Red = HIV Hepatotoxic (LFTs)

Blue = HSV - Methotrexate

Purple = CMV - Lapatinib
Pink = Antifungals - BRC-ABL inhibitors (-TINIB)
VINCA ALKALOIDS (VIN-) - Nevaripine
IV only no intrathecal - (-AZOLE)
- lamasil
Need baseline PFTs before starting -
Bleomycin
Mucositis
(Ph+) CML- Imantinib - Anti-metabolites
o 5-FU infusion
Acne rash in 2 weeks Cetuximab o Capcitabine (PO)
- Folate antagonists
Ocular toxicity cytarabine o methotrexate
o Permetrexed
Neurotoxic - Anthracane derivatives (-RUBICIN)
- Cytarabine (CNS cerebellar synd) o Mitoxantrone
- Vincristie (neuro)
- Paclitaxel (neuro) Magic mouthwash
- Benadryl
Ototoxic - Cytarabine - Maalox
- Nystatin
Interstitial Lung Disease - Erlotinib - Lidocaine viscous
Hand and foot syndrome
Stomatitis Methotrexate - Liposomal doxorubicin
- Capecitabine (PO)
Thrombocytopenia gemcitabine - 5-FU infusion
- Cytarabine
Flu like ssx gemcitabine
Cardiotoxic
Death dt neutropenic sepsis - Pemetrexed - Campothecin D (-OTECAN)
- Podophyllotoxin D. (-POSIDE)
Reversible Encephalopathy (48-72hr post inf) - - Anthracane D. (-RUBICIN)
Ifosfamide o Mitoxantrone
- Alkylating agents
Peripheral Neuropathy o cyclophosphamide
Podophyllotoxin D (-POSIDE) o Ifosfamide
Zalcitabine - Herceptin (Cardiomypathy)
Stavudine
Diarrhea
Bone marrow toxicity - Campothecin D. (-OTECAN)
- Flucytosine - Erlotinib
- Lapatinib
PO agents - 5FU infusion
- Capcitabine
Fluid retention
NOT myelosuppressing - Docetaxel
- Vincristie - Imantinib
- Cisplatin (Amifostine)
- NNRTIs Hypersensitivity rxn
o Nevirapine Cabazitael
o Efavirenz Nab-Pacitaxel

Hemorrhagic cystits
Nephrotoxicity Cyclophiosphamide )
- Cisplatin (dose limiting) Ifosfamide**
- Methotrexate
- Foscarnet (ATN)
- Cidofovir (probenecid + NS) Alopecia
- Amphotericin B (colloidal) - Campothecin D.
o (-OTECAN)
- Podophyllotooxin D. o Hepato and nephrotoxic
o (-POSIDE) - Pemetrexed
- Anthracane D. o Death dt neutropenic sepsis
o (-RUBICIN) Pyrimidines
o Mitoxantrone - 5-FU
o Leucovorin cytotoxicity
QT Prolongation - Capecitabine
- Lapatinib o PO
- Itraconazole o CNS toxic Cerebellar synd
- Fluconazole o Ocular toxicity
- Posaconazole
- Microtubule targeting drugs
Vinca alkaloids (VIN-) IV ONLY NO IT
Infusion rxns - Pacific Yew tree
- Rituximab* (CD20) - Vincristie Neurotoxicity
- Ofatumumab (CD20 infection) - Vinblastine
- Cetuximab (EGFR) Vinorelbine
- Herceptin (HER2) Taxanes (- TAXEL)
- Amphotericin B (colloidal) - Paclitaxel Neurotoxicity
- Docetaxel fluid retention
Dose limiting ADR - Cabazitaxel
- Hematotoxicity - Nab-Paclitaxel
o Zidovudine
o Ganciclovir Topoisomerase Inhibitors
- Nephrotoxicity - Campothecin deriviatives (-OTECAN)
o Cisplatin - Podophyllotoxin derrivatives (-POSIDE)
o Foscarnet (ATN) o Peripheral neuropathy
- Pancreatitis
o Didanosine -
- Myelosuppression Anthracane derrivatives (RUBICIN)
o 5-FU - Doxyrubicin
o capcitabine o Liposomal causes hand foot syndrome
o gemcitabine - Daunorubicin
- Thrombocytopenia - Idarubicin
o Gemcitabine o Lowest cumulative dose
- CNS toxicity, ocular toicity and hand foot synd o Highest cumulative dose
o Cytarabine Mitoxantrone
- Peripheral neuropathy
o Zalcitabine Tamoxifen
o Stavudine - Anti-estrogen
- 2D6 substrate dont use paxil, fulxoetine or
Bevacizumab (VEGF) buproprion - will increase serum levels of
- Thrombotic events tamoxifen
- HTN
- Bleeding
- Nephrotic syndrome Toxicity reduction
- BBW - MESNA Ifosphamide & Cyclophosphamide
o GI perf - Amifoxtine Cisplatin
o Wound dehiscence - Leucovorin MTX
o Fatal hemoptysis

EPO - when Hgb<10 in non-curable cancers for

Antimetabolites anemia dt chemo
Purines - EPO Alfa three times a week
- 6-Mercaptopurine - Darbapoetin Q 1-3 weeks
o decrease dose if taking xanthine
oxidase inhibitor (Zyloprim or Uloric) GCSF use if pt is neutropenic (<1000)
Folate antagonists - G-CSF
- Methotrexate - GM-CSF
o Leukovorin decreases toxicity (rescue tx - Pegfilgrastim
to <0.2)
o Stomatitis