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Phytotherapy RS
Phytotherapy RS
In RBCs, carbonic anhydrase catalyzes the reaction to convert CO2 into H2CO3,
which further breaks down into bicarbonate ions and protons (H+). The
production of bicarbonate ions and protons regulates the pH of the blood,
creating an environment in which your cells can live.
In the lungs, the reaction is reversed as CAE will break down the H2CO3 to CO2
to be exhaled and H2O. This reaction will maintain the PH of blood by
controlling the H2CO3 and Protons.
The common respiratory tract disorders:
➢ upper respiratory tract disorders such as:
Rhinitis
Common cold & influenza (flu)
Sinusitis
Viral cold and flu infection are self-limiting (5-7 days) but may
become complicated by bacterial infections
Herbal treatment:
Nasal decongestant, anti-inflammatory & demlucents (ttt common cold).
Coughing
Cough is a forceful release of air from the lungs that can be
heard in order to clear it of irritants and secretions.
Types of cough:
1) Dry cough: Free of secretions
2) Cough with thick mucus: Secretions, phlegm, sputum.
Mechanism of action:
Form protective layer over the mucus membrane of the epithelium of
pharynx, larynx & trachea so preventing mechanical irritation.
2-Essential oils
Volatile aromatic mixtures of many different components.
Most of the essential oil-containing drugs used to treat cough
by peripheral suppression of cough reflex by decreasing the
sensitivity of cough receptors also have expectorant
properties. (discuss later)
3-Opiates
• They are constituents of opium poppy (Papaver
somniferum) as Morphine and codeine alkaloids.
• with anti-tussive activity.
MOA: Both compounds possess central anti-tussive actions
by their agonist actions on opiate receptors in the
cough center.
Codeine is usually used therapeutically in cough
mixtures.
Disadvantages:
Large doses may cause respiratory depression &
constipation and liable to abuse.
Mechanism of action of herbal products
B- Cough associated diseases
Bronchial Asthma
It is characterized by difficulty in breathing caused by
broncho-spasm and dyspnea in addition to nasal
congestion & discharge.
The clinical features of asthma result from
Inflammatory response in the airways involving local
inflammatory cell accumulation For cytotoxic mediators
(pro-inflammatory) as leukotrienes & free radicals.
Herbs treating asthma
Ephedra: (alkaloids)
(Ephedrine, pseudoephedrine, norephedrine, norpseudoephedrine).
Uses: Ephedrine is a clinically effective anti-asthmatic drug.
Mode of action:
• Ephedrine directly stimulates α1- and ß2- adrenergic receptors.
• There is also an increase in ciliary activity and liquefaction of
tenacious mucus, resulting in a mild expectorant action.
Contraindications:
The drug is contraindicated in patients suffering from:
• Heart conditions
• Hypertension
• Diabetes
• Thyroid disease
Bronchitis
Bronchitis indicating inflammation of the bronchi of the lungs
Acute bronchitis:
Short-term inflammation of the bronchi of the lungs
where it occurs in winter months following the same
symptoms of upper respiratory infection as Coughing
with little mucus, chills, sore throat and slight fever.
Chronic bronchitis
Chronic inflammation causes alveolar hypoventilation,
hypercapnia ( CO2/blood) and hypoxia It follows
symptoms of lower respiratory infection as productive
cough with heavy sputum and air way obstruction.
Phytotherapy of Bronchitis
• Bronchodilators (reduce airway constriction)
• Expectorants and mucolytics (reduce mucus viscosity so
easily expelled in productive coughing)
• Bronchodilators:
Reflex
parasympathatic
Pathway stimulation
B - Direct-acting Expectorants
(Essential oil- containing drugs)
Eucalyptus oil Thyme oil
(leaves of Eucalyptus globulus) (leaves of Thymus vulgaris )
volatile oil volatile oil
85% eucalyptol (cineole( Thymol (31-71%) and carvacrol (2.5-15%).
expectorant, mucolytic & antiseptic expectorant, mucolytic and antitussive
Other cough-associated diseases
Disease Definition Etiology
3) Pneumonia Inflammation of Microorganisms (bacteria, viruses, fungi or
lung alveoli & parasites)= infectious pneumonia
abnormal alveolar
filling with fluid