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com

T Cell Receptor Signaling

TCR/CD3
Ca2+ Complex

LFA-1

CD4
el

CD45
CRAC
Chann

Clustering

LAT

CD28
GADS
Zap-70

PLC1
Actinin Talin

SLP76
Lck

VAV
PI3K

Grb2
F-Actin

Ca2+

NCK
SOS

ADAP
CaM PIP3

Calpain
Wasp PIP2 PKC
Akt
Calcineurin Rac/cdc42

DAG Mat1 Bcl10 Carma1

Ca2+
MEKK
Rel RasGRP MEKKK
IB

NF-B IP3R

IP3
Intracellular NIK
Ras
Ca2+ Store

NFAT
MKK3/6 MKK4/7 IKK
IB Raf IKK IKK
Proteasomal
Degradation p38 JNK Rel
NFAT MEK1/2 IB
NF-B

Erk
IB
Proteasomal
Degradation
sm
opla
Cyt
s
leu Nuclear
Nuc IL-2 NFAT Fos Jun NF-B Rel Membrane
Gene

2004 - 2008 Cell Signaling Technology, Inc. T_Cell_Receptor.ai created September 2004 revised January 2007
 www.cellsignal.com

Signaling Pathways Key

Direct Stimulatory Modification

Kinase
Direct Inhibitory Modification
Phosphatase
Multistep Stimulatory Modification
Transcription Factor
Multistep Inhibitory Modification
Caspase
Tentative Stimulatory Modification

Receptor Tentative Inhibitory Modification

Enzyme Transcriptional Stimulation

Transcriptional Inhibition
Cyclin, pro-apoptotic
Translocation
pro-survival
Separation of Subunits or Cleavage Products
GAP / GEF
Joining of Subunits
GTPase

G-protein, ribosomal subunit

2003 - 2009 Cell Signaling Technology, Inc.