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Simvastatin (Simvador, Zocor)
Simvastatin (Simvador, Zocor)
Simvastatin (Simvador, Zocor)
Follow carefully any lifestyle advice you have been given such as stopping smoking,
avoiding drinking too much alcohol, eating a healthy diet and taking exercise. These also
help to reduce the risk of heart and blood vessel disease.
If you develop any unusual cramps or pains in your muscles, contact your doctor for advice
as soon as possible.
About simvastatin
Type of medicine Alipid-regulating medicine commonly known as a statin
Used for Lowering cholesterol and other lipids in the blood; to reduce the risk of heart and blood vessel disease
Also called Simvador; Zocor; and Inegy (a combination of simvastatin with a medicine called ezetimibe)
Available as Tablets and oral liquid medicine
Lipids, or fats, are made naturally in your body from the food you eat. They are easily stored in your body and
serve as a source of energy. Cholesterol and triglycerides are types of lipid. If the concentration of these lipids in
your blood becomes too high, it leads to a condition called hyperlipidaemia. If it is the concentration of cholesterol
which has become too high, it is called hypercholesterolaemia. Although a high blood concentration of lipids will
not make you feel ill, it can cause a problem if it is left untreated.
People with high lipid levels can develop small fatty patches called atheroma. These patches develop when
excess fat is deposited on to the walls of blood vessels. Over time, these patches can make a blood vessel
narrower and this is called atherosclerosis (sometimes referred to as 'hardening of the arteries'). The narrowing
reduces the blood flow through the artery and increases the risk of a number of heart and blood vessel diseases,
such as heart attack and stroke.
Simvastatin belongs to a group of medicines known as statins (or HMG-CoA reductase inhibitors). It regulates the
amount of cholesterol and other lipids made by your body. It does this by blocking the action of a certain enzyme
(called HMG-CoA reductase) which your body needs to make the fats. This lowers your risk of heart and blood
vessel disease. It can also reduce this risk, even if your cholesterol levels are normal, if you are at an increased
risk of heart disease as a result of other healthcare problems (such as if you have diabetes mellitus).
Simvastatin is available on prescription. The 10 mg strength tablets are also available to buy without a
prescription at a pharmacy if you have been advised by a healthcare professional that simvastatin should form
part of a programme of treatment to reduce your risk of heart disease.
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Before taking simvastatin
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used
if extra care is taken. For these reasons, before you start taking simvastatin it is important that your doctor
knows:
Important: simvastatin has been associated with some more serious side-effects in a very few people. Although
these occur only rarely, it is important that you tell your doctor straightaway if you experience any of the following
symptoms:
If you develop any muscle cramps or pains, particularly if they are in your legs and you also feel unwell
or have a high temperature (fever).
If you feel short of breath or develop an unexplained cough. This is because (in very rare cases) statin
medicines like simvastatin can cause a disease called interstitial lung disease.
If you develop any allergic-type reactions, such as swelling around your mouth or face, or a skin rash.
If you experience any other symptoms which you think may be due to simvastatin, speak with your doctor or
pharmacist for further advice.
Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this
medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is
empty.
This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
If you buy any medicines, check with a pharmacist that they are safe to take with your other medicines.
If you are having an operation or dental treatment, tell the person carrying out the treatment which medicines you are
taking.
Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
If you have any questions about this medicine ask your pharmacist.
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Further reading & references
Manufacturer's PIL, Simvastatin 10 mg/20 mg/40 mg/80 mg Tablets; Aurobindo Pharma - Milpharm Ltd, The electronic
Medicines Compendium. Dated March 2012.
Simvastatin patient information article; Medicines and Healthcare products RegulatoryAgency (MHRA), October 2012
British National Formulary; 68th Edition (Sep 2014) British Medical Association and Royal Pharmaceutical Society of Great
Britain, London
Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical
conditions. EMIS has used all reasonable care in compiling the information but make no warranty as to its
accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions.
For details see our conditions.