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  • Objectives: - Describe The Different Agents, Types and Physiological Effects of Mutations

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    Tricia Ann Caimoso
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    The document describes different types of mutations that can occur during DNA replication. Errors in replication or damage from mutagens can cause point mutations, which are substitutions of a single nucleotide. Frameshift mutations involve the insertion or deletion of nucleotides, shifting the genetic reading frame. Various mutagens like radiation and chemical agents are also discussed as causes of mutations.

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    Biochemistry

    Original Title

    Mutation

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    The document describes different types of mutations that can occur during DNA replication. Errors in replication or damage from mutagens can cause point mutations, which are substitutions of a single nucleotide. Frameshift mutations involve the insertion or deletion of nucleotides, shifting the genetic reading frame. Various mutagens like radiation and chemical agents are also discussed as causes of mutations.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    Download as pdf or txt
    15 views13 pages

    Objectives: - Describe The Different Agents, Types and Physiological Effects of Mutations

    Uploaded by

    Tricia Ann Caimoso
    The document describes different types of mutations that can occur during DNA replication. Errors in replication or damage from mutagens can cause point mutations, which are substitutions of a single nucleotide. Frameshift mutations involve the insertion or deletion of nucleotides, shifting the genetic reading frame. Various mutagens like radiation and chemical agents are also discussed as causes of mutations.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
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    of 13

    5/15/2017

    Objectives
    • Describe the different agents, types and
    physiological effects of mutations

    1
    5/15/2017

    In DNA Replication
    • High fidelity is observed due to the proofreading
    ability of DNA polymerase
    • BUT, errors may still arise and if not repaired,
    there will be MUTATIONS
    • Probability: 1 in every 50 million bases added to
    the nucleotide chain

    Mutation
    • Change in the genetic material
    • Causes:
    1. Errors in DNA replication
    • Mispairingof bases by DNA polymerase
    2. Mutagens
    • Agents that damage DNA

    2
    5/15/2017

    Kinds of DNA Mutation

    3
    5/15/2017

    Point Mutation

    Point Mutation

    4
    5/15/2017

    Non-Sense Mutation

    Same Sense Mutation

    5
    5/15/2017

    Missense Mutation

    Missense Mutation

    6
    5/15/2017

    Frameshift Mutation

    7
    5/15/2017

    Frameshift Mutation

    Frameshift Mutation

    8
    5/15/2017

    Frameshift Mutation

    9
    5/15/2017

    Mutagens

    1. Ionizing Radiation

    10
    5/15/2017

    2. Chemical Agents

    2. Chemical Agents

    11
    5/15/2017

    2. Chemical Agents

    Benzo[a]pyrene

    12
    5/15/2017

    Aflatoxin

    References

    13

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