Dirty Genes Course Copy 1

Disclaimer & Disclosures
 
The information presented here is for informational and educational purposes only. Dr Ben Lynch,
LLC and Dr Ben Lynch will not be liable for any direct, indirect, consequential, special, exemplary, or
other damages arising from the use or misuse of any materials or information published.
 
 
President and CEO of:
 
Dr Ben Lynch (www.drbenlynch.com)
Seeking Health (www.seekinghealth.com)
MTHFR.Net (www.mthfr.net)
(c) 2015: Benjamin Lynch, ND 1

Foundations of Health

How efficient are you?

Why Mitochondria?

ATP – Your Fuel
Quick Facts
1. Amount of ATP in Body (50 g) = same as a AA Battery
2. Amount of ATP Used Daily ~ Body Weight
3. Continuously Recycled - Adenosine > AMP > ADP > ATP
4. Brain uses 20%
5. 40% Used at Rest (BMR) for K+/Na+ Pumps
6. VDAC is the most abundant protein in outer mito membrane which
regulates energy-dependant metabolism and apoptosis.
PMID 19073922
ATP
Quick Facts
1. Five Complexes
2. Complex I and III produce most ROS
3. Mitochondrial complexes IMPORT product from nuclear DNA in order to
function
4. [Glutathione] inside the mitochondria in very high in order to protect against
ROS
Mitochondrial complexes IMPORT product from nDNA in order to function

17
Where are many starting?

Why are they starting here?

Why Starting with SNPs?
• New
• Interesting
• Fun
• Blame
• Ease
Identifies a singular reason for the unexplainable

Where to Start?

Therapeutic Order
Optimizing
SNPs
(Epigenetics)

The lack of phenotype consistency in both
children points toward other genetic 
and environmental factors modifying the
expression of the disease among 
individuals with the same genotype.

What do we chase?

What should we do?

WORK
Passionate about what you do

What do we do?

How do we fix it?

Essentialism

Essentialism

Surviving
- Air -

Quiz
Which is pretty much true?

a) At rest, when we breathe faster than normal, we increase our cellular oxygen content.
b) At rest, when we breathe slower than normal, we increase our cellular oxygen content.
c) We should breathe perfectly so our cellular oxygen content is perfect.
d) A and C
e) B and C

Oxygen Utilization by Organ

Air and Breathing Facts and Key Points
• O2 is highly reactive and produces ROS

• Brain consumes 20% of the body’s oxygen despite only 2% of overall mass
• Brain very susceptible to damage d/t high oxygen consumption
• Mitochondria utilize O2 to form ATP
• Mitochondria contain ↑ [antioxidants] d/t ↑ ROS environment
• Dysfunctional breathing 7x more prevalent in women (14%) vs men (2%)
• Hyperventilation 6% - 10% of population
• 27% (1 in 4) of children dx with exercise-induced asthma had exercise-induced hyperventilation
• Posture greatly affects breathing. (Why isn’t slouching a disease?)

Breathing Pattern?
1) Hemoglobin carries O2
2) O2 must be delivered

How does haemoglobin know where to deliver Oxygen?

Anemia?

Chasing cars?

Ancient Forms of Medicine Know
2,500 – 5,000 yr
old technique

Why do this?

Why do this?

Key Signs of Dysfunctional Breathing
• Sighing
• Yawning
• Snoring
• Slouching
• Rapid breathing
• Holding breath
• Open mouth
• Internally rotated shoulders
• Firing neck/cervical musculature
• Tight thoracic, psoas and abdominal musculature
• Abdomen not moving

Key Symptoms of Dysfunctional Breathing
• Panic
• Anxiety
• Fatigue
• Sore muscles

Key Solutions for Dysfunctional Breathing
• Adaptogens
• Air purifier
• Allergen identification – food and environmental
• Dust mite covers
• Heat vent location
• Flooring
• Immune support
• Education
• Dental work (open mouth)
• Myofascial work
• Plants
• Neti pot
• Yoga / Stretching
• Stand up desk

Surviving
- Shelter -

Shelter and Health Facts and Figures
• 30% new homes have mold (CNN)

• 93% chronic sinus infections due to mold (Mayo Clinic)
• 100% of all types of mold have potential to cause health effects (EPA)

1. Benzene
2. Carbon dioxide
3. Formaldehyde
4. Napthalene
5. Nitrogen dioxide
6. PAH
7. Radon
8. Trichloroethylene
9. Tetrachloroethylene

( + O2-)
( + O2-)
( + O2-)
( + O2-)

Molybdenum loss high in sweat

Lighting
• Blue light ! Increases alertness

• Red/Amber light ! less likely to disrupt sleep / melatonin / breast feeding / night lights
• Blue-free light ! use prior to bedtime and in bedrooms
Physiological effects of blue and red lights

Shelter Key Points to take to the Clinic
• Environmental questionnaire
• Age of home? New or remodeled has more chemicals.
• Chemicals used in home? Around home?
• Sleep hygiene. E-readers?
• Cooking situation. Gas? Electric? Vent? Frying? Oil types?
• Where feel better? At home? Office? Away from both?
MOLD GAS

Surviving
- Water -

Water Functions (some)
• Transports nutrients
• Lubricates joints and organs
• Transports waste
• Regulates body temperature
• Provides cellular and tissue structure
• Facilitates energy transfer
The Hydration Equation: Update on Water Balance and Cognitive Performance

Water and Thirst Facts and Figures
• Infants = 75% water

• Seniors = 55% water
• [fluid]ec = 1/3rd body’s water and [fluid]ic = 2/3rd body’s water
• 20% of children below EFSA standards
• 40% men and 60% of women meet EFSA standards
• Live 3 days without water
• Types: soft, hard, RO, distilled, spring, well, treated
• 22% of daily water intake comes from food (US) – higher in EU
• Cell membranes less permeable = flow of hormones/nutrients in and waste products out
• Cells and brain shrink when dehydrated ! [ionic]ec > [ionic]ic
• Body water loss of 1 – 2% impairs cognitive performance (1 ½ to 3 lb loss in 150 lb person)
• Fluid balance regulated within 300 ml
• Kidneys suffer when having to concentrate urine (high ATP demand)
• Reabsorbed in the colon by aldosterone
Advances in water intake assessment; Water, Hydration and Health; The Hydration Equation:
Update on Water Balance and Cognitive Performance
Water and Organ Percentage
Plasma 92%
Liver 85%
Lungs 83%
Muscles 79%
Kidneys 79%
Brain 73%
Heart 73%
Skin 64%
Bones 31%
Fat 20%
http://water.usgs.gov/edu/propertyyou.html and Gabriel Cousens

Hydration Evaluation
• Urine specific gravity

• Bioelectrical impedance Thirst Weight
• Plasma osmolality
• Plasma sodium
• Plasma hematocrit
• Subjective salivary signs Urine Color
• Subjective skin lift
• Subjective thirst
• Urinary volume
• Urine color
• Morning, pre-void, body weight measured over 3 days. Variation > 1% = dehydration
• Pre and Post Workout weight
• Pre and Post Sauna weight
The Hydration Equation: Update on Water Balance and Cognitive Performance

Key Signs of Dehydration
• Yellow urine
• Skin pinch test
• Frequent urination

Key Symptoms of Dehydration
• Thirst
• Rapid weight loss
• Frequent urination
• Dry skin
• Skin disorders
• Asthma
• Fatigue
• Headache
• Salt craving?

Key Solutions of Dehydration
• Water purifier
• Spring water
• Education
• Electrolytes
• Adaptogens
• Adrenal cortex
• Little to no caffeine (adrenal support / sleep hygiene)
• Appropriate skin care

Surviving
- Food -

Why do we eat?

"Diets" − Problems with all of them
• High Protein
• High Fat
• Low Carb
• Juicing
• Vegetarian
• Ketogenic
DIETARY INTAKE IS DEPENDENT UPON YOUR PATIENT’s: 
• LIFESTYLE,
• ENVIRONMENT,
• GENETICS,
• MEDICAL CONDITIONS

Never Hungry?

Never hungry? 
WHY?!

Overeating or Drinking 
What Happens? 
It's not good...

Carbs from
Alcohol or Food
Glutathione needed
Aerobic metabolism
Inhibited:
Pseudohypoxia!

NADH ↑
NADH > NAD

Alcohol and Yeast

IL-6 induces
Anaerobic
Leads to
satiety
Alternative Routes

Remember what is inside your home –
and outside of it?! TOTAL LOAD

( + O2-)
( + O2-)
( + O2-)
( + O2-)

Gallbladder

Gallbladder Issues
• Cholelithiasis (85% cholesterol stones)

• “Most prevalent and costly digestive diseases, with at least 20 million Americans affected.”
• d/t:
• obesity,
• insulin resistance
• stress
• 1,000,000 new cases of gallstones/yr ! 700,000 cholecystectomies performed ! 3,000 deaths in US
• $6,000,000,000/yr spent on gallstone disease
• “.. If ratio of bile salts and phospholipids and cholesterol is < ~ 10:1, the bile is lithogenic.”
• “12-14 hrs between evening meal and breakfast leads to a fasting bile saturated with cholesterol.”
• “Cholesterol genesis found in patients with gallstones and bile acid synthesis is reduced.”
• “Bile acid formation inhibits HMG-CoA reductase.” -- what drug does this?
• Rate limiting step of bile acid synthesis = Cytochrome P450 enzyme (CYP7A1)
Biliary lipids and cholesterol gallstone disease; Essentials of Medical Biochemistry, Ch. 17

http://www.usmle-forums.com/usmle-step-1-mnemonics/17611-p450-inducers-p450-inhibitors-mnemonics.html
CYTP450 Inhibitors and Promoters
CYP450 inducers  CYP450 inhibitors 
   
Barbituates  Valproate 
St. John's wort  Isoniazid 
Carbamazepine  Cimetidine 
Rifampin  Ketoconazole 
Alcohol (chronic)  Sulfonamides 
Phenytoin  Fluconazole 
Griseofulvin  Alcohol (acute) 
Phenobarbital  Chloramphenicol 
Sulfonylureas Erythromycin (macrolides) 
Amiodarone 
Omeprazole 
Grapefruit juice 
Quinidine

What medical condition
commonly has gallbladder
issues?

163
Protein: 
Balancing Act

GAPS
Paleo
Fitness
Vegans
Vegetarians
Carbotarians
Fitness

Organic Food:
Important?

173
Bonus Info

Ghee 482o F 250o C
180
Take Home Points
• Food is for fuel and rebuilding

• Fuel cannot be utilized if mitochondria are not working
• Nitrogen balance is important. Evaluate ~ 1 g/2.2 lbs body weight for protein intake.
• No diet is ‘the one’. Must be evaluated depending upon the patient’s s/sx
• Food organic, free range, grass fed, home grown – as much as possible
• Excessive glucose is harmful
• Excessive protein is harmful
• Excessive fat is harmful
• Insulin resistance is partially due to NADH excess, bile stagnation and NOS imbalance
• Pseudohypoxia can be just as harmful as hypoxia
• Microbiome contributes to water-soluble nutrient levels. Testing results?
• AKG, Molybdenum, Citrulline, Thiamine and Potassium - ones to watch – or try empirically.

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Disclaimer & Disclosures

(c) 2015: Benjamin Lynch, ND 1

(c) 2015: Benjamin Lynch, ND 2

(c) 2015: Benjamin Lynch, ND 7

(c) 2015: Benjamin Lynch, ND 10

Mitochondrial complexes IMPORT product from nDNA in order to function

(c) 2015: Benjamin Lynch, ND 14

(c) 2015: Benjamin Lynch, ND 18

(c) 2015: Benjamin Lynch, ND 21

(c) 2015: Benjamin Lynch, ND 23

(c) 2015: Benjamin Lynch, ND 24

(c) 2015: Benjamin Lynch, ND 25

(c) 2015: Benjamin Lynch, ND 26

(c) 2015: Benjamin Lynch, ND 32

(c) 2015: Benjamin Lynch, ND 34

Passionate about what you do

(c) 2015: Benjamin Lynch, ND 35

(c) 2015: Benjamin Lynch, ND 38

(c) 2015: Benjamin Lynch, ND 46

(c) 2015: Benjamin Lynch, ND 51

(c) 2015: Benjamin Lynch, ND 54

(c) 2015: Benjamin Lynch, ND 57

Which is pretty much true?

(c) 2015: Benjamin Lynch, ND 58

(c) 2015: Benjamin Lynch, ND 59

• O2 is highly reactive and produces ROS

(c) 2015: Benjamin Lynch, ND 60

(c) 2015: Benjamin Lynch, ND 64

(c) 2015: Benjamin Lynch, ND 65

(c) 2015: Benjamin Lynch, ND 66

(c) 2015: Benjamin Lynch, ND 67

(c) 2015: Benjamin Lynch, ND 73

(c) 2015: Benjamin Lynch, ND 74

(c) 2015: Benjamin Lynch, ND 75

(c) 2015: Benjamin Lynch, ND 87

(c) 2015: Benjamin Lynch, ND 88

(c) 2015: Benjamin Lynch, ND 89

(c) 2015: Benjamin Lynch, ND 90

• 30% new homes have mold (CNN)

(c) 2015: Benjamin Lynch, ND 92

(c) 2015: Benjamin Lynch, ND 95

(c) 2015: Benjamin Lynch, ND 97

(c) 2015: Benjamin Lynch, ND 109

• Blue light ! Increases alertness

Physiological effects of blue and red lights

(c) 2015: Benjamin Lynch, ND 116

(c) 2015: Benjamin Lynch, ND 117

The Hydration Equation: Update on Water Balance and Cognitive Performance

• Infants = 75% water

http://water.usgs.gov/edu/propertyyou.html and Gabriel Cousens

• Urine specific gravity

The Hydration Equation: Update on Water Balance and Cognitive Performance

(c) 2015: Benjamin Lynch, ND 133

(c) 2015: Benjamin Lynch, ND 135

(c) 2015: Benjamin Lynch, ND 136

(c) 2015: Benjamin Lynch, ND 137

(c) 2015: Benjamin Lynch, ND 139

DIETARY INTAKE IS DEPENDENT UPON YOUR PATIENT’s:

(c) 2015: Benjamin Lynch, ND 142

(c) 2015: Benjamin Lynch, ND 144

(c) 2015: Benjamin Lynch, ND 145

(c) 2015: Benjamin Lynch, ND 146

(c) 2015: Benjamin Lynch, ND 151

DIETARY INTAKE IS DEPENDENT UPON YOUR PATIENT’s: 