A. Identify the site.

B. Which drug acts at this particular site.

Sites Drugs acting

Site 1 :Proximal convoluted tubule Acetazolamide

 Site 2: Descending limb of Loop of Henle Osmotic diuretics

Site 3: Ascending limb of loop of Henle- Loop diuretics

Site 4: Distal convoluted tubule Thiazide

Site 5: Distal parts of the nephron ( from the late Potassium sparing diuretics
distal tubule to the collecting duct )
A]Identify the type of receptor.

GABA receptor

B] Identify the ion entering through this receptor?

Chloride ions

A] Identify the type of poisoning.

B] Outline the management of this poisioning.

A]This is a case of organophosphorous poisoning.

B] Termination of further exposure to the poison- fresh air ventilation, wash the skin and mucus membrane with water.

Maintain patent airway, positive pressure respiration if it is failing.

Supportive measures – maintain blood pressure, hydration and control convulsions with diazepam.

Atropine 2mg i.v repeated over 10mins till pupil dilates and heart beat more than 70 beats/ min.

Pralidoxime is injected 1g i.v slowly.

A]Identify the type of poisoning.

B] Name the chelating used to treat this poisioning.

A] These symptoms most likely suggest childhood lead poisoning

B] Chelating agents are used, depending on the severity of symptoms like dimercaprol, EDTA and succimer.
A]Identify the type of receptor.

G protein coupled receptor

B] mention major effector pathways through which this receptor functions?

i. Adenyl cyclase : cAMP pathway

ii. phospholipase C: IP3 –DAG pathway

iii. ion channel regulation

A]Identify the type of receptor.

Nuclear receptor

B] write mechanism of action operating through this receptor?