9   
 9! 
9!
&
 9 /,9
8 9

  
'9  904/ !9
979

 
'9  '!99
 
 8 9
   80988
,9
7
9
!&  &
8  !8 0%11  
8
9
9'
 
87 8  !98
 / 1*
 
 9  9! 
9!
&(%5)
2345267
89:;<;=>?<@A;B>CD>E@<:;=FA?9>C@<:=<G6789
8  -6. !  H8
9&9 /
8&   &9 &8 9, 8
9
9
9
  '9
! 9 9-1*.
 
8 ! 8! 1*9
9!
7  99!7 (I,%JK0)
Y M 
 -0%
34!
.
Y X9
9 -0
%!
.
 89 
 
8 ! 8!  
 91*
  8 ! 8 9 
!!
 998

 H 
  9

8 8L  
 99!7,
 / 9!
 8&  1*
!8-0.! 
 
  
  '9
!  9
-
  H9

9
9
99,
 9!   ! 98
  (M1)&N044,44402O.+-3. &9 9
!9
 !7
NK! 
8 9
+98-1.9N1%
P479
 !98 / ! 
 
  9/8
  '9
!  9
9 
9
8'789
9
  !
,
*Q98  '9
! 9M
-*QM.,  J%J 
! 

 (%)!&9'! 
  '9
!  9
& -
  H9

9

9
99,M1&N044,44402O,98 &9 9
!9
 !7
NK! 8 9
.9
9 ! 9
8
  !9
7 9
 
  &9 -104&1P!
.98
9
9-JJ
&4K!
.R !! 
 9!
7978 9 8 
 

 
,
!9 !9
  9
 99!79
!  7! 
8
978 9  , &,

! 8!  
 91* !98S 

 
! 
 
 T 
7

 
M1&9,98 M1&9  

 
! 
 9
9 ! 9
8

8& 

1*
U89


! 
 99 9
 !98 / 8&  9 
 9
 R
8 9&
8
9
11
K4!
   &9P4
! 
 8&  

8 9(5,K3,K1)
U

8 9& 
8
9
%1
%K!
   &%4
! 
 8& 8
 
 9
 (J,KP)
M 
 9 !  79  8  8 ,989  8797'9 / 9!
 1*
(K%)U
87 
8
9
04 01-55!
.9  8! 
 8& 8 


 
(KK)
0! 
9

9


98&9!89,98 !
-V934.8 
99
9&9  /
8&   
 98 9L9W9, 
87 
!  !9
9
98
!  334
98 !
9


! 
 
89  !9
78!98 / 8&  1*(K5)
S 9
9 ,  / 9!
 8&  1*9&' 8
8(KJ)L
9
9 , 



  97 
9
9
!(%)L9W9,00
8  !8 5%5I9


9
9 
 
9
 75K-04!
. 8& 8 


 98 7 -40!
.98

9
9(3,1,KJ5K)
X9


9
 99!799
9 !98 / 8&   


 U
87
 
89
 8 !98 /  
 9
  9


99
 99!7(55)AL 
1I9



  99! 9989

*QM  0IK%
3401, 


 


22
89
! 2! 

2789
8  99
2 
" !# 
7$ 8
520%
0120023405 6789
8  99
 9

8' 8   
 
  ( 34)34!
*! 
 98   
! 8 + %
34)(4!
*! 
 +98 3 05)005!
*9
9 ,5%-
./0123/245678294:4;<=>9+9


?
! 
 989
9 !99
! 9

 9
 8 !
'
! 
@

ABC?
0DE&983401+ ?

 !
!  !88,5%-
] [9


! 
 9801%%?L 
9! D(D)E%(!
*
 '? 
+041
)5(!
*9
8 ' +')4&!
*
? 
+3&E)0%(!
* 
9 
9? 
+9800)4%!
*!
 !9! 9\ 98  ! 
99 9 
8
!
8 (4)1%!
*  9

] [9


9
9 981&5?L 
9! 3E4)53%!
*
 '? 
+ 

)33!
*9
8 ' + )41!
*
? 
+E()05D!
* 
9 9? 
+
98
 )4E!
*!
 !9! 9\ 98  ! 
99 9 8 9 8 
7 )0&!
*  9

9
9  9

 

,5D+%4-
F272:56GHI:8678294:4;<=J 
9 699
 !98 K 8'  ?L 
6
! 98

9  9
,%0-
B
9
 
 K ?L 
69
] @
  99!7)0
0D!
*,5D+%4+%3-
] @

  99! )0&
05&!
*,5%+5D-
@  

  
8
9
9 3&5% 
! 
 +
?L 
9!7
9 9 35)0D!
*+ !8 33)%0!
*! 
 98 ')0D!
*9
9 
,%4-@ 3E359


99
9 +
?L 
9!79 9 3&)05!
*+
!8 05)E%!
*9
9 98 
)13!
*! 
  '9 K  9
9!790%!
+ !
8934 8 !9! 98

9  9

@ 35!9
9
! 
 +
989
 99! + 8 !9
9!!9

9

 ' ! 
  00!

@

ABC?
0DE&983401+   
  99! +3&9

98(4?L 

9! ')05&!
* 99! ) M! 
+ 9
9*+3&)E3&!
*
 '
? 
+  
9
  
98 )3&!
*+
 
9 9? 
)5&!
*+
 8 !8
9? 
)5&!
*+98 !
 !9!7)3&!
*,5%-
N015258O;6G:4:92G245= 

 K !
6+  9!
!+98' 9


9 
6
9'9 

 

9 8
!   9
9
98' 
 ?L 

9! @88
97+99CP9
 MK9

! 
 97
7 

9!7)+
8 '7+ 
9 9? 
+ 8 !89? 
*
M!8!  !9!  9@


 
8 '  9


  99!7 PA+
9!
9 8?!9 7
M9 898

9
  7 979? 9
9
@88
97+9 8 !
 ! !
  
 !9 9 9? 
 8?M9 89
   !97
.QRRSFT6SUV6FWXNRRWUVSYZNU.
] 6789
8  )6* 9
 9  8 9!9 89
9
9
  ?9
!8 9
)P*+ !   9
 
9!
9989'


9
 !97 '98

98

9
9 ^)_`>
 8 !
`9? '*

22
89
! 2! 

2789
8  99
2 
" !# 
7$ 8
%20&
0120023405 6789
8  99
 9

T 
 :9!9
 
9 
97 
9

 6H  
66

 
:9!9

!
!

99

98 !9
 7
 8JKLMNOPQ0RJ)S
 
:9!9
S9' :R
T H  
6 99UC479989:! 
8! 8'9 6
7
!
7
9

9
 :9!9
JKLMNOPQ0RJ)S67
!
7S9' :R
T H   
9

 6!  
 9
  937F 9

9
: 9
!   ! 98
  J97R6
98
!
9': 9!8J9 
0RJ)S) : 9!

! S9' :R
T H   :9!9
 9! 
 9
9 99!76 97:  9 :9
8 :
:936
9

 !9 899: 
9
9
  '9
! 9 9J7ER
8 9    
 97E '98 
D
9
9H89
 77!  798;'

 !
JHD7;R!
 9J)S 9   7ES9' :R
T V 
 99!7 
'98: 8
 9'! 
9!
8  

 
:9
97 
 +9!78  
  8 893
8 !
    '
 


97
98 8!  !9
99
;
 !8  9! 
9!
 '9 

 8J)S9 
9!
S9' :R
T B
9
 
 3 !
699
  99!7J0
0%!
R6989


 99! J0&
05&!
RJ)S59
 99!7S9' :R
  9
 '(!


) '! 
98* !+

,-.-,-/0-1
023 
45)67 8
 89 
98:9! 
99
 
9
9
  '9
!8 9
77! ;! 3401<03=1
3>9 93 865

76?9( 6789
8  
 

+    !98!7

!
87

 !  !9!  89
+@;'

77! 0%55<0350A5
1)49+B6) 
!  ! 9
   !  
9
9789
8  ;'

77! 
0%=3<&%&%5
C)49+B6) 
78  789
8  D97

!98    !! 9

+@;'

77! 0%5=<010AA&
&23 
45)67 8
 89  !99!
! 99!7EB@8344%<1A40A1%
A 87@+67  +62 
E6
97
9
9
  '9
!8 99
87  8 :9!9

98'F 
8 
9


!
9777! ;! 3444<5=14%
5B 9?6)  62
 6
99 
789
8    98C4
C%79@
5 883403<&53&C
=B 9?67 8
 8623 
45)9 
789
8     8
99&4@
5 883404<&&34=
%* 9 @562@D6  3BB6692E9
9 
7 789
8  9
 97
:9!9
+@;'

77! 0%=1<0C&&%0
04?G699??69?H6E96G3479I ! 99  '8  
9
9

  '9
!8 9@5 883445<&31%5
00?9  9G6?9  96)    66
98 79!
!!
97 789
8  H :

0&79  99!0%=A<&=A3C


22
89
! 2! 

2789
8  99
2 
" !# 
7$ 8
%20&
0120023405 6789
8  99
 9

03&' 
()*+, 8
 -+ &
&+&
 )99
 ! 
 99!7.
) 880/05113213
014 .+494+5 6+
9- 79!
!!
97 789
8  
7

9
9

  89
! 9 99 !99
989*7
)73403104944530/
03: *+ 6+: :+
9; !
  79!
!!
97  


  89
!
8 9 9


! 
789
8  <8

,7! 0/021252/4
0%8
;+49=98 8 9+899 9>,+
9-7
  
 9
9
9
  89
!
 9 9  79!
! 8 8  9!
 7!    '789
8  9
 + !
7+!98 ! 
9 9!

987 !
 !  9!
9
  8? 

9

,7! <! 344/10033//
02, 8
 -+&' 
()*- 79!
!!
97 ! 
 99!7* <! 
0//%1330%5
056  9 9'*- 79!
!9!
 7!    '! 
789
8  .) 88
3440132004
00@99
9' *+ ( +*9'9
*+
97 8 !
  99!7.9 ;8 !  
98
0/551333%3
0/&' 
()*+, 8
 -+&
 )699 ! 7 
99
 
9
9

  89
! 9.) 880/04133320
34*
A 
B+&
 +, 8
 -+&' 
()*!9 !  !9
9

! 
 99!7<8

,7! 0//%10255%
30&99>+ 9B+9
CD+
999 8 
9  !9-
9
9899

9 
6789
8  > &9(  9A D
.,7! 99!3402132/03
33 6&+  9-+*!9
.&>!
  97!  !9
  99!7>.<8


,7! 0/5/101%00/
319986*+>8 ) 
@)+6**+)
9B- !  9!
 
 97 9!98

9


! 87 8 
 <8

,7! 34441/2/34
339 

 -9!
!& 
,7!  7+> !99  <8

 ! 998,7!   

>9<,-9!
!& 
E%1 9  98
9

 
9
9
  89
!8 9<8


,7! 34431041012%
3% !F*+&
 )+, 8
 -+
9<
!  9!  !! 
 079
789
8  <8

,7! 0///1/3%00
32A  8>.+4
9
9+, 8
 -+
96  ' 99
9! 7 8
!
9869,
7  
! 
 99!7<8

,7! 34431043%%0
35A  8>.+&' 
()*+, 8
 -+
9- 
79!9
9,798 ' 
9
9

  89
! 9 9  
! 
 99!7<8

,7! 344%1042%30
30A  8>.+, 8 A&+4
9
9+
96  ' 99
9! 7 8
!
9869,
7  
9
9 99!7<8

,7! 344210401/1
3/:' =6,+A 9*+964+
9)!

9
9
  89
!8 99
9,
 9 (9
   789
8   @
98,7! <! 34451042033
14697 D+)9 ,,+99
  6+
9 9
  9!   ! 98
  7 9! 9
9
789
8  >.<8

,7! 344%10/30123
10*8 @.+4 '

+* 
+
9* 
88 9
  9!   ! 98
  7 9!
  ! 
 9
9789
8  7 8! 7 8
!  9: 9

  89
!8 9
&.<,34451003524
13*!

9+ 
+998 .+
9) ' 
9
9
  89
! 9 99
9,
 9 9
9!! 8 
789
8  
7,7! <! 3401101402


22
89
! 2! 

2789
8  99
2 
" !# 
7$ 8
0420%
0120023405 6789
8  99
 9

11&99'(9
)*(9
(
9+
9
9
  ,9
! 9 99
 
9  9
!   ! 98
   9 -9
    99!7.9!9
+7! /! 340%0
011321
134 74(5 
(9796(
9 
4+ 9 -9
 9


789
8  99
!798 7  


9
9
  ,9
!8 989**: 84  +
9
9  ,
9
! 9(3401(;4<9,
9!
=
1%67, 4(5>4(/

.9?&(
96 9   
.9!9
 9!   !
 98
  ! !
9
8 !
 
 9
9
9
  ,9
! 9 9*
@+7! 
49!340103100%4
1;.94 . 
5( 94(A '(
9*8
!9
 9


 


  ,9
!
8 99
! 
789
8  ,7 9 933  4+ !.
+7! /! 34030011%33
15B &:(4 6(B 6(
96 9!   ! 98
   9
998 !
. 9!

 
 9
9
9
  ,9
! 9   7789
8  9!9! 
 
87C @
/,

+7! D 8& 340300;4044
12+ 8 :&(:  ,'@(>
9
4(
9? 
.9!9
4+.98 7 
9
9

  ,9
! 9 99  
9
9 99! @D 88344;0%0250
11B  C*>*+/3444
9 98 7 9!
!  7
 
9
9
  ,9
!
8 98! 
98!
!99
*
@+7! 49!344000051
34>*+/4 

 +7!   !/!  74 


>*+/
9  !9! 
.9 9( 9  9

,( .97(98
9
9
  ,9
! 9 9*
@+79! /,

3441004%1
30E96F(&86(&8
@6(
9+
9
9
  ,9
! 9 9(>*+/3444
9 98
!9 !9
*
@+79! /,

34410215 005%
33'99D( 5(5 
(
94
9798 9!   ! 98
  ! !
9
;
 
9

 .9!9
  99!79
 !
.!  

8769!
34030
151014
31&99'( &(& )(
9*!
97!97 9


 99!798
 9!   ! 98
  .9 8,
 9 9
; 
9

 .9!9
"
+7! /! 340;0031%%2
334 6'677! 79
84+(9. ?9!
93404010;%1
3%B  C*:9
7 9,
 .4+8 
(!9 !9
9899
@D 8
83443031311
3;E 5>(49BB99
 4  
9
98A !
+
9
9  ,9
! 9
4 /,

+7! D34030123
354 6'(B9 95'*9  9
99
  
 

 4+
@D 8
83443031331
324 6'( 4F677! 79
84+ 
99
 G !
98!  9!
7

9
9
  ,9
!8 9+7! /! 3404000;1
3169! !7&:4+9
 
9
9
  ,9
! 9 99!
!999 9@D 8
8344;0%02%1
%469(69! !7&:99
  

(H9 8( . 9!   !
 98
  .9
9 
 %!9@D 883443031%%1
%0B9 95'(4 6'99
 
9
9
  ,9
!8 998
!9
 
.  9!   ! 98
  @D 88344;0%0203
%35
(&99B'997  
  ! 9
99(
9
99(! 
9!
.

 8(98
 8  97
9

 9


789
8   
 ! 8!


22
89
! 2! 

2789
8  99
2 
" !# 
7$ 8
0020%
0120023405 6789
8  99
 9

&' 
!
97()*&

+79! 0,5,-./5.3
%16 0 (1( !239
   9! 
9!
498
 
9
 ! 
9!
484 !


  ! !
9
 
&
9& 
  9!   ! 98
  98 49 4
!  !9
9
 99!75)*&

+7! 0,.1-06%306
%6(7 
8391+ 8
 2199531(
 *9! 
9!
498 
 9
  &9
!
8 9*&

+7! 0,.0-%.656
%%: 79;19!9
)(1<  =>1
96  9! 
9!
98
  &9
!' 99

789
8  ?9+7!   !*!  7+ 9
87@5)*&

+7! 0,.,-0/4.4%
%/58 >A1*98 751A9 5*1
9A

7 9
7
 89884 

!  !9
9
49!9
 ! 
789
8  )*&

+79! 3444-34/.
%5: 
96;1 72> !  9! 
9!
4 
84 
  
 9
  &9
!
 9 997
9
!4 +7! *! 344/-044%5,
%.+ 8
 21(7 
8398 9  9899
  99!7>+
9
9 
&9
!B 9:  !92 !   9  9899
199 812 98 90,.3
061
%,: 79;169 8:(177;1
96789
8  8 9  199
198 

   1659

*&

+7! 0,5%-6%0
/4+
9
9  &9
! 91188
169! !7(C19!7)1(7 
8391: ;5?=8@1>

9
99 ! 
7 
9
87   &9
! 91 
8 344,0%43
/0(99<  &9
! 9 9>:9!8 ! 1116 98)A1A A>>>1(9
3)1
9
?=8@1C  9DC 7 1(9
 0,,10/,0
/3 C9  ! 
 97
9

 789
8   
&' 
! )
*&

+79! (:  0,//-51%66
/1E 9FA19 6F1903 7 9 9!798    9 4  9!  7
 
789
8  : 8)?=@0,.4-,1/4%
/679
B1>99791<9  901
9+
9
9
  &9
!8 9  98%4 
 +7! *! 0,.%-34%1
/%G <109 91B979 3>!98 7 9 9

9 9
 789
8    8
94 899!7

!
87*&

+7! 0,.0-%.1%0
//9
519

+21& 
1
9B5! 

99  
! 8H 
9
9
  &9
!
 9 9+7! *! 0,.,-161.1
/5(9951+ 8 C(1(
 1
9 99!7 98 !
)3 883403-
%533%
/.A
9
:1+ 8 C(1C  &5)1
9:  !9!99!
 
!  


9
9

  &9
! 9 99
9
9789
8  99!7)3 88344/-%0,43
/,:8 & 77(1(9951;9!
29
9 9!  ! 9
   !
87 3%!9*&


+7! 0,.3-%,5%
54C 991<7 G;1(7731
92 


  &9
8 9   9
9 9
9!75 
BF)*&

+79! 344/-6/00,
50C ;:196<78  9
9 5!+7! 0,.6-3160/0
53*99<189<1*79
=1
9:7

!98!  ! 9
   !
8  9
9 *&


+7! 0,./-/.3%,
51(  +1(  :1( 988 :1
9597  14,!99
789
8  8 
  
 99!! 8 
&   !&94    0,..-56,1

22
89
! 2! 

2789
8  99
2 
" !# 
7$ 8
0320%
0120023405 6789
8  99
 9

5&'!()*+ ,-*'9 .*
9/  !9!  9989
9789
8  09!
34441
1%212
5%.
'*39989-*4 5(9*  8936 
  
 9
  79
!8 99
9
9
 99!7.7! 8! 09911&:02%
5269! !(;<*=95 >*?698)?@ 


9
9
  79
! 9 99
9
9
789
8   ! 8!98
! ), 8834421%052&
55@9955  +*9  .*;  /*
9 7  8
!9
   
! 9!
  



  79
!8 9.7! 8! 09::114%5
5:A99,*;9 
0*?>*
9' 7B 
9!7
! 9
! 
989
9
 99!7*!
 99!7*98
9
9
  79
! 9 9989
  

=?98  79
! 9/
), 88340&1%90::
59;99>*
)*<77)6789
8   ?9898<90951:109!
09:213251
:4'7 =)*+ ,-*+ (

*
9, ( !
789
8  987B 
9!7

!    ! 
 9
9789
8  99!7;)8.3441100433
:0;,-=?')*@?,?C-,?/,,?=63-44+8,80?1,?@8,8+-/-'?87


.7! 092%13%19:
:3, !0<*09)*;( 
5,'*
9,

6! 
989
9789
8  87


.7! 09:915&305
  !109&A 0%4

22
89
! 2! 

2789
8  99
2 
" !# 
7$ 8
0120%
0120023405 6789
8  99
 9

'()*+,-.
/0123453678289:4;28276;68<421703=<>;

?@ABCDEFGHDI@JFKLMKIMJ@NKIDOKCLKPMIQ@
R@SDCMBICT@TFKGUO@GTB@JKICLDJBPCMKI@GICMU@VKUUKWEGP@MT@JKHPUBCBQ@
X@Y@OBJLBDTMIN@ZEF[\@MT@OBVMIBO@DT@D@UB]BU@CFDC@OBJLBDTBT@^_`@PBLJBIC@JKHPDLBO@WMCF@CFB@PLB]MKGT@LBTGUCa@DIO
JKICMIGBT@CK@HBBC@CFMT@JLMCBLMKI@DJLKTT@VKGL@]DUGBT@OGLMIN@D@CFLBBEWBBb@PBLMKOQ@
c@YI@MIJLBDTMIN@ZEF[\@MT@OBVMIBO@DT@D@UB]BU@CFDC@MIJLBDTBT@^_`@PBLJBIC@JKHPDLBO@WMCF@CFB@PLB]MKGT@LBTGUCa@DIO
JKICMIGBT@CK@HBBC@CFMT@JLMCBLMKI@DJLKTT@CFLBB@]DUGBT@OGLMIN@D@CWKEWBBb@PBLMKOQ@
d@YI@GIJFDINBO@ZEF[\@MT@OBVMIBO@DT@D@UB]BU@CFDC@LBHDMIT@WMCF@efg@_`@PBLJBIC@JKHPDLBO@WMCF@CFB@PLB]MKGT
LBTGUCa@DIO@JKICMIGBT@CK@HBBC@CFMT@JLMCBLMKI@DJLKTT@VKGL@]DUGBT@OGLMIN@D@CFLBBEWBBb@PBLMKOQ@
h@YVCBL@DJFMB]MIN@KIB@GIOBCBJCDiUB@ZEF[\@]DUGB@jkl@HmnfHopa@CFB@LMTb@KV@OB]BUKPMIN@NBTCDCMKIDU@CLKPFKiUDTCMJ
IBKPUDTMD@MT@k_@PBLJBICQ@YHBLMJDI@[KUUBNB@KV@qiTCBCLMJMDI@DIO@\rIBJKUKNr@NGMOBUMIBT@DO]MTB@CFDC@DVCBL@CFB@ZEF[\
MT@GIOBCBJCDiUBa@CK@JKICMIGB@CK@HBDTGLB@ZEF[\@HKICFUr@VKL@TMs@HKICFTQ@ADTBO@KI@CFB@BsCLBHBUr@UKW@LMTb@KV@D@LMTB
MI@F[\@DVCBL@MC@iBJKHBT@GIOBCBJCDiUBa@MI@KGL@PLDJCMJBa@WB@JKICMIGB@HKICFUr@ZEF[\@VKUUKWEGP@VKL@CFLBB@HKICFT
DIO@CFBI@VKUUKWEGP@MT@JKHPUBCBQ
\LDPFMJ@_`ltu_@vBLTMKI@_Q`

22
89
! 2! 

2789
8  99
2 
" !# 
7$ 8
0%20&
0120023405 6789
8  99
 9

&'()*+,-)'*./+012'0-*30
4'00.5.63*7'8+)9:.;/<
 
8 ! /'(=2>.?3)3*.@'2>0)3+(:.;/<
 
8 ! A3+2.5
B'*'8+)9:.;/C9
2D9!2E  !9 9F  
DGEH<I99!
!9JC
9
9
  K9
!
 9 9LDE04%MN4',3*).O.6=*,+3*+:.;/<
 
8 ! 6=*,=*=.@'PP:.;/Q 7
LF M
R 7JC9 !  7LC!
9K S
T8MN< U9
!   !
 
 !5=(>V.W.X=27:.;/:
XY&Z@<
 
8 ! 5=>[(=.4.\'*=:.;/<
 
8 ! 
E 
 K
8 ! 9U 8 !   !
  

K7
8
 9 ] 8S
9
9888K7U


 9 
UU  !S98
 ^ 
  !
K
 U 88
 

! 

G  9
7 !8! 

 ^ 8 99
 98 
!  

 9

9898 U 8!
E   !
  

  !7

22
89
! 2! 

2789
8  99
2 
" !# 
7$ 8
0%20%

You might also like