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Suprascapular Nerve Block
Suprascapular Nerve Block
358 Regional Anesthesia and Pain Medicine & Volume 36, Number 4, July-August 2011
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Regional Anesthesia and Pain Medicine & Volume 36, Number 4, July-August 2011 Suprascapular Nerve Block
rax, the scapula can be elevated from the posterior chest wall
by repositioning the ipsilateral hand to the opposite shoulder,
thereby increasing the potential distance the needle must travel
from the skin to chest wall.41
To improve accuracy, the SSN has been localized using
a nerve stimulator,4,14 paresthesia,41 and electromyography
(EMG).42
Superior Approach
The superior approach38,39 was initially described to per-
mit SSNB performed in patients in the supine position, but the
sitting position is the preferred position in clinical practice. In
general, the needle is directed to the lateral half of the oor
of the suprascapular fossa because the supraspinatus muscle is
attached to the medial half. Potential advantages of this approach
include ease of access, no reference to the notch, and extremely
low risk of pneumothorax.38,39
Posterior Approach
The posterior approach is generally performed while the
patient sits on the operating table with the ipsilateral arm lying at
his or her side.2,35,40 The supercial landmarks described in the
posterior approach techniques serve to guide the needle to slide
into the notch. As discussed in the anatomy section, the notch is
not a dened structure in 15% of the population. Furthermore,
FIGURE 2. Superior view of the left shoulder. The course of the
the potential complication of this approach is pneumothorax as suprascapular nerve (shaded) enters the suprascapular fossa
the trajectory of the needle is toward the thoracic cavity. The through the suprascapular notch (SSNo) and then enters the
classic (Wertheim) approach is well described in the literature.2 infrascapular fossa through the spinoglenoid notch (SGNo).
Modication of the landmarks for needle placement has been Reproduced with permission from Ultrasound for Regional
made by several authors.34Y37 To avoid the risk of pneumotho- Anesthesia (www.usra.ca).
Copyright 2011 American Society of Regional Anesthesia and Pain Medicine. Unauthorized reproduction of this article is prohibited.
Chan and Peng Regional Anesthesia and Pain Medicine & Volume 36, Number 4, July-August 2011
FIGURE 3. Variation of morphology of the suprascapular notch. Type I indicates no notch (8.3%); type II, notch with greater
transverse diameter, S2 (41.85%); type III, notch with greater vertical diameter, S1 (41.85%); type IV, bony foramen (7.3%); type V,
notch with bony foramen (0.7%). Adapted from Natsis et al.33 Reproduced with permission from Ultrasound for Regional Anesthesia
(www.usra.ca).
image, the C-arm will often need to be obliquely angled away is independent of the suprascapular notch, which can be absent
from the side of the proposed block and in the cephalocaudad in some individuals. The risk of pneumothorax is substantially
orientation.45 reduced because of the direction of the needle.52
Ultrasound-Guided SSNB
Recently, several articles have been published describing Imaging and EMG to Improve Needle Localization
the technique of US-guided SSNB.16,17,47,48 As US-guided of the SSN
SSNB is a more recent technique and offers the visualization of Despite multiple techniques being published describing
the SSN, suprascapular artery, and the muscle layers, it will be assistance in needle localization, few data exist to guide the
discussed in further detail. clinician on the effectiveness of this technology. In EMG guid-
The ideal site to perform SSNB with US is at the oor of the ance, 1 randomized clinical trial compared landmark-based to
suprascapular fossa, between the suprascapular notch and the EMG-guided SSNB.42 The patient population consisted of
spinoglenoid notch17 (Figs. 2 and 5A, B). At this site, the SSN patients with chronic pain with adhesive capsulitis.42 Although
runs along the oor of the suprascapular fossa covered by the pain scores and shoulder range of motion (ROM) improved after
fascia of supraspinatus in a natural compartment, which will SSNB in both groups, the investigators found that the EMG
contain the spread of the local anesthetic or injectate. Applying a group had signicantly lower pain scores than the landmark-
US-guided injection technique approximated the needle tip to based injection group. However, the follow-up was short, only
the nerve and has been shown to achieve a complete block with a 60 mins after procedure. It is unclear how relevant this nding is
reduced volume of local anesthetic.49 A small volume (5 mL) of for a chronic pain problem.
injectate will result in adequate ooding of the nerve50 with One randomized single-blind trial compared the blind ap-
minimal spread to the brachial plexus.51 Furthermore, this target proach to SSNB with a CT-guided approach.9 This study did not
FIGURE 4. A, Radiograph of the right suprascapular notch. S indicates spine of scapula. White arrow points to the suprascapular notch.
B, C-arm positioning for imaging the suprascapular notch. The patient is placed in prone position. The C-arm is positioned over the
shoulder. To image the suprascapular notch, the C-arm is rotated oblique to the treated side and angled cephalocaudal. Reproduced
with permission from Ultrasound for Regional Anesthesia (www.usra.ca).
Copyright 2011 American Society of Regional Anesthesia and Pain Medicine. Unauthorized reproduction of this article is prohibited.
Regional Anesthesia and Pain Medicine & Volume 36, Number 4, July-August 2011 Suprascapular Nerve Block
FIGURE 5. A, Ultrasonographic image of the suprascapular nerve on the oor of the scapular spine between suprascapular notch and
spinoglenoid notch. Both suprascapular nerve and artery run underneath the fascia of supraspinatus muscle. Suprascapular A and
N indicate suprascapular artery and nerve. Bold arrows outline the oor of the scapula fossa. B, Approximate position of the ultrasound
probe (dark rectangle). The patient can be in sitting or in prone position. Ultrasound scanning is performed with a linear ultrasound
probe (7Y13 MHz) placed in a coronal plane over the suprascapular fossa with a slight anterior tilt. The probe is place in an orientation such
that it is in the short axis to the line joining coracoid process and acromion (reecting the position of the spinoglenoid notch). The
trapezius muscle was removed to show the underlying supraspinatus muscle. Reproduced with permission from Ultrasound for Regional
Anesthesia (www.usra.ca).
nd any signicant difference between the blind or CT-guided strated a signicant reduction in pain, improvement in function,
SSNB in pain scores, disability.9 Both groups showed signicant and a reduction in analgesic medication (81% of study patients)
improvement after SSNB.9 There were no signicant adverse after pulsed RF of the SSN.20
effects in either group, and patient satisfaction scores were high.9 The use of chemical neurolysis for SSNB has mainly been
Recently, the efcacy of US-guided SSNB was compared in the form of case reports.43,54 Injection of phenol causes pro-
with the landmark-based technique.18 In this study, patients with tein coagulation and necrosis when applied directly to the nerve,
chronic nonspecic shoulder pain were randomized with 25 thereby alleviating pain. A larger study involved 16 patients with
patients in each group. The investigators found that, initially, shoulder pain secondary to rheumatoid arthritis. These patients
both groups improved in terms of pain relief. However, the an- received SSNB with prilocaine (4 mL) and 6% aqueous phenol
algesic effect was better sustained at 1 month in the US-guided (4 mL) with signicant reduction in pain and improved shoulder
group compared with the control group.18 Furthermore, al- ROM at 13 weeks of follow-up.55
though there were no complications in the US-guided group, the
control group recorded 2 cases of arterial puncture and 3 cases of SUPRASCAPULAR NERVE BLOCKADE
direct nerve injury with neurologic decit.18
In summary, various approaches have been described for
IN CLINICAL PRACTICE
the blockade of SSN. Disadvantages of the approach using the Suprascapular nerve blockade has been used in acute and
notch as a landmark are the potential absence of the notch in chronic pain states. For acute pain, SSNB has been mainly
some individuals and the potential risk of pneumothorax. The achieved using long-acting local anesthetic solutions alone.
superior approach may negate these disadvantages. On limited
evidence, these studies would suggest that US is useful in ap- Acute Pain
proximating the block needle near the SSN and thereby in in- The studies investigating the efcacy of SSNB in acute
creasing efcacy and reducing complications of SSNB. pain states are summarized in Table 1.
Suprascapular nerve blockade has been used successfully
SUBSTANCES USED FOR BLOCKADE OF THE SSN for the control of postoperative pain after open and arthroscopic
When the needle is placed near the SSN, several methods shoulder surgery (Table 1).4,14,56,57,62 It has been used as the
of nerve blockade have been published. The commonly used sole regional anesthetic technique4,56,57 but also in combination
methods include local anesthetic, steroids, pulsed RF, and with other nerve blocks.3,15,61 Although shoulder arthroscopy
chemical neurolysis. These may be used alone or in combina- recently has become popular as an outpatient procedure, it
tion. Bupivacaine is the popular local anesthetic agent, either remains one of the most painful of the same-day surgical pro-
in the concentration of 0.25%12,38,41 or 0.5%7,8,14,39 described cedures.63 Use of interscalene block had been shown to reduce
in the literature. Epinephrine (1:200,000) is commonly added to the unanticipated readmission rate due substantially to pain.63
the local anesthetic solution to increase the duration of action.8 At present, interscalene brachial plexus block (ISB) is the usual
Injectate volume is highly variable in the literature. However, regional technique used for analgesia during and after shoulder
some authors argue that 5 mL is the optimal volume based on surgery.64Y66 Blockade of the brachial plexus provides more
morphologic evidence.50 complete analgesia of the shoulder joint. Because the SSN
For the treatment of chronic shoulder pain, injectable ste- supplies 70% of the sensory input to the shoulder joint, SSNB
roid (methylprednisolone) is usually added to the local anesthetic allows good control of severe postoperative pain after this
solution. However, the value of this practice has been ques- notoriously painful procedure. Suprascapular nerve blockade
tioned by a double-blinded study8 demonstrating that the addi- decreases pain scores at rest and with movement in the early
tion of methylprednisolone fails to confer any benet. postoperative period and alleviates pain at 24 hours on shoulder
Suprascapular nerve blockade achieved with RF or cryo- abduction.4 Furthermore, a signicant reduction in analgesic
lesion provides a long-lasting effect that can endure for up to dose and demand, discharge time, and the incidence of nausea
18 months.20,43,53 Furthermore, one of these studies demon- has been reported.4
Copyright 2011 American Society of Regional Anesthesia and Pain Medicine. Unauthorized reproduction of this article is prohibited.
362
Chan and Peng
Study Authors Type of Acute Pain Study Design No. Participants Results Conclusions
SSNB as the only form of regional anesthesia
Jerosch et al Arthroscopic shoulder Prospective, nonrandomized 260 patients No difference in baseline VAS SSNB is effective in reducing
(2008)56 surgery: mixed study. Comparison of Received SSNB = 130 scores. Postoperatively, postoperative shoulder pain in
2 consecutive cohorts. significant reduction arthroscopic shoulder surgery.
No nerve block = 130
in VAS scores at 24, 48, SSNB is associated with minimal
and 72 hrs in the SSNB group. complications.
No complications of SSNB.
Singelyn et al Arthroscopic shoulder Prospective, randomized, 120 patients randomized No significant difference in ISBPB is the most efficient regional
(2004)57 acromioplasty blinded study to 4 treatment groups: pain scores between control technique for arthroscopic shoulder
SSNB = 30 and IALA groups. SSNB and ISBPB acromioplasty. SSNB improves
reported significantly less pain analgesia for arthroscopic
IALA = 30
than the other 2 groups. The acromioplasty but is less efficient
ISBPB = 30 ISBPB group had significantly than ISBPB. When ISBPB is
Control (no regional less pain on movement than the contraindicated, SSNB is a clinically
analgesia) = 30 SSNB group. Only the ISBPB appropriate alternative.
group recorded significantly less
morphine consumption
and higher satisfaction.
Regional Anesthesia and Pain Medicine
Ritchie et al Arthroscopic shoulder Randomized, double-blind, 50 patients randomized to: VAS significantly lower in the SSNB is an effective regional anesthetic
&
(1997)4 surgery placebo-controlled study Placebo = 25 SSNB group at 120 and 180 mins. technique for arthroscopic shoulder
VPS score significantly lower in SSNB surgery in improved analgesia,
SSNB = 25
group at 120, 180, and 240 mins. reduced opioid requirements, and less
Significantly reduced morphine nausea and vomiting.
consumption (SSNB group) on
the day of surgery. Significantly
less nausea and vomiting in the
SSNB group. Reduced stay in
ambulatory surgical unit.
Martinez-Barenys Ipsilateral postthoracotomy Randomized, single-blinded 74 patients. Shoulder pain intensity was Shoulder pain after horacotomy does
et al (2010)58 shoulder pain study First group: phrenic group significantly lower in the not seem to arise from the shoulder
(PNI) received 10 mL PNI group compared with the joint. This study suggests that pain
of 2% lidocaine into SSNB group. arises from diaphragmatic irritation.
perinephric fat pad Therefore, routine preemptive blockade
before closure = 37. of the suprascapular nerve is not
recommended.
Second group: SSNB with
10 mL of 0.5% bupivacaine
at completion of surgery = 37.
Copyright 2011 American Society of Regional Anesthesia and Pain Medicine. Unauthorized reproduction of this article is prohibited.
Volume 36, Number 4, July-August 2011
Neal et al (2003)15 Ambulatory nonarthroscopic Prospective randomized 50 patients. Addition of SSNB significantly delayed SSNB combined with ISBPB does not
shoulder surgery study. SSNB and ISBPBYgeneral the time to first significant report of significantly improve outcomes in
anesthesia = 25. pain. However, addition of SSNB ambulatory nonarthroscopic
did not improve PACU measures, shoulder surgery.
Sham injection and
24-hr assessment of pain, supplemental
ISBPBYgeneral
analgesic use, or QOL measures.
anesthesia = 25.
IALA indicates intra-articular local anesthetic; ISBPB, interscalene brachial plexus block; PACU, post anesthesia care unit; PNI, phrenic nerve inltration; QOL, quality of life; SSNB, suprascapular nerve
block; VAS, visual analog scale; VPS, verbal pain scale; VRS, verbal rating scale.
363
Suprascapular Nerve Block
Copyright 2011 American Society of Regional Anesthesia and Pain Medicine. Unauthorized reproduction of this article is prohibited.
364
Chan and Peng
Study Authors Type of Chronic Pain Study Design No. Participants Results Conclusions
Eyigor et al Chlronic shoulder pain Single-blinded, randomized, 50 patients Improvements in pain, ROM of Both intra-articular steroids
(2010)53 93 mo; heterogeneous comparative clinical trial Intra-articular injection of shoulder joint, and quality of and AAN PRF reduced
etiology. Outcome measures: corticosteroid = 25 life in both groups. pain and improved function.
Pain scores using VAS at rest PRF applied to the SSN = 25 In the SSN PRF group, Intra-articular steroids showed
and movement. improvement lasted for 12 wk a greater reduction in pain
Range of motion (ROM) of in VAS, ROM and SPADI. throughout the study period.
shoulder joint. Pain reduction was superior in
Shoulder Pain and Disability the intra-articular group
Index (SPADI) compared with the SSN
Short-Form 36 PRF group.
Beck Depression Inventory
Medication requirements
Complications
Gorthi et al Chronic shoulder pain Prospective randomized 50 patients Both groups recorded Performing SSNB under US
(2010)18 comparative study. SSNB under US guidance significantly reduced pain guidance results in greater
(treatment group) = 25 (VAS) and improved function efficacy of block in pain and
SSNB blind technique (CSS) after procedure. shoulder function measures.
(control group) = 25 The group SSNB US group In addition, US reduces the
showed significantly superior risk of vascular and
VAS and CSS scores compared neurologic complications.
with the control group.
Mitra et al Adhesive capsulitis Retrospective chart 28 consecutive patients After protocol, patients SSNB as part of a multimodal
(2009)71 review over 3 y Received SSNB as part of demonstrated significant therapy protocol improves
a protocol for adhesive improvements in ROM being shoulder function.
Regional Anesthesia and Pain Medicine
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Volume 36, Number 4, July-August 2011
either group
&
365
Suprascapular Nerve Block
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366
TABLE 2. (Continued)
Study Authors Type of Chronic Pain Study Design No. Participants Results Conclusions
Chan and Peng
Dahan et al Frozen shoulder Double-blind randomized 34 patients randomized into Significant reduction in pain in Repeated SSNB with local
(2000)13 (adhesive capsulitis) controlled trial 2 groups: the treatment group (64%) anesthetic alone reduces pain
Treatment: 3 SSNB at 7-d compared with the control compared with placebo but
intervals with 10 mL of group (13%) at 1 mo. does not improve shoulder
bupivacaine 0.5% each block. Nonsignificant improvement in function or shoulder ROM.
Control: same as treatment shoulder function in treatment
group except 10 mL of normal group. No improvement in
saline used for SSNB shoulder ROM.
Jones and Frozen shoulder Randomized trial of 30 patients 30 patients randomized. SSNB produced a faster and SSNB is superior to
Chattopadhyay (adhesive capsulitis) First group: single SSNB more complete reduction in intra-articular steroid injection
(1999)73 Second group: course of pain and restoration of ROM for pain reduction and
intra-articular injections than intra-articular steroid improvements in shoulder
ROM.
Lewis (1999)55 Chronic shoulder pain due to Case series 16 patients Significant reduction in pain The combined SSNB and
rheumatoid or osteoarthritis Treated with combined SSNB intensity (69%) and ACNb with local anesthetic
and ACNb (4 mL of 1% improvement in ROM and phenol provides pain
prilocaine and 4 mL of 6% (36%Y67%) over mean relief and improvement in
aqueous phenol) follow-up of 13 wk. shoulder ROM
Gado and Emery Chronic shoulder pain due to Double-blind comparative 29 patients (58 shoulders) Both groups recorded SSNB is effective for reducing
(1993)8 rheumatoid arthritis study First group: SSNB with local significant improvements shoulder pain and improving
anesthetic (bupivacaine) alone in pain, stiffness and function. But the addition
Second group: SSNB with local ROM up to 3 mo. of steroid does not seem to
anesthetic and steroid Steroid did not improve confer added benefit.
outcomes. In fact, the
bupivacaine-alone group
responded better.
Vecchio et al Chronic shoulder pain due Randomized clinical 28 patients Tendinitis group: SSNB improves the pain of
(1993)11 to rotator cuff lesions controlled trial Divided into tendinitis and tears Significant improvement in rotator cuff pathology for at
Regional Anesthesia and Pain Medicine
tendinitis and tears Tendinitis 15 night pain up to 12 wk, least a 3-mo period. Although
&
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Volume 36, Number 4, July-August 2011
ACNb indicates articular branches of the circumex nerve; CSS, constant shoulder score; CT, computed tomography; EMG, electromyography; MPQ, McGill-Melzack Pain Questionnaire; PRF, pulsed
radiofrequency; ROM, range of motion; SF-36, Short-Form 36 Health Survey; SPADI, Shoulder Pain and Disability Index; SSN, suprascapular nerve; SSNB, suprascapular nerve block; VAS, visual analog
SSNB PRF can provide variable
for surgery.
superior analgesia to the SSNB.57 Only ISB produced signicant
reduction in morphine consumption compared with controls.57
The authors concluded that ISB provided the most effective and
efcient analgesic technique but that SSNB was an appropriate
alternative especially in patients with pulmonary compromise
because SSNB does not affect pulmonary function.57
longer duration of pain relief,
that they are case series and not randomized controlled trials.
The studies discussed previously are limited to arthroscopic
34 shoulders in total
medical management.
received conservative
(1988)43
Copyright 2011 American Society of Regional Anesthesia and Pain Medicine. Unauthorized reproduction of this article is prohibited.
Chan and Peng Regional Anesthesia and Pain Medicine & Volume 36, Number 4, July-August 2011
selected in this manner, then this study found that 85.3% of selected pain and disability in chronic nonspecic shoulder pain after
patients obtained satisfactory pain relief after SSNB.59 SSNB.20,46
In summary, one may conclude that SSNB is not effective The most common pathologic diseases individually studied
in all patients who develop ipsilateral shoulder pain after tho- are chronic pain from rheumatoid arthritis or osteoarthritis, ad-
racotomy. However, in those patients who have localizing signs hesive capsulitis (frozen shoulder), and persistent rotator cuff
suggesting the shoulder pain is musculoskeletal in origin, SSNB lesions.
is an appropriate intervention to relieve pain. This could be
further investigated by a randomized clinical trial. Shoulder Joint Arthritis: Rheumatoid Arthritis
The efcacy of SSNB has been reported in a variety of and Osteoarthritis
other acute pain states68Y70; these were limited to isolated case
A number of studies have assessed the efcacy of SSNB for
reports or small case series and, although promising, require
the pain and disability of arthritis. Some have included both
further investigation.
osteoarthritis and rheumatoid arthritis,5,9,55 whereas others have
focused on rheumatoid arthritis alone.8,43
Chronic Pain Shoulder pain is common in patients with rheumatoid ar-
For patients with chronic pain, SSNB may be both a diag- thritis. Early in this disease process, 40% of patients have
nostic but more commonly a therapeutic procedure. To achieve shoulder involvement, with nearly all eventually having shoulder
more prolonged analgesia for chronic pain, local anesthetic is pain and disability.83 The causes of shoulder pain in this popu-
combined with steroid, phenol, or pulsed RF when SSNB is lation include arthritis in the glenohumeral and acromioclavicular
performed (Table 2). joint, rotator cuff disease, subacromial bursitis, tenosynovitis, and
referred pain from cervical spine disease.83 The goal of SSNB is
Diagnostic Block for Suprascapular Neuropathy to provide better shoulder pain control and movement in patients
Suprascapular neuropathy is believed to be the cause in 1% with long-standing rheumatoid arthritis.
to 2% of patients with shoulder pain.74 The suspicion of sup- Local intra-articular corticosteroid injection and gentle
rascapular neuropathy is suggested by posterior shoulder pain, mobilization may improve rheumatoid shoulder in the early
a history of trauma or traction to the SSN, and weakness and stages of disease.83 However, when glenohumeral damage is
atrophy of the muscles (supraspinatus, infraspinatus) supplied advanced, this treatment option is not as effective.84 Two ran-
by the SSN.29,75Y77 Neuropathy of the SSN can be caused by domized controlled trials have been published to suggest the
traction or compression of the nerve at the spinoglenoid re- efcacy of SSNB. One is a randomized controlled trial com-
gion or the suprascapular notch. The causes of traction or com- paring the efcacy of intra-articular steroid injection with SSNB
pression include trauma, repetitive use, and space-occupying in patients with long-standing rheumatoid arthritis (mean,
lesions.78,79 The differential diagnosis is broad. The diagnosis 17 years), SSNB provided prolonged pain relief (3 mos) and
is often made based on clinical, investigative parameters (elec- superior improvement in shoulder movement.7 Another one is a
trophysiologic and imaging studies) and on exclusion of other double-blind placebo-controlled randomized controlled trial in-
pathologic diseases, mainly rotator cuff pathology, cervical radi- cluding patients experiencing rheumatoid shoulder that was
culopathy, and brachial plexopathy.80 The optimal management performed recently.5 A total of 108 subjects were randomized to
of suprascapular neuropathy has not been determined. Studies receive an injection of 10 mL of bupivacaine 0.5% and 40 mg of
have reported good to excellent results in either nonsurgical man- methylprednisolone into the suprascapular fossa or a placebo
agement81,82 or surgical management.74,75,77 injection of 5 mL of normal saline.5 Suprascapular nerve
Owing to the difculty in differentiating suprascapular blockade was performed using surface anatomic landmarks as
neuropathy from other shoulder pathologic diseases, SSNB can described by Dangoisse et al.39 At 3 months of follow-up, the
be performed to aid in the diagnosis.6 A diagnosis of SSNB is active injection (local anesthetic and steroid) group recorded
often based on clinical history and examination ndings together signicantly superior pain reduction (visual analog scale) and
with electrodiagnostic studies and magnetic resonance imaging.6 functional improvement (Shoulder Pain and Disability Index,
In cases where the diagnosis is uncertain after electrodiagnostic SF-36 scales) compared with the placebo group. A notable
studies, SSNB may be helpful. The test is positive if the pain is nding was that 67% of the patients receiving the active injection
completely relieved.78 improved by at least 10 points on the Shoulder Pain and Dis-
ability Index, which is a signicant clinical improvement.85 The
Chronic Shoulder Pain: General Considerations only adverse effects were minor including chest wall tenderness
in one subject, which resolved, and minor bruising in another
Suprascapular nerve blockade has been widely investigated
subject.5
in a variety of chronic pain conditions (Table 2). A number of
Similarly, SSNB provided signicantly better analgesia and
trials, which examined chronic shoulder pain in a heteroge-
superior movement in patients with long-standing rheumatoid
neous group without looking at individual pathologic diseases,
arthritis who were unresponsive to intra-articular injection of
have been performed.18,20,46,53,72 Of these trials, three were
steroid.8,43 Interestingly, supplementation of the local anesthetic
randomized.18,53,72 Two of these randomized studies compared
solution with steroid conferred no additional benet.8
SSNB to intra-articular steroid for shoulder pain and function.53
The other study compared SSNB under US to SSNB via sur-
face anatomy.18 In these trials, SSNB resulted in signicant Adhesive Capsulitis (Frozen Shoulder)
improvements in pain scores and shoulder function. Also known as adhesive capsulitis, frozen shoulder is
There is only 1 randomized controlled trial that investigated characterized by signicantly restricted shoulder movement in
chronic shoulder pain of either degenerative disease or inam- patients with shoulder pain.12 This condition progresses from
matory in origin.5 This investigation revealed a signicant and pain to pain accompanied by gradually worsening stiffness to
sustained benet in pain and disability scores as well as the range reduced pain accompanied by profound stiffness. The last stage
of movement at weeks 1, 4, and 12.5 The remaining trials con- seems to be self-limiting and recovery is gradual and sponta-
sisted of case series, which showed signicant improvement in neous, with an excellent chance of complete return of function
Copyright 2011 American Society of Regional Anesthesia and Pain Medicine. Unauthorized reproduction of this article is prohibited.
Regional Anesthesia and Pain Medicine & Volume 36, Number 4, July-August 2011 Suprascapular Nerve Block
within 1 to 2 years irrespective of therapy.86,87 The goal of shown promise in providing more sustained analgesia and
treatment in the early stage is to alleviate pain so that physio- functional improvement. However, these studies have mainly
therapy can be effective in restoring normal shoulder movement involved case series.
and activity.87 A comparative clinical trial performing SSNB on
patients with adhesive capsulitis demonstrated a signicant im-
provement in pain and ROM scores, but follow-up was limited to SUPRASCAPULAR NERVE CATHETER
only 90 minutes after SSNB with local anesthetic alone.42 Fur- Although SSN catheters have been used, published
thermore, there was no placebo control.42 A small randomized reports are limited to isolated cases or small case series.90,91
trial (30 patients) compared the effects of SSNB to intra-articular In one cancer case, prolonged analgesia from pain due to me-
shoulder injections for adhesive capsulitis during a longer tastasis to the scapula was achieved by repeated injection
follow-up period.73 The investigators found that SSNB pro- through an epidural catheter, which was advanced into the
duced faster onset and more effective analgesia compared with suprascapular space.91 The catheter was tunneled subcutane-
a series of intra-articular injections.73 Furthermore, signicantly ously, exiting into the supraclavicular area, permitting treatment
improved shoulder function (measured by abduction and exter- of breakthrough pain from scapular movement by repeated in-
nal rotation) was also observed.73 These effects lasted up to jection of 0.5% bupivacaine.91 A more recent correspondence
3 months.73 described placement of the catheter at the spinoglenoid notch
A later placebo-controlled trial examined the response of during shoulder arthroscopy.90 This is done under direct vision by
SSNB with bupivacaine compared with placebo.13 There was a the surgeon.90 However, more outcome data are required to assess
signicant reduction in pain in patients receiving local anesthetic whether this would be benecial for postsurgical pain compared
blockade up to 1 month of follow-up.13 However, no signicant with a single-shot SSNB.
improvement in shoulder function or range of movement was
found. This study did not inject steroid medication as part of COMPLICATIONS
their treatment.13 The complication rate of SSNB is generally low (Table 3).
Possible complications are discussed.
Persistent Rotator Cuff Lesions
1. Pneumothorax
Rotator cuff tendinitis is a common cause of shoulder Although rare (incidence G1%34; Table 1), pneumothorax
pain in adults and may result in considerable morbidity.88,89 is the most serious complication of SSNB. It usually occurs with
Many patients respond to conservative management, including the posterior approach and is caused by advancing the needle
avoiding activities likely to aggravate the lesion, use of nonste- deeper than recommended. The usual depth of needle at which
roidal anti-inammatory drugs, local injection of steroid, and bone contact is made is between 3 and 6.3 cm.34,41,92 When
physiotherapy.88,89 However, signicant symptoms may persist: inserted more than 5 cm, the needle is likely to be at the supras-
in one retrospective, long-term follow-up study, symptoms of capular notch or above the scapula border. To reduce the risk of
severe shoulder pain persisted in approximately 26% of patients pneumothorax, the needle should be withdrawn and redirected at a
after a mean duration of 12 months after the rst presentation slightly different angle until the bone is reached. In addition,
of pain.89 positioning the ipsilateral hand to the opposite shoulder will ele-
In this subset of patients with persistent symptoms, SSNB vate the scapula away from the posterior chest wall, thereby
has been demonstrated to provide effective pain relief and im- increasing the potential distance between the skin and the chest
proved ROM.11 Although the therapeutic effect is temporary wall41 and minimizing the risk of unintentional pneumothorax.
(4Y12 weeks), it can be simply repeated in outpatient settings Penetration of the intercostal space also is unlikely with the
with minimal risk of complications. This block is also an ef- superior approach. For the superior approach,39 the needle is
fective way to control pain in patients awaiting surgery.11 advanced in a direction parallel to the scapula and away from the
Recently, pulsed RF of the SSN has shown promise in direction of the lung; with the anterior approach, the point
providing prolonged analgesia for those patients responding of needle entry is away from the dome of the lung and the needle is
to SSNB (rotator cuff lesion identied on clinical and ra- advanced in a direction perpendicular to the ribs.12
diologic grounds) but where analgesia is not sustained.19
After pulsed RF lesioning, a signicant reduction in pain 2. Intravascular injection
(visual analog scale) and improvement in shoulder function The suprascapular artery and vein are separated from the
(Constant and Oxford shoulder scores) was reported, lasting nerve by the superior transverse ligament of the scapula.22
until 3 months of follow-up.19 These results are similar to Puncture of either vessel during needle insertion may produce a
those of Liliang et al20 who, in addition to improvement in pain systemic toxic reaction after administration of local anesthetic.
and function, also demonstrated a reduction in medication Thus, careful aspiration is essential before injection of the local
requirements in their study group. However, both injection and anesthetic to ensure the absence of vascular puncture.
RF trials did not include a placebo control group, and further
investigation is required to conrm the efcacy of the neural 3. Residual motor block
blockade or ablation technique in the management of rotator Suprascapular nerve blockade reportedly has resulted in
cuff tendinitis. impaired motor function, but the duration and signicance of
In summary, SSNB is effective for short-term pain relief this effect have not been dened or conrmed. In addition,
and improvement in shoulder function in a variety of painful the supraspinatus and infraspinatus are the only muscles
shoulder conditions. The main causes of shoulder pain studied supplied by the SSN, making profound motor blockade un-
were arthritic conditions, rotator cuff lesions, and adhesive likely, in contrast to interscalene block.93
capsulitis. Unfortunately, in many studies, the patient population
was heterogeneous with regard to shoulder pathology. Therefore, 4. Local trauma
interpreting specically which pathologic disease responds best Repeated probing during localization of the suprascap-
to SSNB is difcult to determine. Pulsed RF to the SSN has ular notch can result in signicant trauma, particularly in
Copyright 2011 American Society of Regional Anesthesia and Pain Medicine. Unauthorized reproduction of this article is prohibited.
Chan and Peng Regional Anesthesia and Pain Medicine & Volume 36, Number 4, July-August 2011
muscular patients. In addition to aching at the needle inser- Although the studies mentioned in this review demon-
tion site (Table 1), the patient may also have a vasovagal strate efcacy of SSNB in chronic shoulder pain, there is a lack
response.94 of placebo-controlled trials to provide robust evidence. Many of
the trials were either case series or compared SSNB to another
intervention for shoulder pain (eg, intra-articular steroid injection).
SUMMARY AND FUTURE DIRECTIONS The benecial effect of placebo in the reduction of pain has been
FOR RESEARCH well documented.96 Therefore, future trials should incorporate
On review of the literature discussed here, the uses of SSNB a placebo control when studying SSNB or other methods of
and pulsed RF lesioning of the SSN can be summarized in Table 4. lesioning the SSN with the intent of reducing shoulder pain.
Copyright 2011 American Society of Regional Anesthesia and Pain Medicine. Unauthorized reproduction of this article is prohibited.
Regional Anesthesia and Pain Medicine & Volume 36, Number 4, July-August 2011 Suprascapular Nerve Block
Copyright 2011 American Society of Regional Anesthesia and Pain Medicine. Unauthorized reproduction of this article is prohibited.
Chan and Peng Regional Anesthesia and Pain Medicine & Volume 36, Number 4, July-August 2011
16. Harmon D, Hearty C. Ultrasound-guided suprascapular nerve block 40. Meyer-Witting M, Foster JMG. Suprascapular nerve block in the
technique. Pain Physician. 2007;10:743Y746. management of cancer pain. Anaesthesia. 1992;47:626.
17. Peng PWH, Wiley MJ, Liang J, Bellingham GA. Ultrasound-guided 41. Parris WC. Suprascapular nerve block: a safer technique.
suprascapular nerve block: a correlation with fluoroscopic and cadaveric Anesthesiology. 1990;72:580Y581.
findings. Can J Anesth. 2010;57:143Y148.
42. Karatas GK, Meray L. Suprascapular nerve block for pain relief in
18. Gorthi V, Moon YL, Kang JH. The effectiveness of adhesive capsulitis: a comparison of two different techniques.
ultrasonography-guided suprascapular nerve block for perishoulder Arch Phys Med Rehabil. 2002;83:593Y597.
pain. Orthopedics. 2010;16:238Y241.
43. Brown DE, James DC, Roy S. Pain relief by suprascapular nerve block
19. Kane TPC, Rogers P, Hazelgrove J, Wimsey S, Harper GD. Pulsed in glenohumeral arthritis. Scan J Rheumatol. 1988;17:411Y415.
radiofrequency applied to the suprascapular nerve in painful tear
44. Bonica JJ. Management of Pain. Pittsburgh, PA: Lean and Febiger; 1953.
arthroscopy. J Shoulder Elbow Surg. 2008;17:436Y440.
20. Liliang PC, Lu K, Liang CL, Tsai YD, Hsieh CH, Chen HJ. Pulsed 45. Shah RV, Racz GB. Pulsed mode radiofrequency lesioning of the
radiofrequency lesioning of the suprascapular nerve for chronic suprascapular nerve for the treatment of chronic shoulder pain.
shoulder pain. Pain Med. 2009;10:70Y75. Pain Physician. 2003;6:503Y506.
21. Ajmani ML. The cutaneous branch of the human suprascapular nerve. 46. Schneider-Kolsky ME, Pike J, Connell DA. CT-guided suprascapular
J Anat. 1994;185:439Y442. nerve blocks: a pilot study. Skeletal Radiol. 2004;33:277Y282.
22. Voster W, Lange CPE, Briet RJP, et al. The sensory branch distribution 47. Gofeld M. Ultrasonography in pain medicine: a critical review.
of the suprascapular nerve: An anatomic study. J Shoulder Elbow Pain Pract. 2008;8:226Y240.
Surg. 2008;17:500Y502. 48. Yucesoy C, Akkaya T, Ozel O, et al. Ultrasonographic evaluation
23. Lee HY, Chung IH, Sir WS, et al. Variations of the ventral rami and morphometric measurements of the suprascapular notch.
of the brachial plexus. J Korean Med Sci. 1992;7:19Y24. Surg Radiol Anat. 2009;31:409Y414.
24. Bigliani LU, Dalsey RM, McCann PD, April EW. An anatomical study 49. Riazi S, Carmichael N, Awad I, Holtby RM, McCartney CJ. Effect
of the suprascapular nerve. Arthroscopy. 1990;6:301Y305. of local anaesthetic volume (20 vs 5 mL) on the efficacy and respiratory
consequences of ultrasound-guided interscalene brachial plexus
25. Ozer Y, Grossman JA, Gilbert A. Anatomic observations on the block. Br J Anaesth. 2008;101:549Y556.
suprascapular nerve. Hand Clin. 1995;11:539Y544.
50. Feigl GC, Dorn C, Likar R. What local anesthetic volume should be used
26. Warner JP, Krushell RJ, Masquelet A, Gerber C. Anatomy and for suprascapular nerve block? Reg Anesth Pain Med. 2008;33:571Y573.
relationships of the suprascapular nerve: anatomical constraints to
mobilization of the supraspinatus and intraspinatus muscles in the 51. Feigl GC, Anderhuber F, Dorn C, Pipam W, Rosmarin W, Likar R.
management of massive rotator-cuff tears. J Bone Joint Surg Am. Modified lateral block of the suprascapular nerve: a safe approach and
1992;74:36Y45. how much to inject? A morphological study. Reg Anesth Pain Med.
2007;32:488Y494.
27. Inouye Y. Conduction along the articular branch of the suprascapular
nerve. Acta Neurol Scand. 1978;58:230Y240. 52. Di Lorenzo L, Pappagallo M, Gimigliano R, et al. Pain relief in early
rehabilitation of rotator cuff tendinitis: any role for indirect
28. Mestdagh H, Drizenko A, Ghestem P. Anatomical basis of suprascapular
suprascapular nerve block? Eura Medicophys. 2006;42:195Y204.
nerve syndrome. Anat Clin. 1981;3:67Y71.
53. Eyigor C, Eyigor S, Korkmaz OK, Uyar M. Intra-articular corticosteroid
29. Cummins CA, Messer TM, Nuber GW. Suprascapular nerve
injections versus pulsed radiofrequency in painful shoulder: a prospective,
entrapment. J Bone Joint Surg Am. 2000;82:415Y424.
randomized, single-blinded study. Clin J Pain. 2010;26:386Y392.
30. Alon M, Weiss S, Fishel B, Dekel S. Bilateral suprascapular nerve 54. Rose DL, Kelly CR. Suprascapular nerve block in shoulder pain. J Kans
entrapment syndrome due to an anomalous transverse scapular ligament. Med Soc. 1969;70:135Y136.
Clin Orthop. 1988;234:31Y33.
55. Lewis RN. The use of combined suprascapular and circumflex (articular
31. Cohen SB, Dines DM, Moorman CT. Familial calcification of the
branches) nerve blocks in the management of chronic arthritis of the
superior transverse scapular ligament causing neuropathy.
shoulder joint. Eur J Anaesthesiol. 1999;16:37Y41.
Clin Orthop. 1997;334:131Y135.
56. Jerosch J, Saad M, Greig M, Filler T. Suprascapular nerve block as a
32. Rengacharry SS, Neff JP, Singer PA, Brackett CE. Suprascapular
method of preemptive pain control in shoulder surgery. Knee Surg
entrapment neuropathy: a clinical, anatomical and comparative study.
Sports Traumatol Arthrosc. 2008;16:602Y607.
Part 1: Clinical study. Neurosurgery. 1979;5:441Y446.
57. Singelyn FJ, Lhotel L, Fabre B. Pain relief after arthroscopic shoulder
33. Natsis K, Totlis T, Tsikaras P, Appell HJ, Skandalakis P, Koebke J.
surgery: a comparison of intraarticular analgesia, suprascapular
Proposal for classification of the suprascapular notch: a study
nerve block, and interscalene brachial plexus block. Anesth Analg.
on 423 dried scapulas. Clin Anat. 2007;20:135Y139.
2004;99:589Y592.
34. Moore DC. Block of the suprascapular nerve. In: Moore DC, ed.
58. Martinez-Barenys C, Busquets J, de Castro PE, et al. Randomized
Regional Block. 4th ed. Springfield, IL: Charles C. Thomas Co; 1979.
double-blind comparison of phrenic nerve infiltration and suprascapular
35. Gordh T. Suprascapular nerve block. In: Eriksson E, ed. Illustrated nerve block for ipsilateral shoulder pain after thoracic surgery. Eur J
Handbook in Local Anesthesia. 2nd ed. Copenhagen, Denmark: Cardiothorac Surg. 2011.
Munkgaard; 1979.
59. Saha S, Brish EL, Lowry AM, Boddu K. In select patients, ipsilateral
36. Katz J. Atlas of Regional Anesthesia. 2nd ed. Norwalk, CT: post-thoracotomy shoulder pain relieved by suprascapular nerve
Appleton-Century-Crofts; 1994. block. Am J Ther. March 11, 2010 [epub ahead of print].
37. Granirer LW. A simple technique for suprascapular nerve block. 60. Tan N, Agnew NM, Scawn ND, Pennefather SH, Chester M, Russell
N Y State J Med. 1951;51:1048. GN. Suprascapular nerve block for ipsilateral shoulder pain after
38. Breen TW, Haigh JD. Continuous suprascapular nerve block for thoracic epidural anaglesia: a double-blind comparison of
analgesia of scapular fracture. Can J Anaesth. 1990;37:786Y788. 0.5% bupivacaien and 0.9% saline. Anesth Analg. 2002;94:199Y202.
39. Dangoisse MJ, Wilson DJ, Glynn CJ. MRI and clinical study of an 61. Price DJ. The shoulder block: a new alternative to interscalene brachial
easy and safe technique of suprascapular nerve blockade. plexus blockade for the control of postoperative shoulder pain.
Acta Anaesth Belg. 1994;45:49Y54. Anaesth Intensive Care. 2007;35:575Y581.
Copyright 2011 American Society of Regional Anesthesia and Pain Medicine. Unauthorized reproduction of this article is prohibited.
Regional Anesthesia and Pain Medicine & Volume 36, Number 4, July-August 2011 Suprascapular Nerve Block
62. Barber FA. Suprascapular nerve block for shoulder arthroscopy. 84. Hayes JMW, Cats A. Rheumatoid arthritisVmanagement:end stage
Arthroscopy. 2005;21:1015. and complication. In: Dieppe PA, Klippel JH, eds. Rheumatology.
63. McGrath B, Elgendy H, Chung F, Kamming D, Curti B, King S. Thirty London, UK: Mosby; 1994.
percent of patients have moderate to severe pain 24 hr after ambulatory 85. Green S, Buchbinder R, Forbes A, Bellamy N. A standardized protocol
surgery: a survey of 5703 patients. Can J Anesth. 2004;51:886Y891. for measurement of range of movement of the shoulder using the
64. Brown AR, Weiss R, Greenerg C, et al. Interscalene block for shoulder Plurimeter-V inclinometer and assessment of its intrarater and interrater
arthroscopy: a comparison with general anesthesia. Arthroscopy. variability. Arthritis Care Res. 1998;11:43Y51.
1993;9:295Y300. 86. Grey RG. The natural history of idiopathic frozen shoulder. J Bone
65. DAlessio J, Rosenblum M, Shea K, Freitas D. A retrospective Joint Surg Am. 1978;60:564Y565.
comparison of interscalene and general anesthesia for ambulatory 87. Jayson MIV. Frozen shoulder: adhesive capsulitis. BMJ.
surgery shoulder arthroscopy. Reg Anesth. 1995;20:62Y68. 1981;283:1005Y1006.
66. Borgeat A, Pershak H, Bird P, et al. Patient-controlled interscalene 88. Bigliani LU, Morrison DS. Miscellaneous degenerative disorders of
analgesia with ropivacaine 0.2% versus patient controlled intravenous the shoulder. In: Dee R, Mango E, Hurst LC, eds. Principles of
analgesia after major shoulder surgery: effects on diaphragmatic Orthopedic Practice. New York, NY: McGraw-Hill; 1989.
and respiratory function. Anesthesiology. 2000;92:102Y108. 89. Chard MD, Satelle LM, Hazleman BL. The long term outcome of
67. Price DJ. Axillary (circumflex) nerve block used in association with rotator cuff tendinitis-a review study. Br J Rheumatol.
suprascapular nerve block for the control of pain following total 1988;27:385Y389.
shoulder joint replacement. Reg Anesth Pain Med. 2008;33:280Y281. 90. Coetzee GJ, de Beer JF, Pritchard MG, van Rooyen K. Suprascapular
68. Martinez J, Sala-Blanch X, Ramos I, Gomar C. Combined nerve block: an alternative method of placing a catheter for
infraclavicular plexus block with suprascapular nerve block for continuous nerve block. Reg Anesth Pain Med. 2004;29:75Y76.
humeral head surgery in a patient with respiratory failure: an 91. Mercadante S, Sapio M, Villari P. Suprascapular nerve block by catheter
alternative approach. Anesthesiology. 2003;98:784Y785. for breakthrough shoulder cancer pain. Reg Anesth. 1995;20:343Y346.
69. Price D. High thoracic epidural plus suprascapular nerve block analgesia 92. Edeland HG, Stefansson T. Block of the suprascapular nerve in
for thoracoscapular fusion. Reg Anesth Pain Med. 2007;32:541Y542. reduction of the anterior shoulder dislocation. Acta Anaesth Scand.
70. Fournier R, Haller G, Hoffmeyer P, Gamulin Z. Suprascapular nerve 1973;17:46Y49.
block by a new anterior approach for perioperative analgesia during 93. Roch JJ, Sharrock NE, Neudachin L. Interscalene brachial plexus
major scapular surgery in two patients. Reg Anesth Pain Med. block for shoulder surgery: a proximal paresthesia is effective.
2001;26:288Y289. Anesth Analg. 1992;75:386Y388.
71. Mitra R, Harris A, Umphrey C, Smuck M, Fredericson M. Adhesive 94. Deacon B, Abramowitz J. Fear of needles and vasovagal reactions
capsulitis: a new management protocol to improve passive range among phlebotomy patients. J Anxiety Disord. 2006;7:946Y960.
of movement. PM R. 2009;1:1064Y1069.
95. US Preventive Services Task Force. Guide to Clinical Preventive
72. Taskaynata MA, Yilmaz B, Ozgul A, Yazicioglu K, Kalyon TA. Services: Report of the US Preventive Services Task Force.
Suprascapular nerve block versus steroid injection for non-specific Pennsylvania, PA: Diane Publishing Co; 1989.
shoulder pain. Tohoku J Exp Med. 2005;205:19Y25.
96. Hrobjartsson A, Gotzsche PC. Is the placebo powerless? An analysis of
73. Jones DS, Chattopadhyay C. Suprascapular nerve block for the clinical trials comparing placebo with no treatment. N Engl J Med.
treatment of frozen shoulder in primary care: a randomized trial. 2001;344:1594Y1602.
Br J Gen Pract. 1999;49:39Y41.
97. Ritchie ED, Tong D, Chung F, Norris AM, Miniaci A, Vairavanathan
74. Vastamaki M, Gorannson H. Suprascapular nerve entrapment. SD. Suprascapular nerve block for postoperative pain relief in
Clin Orthop. 1993;297:135Y143. arthroscopic shoulder surgery: a new modality? Anesth Analg.
75. Antoniadis G, Richter HP, Rath S, Braun V, Moese G. Suprascapular 1997;84:1306Y1312.
nerve entrapment: experience with 28 cases. J Neurosurg.
1996;85:1020Y1025.
APPENDIX 1
76. Callahan JD, Scully TB, Shapiro SA, Worth RM. Suprascapular nerve
entrapment: a series of 27 cases. J Neurosurg. 1991;74:893Y896. QUALITY OF EVIDENCE GRADING
AS RECOMMENDED BY THE US PREVENTIVE
77. Post M. Diagnosis and treatment of suprascapular nerve entrapment.
Clin Orthop Relat Res. 1999;223:92Y100. SERVICES TASK FORCE
78. Aiello I, Serra G, Traina GC, Tugnoli V. Entrapment of the suprascapular
nerve at the spinoglenoid notch. Ann Neurol. 1982;12:314Y316. Level of Evidence Description
79. Ogino T, Minami A, Kato H, Hara R, Suzuki K. Entrapment neuropathy
of the suprascapular nerve by a ganglion: a report of three cases.
I Evidence from at least 1 properly designed
randomized controlled trial
J Bone Joint Surg Am. 1991;73:141Y147.
II-1 Evidence obtained from well-designed
80. Walsworth MK, Mills JT, Michener LA. Diagnosing suprascapular controlled trials without randomization
neuropathy in patients with shoulder dysfunction: a report
II-2 Evidence obtained from well-designed
of 5 cases. Physical Therapy. 2004;84:359Y372.
cohort or case-control analytic studies,
81. Martin SD, Warren RF, Martin TL, Kennedy K, OBrien SJ, preferable from more than 1 center or
Wickiewicz TL. Suprascapular neuropathy: results of non-operative research group
treatment. J Bone Joint Surg Am. 1997;79:1159Y1165. II-3 Evidence obtained from multiple time
82. Drez D Jr. Suprascapular neuropathy in the differential diagnosis series with or without the intervention
of rotator cuff injuries. Am J Sports Med. 1976;4:43Y45. III Opinions of respected authorities, based
83. Petersson CJ. Painful shoulders in patients with rheumatoid arthritis.
on clinical experience, descriptive
studies, or reports of expert committees
Scand J Rheumatol. 1986;15:275Y279.
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