Coralan (ANTI ANGINAL)

medication used for the symptomatic management of stable heart related chest pain and heart
failure not fully managed by beta blockers

acts by reducing the heart rate via specific inhibition of the funny channel, a mechanism different from
that of beta blockers and calcium channel blockers, two commonly prescribed antianginal drugs.
Ivabradine is a cardiotonic agent

Ivabradine acts on the If (f is for "funny", so called because it had unusual properties compared with other
current systems known at the time of its discovery) ion current, which is highly expressed in the sinoatrial
node. If is a mixed Na+K+ inward current activated by hyperpolarization and modulated by the autonomic
nervous system. It is one of the most important ionic currents for regulating pacemaker activity in the
sinoatrial (SA) node. Ivabradine selectively inhibits the pacemaker If current in a dose-dependent manner.
Blocking this channel reduces cardiac pacemaker activity, selectively slowing the heart rate and allowing
more time for blood to flow to the myocardium.[10][11] This is in contrast to other commonly used rate-
reducing medications, such as beta-blockers and calcium channel blockers, which not only reduce heart
rate, but also the cardiac contractility. Given the selective decrease in rate without loss of contractility,
ivabradine may prove efficacious for treatment of congestive heart failure without decreases in ejection
fraction.

S/E luminous phenomena

OROFAR-l

Benzoxonium Cl 0.5 mg, lidocaine HCl 0.5 mg per mL soln

Inhibit the replication of respiratory viruses and enhance the effect of interferon (signaling proteins made
and released by host cells in response to the presence of several pathogens)

S/E Skin rashes

Azithromycin

binds to the 50S ribosomal subunit and thus inhibits the biosynthesis of proteins of strains in pathogenic
microorganisms. Thus, reaction inhibited translocation transpeptidation occurs, resulting in the formation
and impaired capacity of the peptide chain, causing bacteriostatic antimicrobial effect. Besides, when
used in high concentrations, at a relatively low density when microorganisms are in the growth phase,
generic Azithromycin may have a bactericidal effect. This effect is usually resorted to in the treatment of
conditions caused by hemolytic Streptococcus group A and pneumococcus.

S/E ausea, diarrhea, abdominal pain, vomiting and flatulence

Ambroxol (Mucolytic)
May increase theoutput of fluid from therespiratory tract byreducing the viscosity& surface tension
of respiratory secretions,thereby removingaccumulatedsecretions from upper & lower airway

Methylprednisolone ( corticosteroid medication )

Unbound glucocorticoids cross cell membranes and bind with high affinity to specific cytoplasmic
receptors, modifying transcription and protein synthesis. By this mechanism, glucocorticoids can inhibit
leukocyte infiltration at the site of inflammation, interfere with mediators of inflammatory response, and
suppress humoral immune responses. The anti-inflammatory actions of corticosteroids are thought to
involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent
mediators of inflammation such as prostaglandins and leukotrienes.

S/E Nausea/vomiting/stomach upset Heartburn

PT TEACHING: Increase potassium, calciumand protein intake.