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Dey'S: Industrial Training at
Dey'S: Industrial Training at
Dey'S: Industrial Training at
At
DEY’S
“Care You Can trust”
Dey’s Medical Stores (Mfg) Pvt. Ltd.
62 Bondel Road, Kolkata-700019
West Bengal.
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ACKNOWLEDGEMENT
The industrial training work is undertaken as a part of the curriculum of
the bachelor of pharmacy (B.Pharm) course of department of pharmaceutical
science of Dibrugarh University, Assam.
The accomplishment of this work require the help and effort of many
people and the work is indifferent. I am grateful to Dr. A. Bhattacharyya the
head of the department of Pharmaceutical science of Didrugarh University for
givin me the opportunity to undergo the industrial training at Dey’s Medical
Stores (Mfg) pvt. Ltd.
It has been a pleasure to undergo training at Dey’s. In spite of its short
duration (01.07.09-30.07.90), the practical experience of industrial work
environment will be a valuable asset to me and will go a long way in enhancing
my prospects in the pharmaceutical field.
I want to convey my sincere thanks specially to Mr. Deepak Banik for his
helping hand in every step here and also to each and every personal of Dey’s
for helping me the formulation industry in a better way. I want to specially
thank the supervisors and in-charges and support.
I express my deep gratitude to the below named persons for their
support and valuable information.
1. Mr. Tapash Benerjee (Personal Manager)
2. Mr. Santanu Roy & Mr. Sanjay Dutt (In-charge tablet dept.)
3. Mr. Arijit Dutta (In charge capsule)
4. Mr. Saradindu Mondal (Supervisor capsule)
5. Mr. Subhankar Biswas (In-charge liquid)
6. Mr. Amarnath Roy (In-charge I-tone)
7. (In-charge Q.C.)
8. Mrs. Sikha Roy (Librarian)
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SOMETHING ABOUT THE COMPANY
Dey’s Medical Stores (Mfg) Pvt. Ltd. Is a private company dealing with the
production of many pharmaceutical products. It was established in 1958. It has
four manufacturing units-three at Kolkata, W.B and other one at Naini,
Allahabad, Uttar Pradesh.
The beginning of Dey’s is fascinating. In 1941, Late Mr.B.N.Dey, the then
Managing Director of this organization, from a mere urge to serve the society,
started a small retail medical store in Kolkata through his unique character
comprising high capabilities with honesty. Soon he was able to gain the
confidence of the medical profession including the stalwarts in the field. During
the 2nd world was, when the supply of essential drugs was uncertain and
much hampered, Dey’s come forward in the field of agency to ensure and
maintain a steady supply of left Saving drugs and appliances to the medical
profession and also to the ailing people of the country.
In 1957 Dey’s took sold step in establish a manufacturing units in the city
of Kolkata its own indigenous know how various dosage forms of drugs-
capsules, tablets, granules, powders, oral liquid, drops etc of all the important
categories of medicines-antibiotics, antiasthma ties, antihypertensive, ant
dysentery, anti-inflammatory. In the year 1971 Dey’s opened a second
manufacturing company at Naini, Allahabad, in the state of Uttar Pradesh.
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CONTENT
1. Tablet......................................................................................................5
2. Capsule……………………………………………………………………………………………….10
4. Quality Control…………………………………………………………………………………….18
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TABLETS
Tableting Methods
Weighing of materials
Granulation
Addition of excipients
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Mixing in planetary mixer
Compression
Packing
Weighing of materials
ADDITION OF EXCIPIENTS
Compression
Packaging
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DURING ONE WEEK OF TRAINING FOLLOWING TABLETSWERE
PROCESSED
Avicel pH101
Milk Of W.G Antacid
Magnesia &Laxative
Etformin W.G Metformin Diabetis
hydrochloride I.P
Liz-M W.G Gliclazide Diabetis
Metformin
hydrochloride
Zovax-500 Amoxycillin Antibiotic
Trihydrate
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Tablet Coating:- Tablet coating is a process of application of a coating
composition to a moving bed of tablet with a concurrent use of a heated air to
facilitate evaporation of the solvent. The distribution of coating is
accomplished by the movement of the tablets either perpendicularly (coating
pan) or vertical (air suspension coater) to the application of the coating
composition.
-Sugar coating
- Enteric coating
Machine used→
→Name – UNICOTA- 36
→Capacity of pan – 50 kg
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Colouring Agents – Titanium dioxide, Brilliant blue, Erythrosine lake colour,
Yellow oxide of Iron
For enteric coating tablets ‘OPAR DYE’ is used along with other materials.
→3 SPRAYING GUNS
→PERISTALTIC PUMP
→AIR INJECTOR
→PRESSURE GAUGE
FIGURE of UNICOTA-36
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CAPSULES
Capsules are solid pharmaceutical doses forms consisting of solids,
semisolids and liquid enclosed in a gelatin shell.
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-: Manufacturing Procedure for Capsules:-
WEIGHING → SEIVING → BLENDING & LUBRICATION ← LACTOSE, STARCH,Mg.STEARATE
PACKING
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ALLOPATHY CAPSULE:
Category → Typhoid
1. LIVINA CAPSULE
a. ACTIVE INGREDIENTS – Kalmegh,Kakamachi,Sarapunkha,
Guduchi,Haritaki,Katuka,Saptapura
b. EXTRACTS OF THE INGREDIENTS – Bhumium laki, Kakilakshy a Indrayva,
Daruharidra,Kasni
c. LUBRICANTS – DCP,Starch, SiO2, Magnesium stearate,Talcum powder
d. PRESERVATIVES – Sodium benzoate
e. USES – In liver ailments, helps and protects liver from hepatotonic
substances, promotes appatite, clear constipation
f. PROCEDURE :-
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2. PROSTINA CAPSULE:
3. TRASINA CAPSULE:
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LIQUID
Liquid formulation are intended for oral administration and external
administration.
This department has only one charging room and one storage room for
the finished product. Every section has one washing room attached with the
packing room which washes the bottle of that particular product.
LIQUID 1:
1. ENTEROMYCETIN SYRUP
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filtered through sparkler filter → filter in charge VAT → chloramphenicol and
isopropyl alcohol in stream VAT → clear solution formed at 62°c-65°c → above
solution in four containers containing water with stirring → amorphous form of
chloramphenicol palminate is formed and is collected → transferred to ball mill
and operated for 2 hrs. with little water to make a slurry → slurry sent to
quality control for intermediate infrared test → after report add TWEEN 20 →
add water and stir for 20-21 hrs. → transfer to mixing VAT in syrup → add ice
cream flavours → volume makeup → sent sample to quality control → then for
I.R. test → filling → capping → labeling →packing.
2. KARPIN LOTION.
Karpin lotion is doubly filtered. 1st through HYFLOW SUPERCEL POWDER (filter
aid powder) dissolved in water and then through sparkler filter (2 beded).
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LIQUID 2.
It is mainly ayurvedic section.
1. LIVINA SYRUP
constipation.
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eyes from all pollutants and adverse environment of modern life. It also helps
to maintain the activity of vision and is very useful in treatment of various eye
ailments.
I.P.
17
QUALITY CONTROL (QC)
Quality control department is a must for every pharmaceutical industry. There
are several aspects of quality control department
A good Q.C. department helps to increase marketability of drug & the profit of
the respective organisation.
1. Chemical Laboratory
2. Pharmacological Laboratory
3. Microbiological Laboratory
CHEMICAL DEPARTMENT:-
1. pH meter
2. Dissolution test apparatus
3. Disintegration test apparatus
4. Friabilator
5. Phase separator apparatus
6. TLC apparatus
7. HPLC apparatus
8. Karl Fischer apparatus
9. Automated Karl Fischer apparatus
10. I.R. Spectroscope
11. Spectrophotometer
12. Centrifuge
13. Viscometer
14. Digital balance with printer.
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Different types of tests done in chemical department are:
1. Dissolution test
2. Disintegration test
3. Hardness test
4. Weight variation test
5. HPLC
6. TLC
7. Titration
8. Friability
9. Absorbance test
10. Solubility test
MICROBIOLOGY LABORATORY:
1. Colorimeter.
2. Double door autoclave
3. Water bath
4. Microscope
5. Incubator
1. Antibiotic assay
2. Vitamin assay
3. Amino assay
4. Microbial limit test
5. Sterility test
6. Spore test
PHARMACOLOGICAL LABORATORY:
In this laboratory the drugs are tested on animals. The tests are:
1. Pyrogen test
2. Toxicity test
3. Eye irritation test
4. Skin irritation test
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Mr. Arijit Dutta (In charge capsule)
Mr. Saradindu Mondal (Supervisor capsule)
Mr. Subhankar Biswas (In-charge liquid)
Mr. Amarnath Roy (In-charge I-tone)
(In-charge Q.C.)
Mrs. Sikha Roy (Librarian)
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