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Lesson #1 Brain Excitements For The 21 Century: Idan Segev
Lesson #1 Brain Excitements For The 21 Century: Idan Segev
Idan Segev
Lesson #1
Brain excitements for the 21st century
Kick start
Great thinkers think about the brain
How it (us) all started?
Brain Blossom worldwide
Structure of modern brain-research centers
The problem with understanding the brain
"You, your joys and sorrows, your
memories and your ambitions, your sense
of personal identity and your free will are in
fact no more than the behavior of a vast
assembly of nerve cells and their
associated molecules"
(Francis Crick, Nobel Laureate 1962 the
father of DNA).
Or
1300
Cultural evolution
Cell Phones, ICT
weight - gr
1200 Today
weight (gr)
1100 Modern Computers
BrainBrain
70 years
1000
900 Science
3,000 years
800
1.8 1.6 1.4 1.2 1 0.8 0.6 0.4 0.2 0
Million years Millions Language/Math
Millions of years ago 5,000 years
Neuroscience of
Neurological & cognitive
Disorders
Computational
&
theoretical
Quantitative Analysis Neuroscience
of Neuronal circuits
The da Vinci generation of brain researchers
Neurobiology &
Psychology
Medicine
2. Janelia farm DC, USA (Industrial scale Inst. for connecting network
level anatomy and physiology to s specific behavior)
Nanometers
Recent Brain-Excitements
S. Ramon Y Cajal
Camillo Golgi
1. We will have, for the first time ever, the blue print (the
anatomical foundation) of a whole (healthy and sick) brain
Brainbow transgenes drive the combinatorial expression of several fluorescent proteins (XFPs) in
neurons, resulting in the colour-tagging of individual cells.
Spikes in a cell
Brain-activated robot arm
Normal
The
Basal
Ganglia
Parkinson
Parkinson
Courtesy of Hagai Berman, Hebrew Univ.
Implanting stimulating electrodes in patients brain (fully alert)
Stimulating
electrodes
Pulse
generator
Deep Brain Stimulation
(For ameliorating Parkisons symptoms)
Post-operation Pre-operation
Patient: Male, 58 years old (PD Eight years, with extreme on-off)
Courtesy of Hagai Bergman, Zvi Israel, Hadassah University Hospital, Jerusalem
Future challenges for BMI
Channel Rhodopsin opens with blue light Natronomonas pharaonis activated with yellow light
Causes spikes Prevents spikes
Courtesy of Henry Markram and the Blue Brain team (EPFL, Switzerland)
Step 1 Mathematical models of neurons spiking activity
real
model
Connecting model components (modeled neurons) as in real cortical circuit
Computer voyage into cortical circuit (the cortical column)
Computer simulation of 10,000 neurons and 100 M
synapses in 2 cubic mm of cortical circuit
(electrical activity is color coded)
End of lesson 1