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Fermentation Process:: X M T X Y T S
Fermentation Process:: X M T X Y T S
Fermentation Process:: X M T X Y T S
The glucose consumption rate can be modeled using Luedeking-Piretlike equation that
neglects the amount of carbon substrate used for product formation. The model is expressed as
follows
S 1 X
ms X
t Y x t
s
where S is the substrate concentration (g/l), Yx is the yield coefficient for cell on
s
The above equation can be integrated which results the following expression:
X o X m e mt X o X m m s X m X o X o e mt
S So ln
Y x X m X 0 X o e mt Y x m Xm
s s
Where S o is the initial substrate concentration (g/l) and X o is the initial concentration (g/l)
Applying the logistic Equation to represent the microbial growth, the model can be written as:
X
m 1
Xm
X o X m e mt
X
X m X o X o e mt
X 1 X
X i X m 1 X
t R X m
Where
V
R
Q
Where R is the hydraulic retention time (h) , V is the fermenter volume (l) and Q is the
Since the feed is sterile X i 0 and the fermenter is at steady state condition the above
1 X
m 1
R X m
S i S o RX ms
YX
s
At steady state and no product in the input flow the above equation can be simplified as
follows
X
P RX m 1
Xm
where P is the product concentration (g/l), is the growth associated product formation