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026 - Suta Prarama
026 - Suta Prarama
026 - Suta Prarama
BB 50 kg Nim 2E+08
Ke 0.07 /jam Kls b1a
Ka 0.90 /jam
F 0.90
VD 75 L
Cp 6.51 mg/L
Table1. Pasien meminum obat hari ke-1 4 kali sehari, hari ke-2
waktu pembetime(jam
dose 1dose2 dose3 dose4 dose5
6:00 AM 0 0.0000
7:00 AM 1 3.4231
8:00 AM 2 4.5834
9:00 AM 3 4.8394
HA
10:00 AM 4 4.7423
11:00 AM 5 4.5152
12:00 PM 6 4.2480 0.0000
RI 1:00
2:00
PM
PM
7
8
3.9762
3.7137
3.4231
4.5834
KE- 3:00
4:00
PM
PM
9
10
3.4652
3.2320
4.8394
4.7423
1 5:00
6:00
PM
PM
11
12
3.0139
2.8103
4.5152
4.2480 0.0000
7:00 PM 13 2.6204 3.9762 3.4231
8:00 PM 14 2.4433 3.7137 4.5834
9:00 PM 15 2.2781 3.4652 4.8394
10:00 PM 16 2.1241 3.2320 4.7423
11:00 PM 17 1.9805 3.0139 4.5152
12:00 AM 18 1.8466 2.8103 4.2480 0.0000
1:00 AM 19 1.7217 2.6204 3.9762 3.4231
2:00 AM 20 1.6053 2.4433 3.7137 4.5834
3:00 AM 21 1.4968 2.2781 3.4652 4.8394
4:00 AM 22 1.3956 2.1241 3.2320 4.7423
5:00 AM 23 1.3013 1.9805 3.0139 4.5152
6:00 AM 24 1.2133 1.8466 2.8103 4.2480 0.0000
7:00 AM 25 1.1313 1.7217 2.6204 3.9762 3.4231
8:00 AM 26 1.0548 1.6053 2.4433 3.7137 4.5834
9:00 AM 27 0.9835 1.4968 2.2781 3.4652 4.8394
HA
RI
HA10:00
11:00
AM
AM
28
29
0.9170
0.8550
1.3956
1.3013
2.1241
1.9805
3.2320
3.0139
4.7423
4.5152
RI12:00
1:00
PM
PM
30
31
0.7972
0.7433
1.2133
1.1313
1.8466
1.7217
2.8103
2.6204
4.2480
3.9762
KE-2:00
3:00
PM
PM
32
33
0.6930
0.6462
1.0548
0.9835
1.6053
1.4968
2.4433
2.2781
3.7137
3.4652
4:00 PM 34 0.6025 0.9170 1.3956 2.1241 3.2320
2 5:00
6:00
PM
PM
35
36
0.5618
0.5238
0.8550
0.7972
1.3013
1.2133
1.9805
1.8466
3.0139
2.8103
7:00 PM 37 0.4884 0.7433 1.1313 1.7217 2.6204
8:00 PM 38 0.4554 0.6930 1.0548 1.6053 2.4433
9:00 PM 39 0.4246 0.6462 0.9835 1.4968 2.2781
10:00 PM 40 0.3959 0.6025 0.9170 1.3956 2.1241
11:00 PM 41 0.3691 0.5618 0.8550 1.3013 1.9805
12:00 AM 42 0.3442 0.5238 0.7972 1.2133 1.8466
1:00 AM 43 0.3209 0.4884 0.7433 1.1313 1.7217
2:00 AM 44 0.2992 0.4554 0.6930 1.0548 1.6053
3:00 AM 45 0.2790 0.4246 0.6462 0.9835 1.4968
4:00 AM 46 0.2601 0.3959 0.6025 0.9170 1.3956
5:00 AM 47 0.2425 0.3691 0.5618 0.8550 1.3013
6:00 AM 48 0.2261 0.3442 0.5238 0.7972 1.2133
7:00 AM 49 0.2108 0.3209 0.4884 0.7433 1.1313
8:00 AM 50 0.1966 0.2992 0.4554 0.6930 1.0548
HA 9:00
10:00
AM
AM
51
52
0.1833
0.1709
0.2790
0.2601
0.4246
0.3959
0.6462
0.6025
0.9835
0.9170
RI11:00
12:00
AM
PM
53
54
0.1593
0.1486
0.2425
0.2261
0.3691
0.3442
0.5618
0.5238
0.8550
0.7972
KE-1:00
2:00
PM
PM
55
56
0.1385
0.1292
0.2108
0.1966
0.3209
0.2992
0.4884
0.4554
0.7433
0.6930
RI 1:00
2:00
PM
PM
7
8
3.9762
3.7137
3.4231
4.5834
KE- 3:00
4:00
PM
PM
9
10
3.4652
3.2320
4.8394
4.7423
1 5:00
6:00
PM
PM
11
12
3.0139
2.8103
4.5152
4.2480 0.0000
7:00 PM 13 2.6204 3.9762 3.4231
8:00 PM 14 2.4433 3.7137 4.5834
9:00 PM 15 2.2781 3.4652 4.8394
10:00 PM 16 2.1241 3.2320 4.7423
11:00 PM 17 1.9805 3.0139 4.5152
12:00 AM 18 1.8466 2.8103 4.2480 0.0000
1:00 AM 19 1.7217 2.6204 3.9762 3.4231
2:00 AM 20 1.6053 2.4433 3.7137 4.5834
3:00 AM 21 1.4968 2.2781 3.4652 4.8394
4:00 AM 22 1.3956 2.1241 3.2320 4.7423
5:00 AM 23 1.3013 1.9805 3.0139 4.5152
6:00 AM 24 1.2133 1.8466 2.8103 4.2480 0.0000
7:00 AM 25 1.1313 1.7217 2.6204 3.9762 3.4231
8:00 AM 26 1.0548 1.6053 2.4433 3.7137 4.5834
9:00 AM 27 0.9835 1.4968 2.2781 3.4652 4.8394
10:00 AM 28 0.9170 1.3956 2.1241 3.2320 4.7423
11:00 AM 29 0.8550 1.3013 1.9805 3.0139 4.5152
HA 12:00
1:00
PM
PM
30
31
0.7972
0.7433
1.2133
1.1313
1.8466
1.7217
2.8103
2.6204
4.2480
3.9762
RI 2:00
3:00
PM
PM
32
33
0.6930
0.6462
1.0548
0.9835
1.6053
1.4968
2.4433
2.2781
3.7137
3.4652
4:00 PM 34 0.6025 0.9170 1.3956 2.1241 3.2320
KE- 5:00
6:00
PM
PM
35
36
0.5618
0.5238
0.8550
0.7972
1.3013
1.2133
1.9805
1.8466
3.0139
2.8103
2 7:00
8:00
PM
PM
37
38
0.4884
0.4554
0.7433
0.6930
1.1313
1.0548
1.7217
1.6053
2.6204
2.4433
9:00 PM 39 0.4246 0.6462 0.9835 1.4968 2.2781
10:00 PM 40 0.3959 0.6025 0.9170 1.3956 2.1241
2
HA 11:00
12:00
AM
PM
53
54
0.1593
0.1486
0.2425
0.2261
0.3691
0.3442
0.5618
0.5238
0.8550
0.7972
RI 1:00
2:00
PM
PM
55
56
0.1385
0.1292
0.2108
0.1966
0.3209
0.2992
0.4884
0.4554
0.7433
0.6930
ari, hari ke-2 3 kali sehari, hari ke-3 2 kali sehari Table 3. total Cp o
0.0000
3.4231
4.5834
4.8394
4.7423
4.5152
4.2480 0.0000
3.9762 3.4231
3.7137 4.5834
3.4652 4.8394
3.2320 4.7423
3.0139 4.5152
2.8103 4.2480 0.0000
2.6204 3.9762 3.4231
2.4433 3.7137 4.5834
2.2781 3.4652 4.8394
2.1241 3.2320 4.7423
1.9805 3.0139 4.5152
1.8466 2.8103 4.2480 0.0000
1.7217 2.6204 3.9762 3.4231
1.6053 2.4433 3.7137 4.5834
1.4968 2.2781 3.4652 4.8394
1.3956 2.1241 3.2320 4.7423
1.3013 1.9805 3.0139 4.5152
1.2133 1.8466 2.8103 4.2480 0.0000
1.1313 1.7217 2.6204 3.9762 3.4231
1.0548 1.6053 2.4433 3.7137 4.5834
0.9835 1.4968 2.2781 3.4652 4.8394
0.9170 1.3956 2.1241 3.2320 4.7423
0.8550 1.3013 1.9805 3.0139 4.5152
0.7972 1.2133 1.8466 2.8103 4.2480 0.0000
0.7433 1.1313 1.7217 2.6204 3.9762 3.4231
0.6930 1.0548 1.6053 2.4433 3.7137 4.5834
0.6462 0.9835 1.4968 2.2781 3.4652 4.8394
0.6025 0.9170 1.3956 2.1241 3.2320 4.7423
0.5618 0.8550 1.3013 1.9805 3.0139 4.5152
0.5238 0.7972 1.2133 1.8466 2.8103 4.2480 0.0000
0.4884 0.7433 1.1313 1.7217 2.6204 3.9762 3.4231
0.4554 0.6930 1.0548 1.6053 2.4433 3.7137 4.5834
0.4246 0.6462 0.9835 1.4968 2.2781 3.4652 4.8394
0.3959 0.6025 0.9170 1.3956 2.1241 3.2320 4.7423
0.3691 0.5618 0.8550 1.3013 1.9805 3.0139 4.5152
0.3442 0.5238 0.7972 1.2133 1.8466 2.8103 4.2480
ble 3. total Cp obat pct pada tabelTable 4. total Cp obat pct pada
10 7.9742 7.9742 4 18
10.0000
11 7.5291 7.5291 4 18
12 7.0583 7.0583 4 18 8.0000
13 10.0197 10.0197 4 18
14 10.7404 10.7404 4 18 6.0000
15 10.5827 10.5827 4 18
16 10.0983 10.0983 4 18 4.0000
17 9.5096 9.5096 4 18
2.0000
18 8.9049 8.9049 4 18
19 11.7415 11.7415 4 18
0.0000
20 12.3457 12.3457 4 18 0 10
21 12.0795 12.0795 4 18
22 11.4939 11.4939 4 18
23 10.8108 10.8108 4 18
24 10.1182 10.1182 4 18
25 12.8728 12.8728 4 18
26 13.4005 13.4005 4 18
27 13.0630 13.0630 4 18
konsentrasi ob
20.0000
28 12.4109 12.4109 4 18
konsentrasi ob
29 11.6658 11.6658 4 18
20.0000
30 10.9153 10.9153 4 18
31 10.1929 13.6160 4 18 18.0000
32 9.5101 14.0936 4 18
33 12.2929 13.7092 4 18 16.0000
34 12.8546 13.0134 4 18
35 12.5518 12.2276 4 18 14.0000
36 11.9334 11.4391 4 18
12.0000
37 11.2203 14.1044 4 18
38 10.4998 14.5489 4 18
10.0000
39 9.8054 14.1337 4 18
40 9.1488 13.4093 4 18 8.0000
41 11.9559 12.5967 4 18
42 12.5404 11.7833 4 18 6.0000
43 12.2589 14.4253 4 18
44 11.6603 14.8481 4 18 4.0000
45 10.9656 14.4127 4 18
2.0000
46 10.2623 13.6694 4 18
47 9.5840 12.8392 4 18 0.0000
48 8.9423 12.0094 4 18 0 10 20
49 8.3403 14.6362 4 18 Cp P
50 7.7775 15.0447 4 18
51 7.2521 14.5960 4 18
52 6.7620 13.8403 4 18
53 9.7281 12.9986 4 18
54 10.4621 12.1580 4 18 konsentrasi obat
55 10.3207 14.7747 4 18
56 9.8530 15.1739 4 18 20.0000
57 9.2804 14.7164 4 18
18.0000
58 8.6910 13.9526 4 18
59 8.1189 13.1033 4 18 16.0000
60 7.5763 12.2556 4 18
61 7.0667 14.8657 4 18 14.0000
62 6.5900 15.2587 4 18
12.0000
63 6.1449 14.7956 4 18
64 5.7296 14.0264 4 18 10.0000
65 8.7654 13.1721 4 18
66 9.5646 12.3198 4 18 8.0000
67 9.4838 14.9255 4 18
6.0000
68 9.0727 15.3145 4 18
69 8.5529 14.8476 4 18 4.0000
70 8.0127 14.0749 4 18
71 7.4864 13.2173 4 18 2.0000
72 6.9866 12.3619 4 18
0.0000
0 10 20 30
Cp PCT nor
MEC
4.0000
2.0000
0.0000
0 10 20 30
Cp PCT nor
MEC
dan 2
18.0000
16.0000
14.0000
12.0000
10.0000
8.0000
6.0000
4.0000
2.0000
0.0000
0 10 20 30 40 50 60 70 80
8.0000
6.0000
4.0000
2.0000
0.0000
8.0000
6.0000
4.0000
2.0000
0.0000
0 10 20 30 40 50 60 70 80
.0000
.0000
.0000
.0000
.0000
.0000
.0000
.0000
.0000
.0000
0 10 20 30 40 50 60 70 80
.0000
.0000
0 10 20 30 40 50 60 70 80