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15 BCR Brochure
15 BCR Brochure
15 BCR Brochure
An AACRAACR International
Special Conference onConference on
TUMOR IMMUNOLOGY
AND IMMUNOTHERAPY:
FRONTIERS IN BASIC
A New Chapter
CANCER RESEARCH
Presented in conjunction with the Cancer Immunology Working Group of the AACR
www.AACR.org/Meetings2015
Fourth
An AACRAACR International
Special Conference onConference on
TUMOR IMMUNOLOGY
FRONTIERS IN BASIC
AND IMMUNOTHERAPY:
CANCER RESEARCH
A New Chapter
Presented in conjunction with the Cancer Immunology Working Group of the AACR
October 23-26, 2015
Pennsylvania Convention Center Philadelphia, PA
CONFERENCE CHAIRPERSON
M. Celeste Simon
Abramson Family Cancer Research Institute,
University of Pennsylvania, Philadelphia, PA
CONFERENCE CO-CHAIRPERSONS
James P. Allison
The University of Texas MD Anderson Cancer Center, Houston, TX
John E. Dick
University of Toronto, Toronto, ON, Canada
Nathanael S. Gray
Dana-Farber Cancer Institute, Boston, MA
Victor E. Velculescu
Johns Hopkins Kimmel Comprehensive Cancer Center, Baltimore, MD
ABOUT THE CONFERENCE SERIES
Editor-in-Chief of the AACRs journal, Molecular Cancer Research, Dr. Karen E. Knudsen, described
the Middlegame Theory, Cancer Style, comparing future strategies of cancer research to that
of the middlegame in chess. That is, the time when piece placement has developed, loose
understanding of potential paths forward has emerged, action and reaction requires lateral thinking
to gain advantage, anticipating next moves becomes essential, and the skirmishes begin. Successful
middlegame play, albeit challenging, is the gateway to a successful endgame. In the parallel to
cancer research, thanks to advances in basic, translational, and clinical research, many key pieces
have been placed (i.e., identification of oncogenes, tumor suppressor genes, causative mutations,
cancer signaling pathways unraveled, cancer vulnerabilities exposed), and all of these pieces are in
place to consider strategy to the ultimate endgame. We are in the middlegame of cancer research,
and Dr. Knudsen emphasizes the importance of innovative basic cancer research to reach the
endgame.
This biennial broad-based meeting will provide a forum for the presentation of the state of
cancer research in the most studied subspecialties in basic cancer research and opportunities for
collaboration that is essential in identifying the needs in the basic cancer research community that
will contribute to the endgame of cancer prevention and treatment in the clinic.
This has been a very popular meeting with students (graduate or medical) and fellows (clinical or
postdoctoral) as it and covers the hottest topics in basic science in a small setting; in fact, since the
inaugural meeting in 2009, this cohort represents 50% of attendees.
Please join us in the AACRs hometown of Philadelphia, PA, for this exciting program featuring the
most current topics in basic cancer research presented by the fields leading experts.
Mentoring roundtables with invited speakers will occur during breakfast and lunch each afternoon.
Please see the General Information section for more details on signing up to participate.
Thursday, October 22, 2015 2:30 p.m.-4:30 p.m. Plenary Session 2: Metabolism
Multifaceted functions of the PD-1 pathway 7:00 a.m.-8:00 a.m. Continental Breakfast
Arlene H. Sharpe, Harvard Medical School, Boston, MA
*For program updates, please visit www.AACR.org/MeetingCalendar and follow the link for Frontiers in Basic Cancer Research.
Epithelial cancer stemness and drug resistance induced by EGFR 2:45 p.m.-4:45 p.m. Plenary Session 5: Epigenetics
inhibition or a range of cellular stresses
Epigenetic therapy can it sensitize to immune checkpoint therapy?
David A. Cheresh, UCSD Moores Cancer Center, San Diego, CA
Stephen B. Baylin, Johns Hopkins University School of Medicine,
Clonal dynamics of normal and malignant human mammary cell Baltimore, MD
growth in xenografts
Cancer epigenetics: From knowledge to application
Connie J. Eaves, BC Cancer Agency, Vancouver, BC, Canada
Manel Esteller, Institut dInvestigaci Biomdica de Bellvitge
(IDIBELL), Barcelona, Spain
10:00 a.m.-10:30 a.m. Coffee Break Chromatin looping factors and cancer
Mathieu Lupien, University Health Network Ontario Cancer
Institute, Toronto, ON, Canada
10:30 a.m.-11:15 a.m. Special Lecture: Converging Concepts
(2) Short talks from Proffered Abstracts
and Emerging Research: Cell of Origin,
Stem Cells, and Genetics
Targeting ubiquitin ligase activity for the treatment of cancer 4:45 p.m.-7:30 p.m. Poster Session A and Reception
Benjamin Ebert, Brigham and Womens Hospital, Boston, MA
Cancer genomics: From data to science to medicine 7:00 a.m.-8:00 a.m. Continental Breakfast
Andy Futreal, The University of Texas MD Anderson Cancer Center,
Houston, TX
8:00 a.m.-10:00 a.m. Plenary Session 6: Tumor
Clonal evolution in breast cancer patients and patient-
Microenvironment and Inflammation
derived xenografts
Samuel Aparicio, BC Cancer Research Center, Vancouver, BC, Ras oncogene in cancer pathogenesis and therapy
Canada Dafna Bar-Sagi, New York University Langone Medical Center,
New York, NY
Deciphering cancer genome evolution in heterogenous tumors
Nicolas McGranahan, The Francis Crick Institute, London, Role of sphingosine-1-phosphate axis in the tumor
United Kingdom microenvironment and development of a novel therapy
for obesity-related triple-negative breast cancer
(2) Short talks from Proffered Abstracts
Sarah Spiegel, Virginia Commonwealth University, Richmond, VA
Lunch on Own for All Other Attendees (2) Short talks from Proffered Abstracts
*For program updates, please visit www.AACR.org/MeetingCalendar and follow the link for Frontiers in Basic Cancer Research.
SCIENTIFIC PROGRAM*
10:30 a.m.-11:15 a.m. Special Lecture: Converging Concepts 4:45 p.m.-7:30 p.m. Poster Session B and Reception
and Emerging Research: Genetics and
New Technologies in Cancer Research
Preclinical strategies to target resistance in colorectal cancer: 10:30 a.m.-11:15 a.m. Closing Keynote
Opportunities and challenges
Signatures of mutational processes
Livio Trusolino, University of Torino Medical School, Torino, Italy
Michael R. Stratton, Wellcome Trust Sanger Institute,
Developing covalent inhibitors to interrogate kinase targets Cambridge, United Kingdom
in cancer
Nathaneal Gray, Dana-Farber Cancer Institute, Boston, MA
Departure
Mechanisms of resistance to targeted therapies in myeloid
malignancies
Neil P. Shah, UCSF School of Medicine, San Francisco, CA
*For program updates, please visit www.AACR.org/MeetingCalendar and follow the link for Frontiers in Basic Cancer Research.
GENERAL INFORMATION
Registration Rates are available until Friday, September 11, 2015. Student1
Registration forms will not be processed without full payment. Copies (Undergraduate and
of checks, government, or other payment orders cannot be accepted. High School) $ 150 $ 150
All fees must be in U.S. currency, drawn on a U.S. bank. Visa, Patient Advocate3 $ 250 $ 350
MasterCard, and American Express are also accepted for payment.
Nonmembers*
Registration Rates
Academic, Government,
Attendee registration includes admission to all lecture sessions, and Not-for-Profit Institutions $ 935 $1,075
poster sessions, conference continental breakfasts on October 23,
Industry $1,125 $1,225
24, 25, and 26, refreshment breaks, and refreshments during the
poster sessions on October 24 and 25. All fees are listed in U.S. Pre-/Postdoctoral Student2 $ 550 $ 680
dollars (USD).
Patient Advocate3 $ 350 $ 450
AACR members must include their member ID number on
Spouse/Guest4 $ 200 $ 200
the registration form or log into their member account when
registering online to obtain the member rates (member dues must Students registering onsite must show a valid student ID.
1
be paid through 2015 prior to registering). Online registrations Nonmember pre-/postdoctoral students must have their registrar, dean,
2
will be confirmed by email immediately. All other registrations will or department head certify that they are enrolled at the university and
be confirmed by email approximately three weeks after receipt. working toward a degree or fellowship in a field related to cancer research.
Receipts can also be obtained online at www.myAACR.org.
If you are a Patient Advocate registering for this conference, you must
3
The spouse/guest fee is only for meals and social activities listed above. It
4
Mentoring Roundtable Breakfasts and Lunches at the time the reservation is made. Cancellations will be accepted
at no charge until three days in advance of arrival. Note that check-
There will be opportunities at breakfast on the mornings of
in time is 4:00 p.m., and check-out time is 12:00 p.m.
October 24, 25, and 26 and lunch on October 23, 24, and 25
where early-career investigators and students can sign up to meet
with conference speakers and other experts. If you would like Travel to Philadelphia, PA
more information, please visit www.AACR.org/MeetingCalendar
and follow the link for the Frontiers in Basic Cancer Research The closest major airport to the conference site is the Philadelphia
conference. Places are limited and available on a first-come, first- International Airport (PHL), located approximately 20 minutes
served basis. The opportunity to sign up ahead of time will be sent from the hotel. The AACR has named Gant Travel Management as
via email prior to the conference, but attendees may also sign up its official travel coordinator for this conference. Gant will provide
for remaining spaces onsite at the Registration Desk. custom itineraries with the lowest applicable airfares and best
journey time.
The conference will be held at the Pennsylvania Convention Center To receive the exclusive discounts, please contact Gant:
and the Philadelphia Marriott Downtown in Philadelphia, PA. The Toll-free: 877-924-2298
Philadelphia Marriott Downtown commands a distinctive presence
with its towering profile in the heart of Philadelphia; the hotels Outside of the U.S. and Canada: 630-227-3818
downtown location surrounds guests with rich revolutionary history Email: aacr@ganttravel.com
and culture reflective of the citys 18th century service as the
nations capital. Gant is open from 7:30 a.m. to 6:00 p.m. U.S. Central Time,
Monday through Friday. A minimal service fee per airline ticket
A reduced conference rate of $229 per night is available issued will be applied. You may also call United Airlines directly
to conference attendees until Tuesday, September 29, at 800-521-4041 and reference ZT2D366688. Book early and take
2015. Reservations may be made online by following the advantage of promotional fares that will give you the greatest
Accommodations and Travel page on www.AACR.org/ discount. Full mileage credit will be earned by frequent flyer
MeetingsCalendar (follow the link to the Frontiers in Basic Cancer club members.
Research conference) or by calling 877-212-5752 and requesting
the AACR 2015 Frontiers in Basic Cancer Research conference
rate. The hotel will accept reservations at the reduced conference Ground Transportation
rate on a space-available basis until the cut-off date. Reservations
Taxi service is readily available between the airport and the
made after this date will be accepted on a first-come, first-served
Philadelphia Marriott Downtown. Taxi service is approximately $40
basis at the nearest available rate. Applied to the room charge will
one-way, plus gratuity. The AACR has arranged for a car rental
be state and local taxes, currently 15.5%. Reservations must be
discount through Hertz. Call Hertz at 800-654-2240 from the U.S.
guaranteed with a major credit card at the time of reservation. A
or 800-263-0600 from Canada, or you may book online. Please
deposit equal to one nights stay will be charged to the credit card
refer to the discount CV#02ST0019.
Amtrak offers a 10% discount off the best available rail fare to Oral Presentations of Highly Rated Abstracts
Philadelphia, PA between October 20, 2015 and October 29, 2015.
Just over ten authors of highly rated abstracts will be invited
To book your reservation, call Amtrak at 800-872-7245 or contact
to present short oral presentations of their work that will be
your local travel agent. Please be sure to refer to Convention Fare
integrated into plenary sessions. All abstracts will be considered.
Code X07Y-930 when making your reservation. This offer is not
valid on the Auto Train and Acela Service. Fare is valid on Amtrak
Regional for all departures seven days a week, except for holiday
blackouts. Offer valid with Sleepers, Business Class, or First Class
Financial Support for Attendance
seats with payment of the full applicable accommodation charges. A variety of award programs are available to offset a portion
of the registration, travel, and subsistence expenses incurred
in attending this conference. For more information on financial
Abstract Submission support and application deadlines, please visit www.AACR.org/
MeetingCalendar and follow the link for the Frontiers in Basic
Individuals interested in submitting an abstract for presentation
Cancer Research conference and Financial Support for
during the conference must do so through the AACR online
more information.
abstract submission service (http://myAACR.aacr.org). Abstract
submissions will only be accepted electronically through the
abstract submission service; paper abstracts will not be accepted.
Scholar-in-Training Awards
Each participant will be given the opportunity to present up to
All graduate and medical students, postdoctoral and clinical
two posters of his or her work. It is expected that the abstract will
fellows, and physicians-in-training who have submitted an abstract
include original data not previously published in a peer-reviewed
and a letter of recommendation to sita@aacr.org, with the
journal or the proceedings of a national meeting. Only those
conference title in the email subject may be considered. Applicants
abstracts that have been reviewed and selected by the Conference
must be AACR members in good standing. To apply for one of
Chairpersons may be presented as posters. The AACR does not
the awards you must submit both your abstract and letter of
proofread for or correct spelling, typographical, grammatical, or
recommendation by Friday, August 14, 2015.
scientific errors, nor can changes be made once the abstract is
submitted. If you have any questions or experience any problems,
please contact AACR Abstract Support at 215-440-9300 or
abstract@aacr.org. Complete abstract submission details may
be found by following the link for the Frontiers in Basic Cancer
Research conference at www.AACR.org/MeetingCalendar. The
abstract submission deadline is Friday, August 14, 2015.
GENERAL INFORMATION
Zip or Postal Code/Country Refund Policy: Requests for refunds must be made in writing. There will be a $75 processing fee
for cancellations before September 25, 2015. After September 25, 2015, no refunds can be given.
Telephone Fax
Financial Support for Attendance
Email AACR is pleased to provide financial assistance to eligible investigators for participation in this
conference, subject to availability of funding. Additional information, including award application
Spouse/Guests name, if registering instructions, is available on the Financial Support for Attendance webpage for this conference.
CONFERENCE CHAIRPERSON
M. Celeste Simon, Abramson Family Cancer Research Institute,
University of Pennsylvania, Philadelphia, PA
CONFERENCE CO-CHAIRPERSONS
James P. Allison, The University of Texas MD Anderson Cancer Center,
Houston, TX
John E. Dick, University of Toronto, Toronto, ON, Canada
Nathanael S. Gray, Dana-Farber Cancer Institute, Boston, MA
Victor E. Velculescu, Johns Hopkins Kimmel Comprehensive Cancer Center,
Baltimore, MD Follow the AACR! DONATE