Professional Documents
Culture Documents
Access - Deep Surveying of Alternative Splicing Complexity in The Human Transcriptome by High-Throughput Sequencing - Nature Genetics
Access - Deep Surveying of Alternative Splicing Complexity in The Human Transcriptome by High-Throughput Sequencing - Nature Genetics
Access - Deep Surveying of Alternative Splicing Complexity in The Human Transcriptome by High-Throughput Sequencing - Nature Genetics
Access
To read this story in full you will need to login or make a
payment (see right).
Brief Communication
Nature Genetics 40, 1413 1415 (2008)
Published online: 2 November 2008 | Corrected online: 28 April 2009 |
doi:10.1038/ng.259
There is an Addendum (June 2009) associated with this Brief
Communication.
Deep surveying of alternative ARTICLE LINKS
splicing complexity in the Figures and
human transcriptome by high tables
throughput sequencing Supplementary
info
Qun Pan1, Ofer Shai1,2, Leo J Lee1,2, Brendan J
Frey1,2 & Benjamin J Blencowe1,3
ARTICLE TOOLS
We carried out the first analysis of Send to a friend
alternative splicing complexity in human Export citation
tissues using mRNASeq data. New splice Export
junctions were detected in 20% of references
multiexon genes, many of which are tissue Rights and
specific. By combining mRNASeq and EST permissions
cDNA sequence data, we estimate that Order
commercial
transcripts from 95% of multiexon genes reprints
undergo alternative splicing and that there
are 100,000 intermediate to high
abundance alternative splicing events in
major human tissues. From a comparison SEARCH
with quantitative alternative splicing PUBMED FOR
microarray profiling data, we also show that Qun Pan
mRNASeq data provide reliable
Ofer Shai
measurements for exon inclusion levels.
Leo J Lee
To read this story in full you will need to Brendan J Frey
login or make a payment (see right). Benjamin J
Blencowe
MORE ARTICLES LIKE THIS
These links to content published by NPG are
automatically generated.
REVIEWS
Comprehensive comparative analysis of
strandspecific RNA sequencing methods
Nature Methods Analysis (01 Sep 2010)
See all 17 matches for Reviews
http://www.nature.com/ng/journal/v40/n12/full/ng.259.html 1/2
28/6/2016 Access : Deep surveying of alternative splicing complexity in the human transcriptome by highthroughput sequencing : Nature Genetics
NEWS AND VIEWS
Molecular biology Power sequencing
Nature News and Views (26 Jun 2008)
The beginning of the end for
microarrays?
Nature Methods News and Views (01 Jul 2008)
See all 4 matches for News And Views
RESEARCH
Alternative isoform regulation in human
tissue transcriptomes
Nature Article (27 Nov 2008)
Splice site strength???dependent activity
and genetic buffering by polyG runs
Nature Structural & Molecular Biology Article (01 Oct
2009)
See all 51 matches for Research
Search: go
© 2016 Macmillan Publishers Limited, part of Springer Nature. All Rights Reserved.
partner of AGORA, HINARI, OARE, INASP, ORCID, CrossRef, COUNTER and COPE
http://www.nature.com/ng/journal/v40/n12/full/ng.259.html 2/2