Lesley Murphy

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Inherited Cancer Risk Leads Travel Blogger to Choose Mastectomy

April 14, 2017 | Lesley Murphy is accustomed to waking up in exotic locations. From
snow-covered Finland to the beaches of Bali, this 29-year-old professional blogger spends
more than 300 days a year documenting her travels to vacation destinations around the
world.

My number one goal is inspiring travel and showing people that if they get out of their
comfort zones, they can make the world a better place, she said.

Recently, however, the Arkansas native took a detour from her globetrotting lifestyle to
focus on a very different subject her future health. About three years ago, Lesley was
living in Argentina when she received the call that her mother, Martha Murphy, was
diagnosed with breast cancer. With no history of breast cancer in her family, the diagnosis
came as a shock.

It was my first year living abroad, and I felt so far away, Lesley said. It was a wash of
emotions. You never want to hear the words mom and cancer in the same sentence.

Martha Murphy, who was living in Fort Smith at the time, felt a lump in her breast before
scheduling a mammogram in early March 2014. After it was confirmed she had stage 1
breast cancer, Martha immediately sought the advice of her next-door neighbor, who
happened to be an oncologist. He recommended genetic testing to determine if she might
have a mutation of one of the BRCA genes, commonly known as the breast cancer genes.

While every person is born with the BRCA1 and BRCA2 genes, women who inherit
mutations of the genes have up to an 80 percent chance of developing breast cancer by age
70. If Martha tested positive for a gene mutation, it would mean her three adult daughters
had the potential for it as well.

My doctor in Fort Smith ordered the genetic test on the same day I was diagnosed, but it
took a few days to receive the results, Martha said.

The morning after her diagnosis, Martha decided she wanted to seek a second opinion at
UAMS, Arkansas only academic health sciences center. After a reassuring visit on March 21
with breast surgeon V. Suzanne Klimberg, M.D., director of the Breast Cancer Program at
the UAMS Winthrop P. Rockefeller Cancer Institute, Martha scheduled a double
mastectomy for 10 days later.
Her breast reconstruction surgery was completed at UAMS in August, followed by an
oophorectomy to remove her ovaries in September. A BRCA gene mutation also can
increase a womans risk of developing ovarian cancer.

When I look back, this experience was just a blip on my radar. While it was happening, I
was in the midst of helping my eldest daughter plan her wedding. I didnt have time to
focus on myself, so Im terribly blessed that I didnt have any complications or need any
chemo or radiation, Martha said.

Klimberg also is a professor of surgery and pathology in the UAMS College of Medicine and
director of the Division of Breast Surgical Oncology.

Martha received the results of her genetic test prior to her visit with Klimberg and was
surprised to discover she did indeed carry the BRCA2 gene mutation. She immediately
knew that she wanted her daughters to be tested as well.

I told them, this is what were going to do. They needed to know if they had the gene
mutation, so they could make informed decisions about their future, Martha said.

Each child of a parent mother or father who carries a mutation in one of the BRCA
genes has a 50 percent chance of inheriting the mutation.

Marthas eldest daughter, Lauren, and youngest, Jordan, both underwent testing at the
UAMS Cancer Genetics Clinic and received mixed results.

After Jordans test came back negative, we were hopeful they all would, Martha said.

That would not be the case, as Laurens results were soon found to be positive for her
moms BRCA2 mutation. The UAMS Cancer Institute is home to the only clinical cancer
genetics team in Arkansas. Although any doctor can order genetic testing which is
conducted using a blood or saliva sample UAMS has the only board-certified geneticists
and genetic counselors in the state who can diagnose rare syndromes and manage complex
cancer syndromes, of which there are more than 50.

As for Lesley, finding time for the genetic screening was a challenge in itself. Because she
was living in South America, did not have domestic insurance, and was launching her
career as a travel blogger, the sense of urgency wasnt strong.
I would be in Arkansas for two days and then gone for a month, so there was never any
time to schedule it. Two years went by before I was home for an extended time. Thats
when Mom encouraged me to get it done, said Lesley, who initially gained fame as a
contestant on season 17 of ABCs The Bachelor.

When her genetic test came back positive for the BRCA2 gene mutation, Lesley knew she
had some choices to make. She looked to Kent McKelvey, M.D., director of Cancer and Adult
Genetics Services, and the UAMS Cancer Genetics Clinic staff for guidance.

Each person ultimately has to make the choices that are best for themselves and their
families. We are here to help people understand the evidence and options and guide them
to make the best informed decisions, said McKelvey, who also is associate professor in the
UAMS College of Medicine Division of Genetics.

For Lesley, those choices were to undergo breast cancer screenings every six months in an
attempt to catch any tumors in their earliest stages and take medication to prevent breast
cancer or have a preventive double mastectomy, followed by reconstruction. With her
travel career in full swing, Lesley said the choice was clear.

Because of my schedule, I didnt foresee the twice-yearly screenings as a realistic option.


While it may sound drastic to some people, having the surgery was definitely the best
option for me, she said.

The fact that Lesley was able to learn about her gene mutation and make the best choice for
herself provides a sense of freedom and empowerment, McKelvey said.

Given her active career and the fact that she gave this decision serious consideration, her
choice to have elective surgery makes perfect sense, he said.

Following the double mastectomy with UAMS breast surgeon Daniela Ochoa, M.D., Lesleys
risk of developing breast cancer will be reduced by about 95 percent. Nothing can eliminate
the risk entirely, McKelvey said, however, surgery is the most effective strategy to
dramatically reduce her risk of breast cancer and eliminate any future need for screenings.
Ochoa is a professor of surgery in the UAMS College of Medicine Division of Breast Surgical
Oncology.

Because of her public image and large social media following, Lesley chose to document her
experience on social media channels including Instagram, Facebook, Twitter and Snapchat.
I saw this as a way to educate people and encourage them to be more knowledgeable
about their own personal health decisions, she said.

After a four-week break from traveling following her April mastectomy, Lesley will hit the
road again in May, this time with Mom by her side.

The doctors think Ill be fine to travel by then, but shell be there for support if I need it,
Lesley said.

She will return to UAMS in late summer to complete her breast reconstruction process
under the direction of plastic surgeon Eric J. Wright, M.D., associate professor in the UAMS
College of Medicine Division of Plastic and Reconstructive Surgery.

Then, its back on a plane to her next destination. I will always travel. I dont know what
my career will eventually evolve into, but travel is definitely what Im passionate about and
what makes me happy, Lesley said.

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